Unintentional non-adherence to chronic prescription medications: How unintentional is it really?

BMC Health Services Research

Volumn 12, Issue 1, 2012, Pages

  Gadkari, Abhijit S ^a   McHorney, Colleen A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; ASTHMA; ATTITUDE TO HEALTH; CHRONIC DISEASE; CROSS-SECTIONAL STUDY; DEPRESSION; DIABETES MELLITUS; FEMALE; HEALTH STATUS; HUMAN; HYPERTENSION; MALE; MIDDLE AGED; OSTEOPOROSIS; PATIENT COMPLIANCE; PREDICTIVE VALUE; PRESCRIPTION; PREVALENCE; PSYCHOLOGICAL ASPECT; QUESTIONNAIRE; SICKNESS IMPACT PROFILE; SOCIAL CLASS; STATISTICAL MODEL; STATISTICS; UNITED STATES;

ADULT; AGED; ASTHMA; CHRONIC DISEASE; CROSS-SECTIONAL STUDIES; DEPRESSIVE DISORDER; DIABETES MELLITUS; DRUG PRESCRIPTIONS; FEMALE; HEALTH KNOWLEDGE, ATTITUDES, PRACTICE; HEALTH STATUS; HUMANS; HYPERTENSION; LOGISTIC MODELS; MALE; MIDDLE AGED; OSTEOPOROSIS; PATIENT COMPLIANCE; PREDICTIVE VALUE OF TESTS; PREVALENCE; QUESTIONNAIRES; SICKNESS IMPACT PROFILE; SOCIAL CLASS; UNITED STATES;

EID: 84859760163     PISSN: None     EISSN: 14726963     Source Type: Journal    
DOI: 10.1186/1472-6963-12-98     Document Type: Article

References (79)

