Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria

Nature

Volumn 435, Issue 7045, 2005, Pages 1117-1121

  Fairhurst, Rick M ^a   Baruch, Dror I ^a   Brittain, Nathaniel J ^a   Ostera, Graciela R ^a   Wallach, John S ^a   Hoang, Holly L ^b   Hayton, Karen ^a   Guindo, Aldiouma ^c   Makobongo, Morris O ^a   Schwartz, Owen M ^a   Tounkara, Anatole ^d   Doumbo, Ogobara K ^c   Diallo, Dapa A ^c   Fujioka, Hisashi ^e   Ho, May ^b   Wellems, Thomas E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF BAMAKO   (Mali)

^d Ministry of Health   (Mali)

^e CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CYTOLOGY; DISEASE CONTROL; DISEASES; HEMOGLOBIN; MUTAGENESIS;

ERYTHROSITE; MALARIA; MUTATION; PLASMODIUM FALCIPARUM;

CELLS;

BETA GLOBIN; BIOLOGICAL MARKER; CD36 ANTIGEN; CELL ADHESION MOLECULE; GLUTAMIC ACID; HEMOGLOBIN A; HEMOGLOBIN C; INTERCELLULAR ADHESION MOLECULE 1; LIGAND; LYSINE; MEMBRANE PROTEIN; PFEMP 1 PROTEIN; PLASMODIUM FALCIPARUM ERYTHROCYTE MEMBRANE PROTEIN 1; UNCLASSIFIED DRUG;

MEDICINE;

AMINO ACID SUBSTITUTION; ANTIGEN EXPRESSION; ARTICLE; CELL SURFACE; CONTROLLED STUDY; ENDOTHELIUM CELL; ERYTHROCYTE; ERYTHROCYTE ADHESIVENESS; HEMAGGLUTINATION; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; INFECTION RESISTANCE; MALARIA; MALARIA FALCIPARUM; MICROVASCULATURE; MONOLAYER CULTURE; MUTATION; NEGRO; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; ROSETTE FORMATION; SENESCENCE; SURFACE PROPERTY;

ANIMALS; ANTIBODIES; ANTIGENS, CD36; CELL ADHESION; ERYTHROCYTE AGGREGATION; ERYTHROCYTES; FLOW CYTOMETRY; HEMEPROTEINS; HEMOGLOBIN C; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MALARIA; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS;

PLASMODIUM FALCIPARUM;

EID: 21344463107     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03631     Document Type: Article

References (30)

