Assessing medication adherence: Options to consider

International Journal of Clinical Pharmacy

Volumn 36, Issue 1, 2014, Pages 55-69

  Lehmann, Audrey ^a,b,c   Aslani, Parisa ^d   Ahmed, Rana ^d   Celio, Jennifer ^e,f   Gauchet, Aurelie ^a,g   Bedouch, Pierrick ^a,b,c   Bugnon, Olivier ^e,f   Allenet, Benoît ^a,b,c   Schneider, Marie Paule ^e,f,h  

^a UNIV GRENOBLE ALPES   (France)

^b LABORATOIRE TIMC IMAG   (France)

^c GRENOBLE UNIVERSITY HOSPITAL   (France)

^d UNIVERSITY OF SYDNEY   (Australia)

^e UNIVERSITY OF GENEVA   (Switzerland)

^f UNIVERSITY OF LAUSANNE   (Switzerland)

^g UNIVERSITÉ GRENOBLE ALPES   (France)

^h POLICLINIQUE MÉDICALE UNIVERSITAIRE   (Switzerland)

Author keywords

Adherence assessment; Electronic monitoring; Medication; Medication adherence; Patient compliance; Pharmacy refills; Prescription claims database; Self report

Indexed keywords

BEHAVIOR CHANGE; CAREGIVER; CHRONIC DISEASE; DRUG SELF ADMINISTRATION; FAMILY; HEALTH CARE; HEALTH CARE PERSONNEL; HEALTH PRACTITIONER; HUMAN; INTERVIEW; LONG TERM CARE; MEDICATION COMPLIANCE; MEMORY BIAS; ORGAN TRANSPLANTATION; PHARMACY; POLYPHARMACY; PRESCRIPTION; PRIORITY JOURNAL; RECALL; REVIEW; SELF EVALUATION; SELF REPORT; SOCIAL DESIRABILITY; TELEPHONE INTERVIEW; TRIANGULATION; VISUAL ANALOG SCALE; DRUG UTILIZATION; ELECTRONIC MEDICAL RECORD; HEALTH INSURANCE; META ANALYSIS; STATISTICS AND NUMERICAL DATA;

CHRONIC DISEASE; DRUG UTILIZATION; ELECTRONIC HEALTH RECORDS; HUMANS; INSURANCE, PHARMACEUTICAL SERVICES; MEDICATION ADHERENCE; SELF REPORT;

EID: 84899473225     PISSN: 22107703     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11096-013-9865-x     Document Type: Review

References (115)