1. Medication compliance and persistence: terminology and definitions. Cramer JA, Roy A, Burrell A, Fairchild CJ, Fuldeore MJ, Ollendorf DA, Wong PK, Value Health 2008 11 44 47 (Pubitemid 351160875)
2. Patient adherence and medical treatment outcomes: a meta-analysis. DiMatteo MR, Giordani PJ, Lepper HS, Croghan TW, Med Care 2002 40 794 811
3. The significance of compliance and persistence in the treatment of diabetes, hypertension and dyslipidaemia: a review. Cramer JA, Benedict A, Muszbek N, Keskinaslan A, Khan ZM, Int J Clin Pract 2008 62 76 87 (Pubitemid 350294021)
4. Intentional and unintentional medication non-adherence: a comprehensive framework for clinical research and practice? A discussion paper. Lehane E, McCarthy G, Int J Nurs Stud 2007 44 1468 1477
5. An examination of the intentional and unintentional aspects of medication non-adherence in patients diagnosed with hypertension. Lehane E, McCarthy G, J Clin Nurs 2007 16 698 706
6. Intentional and unintentional nonadherence: a study of decision making. Wroe AL, J Behav Med 2002 25 355 372 (Pubitemid 37486630)
7. Intentional and unintentional nonadherence to antihypertensive medication. Lowry KP, Dudley TK, Oddone EZ, Bosworth HB, Ann Pharmacother 2005 39 1198 1203 (Pubitemid 40943169)
8. Patient nonadherence to medication in inflammatory bowel disease. Sewitch MJ, Abrahamowicz M, Barkun A, Bitton A, Wild GE, Cohen A, Dobkin PL, Am J Gastroenterol 2003 98 1535 1544 (Pubitemid 36875345)
9. Exploring chronic myeloid leukemia patients reasons for not adhering to the oral anticancer drug imatinib as prescribed. Eliasson L, Clifford S, Barber N, Marin D, Leuk Res 2011 35 626 630
10. Intentional and unintentional nonadherence to ocular hypotensive treatment in patients with glaucoma. Rees G, Leong O, Crowston JG, Lamoureux EL, Ophthalmology 2010 117 903 908
11. Medication non-fulfillment rates and reasons for non-fulfillment: narrative systematic review. Gadkari A, McHorney C, CMRO 2010 26 683 705
12. Helping patients follow prescribed treatment: clinical applications. Haynes RB, McDonald HP, Garg AX, JAMA 2002 288 2880 2883 (Pubitemid 35425074)
13. Adherence to medication. Osterberg L, Blaschke T, N Engl J Med 2005 353 487 497 (Pubitemid 41127293)
14. Patients problems with new medication for chronic conditions. Barber N, Parsons J, Clifford S, Darracott R, Horne R, Qual Saf Health Care 2004 13 172 175 (Pubitemid 38797501)
15. Adherence in adolescents and young adults following heart or heart-lung transplantation. Wray J, Waters S, Radley-Smith R, Sensky T, Pediatr Transplant 2006 10 694 700 (Pubitemid 44186291)
16. Nonadherence in inflammatory bowel disease: results of factor analysis. Cerveny P, Bortlik M, Kubena A, Vlcek J, Lakatos PL, Lukas M, Inflamm Bowel Dis 2007 13 1244 1249 (Pubitemid 47597771)
17. Depression, medication adherence, and service utilization in systemic lupus erythematosus. Julian LJ, Yelin E, Yazdany J, Panopalis P, Trupin L, Criswell LA, Katz P, Arthritis & Rheumatism-Arthritis Care & Research 2009 61 240 246
18. Electronic reminders to improve medication adherence-are they acceptable to the patient? Sahm L, Maccurtain A, Hayden J, Roche C, Richards HL, Pharm World Sci 2009 31 627 629
19. Daleboudt GM, Broadbent E, McQueen F, Kaptein AA Intentional and unintentional treatment non-adherence in patients with systemic lupus erythematosus, Arthritis Care Res 2010 [EPub ahead of print]
20. Treatment adherence of cancer patients to orally administered chemotherapy: insights from a Greek study using a self-reported questionnaire. Saratsiotou I, Kordoni M, Bakogiannis C, Livadarou E, Skarlos D, Kosmidis PA, Razis E, J Oncol Pharm Pract 2011 17 304 311
21. Unintentional non-adherence and belief in medicines in older adults. Unni EJ, Farris KB, Patient Educ Couns 2011 83 265 268
22. Development of new concepts of non-adherence measurements among users of antihypertensives medicines. Kjeldsen L, Bjerrum L, Herborg H, Knudsen P, Rossing C, Sondergaard B, Int J Clin Pharm 2011 33 572 656
23. Lindquist LA, Go L, Fleisher J, Jain N, Friesema E, Baker DW Relationship of health literacy to intentional and unintentional non-adherence of hospital discharge m edications, J Gen Intern Med 2011 [EPub ahead of print]
24. Patients decisions about whether or not to take antihypertensive drugs: qualitative study. Benson J, Britten N, BMJ 2002 325 873
25. Strategies for coping in a complex world: adherence behavior among older adults with chronic illness. Elliott RA, Ross-Degnan D, Adams AS, Safran DG, Soumerai SB, J Gen Intern Med 2007 22 805 810 (Pubitemid 46763986)
26. The adherence estimator: a brief, proximal screener for patient propensity to adhere to prescription medications for chronic disease. McHorney C, Curr Med Res Opin 2009 25 215 238
27. Individual patients hold different beliefs to prescription medications to which they persist vs. non-persist and persist vs. non-fulfill. McHorney C, Gadkari A, Patient Prefer Adherence 2010 4 187 195
