Losartan inhibits endothelial-to-mesenchymal transformation in mitral valve endothelial cells by blocking transforming growth factor-β-induced phosphorylation of ERK

Biochemical and Biophysical Research Communications

Volumn 446, Issue 4, 2014, Pages 870-875

  Wylie Sears, Jill ^a   Levine, Robert A ^b   Bischoff, Joyce ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Endothelial cells; Endothelial to mesenchymal transformation; ERK; Losartan; Mitral valve; TGF

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN II; GELATINASE A; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE; SMAD3 PROTEIN; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL CELL; ARTICLE; CAROTID ARTERY; CELL TRANSFORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENDOTHELIAL TO MESENCHYMAL TRANSFORMATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENE EXPRESSION; INTRACELLULAR SIGNALING; MITRAL VALVE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ENDOTHELIAL CELLS; ENDOTHELIAL TO MESENCHYMAL TRANSFORMATION; ERK; LOSARTAN; MITRAL VALVE; TGFΒ;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; CELLS, CULTURED; ENDOTHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; LOSARTAN; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITRAL VALVE; PHOSPHORYLATION; RECEPTORS, ANGIOTENSIN; RECOMBINANT PROTEINS; SHEEP; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84899494057     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.03.014     Document Type: Article

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