A novel porcine model of ventilator-associated pneumonia caused by oropharyngeal challenge with pseudomonas aeruginosa

Anesthesiology

Volumn 120, Issue 5, 2014, Pages 1205-1215

  Li Bassi, Gianluigi ^a,b,c   Rigol, Montserrat ^a,b   Marti, Joan Daniel ^a,b,c   Saucedo, Lina ^a   Ranzani, Otavio T ^a,c   Roca, Ignasi ^b,d   Cabanas, Maria ^a   Muñoz, Laura ^b,d   Giunta, Valeria ^a,c,d   Luque, Nestor ^a   Rinaudo, Mariano ^a   Esperatti, Mariano ^a,c   Fernandez Barat, Laia ^a,b,c   Ferrer, Miquel ^a,b,c   Vila, Jordi ^b   Ramirez, Jose ^d   Torres, Antoni ^a,b,c,d  

^a HOSPITAL CLÍNIC   (Spain)

^b INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; AUTOPSY; BACTERIAL COLONIZATION; BODY TEMPERATURE; BORDETELLA BRONCHISEPTICA; BREATHING MECHANICS; COLONY FORMING UNIT; CONTROLLED STUDY; ENDOTRACHEAL INTUBATION; ESCHERICHIA COLI; FEMALE; HISTOLOGY; LEUKOCYTE; LEUKOCYTE COUNT; LUNG FUNCTION; LUNG GAS EXCHANGE; LUNG HEMODYNAMICS; LUNG INFECTION; NONHUMAN; OROPHARYNX; PORCINE MODEL; PRIORITY JOURNAL; PROVOCATION TEST; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; PULMONARY SHUNT; RESPIRATION CONTROL; SUPPURATION; TIDAL VOLUME; TRACHEAL ASPIRATION PROCEDURE; VENTILATOR ASSOCIATED PNEUMONIA;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; OROPHARYNX; PNEUMONIA, VENTILATOR-ASSOCIATED; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; SWINE;

EID: 84899484557     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0000000000000222     Document Type: Article

References (45)

