-
1
-
-
84981839006
-
The rate of mutation of human genes
-
Haldane JB. The rate of mutation of human genes. Hereditas 1949; 35:267-273.
-
(1949)
Hereditas
, vol.35
, pp. 267-273
-
-
Haldane, J.B.1
-
2
-
-
84861344450
-
Haemoglobinopathies and the clinical epidemiology of malaria: A systematic review and meta-analysis
-
Taylor SM, Parobek CM, Fairhurst RM. Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta-analysis. Lancet Infect Dis 2012; 12:457-468.
-
(2012)
Lancet Infect Dis
, vol.12
, pp. 457-468
-
-
Taylor, S.M.1
Parobek, C.M.2
Fairhurst, R.M.3
-
3
-
-
33947697792
-
X-linked G6PD deficiency protects hemizygous males but not heterozygous females against severe malaria
-
Guindo A, Fairhurst RM, Doumbo OK, et al. X-linked G6PD deficiency protects hemizygous males but not heterozygous females against severe malaria. PLoS Med 2007; 4:e66.
-
(2007)
PLoS Med
, vol.4
-
-
Guindo, A.1
Fairhurst, R.M.2
Doumbo, O.K.3
-
4
-
-
36849062993
-
Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting
-
Rowe JA, Handel IG, Thera MA, et al. Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting. Proc Natl Acad Sci USA 2007; 104:17471-17476.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 17471-17476
-
-
Rowe, J.A.1
Handel, I.G.2
Thera, M.A.3
-
5
-
-
34249679269
-
Hemoglobin variants and disease manifestations in severe falciparum malaria
-
May J, Evans JA, Timmann C, et al. Hemoglobin variants and disease manifestations in severe falciparum malaria. JAMA 2007; 297:2220-2226.
-
(2007)
JAMA
, vol.297
, pp. 2220-2226
-
-
May, J.1
Evans, J.A.2
Timmann, C.3
-
6
-
-
27644566200
-
Negative epistasis between the malaria-protective effects of alpha\+-thalassemia and the sickle cell trait
-
Williams TN, Mwangi TW, Wambua S, et al. Negative epistasis between the malaria-protective effects of alpha\+-thalassemia and the sickle cell trait. Nat Genet 2005; 37:1253-1257.
-
(2005)
Nat Genet
, vol.37
, pp. 1253-1257
-
-
Williams, T.N.1
Mwangi, T.W.2
Wambua, S.3
-
7
-
-
11344284113
-
Host polymorphisms and the incidence of malaria in Ugandan children
-
Parikh S, Dorsey G, Rosenthal PJ. Host polymorphisms and the incidence of malaria in Ugandan children. Am J Trop Med Hyg 2004; 71:750-753.
-
(2004)
Am J Trop Med Hyg
, vol.71
, pp. 750-753
-
-
Parikh, S.1
Dorsey, G.2
Rosenthal, P.J.3
-
8
-
-
0035891266
-
Haemoglobin C protects against clinical Plasmodium falciparum malaria
-
Modiano D, Luoni G, Sirima BS, et al. Haemoglobin C protects against clinical Plasmodium falciparum malaria. Nature 2001; 414:305-308.
-
(2001)
Nature
, vol.414
, pp. 305-308
-
-
Modiano, D.1
Luoni, G.2
Sirima, B.S.3
-
9
-
-
0032926908
-
Influence of hemoglobin e trait on the severity of falciparum malaria
-
Hutagalung R, Wilairatana P, Looareesuwan S, et al. Influence of hemoglobin E trait on the severity of falciparum malaria. J Infect Dis 1999; 179:283-286.
-
(1999)
J Infect Dis
, vol.179
, pp. 283-286
-
-
Hutagalung, R.1
Wilairatana, P.2
Looareesuwan, S.3
-
11
-
-
79954524464
-
A role for fetal hemoglobin and maternal immune IgG in infant resistance to Plasmodium falciparum malaria
-
Amaratunga C, Lopera-Mesa TM, Brittain NJ, et al. A role for fetal hemoglobin and maternal immune IgG in infant resistance to Plasmodium falciparum malaria. PloS One 2011; 6:e14798.
