An experimental model of pneumonia induced by methicillin-resistant Staphylococcus aureus in ventilated piglets

European Respiratory Journal

Volumn 36, Issue 4, 2010, Pages 901-906

  Martinez Olondris P ^a,c   Sibila, O ^a,c   Agusti C ^a,c   Rigol, M ^a,b,c   Soy, D ^a,c   Esquinas, C ^a,c   Piner R ^a,c   Luque, N ^a,c   Guerrero, L ^a   Quera, M A ^a   Marco, F ^a   De La Bellacasa, J P ^a   Ramirez, J ^a   Torres, A ^a,c  

^a HOSPITAL CLÍNIC   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Animal model; Inflammatory response; Methicillin resistant Staphylococcus aureus; Ventilator associated pneumonia

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; INTERLEUKIN 12; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BRONCHOSCOPY; COLONY FORMING UNIT; DISEASE SEVERITY; EXPERIMENTAL MODEL; HISTOPATHOLOGY; INTUBATION; LUNG LAVAGE; LUNG VENTILATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NECROSIS; NONHUMAN; PIGLET; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; VENTILATOR ASSOCIATED PNEUMONIA;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOLOGICAL MARKERS; BODY WEIGHT; BRONCHOALVEOLAR LAVAGE; DISEASE MODELS, ANIMAL; INFLAMMATION; LUNG; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PNEUMONIA; RESPIRATION, ARTIFICIAL; SWINE; TEMPERATURE; TIME FACTORS;

EID: 77957842902     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00176709     Document Type: Article

References (31)

