X-linked G6PD deficiency protects hemizygous males but not heterozygous females against severe malaria

PLoS Medicine

Volumn 4, Issue 3, 2007, Pages 516-522

  Guindo, Aldiouma ^a,b   Fairhurst, Rick M ^b   Doumbo, Ogobara K ^a   Wellems, Thomas E ^b   Diallo, Dapa A ^a  

^a UNIVERSITY OF BAMAKO   (Mali)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE A; GLUCOSE-6-PHOSPHATE DEHYDROGENASE A-;

ARTICLE; BRAIN MALARIA; CHILD; CONTROLLED STUDY; ENDEMIC DISEASE; ETHNICITY; FEMALE; GLYCOGEN STORAGE DISEASE TYPE 1; HEMIZYGOSITY; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALARIA; MALE; MOSAICISM; PARASITE; X CHROMOSOME LINKED DISORDER; ALLELE; CASE CONTROL STUDY; GENETIC SELECTION; GENETICS; GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY; HETEROZYGOTE; IMMUNOLOGY; INNATE IMMUNITY; MALI; PRESCHOOL CHILD; SEX DIFFERENCE; X CHROMOSOMAL INHERITANCE; X CHROMOSOME;

ALLELES; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, X; FEMALE; GENES, X-LINKED; GENETIC DISEASES, X-LINKED; GLUCOSEPHOSPHATE DEHYDROGENASE; GLUCOSEPHOSPHATE DEHYDROGENASE DEFICIENCY; HETEROZYGOTE; HUMANS; IMMUNITY, INNATE; MALARIA; MALE; MALI; SELECTION, GENETIC; SEX FACTORS;

EID: 33947697792     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.0040066     Document Type: Article

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