1. Nunes V, Neilson J, O'Flynn N, Calvert N, Kuntze S, Smithson H, et al. Clinical Guidelines and Evidence Review for Medicines Adherence: involving patients in decisions about prescribed medicines and supporting adherence [Internet]. London, National Collaborating Centre for Primary Care and Royal College of General Practitioners; 2009. 364p. [cited 2013 Jul 16]. Available from: http://www.nice.org.uk/nicemedia/pdf/CG76FullGuideline.pdf.
2. Haynes RB, Ackloo E, Sahota N, McDonald HP, Yao X. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2008(2):Cd000011.
3. Golay A. Pharmacoeconomic aspects of poor adherence: can better adherence reduce healthcare costs? J Med Econ. 2011; 14(5):594-608.
4. Gadkari AS, McHorney CA. Medication nonfulfillment rates and reasons: narrative systematic review. Curr Med Res Opin. 2010;26(3):683-705.
5. Haynes RB, McDonald HP, Garg AX. Helping patients follow prescribed treatment: clinical applications. JAMA. 2002; 288(22):2880-3. (Pubitemid 35425074)
6. Sabate E. Adherence to long-term therapies: Evidence for action [Internet]. Geneva: World Health Organisation; 2003. 196 p. [cited 2013 Jul 16]. Available from: http://whqlibdoc.who.int/publications/2003/9241545992.pdf.
7. Vrijens B, De Geest S, Hughes DA, Przemyslaw K, Demonceau J, Ruppar T, et al. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol. 2012;73(5):691-705.
8. Burrell A, Wong P, Ollendorf D, Fuldeore M, Roy A, Fairchild C, et al. Defining compliance/adherence and persistence. ISPOR Special Interest Working Group. Value Health. 2005;8:A194-5.
9. Baudrant-Boga M, Lehmann A, Allenet B. Thinking differently the patient medication compliance: from an injunctive posture to a working alliance between the patient and the healthcare provider: concepts and determinants. Ann Pharm Fr. 2012;70(1):15-25 French.
10. Schneider MP, Herzig L, Hampai DH, Bugnon O. Medication adherence in chronic patients: from its concepts to its management in primary care. Rev Med Suisse. 2013;9(386):1032-6 French.
11. Allenet B, Baudrant M, Lehmann A, Gauchet A, Roustit M, Bedouch P, et al. How can we evaluate medication adherence? What are the methods? Ann Pharm Fr. 2013;71(2):135-41 French.
12. Horne R, Weinman J, Barber N, Elliot R, Morgan M. Concordance, adherence and compliance in medicine taking. London: Report for the National Co-ordinating Centre for NHS Service Delivery and Organisation R & D; 2005.
13. Dunbar-Jacob J, Sereika SM, Houze M, Luyster FS, Callan JA. Accuracy of measures of medication adherence in a cholesterol-lowering regimen. West J Nurs Res. 2012;34(5):578-97.
14. Vollmer WM, Xu M, Feldstein A, Smith D, Waterbury A, Rand C. Comparison of pharmacy-based measures of medication adherence. BMC Health Serv Res. 2012;12:155.
15. McCarberg BH. A critical assessment of opioid treatment adherence using urine drug testing in chronic pain management. Postgrad Med. 2011;123(6):124-31.
16. Cook P, Schmiege S, McClean M, Aagaard L, Kahook M. Practical and analytic issues in the electronic assessment of adherence. West J Nurs Res. 2012;34(5):598-620.
17. Garfield S, Clifford S, Eliasson L, Barber N, Willson A. Suitability of measures of self-reported medication adherence for routine clinical use: a systematic review. BMC Med Res Methodol. 2011;11:149.
18. Spoelstra SL, Given CW. Assessment and measurement of adherence to oral antineoplastic agents. Semin Oncol Nurs. 2011;27(2):116-32.
19. Mora PA, Berkowitz A, Contrada RJ, Wisnivesky J, Horne R, Leventhal H, et al. Factor structure and longitudinal invariance of the Medical Adherence Report Scale-Asthma. Psychol Health. 2011;26(6):713-27.
