Adenosine triphosphate concentrations are higher in the brain of APOE3- compared to APOE4-targeted replacement mice and can be modulated by curcumin

Genes and Nutrition

Volumn 9, Issue 3, 2014, Pages

  Chin, Dawn ^a   Hagl, Stephanie ^b   Hoehn, Annika ^c   Huebbe, Patricia ^a   Pallauf, Kathrin ^a   Grune, Tilman ^c   Frank, Jan ^d   Eckert, Gunter P ^b   Rimbach, Gerald ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^d UNIVERSITY OF HOHENHEIM   (Germany)

Author keywords

APOE; ATP synthesis; Curcumin; Mice; Mitochondrial function

Indexed keywords

ADENOSINE TRIPHOSPHATE; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; CURCUMIN; GA BINDING PROTEIN; GUANINE ADENINE REPEAT BINDING PROTEIN ALPHA; MESSENGER RNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APOE3 GENE; APOE4 GENE; ARTICLE; BIOGENESIS; BRAIN CORTEX; BRAIN LEVEL; BRAIN TISSUE; CONTROLLED STUDY; DIETARY INTAKE; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION REGULATION;

CURCUMA LONGA; MURINAE; MUS;

EID: 84899487619     PISSN: 15558932     EISSN: 18653499     Source Type: Journal    
DOI: 10.1007/s12263-014-0397-3     Document Type: Article

References (42)

1. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB (2007) Bioavailability of curcumin: problems and promises. Mol Pharm 4(6):807-818. doi:10.1021/ mp700113r
2. Baum L, Lam CW, Cheung SK, Kwok T, Lui V, Tsoh J, Lam L, Leung V, Hui E, Ng C, Woo J, Chiu HF, Goggins WB, Zee BC, Cheng KF, Fong CY, Wong A, Mok H, Chow MS, Ho PC, Ip SP, Ho CS, Yu XW, Lai CY, Chan MH, Szeto S, Chan IH, Mok V (2008) Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease. J Clin Psychopharmacol 28(1):110-113. doi:10.1097/jcp.0b013e318160862c
3. Bhawana Basniwal RK, Buttar HS, Jain VK, Jain N (2011) Curcumin nanoparticles: preparation, characterization, and antimicrobial study. J Agric Food Chem 59(5):2056-2061. doi:10.1021/jf104402t
4. Boesch-Saadatmandi C, Wolffram S, Minihane AM, Rimbach G (2009) Effect of apoE genotype and dietary quercetin on blood lipids and TNF-alpha levels in apoE3 and apoE4 targeted gene replacement mice. Br J Nutr 101(10):1440-1443. doi:10.1017/S0007114508102434
5. Calabrese V, Cornelius C, Dinkova-Kostova AT, Calabrese EJ, Mattson MP (2010) Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid Redox Signal 13(11):1763-1811. doi:10.1089/ars.2009.3074
6. Chandra V, Ganguli M, Pandav R, Johnston J, Belle S, DeKosky ST (1998) Prevalence of Alzheimer's disease and other dementias in rural India: the Indo-US study. Neurology 51(4):1000-1008 (Pubitemid 28473391)
7. Chandra V, Pandav R, Dodge HH, Johnston JM, Belle SH, DeKosky ST, Ganguli M (2001) Incidence of Alzheimer's disease in a rural community in India: the Indo-US study. Neurology 57(6):985-989 (Pubitemid 32880190)
8. Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW (2011) Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease. J Biol Chem 286(7):5215-5221. doi:10.1074/jbc.M110.151084
9. Chen HK, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji ZS, Balestra ME, Walker DW, Xu Q, Jeong DE, Budamagunta MS, Voss JC, Freedman SB, Weisgraber KH, Huang Y, Mahley RW (2012) Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons. J Biol Chem 287(8):5253-5266. doi:10.1074/jbc.M111.276162
10. Chin D, Huebbe P, Pallauf K, Rimbach G (2013) Neuroprotective properties of curcumin in Alzheimer's disease-merits and limitations. Curr Med Chem 20(32):3955-3985
11. Chin D, Huebbe P, Frank J, Rimbach G, Pallauf K (2014) Curcumin may impair iron status when fed to mice for six months. Redox Biology. doi:http://dx.doi.org/10.1016/j.redox.2014.01.018
12. Dikshit P, Goswami A, Mishra A, Chatterjee M, Jana NR (2006) Curcumin induces stress response, neurite outgrowth and prevent NF-kappaB activation by inhibiting the proteasome function. Neurotox Res 9(1):29-37
13. Eckert GP, Renner K, Eckert SH, Eckmann J, Hagl S, Abdel-Kader RM, Kurz C, Leuner K, Muller WE (2012) Mitochondrial dysfunction - a pharmacological target in Alzheimer's disease. Mol Neurobiol 46(1):136-150. doi:10.1007/s12035- 012-8271-z
14. Eckert GP, Schiborr C, Hagl S, Abdel-Kader R, Muller WE, Rimbach G, Frank J (2013) Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse-prone 8. Neurochem Int 62(5):595-602. doi:10.1016/j.neuint.2013.02.014
15. Esatbeyoglu T, Huebbe P, Ernst IM, Chin D, Wagner AE, Rimbach G (2012) Curcumin - from molecule to biological function. Angew Chem Int Ed Engl 51(22):5308-5332. doi:10.1002/anie.201107724
16. Hasima N, Aggarwal BB (2013) Targeting proteasomal pathways by dietary curcumin for cancer prevention and treatment. Curr Med Chem. doi:10.2174/09298673113206660135
17. Hauptmann S, Scherping I, Drose S, Brandt U, Schulz KL, Jendrach M, Leuner K, Eckert A, Muller WE (2009) Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice. Neurobiol Aging 30(10):1574-1586. doi:10.1016/j.neurobiolaging.2007.12.005
18. Hishikawa N, Takahashi Y, Amakusa Y, Tanno Y, Tuji Y, Niwa H, Murakami N, Krishna UK (2012) Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms of dementia. Ayu 33(4):499-504. doi:10.4103/0974- 8520.110524
19. Hondares E, Mora O, Yubero P, Rodriguez de la Concepcion M, Iglesias R, Giralt M, Villarroya F (2006) Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1alpha gene transcription: an autoregulatory loop controls PGC-1alpha expression in adipocytes via peroxisome proliferator-activated receptor-gamma coactivation. Endocrinology 147(6):2829-2838. doi:en.2006-0070
20. Huebbe P, Jofre-Monseny L, Boesch-Saadatmandi C, Minihane AM, Rimbach G (2007) Effect of apoE genotype and vitamin E on biomarkers of oxidative stress in cultured neuronal cells and the brain of targeted replacement mice. J Physiol Pharmacol 58(4):683-698
21. Huebbe P, Nebel A, Siegert S, Moehring J, Boesch-Saadatmandi C, Most E, Pallauf J, Egert S, Muller MJ, Schreiber S, Nothlings U, Rimbach G (2011) APOE epsilon4 is associated with higher vitamin D levels in targeted replacement mice and humans. FASEB J 25(9):3262-3270. doi:10.1096/fj.11-180935