-
(2011)
PloS One
, vol.6
-
-
Amaratunga, C.1
Lopera-Mesa, T.M.2
Brittain, N.J.3
-
12
-
-
0020637632
-
Falciparum malaria and beta-thalassaemia trait in northern Liberia
-
Willcox M, Bjorkman A, Brohult J. Falciparum malaria and beta-thalassaemia trait in northern Liberia. Ann Trop Med Parasitol 1983; 77:335-347.
-
(1983)
Ann Trop Med Parasitol
, vol.77
, pp. 335-347
-
-
Willcox, M.1
Bjorkman, A.2
Brohult, J.3
-
13
-
-
22044457291
-
Both heterozygous and homozygous alpha\+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya
-
Williams TN, Wambua S, Uyoga S, et al. Both heterozygous and homozygous alpha\+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya. Blood 2005; 106:368-371.
-
(2005)
Blood
, vol.106
, pp. 368-371
-
-
Williams, T.N.1
Wambua, S.2
Uyoga, S.3
-
14
-
-
0017077503
-
The resistance factor to Plasmodium vivax in blacks. The Duffy-blood-group genotype
-
Miller LH, Mason SJ, Clyde DF, McGinniss MH. The resistance factor to Plasmodium vivax in blacks. The Duffy-blood-group genotype. N Engl J Med 1976; 295:302-304.
-
(1976)
N Engl J Med
, vol.295
, pp. 302-304
-
-
Miller, L.H.1
Mason, S.J.2
Clyde, D.F.3
McGinniss, M.H.4
-
15
-
-
0345827588
-
A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria
-
Cockburn IA, Mackinnon MJ, O'Donnell A, et al. A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria. Proc Natl Acad Sci USA 2004; 101:272-277.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 272-277
-
-
Cockburn, I.A.1
MacKinnon, M.J.2
O'Donnell, A.3
-
16
-
-
42549137072
-
Pyruvate kinase deficiency and malaria
-
Ayi K, Min-Oo G, Serghides L, et al. Pyruvate kinase deficiency and malaria. N Engl J Med 2008; 358:1805-1810.
-
(2008)
N Engl J Med
, vol.358
, pp. 1805-1810
-
-
Ayi, K.1
Min-Oo, G.2
Serghides, L.3
-
17
-
-
0024996858
-
Growth of Plasmodium falciparum in human erythrocytes containing abnormal membrane proteins
-
Schulman S, Roth EF Jr, Cheng B, et al. Growth of Plasmodium falciparum in human erythrocytes containing abnormal membrane proteins. Proc Natl Acad Sci USA 1990; 87:7339-7343.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 7339-7343
-
-
Schulman, S.1
Roth Jr., E.F.2
Cheng, B.3
-
18
-
-
0028810385
-
Ovalocytosis and cerebral malaria
-
Genton B, Al-Yaman F, Mgone CS, et al. Ovalocytosis and cerebral malaria. Nature 1995; 378:564-565.
-
(1995)
Nature
, vol.378
, pp. 564-565
-
-
Genton, B.1
Al-Yaman, F.2
Mgone, C.S.3
-
19
-
-
84856408211
-
-
World Health Organization Geneva
-
World Health Organization. World Malaria Report 2011. Geneva, 2012.
-
(2012)
World Malaria Report 2011
-
-
-
20
-
-
77956544478
-
The international limits and population at risk of Plasmodium vivax transmission in 2009
-
Guerra CA, Howes RE, Patil AP, et al. The international limits and population at risk of Plasmodium vivax transmission in 2009. PLoS Negl Trop Dis 2010; 4:e774.
-
(2010)
PLoS Negl Trop Dis
, vol.4
-
-
Guerra, C.A.1
Howes, R.E.2
Patil, A.P.3
-
21
-
-
77955027421
-
Estimating the global clinical burden of Plasmodium falciparum malaria in 2007
-
Hay SI, Okiro EA, Gething PW, et al. Estimating the global clinical burden of Plasmodium falciparum malaria in 2007. PLoS Med 2010; 7:e1000290.
-
(2010)
PLoS Med
, vol.7
-
-
Hay, S.I.1
Okiro, E.A.2
Gething, P.W.3
-
22
-
-
84866524806
-
Genome-wide association study indicates two novel resistance loci for severe malaria
-
Timmann C, Thye T, Vens M, et al. Genome-wide association study indicates two novel resistance loci for severe malaria. Nature 2012; 489:443-446.