20. Vervloet M, van Dijk L, Santen-Reestman J, van Vlijmen B, Bouvy ML, de Bakker DH. Improving medication adherence in diabetes type 2 patients through Real Time Medication Monitoring: a randomised controlled trial to evaluate the effect of monitoring patients' medication use combined with short message service (SMS) reminders. BMC Health Serv Res. 2011;11:5.
21. Devulapalli KK, Ignacio RV, Weiden P, Cassidy KA, Williams TD, Safavi R, et al. Why do persons with bipolar disorder stop their medication? Psychopharmacol Bull. 2010;43(3):5-14.
22. Sajatovic M, Velligan DI, Weiden PJ, Valenstein MA, Ogedegbe G. Measurement of psychiatric treatment adherence. J Psychosom Res. 2010;69(6):591-9.
23. Shi L, Liu J, Koleva Y, Fonseca V, Kalsekar A, Pawaskar M. Concordance of adherence measurement using self-reported adherence questionnaires and medication monitoring devices. Pharmacoeconomics. 2010;28(12):1097-107.
24. Nakonezny PA, Hughes CW, Mayes TL, Sternweis-Yang KH, Kennard BD, Byerly MJ, et al. A comparison of various methods of measuring antidepressant medication adherence among children and adolescents with major depressive disorder in a 12-week open trial of fluoxetine. J Child Adolesc Psychopharmacol. 2010;20(5):431-9.
25. Shi L, Liu J, Fonseca V, Walker P, Kalsekar A, Pawaskar M. Correlation between adherence rates measured by MEMS and self-reported questionnaires: a meta-analysis. Health Qual Life Outcomes. 2010;8:99.
26. Carter BL, van Mil JWF. Comparative effectiveness research: evaluating pharmacist interventions and strategies to improve medication adherence. Am J Hypertens. 2010;23(9):949-55.
27. Velligan D, Sajatovic M, Valenstein M, Riley WT, Safren S, Lewis-Fernandez R, et al. Methodological challenges in psychiatric treatment adherence research. Clin Schizophr Relat Psychoses. 2010;4(1):74-91.
28. Cohen HW, Shmukler C, Ullman R, Rivera CM, Walker EA. Measurements of medication adherence in diabetic patients with poorly controlled HbA(1c). Diabet Med. 2010;27(2):210-6.
29. Dobbels F, Berben L, De Geest S, Drent G, Lennerling A, Whittaker C, et al. The psychometric properties and practicability of self-report instruments to identify medication nonadherence in adult transplant patients: a systematic review. Transplantation. 2010;90(2):205-19.
30. Greenlaw SM, Yentzer BA, O'Neill JL, Balkrishnan R, Feldman SR. Assessing adherence to dermatology treatments: a review of self-report and electronic measures. Skin Res Technol. 2010;16(2):253-8.
31. Muzzarelli S, Brunner-La Rocca H, Pfister O, Foglia P, Moschovitis G, Mombelli G, et al. Adherence to the medical regime in patients with heart failure. Eur J Heart Fail. 2010;12(4):389-96.
32. Berk L, Hallam KT, Colom F, Vieta E, Hasty M, Macneil C, et al. Enhancing medication adherence in patients with bipolar disorder. Hum Psychopharmacol. 2010;25(1):1-16.
33. Cohen JL, Mann DM, Wisnivesky JP, Home R, Leventhal H, Musumeci-Szabo TJ, et al. Assessing the validity of self-reported medication adherence among inner-city asthmatic adults: the Medication Adherence Report Scale for Asthma. Ann Allergy Asthma Immunol. 2009;103(4):325-31.
34. Bell DJ, Wootton D, Mukaka M, Montgomery J, Kayange N, Chimpeni P, et al. Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanildapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi. Malar J. 2009;8:204.
35. Velligan DI, Weiden PJ, Sajatovic M, Scott J, Carpenter D, Ross R, et al. The expert consensus guideline series: adherence problems in patients with serious and persistent mental illness. J Clin Psychiatry. 2009;70(Suppl 4):1-46 quiz 7-8.
36. Hansen RA, Kim MM, Song L, Tu W, Wu J, Murray MD. Comparison of methods to assess medication adherence and classify nonadherence. Ann Pharmacother. 2009;43(3):413-22.
37. Vreeman RC, Wiehe SE, Pearce EC, Nyandiko WM. A systematic review of pediatric adherence to antiretroviral therapy in low- and middle-income countries. Pediatr Infect Dis J. 2008;27(8):686-91.
