Insulin in human milk and the use of hormones in infant formulas

Nestle Nutrition Institute Workshop Series

Volumn 77, Issue , 2013, Pages 57-64

  Shamir, Raanan ^a,b   Shehadeh, Naim ^c,d  

^a SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c MEYER CHILDREN S HOSPITAL   (Israel)

^d TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

INSULIN; SOMATOMEDIN C;

ARTIFICIAL MILK; BREAST MILK; DIET SUPPLEMENTATION; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HUMAN; INFANT; INTESTINE; NEWBORN; PREMATURITY;

DIETARY SUPPLEMENTS; HUMANS; INFANT; INFANT FORMULA; INFANT, NEWBORN; INFANT, PREMATURE; INSULIN; INSULIN-LIKE GROWTH FACTOR I; INTESTINES; MILK, HUMAN;

EID: 84899467645     PISSN: 16642147     EISSN: 16642155     Source Type: Book Series    
DOI: 10.1159/000351384     Document Type: Conference Paper

References (34)

1. Agostoni C, Braegger C, Decsi T, et al: Breast-feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 2009; 49: 112-125.
2. Koldovský O: Hormonally active peptides in human milk. Acta Paediatr Suppl 1994; 402: 89-93.
3. Corpeleijn WE, van Vliet I, de Gast-Bakker DA, et al: Effect of enteral IGF-1 supplementation on feeding tolerance, growth, and gut permeability in enterally fed premature neonates. J Pediatr Gastroenterol Nutr 2008; 46: 184-190.
4. Shehadeh N, Shamir R, Berant M, Etzioni A: Insulin in human milk and the prevention of type 1 diabetes. Pediatr Diabetes 2001; 2: 175-177.
5. Shehadeh N, Gelertner L, Blazer S, et al: The importance of insulin content in infant diet: suggestion for a new infant formula. Acta Pediatr 2001; 90: 93-95.
6. Shehadeh N, Khaesh-Goldberg E, Shamir R, et al: Insulin in human milk: postpartum changes and effect of gestational age. Arch Dis Child Fetal Neonatal Ed 2003; 88:F214-F216.
7. Agostoni C, Braegger C, Decsi T, et al: Breast-feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 2009; 49: 112-125.
8. Koldovský O: Hormonally active peptides in human milk. Acta Paediatr Suppl 1994; 402: 89-93.
9. Corpeleijn WE, van Vliet I, de Gast-Bakker DA, et al: Effect of enteral IGF-1 supplementation on feeding tolerance, growth, and gut permeability in enterally fed premature neonates. J Pediatr Gastroenterol Nutr 2008; 46: 184-190.
10. Shehadeh N, Shamir R, Berant M, Etzioni A: Insulin in human milk and the prevention of type 1 diabetes. Pediatr Diabetes 2001; 2: 175-177.
11. Shehadeh N, Gelertner L, Blazer S, et al: The importance of insulin content in infant diet: suggestion for a new infant formula. Acta Pediatr 2001; 90: 93-95.
12. Shehadeh N, Khaesh-Goldberg E, Shamir R, et al: Insulin in human milk: postpartum changes and effect of gestational age. Arch Dis Child Fetal Neonatal Ed 2003; 88:F214-F216.
13. Shehadeh N, Aslih N, Shihab S, et al: Human milk beyond one year post-partum: lower content of protein, calcium and saturated very long chain fatty acids. J Pediatr 2006; 148: 122-124.
14. Shehadeh N, Sukhotnik I, Shamir R: Gastrointestinal tract as a target organ for orally administered insulin. J Pediatr Gastroenterol Nutr 2006; 43: 276-281.
15. Ben Lulu S, Coran AG, Mogilner JG, et al: Oral insulin stimulates intestinal epithelial cell turnover in correlation with insulin-receptor expression along the villus-crypt axis in a rat model of short bowel syndrome. Pediatr Surg Int 2010; 26: 37-44.