1. Infectious Diseases Society of America: Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005; 171:388-416
2. Ibrahim EH, Tracy L, Hill C, Fraser VJ, Kollef MH: The occurrence of ventilator-associated pneumonia in a community hospital: Risk factors and clinical outcomes. Chest 2001; 120:555-61 (Pubitemid 32881275)
3. Rello J, Ollendorf DA, Oster G, Vera-Llonch M, Bellm L, Redman R, Kollef MH; VAP Outcomes Scientific Advisory Group: Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest 2002; 122:2115-21 (Pubitemid 36051151)
4. Warren DK, Shukla SJ, Olsen MA, Kollef MH, Hollenbeak CS, Cox MJ, Cohen MM, Fraser VJ: Outcome and attributable cost of ventilator-associated pneumonia among intensive care unit patients in a suburban medical center. Crit Care Med 2003; 31:1312-7 (Pubitemid 36583837)
5. Rouby JJ, Bouhemad B, Monsel A, Brisson H, Arbelot C, Lu Q; Nebulized Antibiotics Study Group: Aerosolized antibiotics for ventilator-associated pneumonia: Lessons from experimental studies. Anesthesiolog y 2012; 117:1364-80
6. Johanson WG Jr, Holcomb JR, Coalson JJ: Experimental diffuse alveolar damage in baboons. Am Rev Respir Dis 1982; 126:142-51 (Pubitemid 12090872)
7. Campbell GD, Coalson JJ, Johanson WG Jr: The effect of bacterial superinfection on lung function after diffuse alveolar damage. Am Rev Respir Dis 1984; 129:974-8 (Pubitemid 14111756)
8. Crouch TW, Higuchi JH, Coalson JJ, Johanson WG Jr: Pathogenesis and prevention of nosocomial pneumonia in a nonhuman primate model of acute respiratory failure. Am Rev Respir Dis 1984; 130:502-4 (Pubitemid 14029785)
9. Marquette CH, Mensier E, Copin MC, Desmidt A, Freitag L, Witt C, Petyt L, Ramon P: Experimental models of tracheobronchial stenoses: A useful tool for evaluating airway stents. Ann Thorac Surg 1995; 60:651-6
10. Marquette CH, Wallet F, Copin MC, Wermert D, Desmidt A, Ramon P, Courcol R, Tonnel AB: Relationship between microbiologic and histologic features in bacterial pneumonia. Am J Respir Crit Care Med 1996; 154(6 Pt 1):1784-7 (Pubitemid 26424951)
11. Marquette CH, Wermert D, Wallet F, Copin MC, Tonnel AB: Characterization of an animal model of ventilator-acquired pneumonia. Chest 1999; 115:200-9 (Pubitemid 29047076)
12. Li Bassi G, Zanella A, Cressoni M, Stylianou M, Kolobow T: Following tracheal intubation, mucus flow is reversed in the semirecumbent position: Possible role in the pathogenesis of ventilator-associated pneumonia. Crit Care Med 2008; 36:518-25 (Pubitemid 351158628)
13. Panigada M, Berra L, Greco G, Stylianou M, Kolobow T: Bacterial colonization of the respiratory tract following tracheal intubation-effect of gravity: An experimental study. Crit Care Med 2003; 31:729-37 (Pubitemid 36379575)
14. Zanella A, Cressoni M, Epp M, Hoffmann V, Stylianou M, Kolobow T: Effects of tracheal orientation on development of ventilator-associated pneumonia: An experimental study. Intensive Care Med 2012; 38:677-85
15. Goldstein I, Bughalo MT, Marquette CH, Lenaour G, Lu Q, Rouby JJ; Experimental ICU Study Group: Mechanical ventilation-induced air-space enlargement during experimental pneumonia in piglets. Am J Respir Crit Care Med 2001; 163:958-64 (Pubitemid 32275871)
16. Goldstein I, Wallet F, Nicolas-Robin A, Ferrari F, Marquette CH, Rouby JJ: Lung deposition and efficiency of nebulized amikacin during Escherichia coli pneumonia in ventilated piglets. Am J Respir Crit Care Med 2002; 166:1375-81 (Pubitemid 35292705)
17. Luna CM, Baquero S, Gando S, Patrón JR, Morato JG, Sibila O, Absi R, Famiglietti A, Vay CA, Von Stecher F, Agustí C, Torres A: Experimental severe Pseudomonas aeruginosa pneumonia and antibiotic therapy in piglets receiving mechanical ventilation. Chest 2007; 132:523-31 (Pubitemid 47282384)
18. Martinez-Olondris P, Sibila O, Agustí C, Rigol M, Soy D, Esquinas C, Piñer R, Luque N, Guerrero L, Quera MÁ, Marco F, de la Bellacasa JP, Ramirez J, Torres A: An experimental model of pneumonia induced by methicillin-resistant Staphylococcus aureus in ventilated piglets. Eur Respir J 2010; 36:901-6
19. Guide for the care and use of laboratory animals. Washington, D.C., National Academies Press, 2011
20. Li Bassi G, Saucedo L, Marti JD, Rigol M, Esperatti M, Luque N, Ferrer M, Gabarrus A, Fernandez L, Kolobow T, Torres A: Effects of duty cycle and positive end-expiratory pressure on mucus clearance during mechanical ventilation*. Crit Care Med 2012; 40:895-902
21. Farré R, Rotger M, Ferre M, Torres A, Navajas D: Automatic regulation of the cuff pressure in endotracheally-intubated patients. Eur Respir J 2002; 20:1010-3 (Pubitemid 35175142)
22. Martinez-Olondris P, Rigol M, Soy D, Guerrero L, Agusti C, Quera MA, Li Bassi G, Esperatti M, Luque N, Liapikou M, Filella X, Marco F, de la Bellacasa JP, Torres A: Efficacy of linezolid compared to vancomycin in an experimental model of pneumonia induced by methicillin-resistant Staphylococcus aureus in ventilated pigs. Crit Care Med 2012; 40:162-8
23. Fartoukh M, Maitre B, Honoré S, Cerf C, Zahar JR, Brun-Buisson C: Diagnosing pneumonia during mechanical ventilation: The clinical pulmonary infection score revisited. Am J Respir Crit Care Med 2003; 168:173-9 (Pubitemid 36920970)