38. Zelikovsky N, Schast AP. Eliciting accurate reports of adherence in a clinical interview: development of the Medical Adherence Measure. Pediatr Nurs. 2008;34(2):141-6.
39. Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich). 2008;10(5):348-54.
40. Tzeng JI, Chang CC, Chang HJ, Lin CC. Assessing analgesic regimen adherence with the Morisky Medication Adherence Measure for Taiwanese patients with cancer pain. J Pain Symptom Manage. 2008;36(2):157-66.
41. Zeller A, Schroeder K, Peters TJ. An adherence self-report questionnaire facilitated the differentiation between nonadherence and nonresponse to antihypertensive treatment. J Clin Epidemiol. 2008;61(3):282-8.
42. Reynolds NR, Sun J, Nagaraja HN, Gifford AL, Wu AW, Chesney MA. Optimizing measurement of self-reported adherence with the ACTG Adherence Questionnaire: a cross-protocol analysis. J Acquir Immune Defic Syndr. 2007;46(4):402-9. (Pubitemid 350098690)
43. Gossec L, Tubach F, Dougados M, Ravaud P. Reporting of adherence to medication in recent randomized controlled trials of 6 chronic diseases: a systematic literature review. Am J Med Sci. 2007;334(4):248-54. (Pubitemid 351339282)
44. Cramer JA, Benedict A, Muszbek N, Keskinaslan A, Khan ZM. The significance of compliance and persistence in the treatment of diabetes, hypertension and dyslipidaemia: a review. Int J Clin Pract. 2008;62(1):76-87. (Pubitemid 350294021)
45. Gehi AK, Ali S, Na B, Whooley MA. Self-reported medication adherence and cardiovascular events in patients with stable coronary heart disease: the heart and soul study. Arch Intern Med. 2007;167(16):1798-803. (Pubitemid 47403069)
46. Bender BG, Bartlett SJ, Rand CS, Turner C, Wamboldt FS, Zhang L. Impact of interview mode on accuracy of child and parent report of adherence with asthma-controller medication. Pediatrics. 2007;120(3):e471-7. (Pubitemid 47358258)
47. Parker CS, Chen Z, Price M, Gross R, Metlay JP, Christie JD, et al. Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: results from the IN-RANGE study. J Gen Intern Med. 2007;22(9):1254-9. (Pubitemid 47247293)
48. Bryson CL, Au DH, Young B, McDonell MB, Fihn SD. A refill adherence algorithm for multiple short intervals to estimate refill compliance (ReComp). Med Care. 2007;45(6):497-504.
49. Elm JJ, Kamp C, Tilley BC, Guimaraes P, Fraser D, Deppen P, et al. Self-reported adherence versus pill count in Parkinson's disease: the NET-PD experience. Mov Disord. 2007;22(6):822-7. (Pubitemid 46800103)
50. Wetzels GE, Nelemans PJ, Schouten JS, Dirksen CD, van der Weijden T, Stoffers HE, et al. Electronic monitoring of adherence as a tool to improve blood pressure control. A randomized controlled trial. Am J Hypertens. 2007;20(2):119-25. (Pubitemid 46157263)
51. Safren SA, Duran P, Yovel I, Perlman CA, Sprich S. Medication adherence in psychopharmacologically treated adults with ADHD. J Atten Disord. 2007;10(3):257-60.
52. Escalada P, Griffiths P. Do people with cancer comply with oral chemotherapy treatments? Br J Commun Nurs. 2006;11(12): 532-6.
53. Berg KM, Arnsten JH. Practical and conceptual challenges in measuring antiretroviral adherence. J Acquir Immune Defic Syndr. 2006;43(Suppl 1):S79-87. (Pubitemid 44885645)
54. Hearnshaw H, Lindenmeyer A. What do we mean by adherence to treatment and advice for living with diabetes? A review of the literature on definitions and measurements. Diabet Med. 2006;23(7):720-8. (Pubitemid 44366069)
55. Velligan DI, Lam YW, Glahn DC, Barrett JA, Maples NJ, Ereshefsky L, et al. Defining and assessing adherence to oral antipsychotics: a review of the literature. Schizophr Bull. 2006;32(4):724-42. (Pubitemid 44412860)
56. Pratt SI, Mueser KT, Driscoll M, Wolfe R, Bartels SJ. Medication nonadherence in older people with serious mental illness: prevalence and correlates. Psychiatr Rehabil J. 2006;29(4):299-310.
