Use and acute toxicity associated with the novel psychoactive substances diphenylprolinol (D2PM) and desoxypipradrol (2-DPMP)

Clinical Toxicology

Volumn 50, Issue 8, 2012, Pages 727-732

  Wood, David M ^a   Dargan, Paul I ^b  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

2 DPMP; Acute toxicity; D2PM; Desoxypipradrol; Diphenyl 2 pyrrolidinemethanol; Diphenylprolinol; Pipradrol; Recreational drugs

Indexed keywords

COCAINE; DESOXYPIPRADROL; DIPHENYLPROLINOL; DOPAMINE; FLUOROTROPACOCAINE; PIPRADOL; PSYCHOTROPIC AGENT; UNCLASSIFIED DRUG;

AGITATION; ANXIETY; ATTENTION DEFICIT DISORDER; BRUXISM; CLINICAL FEATURE; DRUG ACTIVITY; DRUG BINDING; DRUG FATALITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG USE; EUPHORIA; HEART PALPITATION; HUMAN; HYPERTENSION; INSOMNIA; NEUROPSYCHIATRY; NONHUMAN; PREVALENCE; PSYCHOSIS; REVIEW; RISK ASSESSMENT; SWEATING; TACHYCARDIA; THORAX PAIN;

ANIMALS; EUROPE; HUMANS; PIPERIDINES; PSYCHOTROPIC DRUGS; PYRROLIDINES; STREET DRUGS; TIME FACTORS; UNITED STATES;

ANIMALIA;

EID: 84865602440     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650.2012.716158     Document Type: Review

References (29)