-
(2012)
Nature
, vol.489
, pp. 443-446
-
-
Timmann, C.1
Thye, T.2
Vens, M.3
-
23
-
-
77950255546
-
Genetic variation in human HBB is associated with Plasmodium falciparum transmission
-
Gouagna LC, Bancone G, Yao F, et al. Genetic variation in human HBB is associated with Plasmodium falciparum transmission. Nat Genet 2010; 42:328-331.
-
(2010)
Nat Genet
, vol.42
, pp. 328-331
-
-
Gouagna, L.C.1
Bancone, G.2
Yao, F.3
-
24
-
-
84860327229
-
Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait
-
Gong L, Maiteki-Sebuguzi C, Rosenthal PJ, et al. Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait. Blood 2012; 119:3808-3814.
-
(2012)
Blood
, vol.119
, pp. 3808-3814
-
-
Gong, L.1
Maiteki-Sebuguzi, C.2
Rosenthal, P.J.3
-
25
-
-
84859024250
-
Iron deficiency protects against severe Plasmodium falciparum malaria and death in young children
-
Gwamaka M, Kurtis JD, Sorensen BE, et al. Iron deficiency protects against severe Plasmodium falciparum malaria and death in young children. Clin Infect Dis 2012; 54:1137-1144.
-
(2012)
Clin Infect Dis
, vol.54
, pp. 1137-1144
-
-
Gwamaka, M.1
Kurtis, J.D.2
Sorensen, B.E.3
-
26
-
-
84866669398
-
Reduced risk of Plasmodium vivax malaria in Papua New Guinean children with Southeast Asian ovalocytosis in two cohorts and a case-control study
-
Rosanas-Urgell A, Lin E, Manning L, et al. Reduced risk of Plasmodium vivax malaria in Papua New Guinean children with Southeast Asian ovalocytosis in two cohorts and a case-control study. PLoS Med 2012; 9:e1001305.
-
(2012)
PLoS Med
, vol.9
-
-
Rosanas-Urgell, A.1
Lin, E.2
Manning, L.3
-
27
-
-
72149127949
-
Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians
-
Louicharoen C, Patin E, Paul R, et al. Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians. Science 2009; 326:1546-1549.
-
(2009)
Science
, vol.326
, pp. 1546-1549
-
-
Louicharoen, C.1
Patin, E.2
Paul, R.3
-
28
-
-
77953266955
-
The impact of phenotypic and genotypic G6PD deficiency on risk of Plasmodium vivax infection: A case-control study amongst Afghan refugees in Pakistan
-
Leslie T, Briceno M, Mayan I, et al. The impact of phenotypic and genotypic G6PD deficiency on risk of Plasmodium vivax infection: a case-control study amongst Afghan refugees in Pakistan. PLoS Med 2010; 7:e1000283.
-
(2010)
PLoS Med
, vol.7
-
-
Leslie, T.1
Briceno, M.2
Mayan, I.3
-
29
-
-
84878481415
-
Hemoglobinopathies: Slicing the Gordian knot of Plasmodium falciparum malaria pathogenesis
-
Taylor SM, Cerami C, Fairhurst RM. Hemoglobinopathies: slicing the Gordian knot of Plasmodium falciparum malaria pathogenesis. PLoS Pathog 2013; 9:e1003327.
-
(2013)
PLoS Pathog
, vol.9
-
-
Taylor, S.M.1
Cerami, C.2
Fairhurst, R.M.3
-
30
-
-
82855184916
-
Hemoglobins S and C interfere with actin remodeling in Plasmodium falciparum-infected erythrocytes
-
Cyrklaff M, Sanchez CP, Kilian N, et al. Hemoglobins S and C interfere with actin remodeling in Plasmodium falciparum-infected erythrocytes. Science 2011; 334:1283-1286.
-
(2011)
Science
, vol.334
, pp. 1283-1286
-
-
Cyrklaff, M.1
Sanchez, C.P.2
Kilian, N.3
-
31
-
-
84865151210
-
Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance
-
LaMonte G, Philip N, Reardon J, et al. Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance. Cell Host Microb 2012; 12:187-199.
-
(2012)
Cell Host Microb
, vol.12
, pp. 187-199
-
-
Lamonte, G.1
Philip, N.2
Reardon, J.3
-
32
-
-
80155198402
-
Hemoglobin S and C heterozygosity enhances neither the magnitude nor breadth of antibody responses to a diverse array of Plasmodium falciparum antigens
-
Tan X, Traore B, Kayentao K, et al. Hemoglobin S and C heterozygosity enhances neither the magnitude nor breadth of antibody responses to a diverse array of Plasmodium falciparum antigens. J Infect Dis 2011; 204: 1750-1761.