57. Chia LR, Schlenk EA, Dunbar-Jacob J. Effect of personal and cultural beliefs on medication adherence in the elderly. Drugs Aging. 2006;23(3):191-202.
58. Andrade SE, Kahler KH, Frech F, Chan KA. Methods for evaluation of medication adherence and persistence using automated databases. Pharmacoepidemiol Drug Saf. 2006;15(8):565-74. (Pubitemid 44336271)
59. Kerr T, Walsh J, Lloyd-Smith E, Wood E. Measuring adherence to highly active antiretroviral therapy: implications for research and practice. Curr HIV/AIDS Rep. 2005;2(4):200-5.
60. Hess LM, Saboda K, Malone DC, Salasche S, Warneke J, Alberts DS. Adherence assessment using medication weight in a phase IIb clinical trial of difluoromethylornithine for the chemoprevention of skin cancer. Cancer Epidemiol Biomarkers Prev. 2005;14(11 Pt 1):2579-83. (Pubitemid 41752718)
61. Sikka R, Xia F, Aubert RE. Estimating medication persistency using administrative claims data. Am J Manag Care. 2005;11(7):449-57. (Pubitemid 41022729)
62. MacLaughlin E, Raehl C, Treadway A, Sterling T, Zoller D, Bond C. Assessing medication adherence in the elderly: which tools to use in clinical practice? Drugs Aging. 2005;22(3):231-55. (Pubitemid 40529889)
63. Nieuwkerk PT, Oort FJ. Self-reported adherence to antiretroviral therapy for HIV-1 infection and virologic treatment response: a meta-analysis. J Acquir Immune Defic Syndr. 2005;38(4):445-8. (Pubitemid 40381555)
64. Dolder CR, Lacro JP, Warren KA, Golshan S, Perkins DO, Jeste DV. Brief evaluation of medication influences and beliefs: development and testing of a brief scale for medication adherence. J Clin Psychopharmacol. 2004;24(4):404-9. (Pubitemid 38944139)
65. Garber MC, Nau DP, Erickson SR, Aikens JE, Lawrence JB. The concordance of self-report with other measures of medication adherence: a summary of the literature. Med Care. 2004;42(7):649-52.
66. DiMatteo MR. Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. Med Care. 2004;42(3):200-9 Epub 2004/04/13.
67. Butler JA, Peveler RC, Roderick P, Horne R, Mason JC. Measuring compliance with drug regimens after renal transplantation: comparison of self-report and clinician rating with electronic monitoring. Transplantation. 2004;77(5):786-9. (Pubitemid 38366993)
68. Vik SA, Maxwell CJ, Hogan DB. Measurement, correlates, and health outcomes of medication adherence among seniors. Ann Pharmacother. 2004;38(2):303-12. (Pubitemid 38112246)
69. Feinn R, Tennen H, Cramer J, Kranzler HR. Measurement and prediction of medication compliance in problem drinkers. Alcohol Clin Exp Res. 2003;27(8):1286-92. (Pubitemid 36999219)
70. Loayza N, Crettol S, Riquier F, Eap CB. Adherence to antidepressant treatment: what the doctor thinks and what the patient says. Pharmacopsychiatry. 2012;45(5):204-7.
71. Jay MS, DuRant RH, Shoffitt T, Linder CW, Litt IF. Effect of peer counselors on adolescent compliance in use of oral contraceptives. Pediatrics. 1984;73(2):126-31. (Pubitemid 14188491)
72. Choo PW, Rand CS, Inui TS, Lee ML, Cain E, Cordeiro-Breault M, et al. Validation of patient reports, automated pharmacy records, and pill counts with electronic monitoring of adherence to antihypertensive therapy. Med Care. 1999;37(9):846-57.
73. Simoni JM, Kurth AE, Pearson CR, Pantalone DW, Merrill JO, Frick PA. Self-report measures of antiretroviral therapy adherence: a review with recommendations for HIV research and clinical management. AIDS Behav. 2006;10(3):227-45.
74. Williams AB, Amico KR, Bova C, Womack JA. A proposal for quality standards for measuring medication adherence in research. AIDS Behav. 2013;17(1):284-97.
75. George J, Mackinnon A, Kong DC, Stewart K. Development and validation of the Beliefs and Behaviour Questionnaire (BBQ). Patient Educ Couns. 2006;64(1-3):50-60. (Pubitemid 44772940)