24. Rouby JJ, Martin De Lassale E, Poete P, Nicolas MH, Bodin L, Jarlier V, Le Charpentier Y, Grosset J, Viars P: Nosocomial bronchopneumonia in the critically ill. Histologic and bacteriologic aspects. Am Rev Respir Dis 1992; 146:1059-66
25. Johanson WG Jr, Seidenfeld JJ, Gomez P, de los Santos R, Coalson JJ: Bacteriologic diagnosis of nosocomial pneumonia following prolonged mechanical ventilation. Am Rev Respir Dis 1988; 137:259-64
26. Johanson WG Jr, Seidenfeld JJ, de los Santos R, Coalson JJ, Gomez P: Prevention of nosocomial pneumonia using topical and parenteral antimicrobial agents. Am Rev Respir Dis 1988; 137:265-72 (Pubitemid 18050169)
27. Sartorius A, Lu Q, Vieira S, Tonnellier M, Lenaour G, Goldstein I, Rouby JJ: Mechanical ventilation and lung infection in the genesis of air-space enlargement. Crit Care 2007; 11:R14
28. Sibila O, Agustí C, Torres A, Baquero S, Gando S, Patrón JR, Morato JG, Goffredo DH, Bassi N, Luna CM: Experimental Pseudomonas aeruginosa pneumonia: Evaluation of the associated inflammatory response. Eur Respir J 2007; 30:1167-72 (Pubitemid 351194765)
29. Sibila O, Luna CM, Agustí C, Baquero S, Gando S, Patrón JR, Morato JG, Absi R, Bassi N, Torres A: Effects of glucocorticoids in ventilated piglets with severe pneumonia. Eur Respir J 2008; 32:1037-46
30. Feldman C, Kassel M, Cantrell J, Kaka S, Morar R, Goolam Mahomed A, Philips JI: The presence and sequence of endotracheal tube colonization in patients undergoing mechanical ventilation. Eur Respir J 1999; 13:546-51 (Pubitemid 29180163)
31. Dullenkopf A, Gerber A, Weiss M: Fluid leakage past tracheal tube cuffs: Evaluation of the new Microcuff endotracheal tube. Intensive Care Med 2003; 29:1849-53 (Pubitemid 37373839)
32. Li Bassi G, Ranzani OT, Marti JD, Giunta V, Luque N, Isetta V, Ferrer M, Farre R, Pimentel GL, Torres A: An in vitro study to assess determinant features associated with fluid sealing in the design of endotracheal tube cuffs and exerted tracheal pressures. Crit Care Med 2013; 41:518-26
33. Zanella A, Scaravilli V, Isgrò S, Milan M, Cressoni M, Patroniti N, Fumagalli R, Pesenti A: Fluid leakage across tracheal tube cuff, effect of different cuff material, shape, and positive expiratory pressure: A bench-top study. Intensive Care Med 2011; 37:343-7
34. Pitts R, Fisher D, Sulemanji D, Kratohvil J, Jiang Y, Kacmarek R: Variables affecting leakage past endotracheal tube cuffs: A bench study. Intensive Care Med 2010; 36:2066-73
35. Lucangelo U, Zin WA, Antonaglia V, Petrucci L, Viviani M, Buscema G, Borelli M, Berlot G: Effect of positive expiratory pressure and type of tracheal cuff on the incidence of aspiration in mechanically ventilated patients in an intensive care unit. Crit Care Med 2008; 36:409-13 (Pubitemid 351158612)
36. van Kaam AH, Lachmann RA, Herting E, De Jaegere A, van Iwaarden F, Noorduyn LA, Kok JH, Haitsma JJ, Lachmann B: Reducing atelectasis attenuates bacterial growth and translocation in experimental pneumonia. Am J Respir Crit Care Med 2004; 169:1046-53 (Pubitemid 38543645)
37. Tilson MD, Bunke MC, Smith GJ, Katz J, Cronau L, Barash PG, Baue AE: Quantitative bacteriology and pathology of the lung in experimental Pseudomonas pneumonia treated with positive end-expiratory pressure (PEEP). Surgery 1977; 82:133-40 (Pubitemid 8127014)
38. Manzano F, Fernández-Mondéjar E, Colmenero M, Poyatos ME, Rivera R, Machado J, Catalán I, Artigas A: Positive-end expiratory pressure reduces incidence of ventilator-associated pneumonia in nonhypoxemic patients. Crit Care Med 2008; 36:2225-31
39. Ouanes I, Lyazidi A, Danin PE, Rana N, Di Bari A, Abroug F, Louis B, Brochard L: Mechanical influences on fluid leakage past the tracheal tube cuff in a benchtop model. Intensive Care Med 2011; 37:695-700
40. Torres A, el-Ebiary M, Padró L, Gonzalez J, de la Bellacasa JP, Ramirez J, Xaubet A, Ferrer M, Rodriguez-Roisin R: Validation of different techniques for the diagnosis of ventilator-associated pneumonia. Comparison with immediate postmortem pulmonary biopsy. Am J Respir Crit Care Med 1994; 149(2 Pt 1):324-31
41. Timsit JF, Misset B, Renaud B, Goldstein FW, Carlet J: Effect of previous antimicrobial therapy on the accuracy of the main procedures used to diagnose nosocomial pneumonia in patients who are using ventilation. Chest 1995; 108:1036-40
42. Souweine B, Veber B, Bedos JP, Gachot B, Dombret MC, Regnier B, Wolff M: Diagnostic accuracy of protected specimen brush and bronchoalveolar lavage in nosocomial pneumonia: impact of previous antimicrobial treatments. Crit Care Med 1998; 26:236-44 (Pubitemid 28082683)
43. Ambrosio AM, Luo R, Fantoni DT, Gutierres C, Lu Q, Gu WJ, Otsuki DA, Malbouisson LM, Auler JO Jr, Rouby JJ; Experimental ARDS Study Group: Effects of positive end-expiratory pressure titration and recruitment maneuver on lung inflammation and hyperinflation in experimental acid aspiration-induced lung injury. Anesthesiolog y 2012; 117:1322-34
44. Adair CG, Gorman SP, Feron BM, Byers LM, Jones DS, Goldsmith CE, Moore JE, Kerr JR, Curran MD, Hogg G, Webb CH, McCarthy GJ, Milligan KR: Implications of endotracheal tube biofilm for ventilator-associated pneumonia. Intensive Care Med 1999; 25:1072-6 (Pubitemid 29525061)
45. Nseir S, Makris D, Mathieu D, Durocher A, Marquette CH: Intensive care unit-acquired infection as a side effect of sedation. Crit Care 2010; 14:R30