1. American Thoracic Society, Infectious Diseases Society of America, Guidelines for the management of adults with hospital-acquired, ventilator-associated and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005; 171: 388-416.
2. Marquette CH, Wermert D, Wallet F, et al. Characterization of an animal model of ventilator-acquired pneumonia. Chest 1999; 115: 200-209.
3. Wermert D, Marquette CH, Copin MC, et al. Influence of pulmonary bacteriology and histology on the yield of diagnostic procedures in ventilator-acquired pneumonia. Am J Respir Crit Care Med 1998; 158: 139-147.
4. Goldstein I, Bughalo MT, Marquette CH, et al. Mechanical ventilation-induced air-space enlargement during experimental pneumonia in piglets. Am J Respir Crit Care Med 2001; 163: 958-964.
5. Goldstein I, Wallet F, Nicolas-Robin A, et al. Lung deposition and efficiency of nebulized amikacin during Escherichia coli pneumonia in ventilated piglets. Am J Respir Crit Care Med 2002; 166: 1375-1381.
6. Elman M, Goldstein I, Marquette CH, et al. Influence of lung aeration on pulmonary concentrations of nebulized and intravenous amikacin in ventilated piglets with severe bronchopneumonia. Anesthesiology 2002; 97: 199-206.
7. Tonnellier M, Ferrari F, Goldstein I, et al. Intravenous versus nebulized ceftazidime in ventilated piglets with and without experimental bronchopneumonia: comparative effects of helium and nitrogen. Anesthesiology 2005; 102: 995-1000.
8. Luna CM, Baquero S, Gando S, et al. Experimental severe Pseudomonas aeruginosa pneumonia and antibiotic therapy in piglets receiving mechanical ventilation. Chest 2007; 132: 523-531.
9. Sibila O, Agustí C, Torres A, et al. Experimental Pseudomonas aeruginosa pneumonia: evaluation of the associated inflammatory response. Eur Respir J 2007; 30: 1167-1172. (Pubitemid 351194765)
10. National Nosocomial Infections Surveillance (NNIS) System report, data summary from October 1986 through April 1998. www.cdc.gov/ncidod/dhqp/pdf/nnis/ sar98net.PDF Date last updated, 1998.
11. Kollef MH, Morrow LE, Niederman MS, et al. Clinical characteristics and treatment patterns among patients with ventilator-associated pneumonia. Chest 2006; 129: 1210-1218.
12. Rossi A, Polese G, Brandi G, et al. Intrinsic positive end-expiratory pressure (PEEPi). Intensive Care Med 1995; 21: 522-536.
13. Sibila O, Luna CM, Agustí C, et al. Effects of glucocorticoids in ventilated piglets with severe pneumonia. Eur Respir J 2008; 32: 1037-1046.
14. El-Ebiary M, Torres A, González J, et al. Quantitative cultures of endotracheal aspirates for the diagnosis of ventilator-associated pneumonia. Am Rev Respir Dis 1993; 148: 1552-1557.
15. Balows A, Hausler WJJ, eds. Manual of Clinical Microbiology. 5th Edn. Washington, American Society for Microbiology, 1991.
16. Marquette CH, Copin MC, Wallet F, et al. Diagnostic tests for pneumonia in ventilated patients: prospective evaluation of diagnostic accuracy using histology as a diagnostic gold standard. Am J Respir Crit Care Med 1995; 151: 1878-1888.
17. Bauer TT, Montón C, Torres A, et al. Comparison of systemic cytokine levels in patients with acute respiratory distress syndrome, severe pneumonia, and controls. Thorax 2000; 55: 46-52.
18. US National Institutes of Health. Guide for the Care and Use of Laboratory Animals. http://oacu.od.nih.gov/regs/guide.pdf Date last updated: 1996.
19. Antunes G, Evans SA, Lordan JL, et al. Systemic cytokine levels in community-acquired pneumonia and their association with disease severity. Eur Respir J 2002; 20: 990-995.
20. Cosgrove SE, Sakoulas G, Prencevich EN, et al. Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis. Clin Infect Dis 2003; 36: 53-59.
21. Panlilio AL, Culver DH, Gaynes RP, et al. Methicillin-resistant Staphylococcus aureus in US hospitals, 1975-1991. Infect Control Hosp Epidemiol 1992; 13: 582-586.
22. Maranan MC, Moreira B, Boyle-Vavra S, et al. Antimicrobial resistance in staphylococci: epidemiology, molecular mechanisms, and clinical relevance. Infect Dis Clin North Am 1997; 11: 813-849.
23. Oztoprak N, Cevik MA, Akinci E. Risk factors for ICU-acquired methicillin-resistant Staphylococcus aureus infections. Am J Infect Control. 2006; 34: 1-5.
24. Vincent JL, Bihari DJ, Suter PM, et al. The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee. JAMA 1995; 274: 639-644.
25. Bodi M, Ardonuy C, Rello J. Impact of Gram-positive resistance on outcome of nosocomial pneumonia. Crit Care Med 2001; 29: 82-86.
26. Boucher HW, Corey GR. Epidemiology of methicillin-resistant Staphylococcus aureus. Clin Infect Dis 2008; 46: S344-S349.
27. Kollef MH. Limitations of vancomycin in the management of resistant Staphylococcal Infections. Clin Infect Dis 2007; 45: S191-S195.
28. Wunderink RG, Mendelson MH, Somero MS, et al. Early microbiological response to linezolid versus vancomycin in ventilator-associated pneumonia due to methicillin-resistant Staphylococcus aureus. Chest 2008; 134: 1200-1207.
29. van Dalen R, Vree TB. Pharmacokinetics of antibiotics in critically ill patients. Intensive Care Med 1990; 16: Suppl. 3, S235-S238.
30. Pea F, Porreca L, Baraldo M, et al. High vancomycin dosage regimens required by intensive care unit patients cotreated with drugs to improve haemodynamics following cardiac surgical procedures. J Antimicrob Chemother 2000; 45: 329-335.
31. Luna CM, Bruno DA, García-Morato J, et al. Effect of linezolid compared with glycopeptides in methicillin-resistant Staphylococcus aureus severe pneumonia in piglets. Chest 2009; 135: 1564-1571.