76. Gadkari AS, McHorney CA. Unintentional non-adherence to chronic prescription medications: how unintentional is it really? BMC Health Serv Res. 2012;12:98.
77. Paterson C, Britten N. A narrative review shows the unvalidated use of self-report questionnaires for individual medication as outcome measures. J Clin Epidemiol. 2005;58(10):967-73. (Pubitemid 41316439)
78. Kimberlin CL, Winterstein AG. Validity and reliability of measurement instruments used in research. Am J Health Syst Pharm. 2008;65(23):2276-84.
79. Zogg JB, Woods SP, Sauceda JA, Wiebe JS, Simoni JM. The role of prospective memory in medication adherence: a review of an emerging literature. J Behav Med. 2012;35(1):47-62.
80. LaFleur J, Oderda GM. Methods to measure patient compliance with medication regimens. J Pain Palliat Care Pharmacother. 2004;18(3):81-7. (Pubitemid 39392188)
81. Lu M, Safren SA, Skolnik PR, Rogers WH, Coady W, Hardy H, et al. Optimal recall period and response task for self-reported HIV medication adherence. AIDS Behav. 2008;12(1):86-94. (Pubitemid 351143454)
82. Doro P, Benko R, Czako A, Matuz M, Thurzo F, Soos G. Optimal recall period in assessing the adherence to antihypertensive therapy: a pilot study. Int J Clin Pharm. 2011;33(4):690-5.
83. Matza LS, Yu-Isenberg KS, Coyne KS, Park J, Wakefield J, Skinner EP, et al. Further testing of the reliability and validity of the ASK-20 adherence barrier questionnaire in a medical center outpatient population. Curr Med Res Opin. 2008;24(11):3197-206.
84. Krummenacher I, Cavassini M, Bugnon O, Schneider MP. An interdisciplinary HIV-adherence program combining motivational interviewing and electronic antiretroviral drug monitoring. AIDS Care. 2011;23(5):550-61.
85. Gertsch A, Michel O, Locatelli I, Bugnon O, Rickenbach M, Cavassini M, et al. Adherence to antiretroviral treatment decreases during postpartum compared to pregnancy: a longitudinal electronic monitoring study. AIDS Patient Care STDS. 2013;27(4):208-10.
86. Burnier M, Schneider MP, Chiolero A, Stubi CL, Brunner HR. Electronic compliance monitoring in resistant hypertension: the basis for rational therapeutic decisions. J Hypertens. 2001;19(2):335-41. (Pubitemid 32116286)
87. de Bruin M, Hospers HJ, van den Borne HW, Kok G, Prins JM. Theory- and evidence-based intervention to improve adherence to antiretroviral therapy among HIV-infected patients in the Netherlands: a pilot study. AIDS Patient Care STDS. 2005;19(6):384-94. (Pubitemid 40962013)
88. Dayer L, Heldenbrand S, Anderson P, Gubbins PO, Martin BC. Smartphone medication adherence apps: potential benefits to patients and providers. J Am Pharm Assoc (2003). 2013;53(2):172-81.
89. Broomhead S, Mars M. Retrospective return on investment analysis of an electronic treatment adherence device piloted in the Northern Cape Province. Telemed J E Health. 2012;18(1):24-31.
90. Haberer JE, Kahane J, Kigozi I, Emenyonu N, Hunt P, Martin J, et al. Real-time adherence monitoring for HIV antiretroviral therapy. AIDS Behav. 2010;14(6):1340-6.
91. Ingerski LM, Hente EA, Modi AC, Hommel KA. Electronic measurement of medication adherence in pediatric chronic illness: a review of measures. J Pediatr. 2011;159(4):528-34.
92. Daniels T, Goodacre L, Sutton C, Pollard K, Conway S, Peckham D. Accurate assessment of adherence: self-report and clinician report vs electronic monitoring of nebulizers. Chest. 2011;140(2):425-32.
93. Hermann MM, Ustundag C, Diestelhorst M. Electronic compliance monitoring of topical treatment after ophthalmic surgery. Int Ophthalmol. 2010;30(4):385-90.
94. Haberer JE, Robbins GK, Ybarra M, Monk A, Ragland K, Weiser SD, et al. Real-time electronic adherence monitoring is feasible, comparable to unannounced pill counts, and acceptable. AIDS Behav. 2012;16(2):375-82.