22. Jiao Y, Wilkinson JT, Di X, Wang W, Hatcher H, Kock ND, D'Agostino R Jr, Knovich MA, Torti FM, Torti SV (2009) Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Blood 113(2):462-469. doi:10.1182/blood-2008-05-155952
23. Jofre-Monseny L, Minihane AM, Rimbach G (2008) Impact of apoE genotype on oxidative stress, inflammation and disease risk. Mol Nutr Food Res 52(1):131-145. doi:10.1002/mnfr.200700322 (Pubitemid 351211806)
24. Kamer AR, Craig RG, Pirraglia E, Dasanayake AP, Norman RG, Boylan RJ, Nehorayoff A, Glodzik L, Brys M, de Leon MJ (2009) TNF-alpha and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects. J Neuroimmunol 216(1-2):92-97. doi:10.1016/j.jneuroim.2009.08. 013
25. Knouff C, Hinsdale ME, Mezdour H, Altenburg MK, Watanabe M, Quarfordt SH, Sullivan PM, Maeda N (1999) Apo E structure determines VLDL clearance and atherosclerosis risk in mice. J Clin Invest 103(11):1579-1586. doi:10.1172/JCI6172
26. Mattson MP, Cheng A (2006) Neurohormetic phytochemicals: low-dose toxins that induce adaptive neuronal stress responses. Trends Neurosci 29(11):632-639. doi:10.1016/j.tins.2006.09.001 (Pubitemid 44602260)
27. Ongwijitwat S, Liang HL, Graboyes EM, Wong-Riley MT (2006) Nuclear respiratory factor 2 senses changing cellular energy demands and its silencing down-regulates cytochrome oxidase and other target gene mRNAs. Gene 374:39-49. doi:S0378-1119(06)00041-2
28. Puigserver P, Spiegelman BM (2003) Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev 24(1):78-90 (Pubitemid 36223280)
29. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92(6):829-839 (Pubitemid 28155321)
30. Ringman JM, Frautschy SA, Teng E, Begum AN, Bardens J, Beigi M, Gylys KH, Badmaev V, Heath DD, Apostolova LG, Porter V, Vanek Z, Marshall GA, Hellemann G, Sugar C, Masterman DL, Montine TJ, Cummings JL, Cole GM (2012) Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study. Alzheimers Res Ther 4(5):43. doi:alzrt146
31. Rinwa P, Kaur B, Jaggi AS, Singh N (2010) Involvement of PPAR-gamma in curcumin-mediated beneficial effects in experimental dementia. Naunyn Schmiedebergs Arch Pharmacol 381(6):529-539. doi:10.1007/s00210-010-0511-z
32. Riviere GR, Riviere KH, Smith KS (2002) Molecular and immunological evidence of oral treponema in the human brain and their association with Alzheimer's disease. Oral Microbiol Immunol 17(2):113-118. doi:omi170209
33. Schiborr C, Eckert GP, Rimbach G, Frank J (2010) A validated method for the quantification of curcumin in plasma and brain tissue by fast narrow-bore high-performance liquid chromatography with fluorescence detection. Anal Bioanal Chem 397(5):1917-1925. doi:10.1007/s00216-010-3719-3
34. Sparks Stein P, Steffen MJ, Smith C, Jicha G, Ebersole JL, Abner E, Dawson D 3rd (2012) Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease. Alzheimers Dement 8(3):196-203. doi:10.1016/j.jalz. 2011.04.006
35. Stolzing A, Grune T (2003) Impairment of protein homeostasis and decline of proteasome activity in microglial cells from adult Wistar rats. J Neurosci Res 71(2):264-271. doi:10.1002/jnr.10478 (Pubitemid 36055471)
36. Strittmatter WJ, Roses AD (1996) Apolipoprotein E and Alzheimer's disease. Annu Rev Neurosci 19:53-77. doi:10.1146/annurev.ne.19.030196.000413 (Pubitemid 26080822)
37. Sullivan PM, Mezdour H, Aratani Y, Knouff C, Najib J, Reddick RL, Quarfordt SH, Maeda N (1997) Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. J Biol Chem 272(29):17972-17980 (Pubitemid 27306374)
38. Sullivan PM, Mezdour H, Quarfordt SH, Maeda N (1998) Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2. J Clin Invest 102(1):130-135. doi:10.1172/JCI2673 (Pubitemid 28323839)
39. Tayler H, Fraser T, Miners JS, Kehoe PG, Love S (2010) Oxidative balance in Alzheimer's disease: relationship to APOE, Braak tangle stage, and the concentrations of soluble and insoluble amyloid-beta. J Alzheimers Dis 22(4):1363-1373. doi:10.3233/JAD-2010-101368
40. Vitaglione P, Barone Lumaga R, Ferracane R, Radetsky I, Mennella I, Schettino R, Koder S, Shimoni E, Fogliano V (2012) Curcumin bioavailability from enriched bread: the effect of microencapsulated ingredients. J Agric Food Chem 60(13):3357-3366. doi:10.1021/jf204517k
41. Wang HM, Zhao YX, Zhang S, Liu GD, Kang WY, Tang HD, Ding JQ, Chen SD (2010) PPARgamma agonist curcumin reduces the amyloid-beta-stimulated inflammatory responses in primary astrocytes. J Alzheimers Dis 20(4):1189-1199. doi:10.3233/JAD-2010-091336
42. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM (1999) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98(1):115-124. doi:S0092-8674(00)80611-X