PML-nuclear bodies decrease with age and their stress response is impaired in aged individuals

BMC Geriatrics

Volumn 14, Issue 1, 2014, Pages

  Wenger, Barbara ^a   Schwegler, Manuela ^a   Brunner, Maria ^a   Daniel, Christoph ^a   Schmidt, Manfred ^a   Fietkau, Rainer ^a   Distel, Luitpold V ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Aging; PML Nuclear bodies; Senescence; Stress response; H2AX

Indexed keywords

NUCLEAR PROTEIN; PML PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGED; AGING; CELL NUCLEUS; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; OXIDATIVE STRESS; PATHOLOGY; PHYSIOLOGY; PROSPECTIVE STUDY; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; AGING; CELL NUCLEUS; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; NUCLEAR PROTEINS; OXIDATIVE STRESS; PROSPECTIVE STUDIES; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; YOUNG ADULT;

EID: 84899472911     PISSN: None     EISSN: 14712318     Source Type: Journal    
DOI: 10.1186/1471-2318-14-42     Document Type: Article

References (17)

1. Pondering the promyelocytic leukemia protein (PML) puzzle: possible functions for PML nuclear bodies. Borden KL, Mol Cell Biol 2002 22 15 5259 5269 10.1128/MCB.22.15.5259-5269.2002 12101223
2. Functional connection between Rad51 and PML in homology-directed repair. Boichuk S, Hu L, Makielski K, Pandolfi PP, Gjoerup OV, PLoS One 2011 6 10 25814 10.1371/journal.pone.0025814 21998700
3. Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR. Dellaire G, Ching RW, Ahmed K, Jalali F, Tse KC, Bristow RG, Bazett-Jones DP, J Cell Biol 2006 175 1 55 66 10.1083/jcb.200604009 17030982
4. PML is induced by oncogenic ras and promotes premature senescence. Ferbeyre G, de Stanchina E, Querido E, Baptiste N, Prives C, Lowe SW, Genes Dev 2000 14 16 2015 2027 10950866
5. What has senescence got to do with cancer? Dimri GP, Cancer Cell 2005 7 6 505 512 10.1016/j.ccr.2005.05.025 15950900
6. PML nuclear bodies: dynamic sensors of DNA damage and cellular stress. Dellaire G, Bazett-Jones DP, Bioessays 2004 26 9 963 977 10.1002/bies.20089 15351967
7. Promyelocytic leukemia nuclear bodies support a late step in DNA double-strand break repair by homologous recombination. Yeung PL, Denissova NG, Nasello C, Hakhverdyan Z, Chen JD, Brenneman MA, J Cell Biochem 2012 113 5 1787 1799 22213200
8. Structural basis of gammaH2AX recognition by human PTIP BRCT5-BRCT6 domains in the DNA damage response pathway. Yan W, Shao Z, Li F, Niu L, Shi Y, Teng M, Li X, FEBS letters 2011 585 24 3874 3879 10.1016/j.febslet.2011.10.045 22064073
9. gamma-H2AX as a biomarker of DNA damage induced by ionizing radiation in human peripheral blood lymphocytes and artificial skin. Redon CE, Dickey JS, Bonner WM, Sedelnikova OA, Adv Space Res 2009 43 8 1171 1178 10.1016/j.asr.2008.10.011 20046946
10. Detailed analysis of DNA repair and senescence marker kinetics over the life span of a human fibroblast cell line. Endt H, Sprung CN, Keller U, Gaipl U, Fietkau R, Distel LV, J Gerontol A Biol Sci Med Sci 2011 66 4 367 375 21081476
11. Cellular senescence: when bad things happen to good cells. Campisi J, d'Adda di Fagagna F, Nat Rev Mol Cell Biol 2007 8 9 729 740 10.1038/nrm2233 17667954
12. A senescent cell bystander effect: senescence-induced senescence. Nelson G, Wordsworth J, Wang C, Jurk D, Lawless C, Martin-Ruiz C, von Zglinicki T, Aging Cell 2012 11 2 345 349 10.1111/j.1474-9726.2012.00795.x 22321662
13. Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Bernardi R, Pandolfi PP, Nat Rev Mol Cell Biol 2007 8 12 1006 1016 10.1038/nrm2277 17928811
14. Age-dependent down-regulation of DNA polymerase delta1 in human lymphocytes. Wang JL, Guo HL, Wang PC, Liu CG, Mol Cell Biochem 2012 371 1-2 157 163 10.1007/s11010-012-1432-6 22915169
15. Delayed kinetics of DNA double-strand break processing in normal and pathological aging. Sedelnikova OA, Horikawa I, Redon C, Nakamura A, Zimonjic DB, Popescu NC, Bonner WM, Aging Cell 2008 7 1 89 100 10.1111/j.1474-9726.2007. 00354.x 18005250
16. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, Scholz CJ, Kumar S, Herndon JG, Alexandru D, Cojocaru GR, Dandekar T, Popa-Wagner A, PLoS One 2012 7 12 50985 10.1371/journal.pone.0050985 23251410
17. Prolonged gaseous hypothermia prevents the upregulation of phagocytosis-specific protein annexin 1 and causes low-amplitude EEG activity in the aged rat brain after cerebral ischemia. Joseph C, Buga AM, Vintilescu R, Balseanu AT, Moldovan M, Junker H, Walker L, Lotze M, Popa-Wagner A, J Cereb Blood Metab Official J Int Soc Cereb Blood Flow Metab 2012 32 8 1632 1642 10.1038/jcbfm.2012.65