95. Arnet I, Walter PN, Hersberger KE. Polymedication Electronic Monitoring System (POEMS) - a new technology for measuring adherence. Front Pharmacol. 2013;4:26.
96. Santschi V, Wuerzner G, Schneider MP, Bugnon O, Burnier M. Clinical evaluation of IDAS II, a new electronic device enabling drug adherence monitoring. Eur J Clin Pharmacol. 2007;63(12):1179-84. (Pubitemid 350112756)
97. De Bleser L, Vincke B, Dobbels F, Happ MB, Maes B, Vanhaecke J, et al. A new electronic monitoring device to measure medication adherence: usability of the Helping Hand. Sensors (Basel). 2010;10(3):1535-52.
98. Schmidt S, Sheikzadeh S, Beil B, Patten M, Stettin J. Acceptance of telemonitoring to enhance medication compliance in patients with chronic heart failure. Telemed J E Health. 2008;14(5):426-33. (Pubitemid 351913551)
99. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353(5):487-97. (Pubitemid 41127293)
100. Steiner JF, Prochazka AV. The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol. 1997;50(1):105-16. (Pubitemid 27089212)
101. Vink NM, Klungel OH, Stolk RP, Denig P. Comparison of various measures for assessing medication refill adherence using prescription data. Pharmacoepidemiol Drug Saf. 2009;18(2):159-65.
102. Watanabe JH, Bounthavong M, Chen T. Revisiting the medication possession ratio threshold for adherence in lipid management. Curr Med Res Opin. 2013;29(3):175-80.
103. McKenzie MC, Lenz TL, Gillespie ND, Skradski JJ. Medication Adherence Improvements in Employees Participating in a Pharmacist-Run Risk Reduction Program [Internet]. Innov Pharm. 2012;3(4):article 94. [cited 2013 Jul 16]. Available from: http://www.pharmacy.umn.edu/innovations/prod/groups/cop/@pub/ @cop/@innov/documents/article/cop-421024.pdf.
104. Karve S, Cleves MA, Helm M, Hudson TJ, West DS, Martin BC. Good and poor adherence: optimal cut-point for adherence measures using administrative claims data. Curr Med Res Opin. 2009;25(9):2303-10.
105. Cramer JA, Roy A, Burrell A, Fairchild CJ, Fuldeore MJ, Ollendorf DA, et al. Medication compliance and persistence: terminology and definitions. Value Health. 2008;11(1):44-7. (Pubitemid 351160875)
106. Peterson AM, Nau DP, Cramer JA, Benner J, Gwadry-Sridhar F, Nichol M. A checklist for medication compliance and persistence studies using retrospective databases. Value Health. 2007;10(1):3-12. (Pubitemid 46161090)
107. Blaschke TF, Osterberg L, Vrijens B, Urquhart J. Adherence to medications: insights arising from studies on the unreliable link between prescribed and actual drug dosing histories. Annu Rev Pharmacol Toxicol. 2012;52:275-301.
108. Lachaine J, Beauchemin C, Sasane R, Hodgkins PS. Treatment patterns, adherence, and persistence in ADHD: a Canadian perspective. Postgrad Med. 2012;124(3):139-48.
109. Krueger KP, Berger BA, Felkey B. Medication adherence and persistence: a comprehensive review. Adv Ther. 2005;22(4):313-56. (Pubitemid 43003324)
110. Marcum ZA, Gellad WF. Medication adherence to multidrug regimens. Clin Geriatr Med. 2012;28(2):287-300.
111. Murray MD, Morrow DG, Weiner M, Clark DO, Tu W, Deer MM, et al. A conceptual framework to study medication adherence in older adults. Am J Geriatr Pharmacother. 2004;2(1):36-43. (Pubitemid 38559457)
112. Jonikas MA, Mandl KD. Surveillance of medication use: early identification of poor adherence. J Am Med Inf Assoc. 2012;19(4):649-54.
113. Palli SR, Kamble PS, Chen H, Aparasu RR. Persistence of stimulants in children and adolescents with attention-deficit/ hyperactivity disorder. J Child Adolesc Psychopharmacol. 2012;22(2):139-48.
114. Digital Health Feedback System. Proteus Digital Health 2013. [cited 2013 Jul 16]. Available from: http://www.proteusdigitalhealth.com/technology/digital- health-feedback-system/.
115. Haynes RB, Sackett DL. Compliance with therapeutic regimens. Baltimore: John Hopkins Univ. Press; 1976 293 p.