28. Does knowledge matter? Intentional medication nonadherence among middle-aged Korean Americans with high blood pressure. Kim EY, Han HR, Jeong S, Kim KB, Park H, Kang E, Shin HS, J Cardiovasc Nurs 2007 22 397 404
29. Understanding different beliefs held by adherers, unintentional nonadherers, and intentional nonadherers: Application of the necessity-concerns framework. Clifford S, Barber N, Horne R, J Psychosom Res 2008 64 41 46 (Pubitemid 350297299)
30. Comparison of individual perceptions of medication costs and benefits between intentional and unintentional medication non-adherence among Japanese patients. Iihara N, Kurosaki Y, Miyoshi C, Takabatake K, Morita S, Hori K, Patient Educ Couns 2008 70 292 299
31. Information-Motivation-Behavioral Skills barriers associated with intentional versus unintentional ARV non-adherence behavior among HIV-positive patients in clinical care. Norton WE, Amico KR, Fisher WA, Shuper PA, Ferrer RA, Cornman DH, Trayling CA, Redding C, Fisher JD, AIDS Care 2010 22 979 987
32. National Center for Health Statistics, Health, United States, 2010: With Special Feature on Death and Dying Department of Health and Human Services, Hyattsville 2011
33. DeVol R, Bedroussian A, Charuworn A, Chatterjee A, Kim I, Kim S, An Unhealthy America: The Economic Burden of Chronic Disease The Milken Institure, Santa Monica, CA 2007
34. The American Association for Public Opinion Research, Standard Definitions: Final Dispositions of Case Codes and Outcomes Rates for Surveys 2006 http://www.aapor.org/standards.asp Available at: [last accessed 5 May 2007]
35. Concurrent and predictive validity of a self-reported measure of medication adherence. Morisky DE, Green LW, Levine DM, Med Care 1986 24 67 74 (Pubitemid 16125389)
36. The Beliefs about Medicines Questionnaire: The development and evaluation of a new method for assessing the cognitive representation of medication. Horne R, Weinman J, Hankins M, Psychol Health 1999 14 1 24
37. Development and testing of the Hill-Bone Compliance to High Blood Pressure Therapy Scale. Kim MT, Hill MN, Bone LR, Levine DM, Prog Cardiovasc Nurs 2000 15 90 96
38. Drug therapy concerns questionnaire: Initial development and refinement. Blalock SJ, Patel RA, J Am Pharm Assoc 2005 45 160 169 (Pubitemid 46037309)
39. Physician-patient communication about prescription medication nonadherence: A 50-state study of America's seniors. Wilson IB, Schoen C, Neuman P, Strollo MK, Rogers WH, Chang H, Safran DG, J Gen Intern Med 2007 22 6 12 (Pubitemid 47308785)
40. The moderator mediator variable distinction in social psychological-research-Conceptual, strategic, and statistical considerations. Baron RM, Kenny DA, J Pers Soc Psychol 1986 51 1173 1182
41. Beyond Baron and Kenny: Statistical mediation analysis in the new millennium. Hayes AF, Commun Monogr 2009 76 408 420
42. A comparison of methods to test mediation and other intervening variable effects. MacKinnon DP, Lockwood CM, Hoffman JM, West SG, Sheets V, Psychol Methods 2002 7 83 104
43. Mediation in experimental and nonexperimental studies: New procedures and recommendations. Shrout PE, Bolger N, Psychol Methods 2002 7 422 445
44. Required sample size to detect the mediated effect. Fritz MS, MacKinnon DP, Psychol Sci 2007 18 233 239
45. The effects of trust in physician on self-efficacy, adherence and diabetes outcomes. Lee YY, Lin JL, Soc Sci Med 2009 68 1060 1068
46. Intrusive thoughts and psychological adjustment to breast cancer: Exploring the moderating and mediating role of global meaning and emotional expressivity. Anagnostopoulos F, Slater J, Fitzsimmons D, J Clin Psychol Medical Settings 2010 17 137 149
47. Autistic traits in the general population: What mediates the link with depressive and anxious symptomatology? Rosbrook A, Whittingham K, Research in Autism Spectrum Disorders 2010 4 415 424
48. An improved Bonferroni procedure for multiple tests of significance. Simes RJ, Biometrika 1986 73 751 754
49. Confidence limits for the indirect effect: Distribution of the product and resampling methods. Mackinnon DP, Lockwood CM, Williams J, Multivar Behav Res 2004 39 99 128 (Pubitemid 38882481)
50. A comparison of single sample and bootstrap methods to assess mediation in cluster randomized trials. Pituch KA, Stapleton LM, Kang JY, Multivar Behav Res 2006 41 367 400
51. Testing mediation and suppression effects of latent variables- Bootstrapping with structural equation models. Cheung GW, Lau RS, Organ Res Methods 2008 11 296 325
52. Testing mediation in nursing research Beyond Baron and Kenny. Krause MR, Serlin RC, Ward SE, Rony YZ, Ezenwa MO, Naab F, Nurs Res 2010 59 288 294
53. Medication non-adherence in women with fibromyalgia. Sewitch MJ, Dobkin PL, Bernatsky S, Baron M, Starr M, Cohen M, Fitzcharles MA, Rheumatology 2004 43 648 654 (Pubitemid 38628198)
54. Intentional and non-intentional non-adherence to medication amongst breast cancer patients. Atkins L, Fallowfield L, Eur J Cancer 2006 42 2271 2276 (Pubitemid 44307611)