16. Buts JP, De Keyser N, Marandi S, et al: Expression of insulin receptors and of 60-kDa receptor substrate in rat mature and immature enterocytes. Am J Physiol Gastrointest Liver Physiol 1997; 273:G217-G226.
17. Georgiev IP, Georgieva TM, Pfaffl M, et al: Insulin-like growth factor and insulin receptors in intestinal mucosa of neonatal calves. J Endocrinol 2003; 176: 121-132.
18. Buts JP, De Keyser N, Sokal EM, et al: Oral insulin is biologically active on rat immature enterocytes. J Pediatr Gastroenterol Nutr 1997; 25: 230-232.
19. Shulman R: Oral insulin increases small intestinal mass and disaccharidase activity in the newborn miniature pig. Pediatr Res 1990; 28: 171-175.
20. Huo YJ, Wang T, Xu RJ, et al: Dietary insulin affects leucine aminopeptidase, growth hormone, insulin-like growth factor I and insulin receptors in the intestinal mucosa of neonatal pigs. Biol Neonate 2006; 89: 265-273.
21. Kinouchi T, Koizumi K, Kuwata T, et al: Milk-borne insulin with trypsin inhibitor in milk induces pancreatic amylase development at the onset of weaning in rats. J Pediatr Gastroenterol Nutr 2000; 30: 515-521.
22. Shamir R, Muslach M, Sukhotnik I, et al: Oral insulin supplementation in rats. Intestinal and systemic effects after weaning. Dig Dis Sci 2005; 50: 1239-1244.
23. Sukhotnik I, Shehadeh N, Shamir R, et al: Oral insulin enhances intestinal re-growth following massive small bowel resection in rat. Dig Dis Sci 2005; 50: 2379-2385.
24. Sukhotnik I, Shehadeh N, Mogilner J, et al: Beneficial effects of oral insulin on intestinal recovery following ischemia-reperfusion injury in rat. J Surg Res 2005; 128: 108-113.
25. Sukhotnik I, Shehadeh N, Coran AG, et al: Oral insulin enhances cell proliferation and decreases enterocyte apopotosis during methotrexate-induced mucositis in a rat. J Pediatr Gastroenterol Nutr 2008; 47: 115-122.
26. Shamir R, Kolacek S, Koletzko S, et al: Oral insulin supplementation in pediatric short bowel disease. A pilot observational study. J Pediatr Gastroenterol Nutr 2009; 49: 108-111.
27. Shulman RJ: Effect of enteral administration of insulin on intestinal development and feeding tolerance in preterm infants: a pilot study. Arch Dis Child Fetal Neonatal Ed 2002; 86:F131-F133.
28. Mosinger B, Placer Z, Koldovsky O: Passage of insulin through the wall of the gastro-intestinal tract of the infant rat. Nature 1959; 184(suppl 16):1245-1246.
29. Eshach Adiv O, Mandel H, Shehadeh N, et al: Influence of co-administration of oral insulin and docosahexaenoic acid in mice. J Nutr Biochem 2004; 15: 638-643.
30. Shamir R, Shehadeh N, Rosenblat M, et al: Oral insulin supplementation attenuates atherosclerosis progression in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2003; 23: 104-110.
31. Shehadeh N, Wies R, Eishach O, et al: Influence of oral insulin supplementation on carbohydrate, lipid and protein metabolism in weaned Balb/c mice. J Pediatr Endocrinol Metab 2003; 16: 431-437.
32. Meddings JB, Jarand J, Urbanski SJ, et al: Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat. Am J Physiol Gastrointest Liver Physiol 1999; 276:G951-G957.
33. Harada E, Syuto B: Precocious cessation of intestinal macromolecular transmission and sucrase development induced by insulin in adrenalectomized suckling rat. Comp Biochem Physiol A Comp Physiol 1991; 99: 327-331.
34. Skyler JS, Zrischer JP, Wolfsdorf J, et al: Effects of oral insulin in relatives of patients with type 1 diabetes: the Diabetes Prevention Trial-Type 1 . Diabetes Care 2005; 28: 1068-1076.