1. W ood D M, D argan P I. N ovel psychoactive substances: how to understand the acute toxicity associated with the use of these substances. Ther Drug Monitoring 2012; 34: 363-367.
2. W ood D M, D argan P I. U nderstanding how data triangulation identifi es acute toxicity of novel psychoactive drugs. J Med Toxicol 2012; In press [DOI: 10.1007/s13181-012-0241-3].
3. Prosser JM, Nelson LS. The toxicology of bath salts: a review of synthetic cathinones. J Med Toxicol 2012; 8: 33-42.
4. Hill SL, Thomas SH. Clinical toxicology of newer recreational drugs. Clin Toxicol (Phila) 2011; 49: 705-719.
5. European Monitoring Centre for Drugs and Drug Addiction. Annual Report 2011: The state of the drugs problem in Europe. Available from: http://www.emcdda.europa.eu/attachements.cfm/att-143743-EN-EMCDDA-AR2011-EN.pdf [Last accessed 9th July 2012].
6. Schep LJ, Slaughter RJ, Vale JA, Beasley DM, Gee P. The clinical toxicology of the designer "party pills" benzylpiperazine and trifl uoromethylphenylpiperazine. Clin Toxicol (Phila) 2011; 49: 131-141.
7. Advisory Council on the Misuse of Drugs: Consideration of Desoxypipradrol (2-DPMP) and related pipdradrol compounds. Available from: http://www.homeoffi ce.gov.uk/publications/agenciespublic-bodies/acmd1/desoxypipradrol-report? view-Binary [last accessed 9th July 2012].
8. B ellucci G. ( 2-Diphenylmethyl-piperidine hydrochloride and the methyl ester of 2-chloro-2-phenyl-2-(2-piperidyl)-acetic acid), drugs with waking effect in anaesthesia. Minerva Anestesiologica 1955; 21: 125-128.
9. Davidson C, Ramsey J. Desoxypipradrol is more potent than cocaine on evoked dopamine effl ux in the nucleus accumbens. J Psychopharm 2012; 26: 1036-1041.
10. Pyrrolidine derivatives US patent application. ( Jackson PF and Guildford Pharmaceuticals; Patent number 5,650,521). Available from: http://v3.espacenet. com/origdoc?CY-gb&LG-en&DB-EPODOC&IDX-US5650521&DOC- dcb65d04ab6724e097530cc48c44ebbb62 [Last accessed 9th July 2012].
11. Herbert JX, Daly F, Tracey JA. Whacked. BMJ rapid response 15 July 2010. Available from: http://www.bmj.com/rapid-response/2011/11/02/whacked [Last accessed 9th July 2012].
12. James DA, Potts S, Thomas SHL, Chincholkr VM, Clarke S, Dear J, Ramsey J. Clinical Features associated with recreational use of ' Ivory Wave ' preparations containing desoxypipradrol. Clin Tox (Philad) 2011; 49: 201.
13. Murray DB, Potts S, Haxton C, Jackson G, Sandilands EA, Ramsey J, et al. ' Ivory Wave ' toxicity in recreational drug users: integration of clinical and poisons information services to manage legal high poisoning. Clin Tox (Phila) 2012; 50: 108-113.
14. L idder S, D argan P I, S exton S, B utton J, R amsey J, H olt D W, Wood DM. Cardiovascular toxicity associated with recreational use of diphenylprolinol (diphenyl-2-pyrrolidinemethanol) [D2PM]). J Med Toxicol 2008; 4: 167-169.
15. Wood D M, P uchnarewicz M, Johnston A, Dargan P I. A case series of individuals with analytically confi rmed acute diphenyl-2-pyrrolidinemethanol (D2PM) toxicity. Eur J Clin Pharmacol 2012; 68: 349-353.
16. Drugs Forum. Experiences 2-DPMP/desoxypipradol trip reports. Available from: http://www.drugs-forum.com/forum/showthread.php? t-125430 [Last accessed 9th July 2012].
17. Drugs Forum. Experiences-Diphenyl-2-Pyrrolidinyl-Methanol (diphenylprolinol) trip reports. Available from: http://www.drugsforum. com/forum/showthread.php?t-41534 [Last accessed 9th July 2012].
18. Erowid (2-DPMP) Desoxypipradrol Reports. Available from: https://www.erowid.org/experiences/subs/exp-Desoxypipradrol-.shtml [Last accessed 9th July 2012].
19. Erowid (D2PM) Diphenyl-2-pyrrolidinemethanol Reports. Available from: http://www.erowid.org/experiences/subs/exp-Diphenyl2-pyrrolidinemethanol.shtml [Last accessed 9th July 2012].
20. Blue Ray. Desoxypipradrol-First Experience-5mg. Available from: http://www.bluelight.ru/vb/threads/363832-Desoxypipradrol-First-Experience-5mg [Last accessed 9th July 2012].
21. European Monitoring Centre for Drugs and Drug Addiction. Briefi ng paper: Online sales of new psychoactive substances/' legal highs ': Summary of results from the 2011 multilingual snapshots. Available from: http://www.emcdda.europa. eu/attachements.cfm/att-143801-EN-SnapshotSummary.pdf [Last accessed 9th July 2012].
22. Dick D, Torrance C. Drugs Survey. MixMag 2010; 225: 44-53.
23. Winstock A. Drug Survey. MixMag 2011; 238: 50-59.
24. Winstock A. MixMag/Global Drugs Survey. MixMag 2012; 251: 68-73.
25. M easham F, W ood D M, D argan P I, M oore K. T he rise in legal highs: prevalence and patterns in the use of illegal drugs and fi rst-and second-generation " legal highs " in South London gay dance clubs J Subs Use 2011; 16: 263-272.
26. W ood D M, H unter L, M easham F, D argan P I. L imited use of novel psychoactive substances in South London nightclubs. QJM 2012 In Press.
27. Dargan P I, B utton J, Hawkins L, Archer J R, Ovaska H, Lidder S, et al. Detection of the pharmaceutical agent glaucine as a recreational drug. Eur J Clin Pharmacol 2008; 64: 553-554.
28. Rovinskia VI. A case of hallucinogen-like action of glaucine. Klin Med (Mosk) 1989; 67: 107-108.
29. R ovinskia V I. A cute glaucine syndrome in the physician' s practice: the clinical picture and potential danger. Klin Med (Mosk) 2006; 84: 68-70.