55. The patients perspective: adherence or non-adherence to asthma controller therapy? Ulrik CS, Backer V, Soes-Petersen U, Lange P, Harving H, Plaschke PP, J Asthma 2006 43 701 704 (Pubitemid 44722128)
56. Bipolar affective disorder: medication adherence and satisfaction with treatment and guidance by the health team in a mental health service. Miasso AI, Monteschi M, Giacchero KG, Rev Lat Am Enfermagem 2009 17 548 556
57. Effective chronic disease management: Patients' perspectives on medication-related problems. Gordon K, Smith F, Dhillon S, Patient Educ Couns 2007 65 407 415 (Pubitemid 46241782)
58. Medication adherence: its importance in cardiovascular outcomes. Ho PM, Bryson CL, Rumsfeld JS, Circulation 2009 119 3028 3035
59. Health beliefs and attitudes toward the prevention of osteoporosis in older women. Hsieh C, Novielli KD, Diamond JJ, Cheruva D, Menopause 2001 8 372 376 (Pubitemid 32826171)
60. Reasons and risk: Factors underlying women's perceptions of susceptibility to osteoporosis. Gerend MA, Erchull MJ, Aiken LS, Maner JK, Maturitas 2006 55 227 237 (Pubitemid 44397348)
61. U.S. Census Bureau, United States-Income in the Past 12 Months 2009 http://factfinder.census.gov/servlet/STTable?-bm=y&-geo-id=01000US&- qr-name=ACS-2009-1YR-G00-S1901&-ds-name=ACS-2009-1YR-G00-&-lang= en&-redoLog=false Available at: [Last accessed 28 December 2010]
62. U.S. Census Bureau, United States-Educational Attainment 2009 2010 http://factfinder.census.gov/servlet/STTable?-bm=y&-geo-id= 01000US&-qr-name=ACS-2009-1YR-G00-S1501&-ds-name=ACS-2009-1YR-G00-&- lang=en&-redoLog=false Available at: {last accessed 28 December 2010}
63. U.S. Census Bureau, Resident Population by Sex, Race, and Hispanic Origin Status 2010 http://www.census.gov/compendia/statab/cats/population/estimates- and-projections-by-agesex-raceethnicity.html Available at: -[Last accessed 28 December 2010].
64. Predictive validity of a medication adherence measure in an outpatient setting. Morisky DE, Ang A, Krousel-Wood M, Ward H, J Clin Hypertens 2008 10 348 354
65. The meaning of medications: another look at compliance. Conrad P, Soc Sci Med 1985 20 29 37 (Pubitemid 15235565)
66. We are the experts: people with asthma talk about their medicine information needs. Raynor DK, Savage I, Knapp P, Henley J, Patient Educ Couns 2004 53 167 174 (Pubitemid 38622061)
67. Adherence and outcomes associated with copayment burden in schizophrenia: a cross-sectional survey. Kim E, Gupta S, Bolge S, Chen CC, Whitehead R, Bates JA, J Med Econ 2010 13 185 192
68. Social context, the struggle with uncertainty, and subjective risk as meaning-rich constructs for explaining HBP noncompliance. Proulx M, Leduc N, Vandelac L, Gregoire JP, Collin J, Patient Educ Couns 2007 68 98 106 (Pubitemid 47126797)
69. Patients' beliefs about prescribed medicines and their role in adherence to treatment in chronic physical illness. Horne R, Weinman J, J Psychosom Res 1999 47 555 567 (Pubitemid 30029305)
70. Long-term persistence in use of statin therapy in elderly patients. Benner JS, Glynn RJ, Mogun H, Neumann PJ, Weinstein MC, Avorn J, JAMA 2002 288 455 4561
71. Systematic review and meta-analysis of real-world adherence to drug therapy for osteoporosis. Kothawala P, Badamgarav E, Ryu S, Miller RM, Halbert RJ, Mayo Clin Proc 2007 82 1493 1501 (Pubitemid 350211697)
72. Discontinuation of and changes in treatment after start of new courses of antihypertensive drugs: A study of a United Kingdom population. Jones JK, Gorkin L, Lian JF, Staffa JA, Fletcher AP, BMJ 1995 311 293 295
73. Predictors of adherence with antihypertensive and lipid-lowering therapy. Chapman RH, Benner JS, Petrilla AA, Tierce JC, Collins SR, Battleman DS, Schwartz JS, Arch Intern Med 2005 165 1147 1152 (Pubitemid 40720739)
74. Persistence with treatment in newly treated middle-aged patients with essential hypertension. Perreault S, Lamarre D, Blais L, Dragomir A, Berbiche D, Lalonde L, Laurier C, St-Maurice F, Collin J, Ann Pharmacother 2005 39 1401 1408 (Pubitemid 41197117)
75. Does synchronizing initiation of therapy affect adherence to concomitant use of antihypertensive and lipid-lowering therapy? Agarwal S, Tang SS, Rosenberg N, Pettitt D, McLaughlin T, Joyce A, Schwartz JS, Am J Ther 2009 16 119 126
76. Duration and adherence of antidepressant treatment (2003 to 2007) based on prescription database. Serna MC, Cruz I, Real J, Gasco E, Galvan L, Eur Psychiatry 2010 25 206 213
77. Comparing adherence and persistence across 6 chronic medication classes. Yeaw J, Benner JS, Walt JG, Sian S, Smith DB, J Manag Care Pharm 2009 15 728 740
78. Diagnosing potential noncompliance. Physicians' ability in a behavioral dimension of medical care. Mushlin AI, Appel FA, Arch Intern Med 1977 137 318 321 (Pubitemid 9041305)
79. Patients cooperation with a medical regimen. Difficulties in identifying the noncooperator. Caron HS, Roth HP, JAMA 1968 203 922 926