-
(2011)
J Infect Dis
, vol.204
, pp. 1750-1761
-
-
Tan, X.1
Traore, B.2
Kayentao, K.3
-
33
-
-
79955528559
-
Sickle hemoglobin confers tolerance to Plasmodium infection
-
Ferreira A, Marguti I, Bechmann I, et al. Sickle hemoglobin confers tolerance to Plasmodium infection. Cell 2011; 145:398-409.
-
(2011)
Cell
, vol.145
, pp. 398-409
-
-
Ferreira, A.1
Marguti, I.2
Bechmann, I.3
-
34
-
-
84883628670
-
Biochemical and immunological mechanisms by which sickle cell trait protects against malaria
-
Gong L, Parikh S, Rosenthal PJ, Greenhouse B. Biochemical and immunological mechanisms by which sickle cell trait protects against malaria. Malaria J 2013; 12:317.
-
(2013)
Malaria J
, vol.12
, pp. 317
-
-
Gong, L.1
Parikh, S.2
Rosenthal, P.J.3
Greenhouse, B.4
-
35
-
-
21344463107
-
Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria
-
Fairhurst RM, Baruch DI, Brittain NJ, et al. Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria. Nature 2005; 435:1117-1121.
-
(2005)
Nature
, vol.435
, pp. 1117-1121
-
-
Fairhurst, R.M.1
Baruch, D.I.2
Brittain, N.J.3
-
36
-
-
38949087305
-
Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin
-
Cholera R, Brittain NJ, Gillrie MR, et al. Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin. Proc Natl Acad Sci USA 2008; 105:991-996.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 991-996
-
-
Cholera, R.1
Brittain, N.J.2
Gillrie, M.R.3
-
37
-
-
0004938385
-
Erythrocytic mechanism of sickle cell resistance to malaria
-
Friedman MJ. Erythrocytic mechanism of sickle cell resistance to malaria. Proc Natl Acad Sci USA 1978; 75:1994-1997.
-
(1978)
Proc Natl Acad Sci USA
, vol.75
, pp. 1994-1997
-
-
Friedman, M.J.1
-
38
-
-
0018138792
-
Cellular mechanism for the protective effect of haemoglobin S against P. Falciparum malaria
-
Pasvol G, Weatherall DJ, Wilson RJ. Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malaria. Nature 1978; 274: 701-703.
-
(1978)
Nature
, vol.274
, pp. 701-703
-
-
Pasvol, G.1
Weatherall, D.J.2
Wilson, R.J.3
-
39
-
-
48649100900
-
The genomic analysis of erythrocyte microRNA expression in sickle cell diseases
-
Chen SY, Wang Y, Telen MJ, Chi JT. The genomic analysis of erythrocyte microRNA expression in sickle cell diseases. PloS One 2008; 3: e2360.
-
(2008)
PloS One
, vol.3
-
-
Chen, S.Y.1
Wang, Y.2
Telen, M.J.3
Chi, J.T.4
-
40
-
-
84877258007
-
Treatment of HCV infection by targeting microRNA
-
Janssen HL, Reesink HW, Lawitz EJ, et al. Treatment of HCV infection by targeting microRNA. N Engl J Med 2013; 368:1685-1694.
-
(2013)
N Engl J Med
, vol.368
, pp. 1685-1694
-
-
Janssen, H.L.1
Reesink, H.W.2
Lawitz, E.J.3
-
41
-
-
22144467359
-
An immune basis for malaria protection by the sickle cell trait
-
Williams TN, Mwangi TW, Roberts DJ, et al. An immune basis for malaria protection by the sickle cell trait. PLoS Med 2005; 2:e128.
-
(2005)
PLoS Med
, vol.2
-
-
Williams, T.N.1
Mwangi, T.W.2
Roberts, D.J.3
-
42
-
-
80052319291
-
Microvascular sequestration of Plasmodium falciparum
-
Beaudry JT, Fairhurst RM. Microvascular sequestration of Plasmodium falciparum. Blood 2011; 117:6410-6410.
-
(2011)
Blood
, vol.117
, pp. 6410-6410
-
-
Beaudry, J.T.1
Fairhurst, R.M.2
|