1. Agarwal, A. et al. Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S. Blood 96, 2358-2363 (2000).
2. Modiano, D. et al. Haemoglobin C protects against clinical Plasmodium falciparum malaria. Nature 414, 305-308 (2001).
3. Flint, J., Harding, R. M., Boyce, A. J. & Clegg, J. B. The population genetics of the haemoglobinopathies. Baillieres Clin. Haematol. 11, 1-51 (1998).
4. Allison, A. C. Genetic factors in resistance to malaria. Ann. NY Acad. Sci. 91, 710-729 (1961).
5. Friedman, M. J., Roth, E. F., Nagel, R. L. & Trager, W. The role of hemoglobins C, S, and Nbalt in the inhibition of malaria parasite development in vitro. Am. J. Trop. Med. Hyg. 28, 777-780 (1979).
6. Fairhurst, R. M., Fujioka, H., Hayton, K., Collins, K. F. & Wellems, T. E. Aberrant development of Plasmodium falciparum in hemoglobin CC red cells: implications for the malaria protective effect of the homozygous state. Blood 101, 3309-3315 (2003).
7. Miller, L. H., Baruch, D. I., Marsh, K. & Doumbo, O. K. The pathogenic basis of malaria. Nature 415, 673-679 (2002).
8. Baruch, D. I. et al. Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes. Cell 82, 77-87 (1995).
9. Rowe, J. A., Moulds, J. M., Newbold, C. I. & Miller, L. H. P. falciparum resetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1. Nature 388, 292-295 (1997).
10. Yipp, B. G. et al. Synergism of multiple adhesion molecules in mediating cytoadherence of Plasmodium falciparum-infected erythrocytes to microvascular endothelial cells under flow. Blood 96, 2292-2298 (2000).
11. Rowe, A., Obeiro, J., Newbold, C. I. & Marsh, K. Plasmodium falciparum resetting is associated with malaria severity in Kenya. Infect. Immun. 63, 2323-2326 (1995).
12. Marsh, K., Otoo, L., Hayes, R. I., Carson, D. C. & Greenwood, B. M. Antibodies to blood stage antigens of Plasmodium falciparum in rural Gambians and their relation to protection against infection. Trans. R. Soc. Trop. Med. Hyg. 83, 293-303 (1989).
13. Bull, P. C. et al. Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria. Nature Med. 4, 358-360 (1998).
14. Crabb, B. S. et al. Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress. Cell 89, 287-296 (1997).
15. Oh, S. S. et al. Plasmodium falciparum erythrocyte membrane protein 1 is anchored to the actin-spectrin junction and knob-associated histidine-rich protein in the erythrocyte skeleton. Mol. Biochem. Parasitol. 108, 237-247 (2000).
16. Arie, T., Fairhurst, R. M., Brittain, N. J., Wellems, T. E. & Dvorak, J. A. Hemoglobin C modulates the surface topology of Plasmodium falciparum-infected erythrocytes. J. Struct. Biol. 50, 163-169 (2005).
17. Williams, A. R. & Morris, D. R. The internal viscosity of the human erythrocyte may determine its lifespan in vivo. Scand. J. Haematol. 24, 57-62 (1980).
18. Huisman, T. H. Chromatographic separation of hemoglobins A 2 and C. The quantities of hemoglobin A 2 in patients with AC trait, CC disease, and C-β-thalassemia. Clin. Chim. Acta 40, 159-163 (1972).
19. Bunn, H. F. et al. Molecular and cellular pathogenesis of hemoglobin SC disease. Proc. Natl Acad. Sci. USA 79, 7527-7531 (1982).
20. Charache, S., Conley, C. L., Waugh, D. F., Ugoretz, R. J. & Spurrell, J. R. Pathogenesis of hemolytic anemia in homozygous hemoglobin C disease. J. Clin. Invest. 46, 1795-1811 (1967).
21. Murphy, J. R. Influence of temperature and method of centrifugation on the separation of erythrocytes. J. Lab. Clin. Med. 82, 334-341 (1973).
22. Low, P. S., Waugh, S. M., Zinke, K. & Drenckhahn, D. The role of hemoglobin denaturation and band 3 clustering in red blood cell aging. Science 227, 531-533 (1985).
23. MacDonald, V. W. & Charache, S. Drug-induced oxidation and precipitation of hemoglobins A. S and C. Biochim. Biophys. Acta 701, 39-44 (1982).
24. Kaul, D. K., Roth, E. F. Jr, Nagel, R. L., Howard, R. J. & Handunnetti, S. M. Resetting of Plasmodium falciparum-infected red blood cells with uninfected red blood cells enhances microvascular obstruction under flow conditions. Blood 78, 812-819 (1991).
25. MacPherson, G. G., Warrell, M. J., White, N. J., Looareesuwan, S. & Warrell, D. A. Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration. Am. J. Pathol. 119, 385-401 (1985).
26. Ricke, C. H. et al. Plasma antibodies from malaria-exposed pregnant women recognize variant surface antigens on Plasmodium falciparum-infected erythrocytes in a parity-dependent manner and block parasite adhesion to chondroitin sulfate A. J. Immunol. 165, 3309-3316 (2000).
27. Ruwende, C. et al. Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria. Nature 376, 246-249 (1995).
28. Gamain, B. et al. The surface variant antigens of Plasmodium falciparum contain cross-reactive epitopes. Proc. Natl Acad. Sci. USA 98, 2664-2669 (2001).
29. Giribaldi, G., Ulliers, D., Mannu, F., Arese, P. & Turrini, F. Growth of Plasmodium falciparum induces stage-dependent haemichrome formation, oxidative aggregation of band 3, membrane deposition of complement and antibodies, and phagocytosis of parasitized erythrocytes. Br. J. Haematol. 113, 492-499 (2001).
30. Winterbourne, C. C. in CRC Handbook of Methods of Oxygen Radical Research (ed. Greenwald, R. A.) 137-141 (CRC Press, Boca Raton, 1985).