Intestinal and systemic effects of oral insulin supplementation in rats after weaning

Digestive Diseases and Sciences

Volumn 50, Issue 7, 2005, Pages 1239-1244

  Shamir, Raanan ^a   Muslach, Muhamed ^a   Sukhotnik, Igor ^b   Perlman, Rina ^c   Diamond, Eric ^c   Mogilner, Jorge ^b   Shehadeh, Naim ^a  

^a MEYER CHILDREN S HOSPITAL   (Israel)

^b BNAI ZION MEDICAL CENTER   (Israel)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Intestine; Mucosa; Oral insulin; Postweaning period; Rat

Indexed keywords

DNA; HUMAN INSULIN; INSULIN; WATER; LIPID; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET RESTRICTION; DNA CONTENT; DRUG EFFECT; DUODENUM; GLUCOSE BLOOD LEVEL; HISTOLOGY; INSULIN BLOOD LEVEL; INTESTINE MUCOSA; INTESTINE VILLUS; JEJUNUM; LIPID BLOOD LEVEL; MALE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; RAT; WEANING; ANIMAL; BLOOD; ILEUM; INTESTINE; METABOLISM; ORAL DRUG ADMINISTRATION; ORGAN SIZE; SPRAGUE DAWLEY RAT; TIME;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; DNA; ILEUM; INSULIN; INTESTINAL MUCOSA; INTESTINES; JEJUNUM; LIPIDS; MALE; ORGAN SIZE; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; WEANING;

EID: 23044511566     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-005-2766-7     Document Type: Article

References (29)

1. Carver JD, Barness LA: Trophic factors for the gastrointestinal tract. Clin Perinatol 23:265-285, 1996
2. Arsenault P, Menard D: Insulin influences the maturation and proliferation of suckling mouse intestinal mucosa in serum free organ culture. Biol Neonate 46:229-236, 1984
3. Shulman RJ: Oral insulin increases small intestinal mass and disaccharidase activity in the newborn miniature pig. Pediatr Res 28:171-175, 1990
4. Buts JP, de Kayser N, Dive C: Intestinal development in the suckling rat: effect of insulin on the maturation of villous and crypt cell functions. Eur J Clin Invest 18:391-398, 1988
5. Marandi S, De Keyser N, Saliez A, Maernoudt AS, Sokal EM, Stilmant C, Rider MH, Buts JP: Insulin signal transduction in rat small intestine: role of MAP kinases in expression of mucosal hydrolases. Am J Physiol Gastrointest Liver Physiol 280:G229-G240, 2001
6. Kinouchi T, Koizumi K, Kuwata T, Yajima T: Milk borne insulin with trypsin inhibitor in milk induces pancreatic amylase develop-ment at the onset of weaning in rats. J Pediatr Gastroenterol Nutr 30:515-521, 2000
7. Buts JP, De Keyser N, Kolanowski J, Van Hoof F: Hormonal regulation of the rat small intestine: responsiveness of villous and crypt cells to insulin during the suckling period and unresponsiveness after weaning. Pediatr Res 27:161-164, 1990
8. Meddings JB, Jarand S, Urbanski J, Hardin J, Gall D: Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat. Am J Physiol 276:G951-G957, 1999
9. Shehadeh N, Wies R, Eshach-Adiv O, Berant M, Etzioni A, Shamir R: Influence of oral insulin supplementation on carbohydrate, lipid and protein metabolism in weaned Balb/c mice. J Pediatr Endocrinol Metab 16:431-437, 2003
10. Eshach Adiv O, Mandel H, Shehadeh N, Knopf C, Shen-Or Z, Shamir R: Influence of co-administration of oral insulin and docosahexaenoic acid in mice. J Nutr Biochem (in press)
11. 0) mice. Arterioscler Thromb Vasc Biol 23:104-110, 2003
12. Chomczynski P: A reagent for the single- step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. BioTechniques 15:532-536, 1993
13. Roeschlau P, Bernt E, Gruber W: Enzymatic determination of total cholesterol in serum. Z Klin Chem Klin Biochem 12:226, 1974
14. Wahlefeld AW: Triglyceride determination after enzymatic hydrolysis. In Methods of Enzymatic Analysis, 2nd Engl ed. Wahlefeld AW, Bergmeyer HV (eds). New York, Academic Press, 1974, pp 1831-1835
15. Cervaska S, Kovacev V, Stanbovski M, Kalamalas E: The presence of immunologically reactive insulin in milk of women during the first week of lactation and its relation to changes in plasma insulin concentration. Acta Facult Skopje Jug Univ Med Facult Godsien 21:35-41, 1975
16. Shehadeh N, Shamir R, Berant M, Etzioni A: Insulin in human milk and the prevention of type 1 diabetes. Pediatr Diabetes 2:175-177, 2001
17. Mosinger B, Placer Z, Koldowsky O: Passage of insulin through the wall of the gastrointestinal tract of the infant rat. Nature 184:1245-1246, 1959
18. Arsenault P, Menard D: Insulin influences the maturation and proliferation of suckling mouse intestinal mucosa in serum-free organ culture. Biol Neonate 46:229-236, 1984
19. Buts JP, De Keyser N, Marandi S, Maernoudt AS, Sokal EM, Rahier J, Hermans D: Expression of insulin receptors and of 60-kDa receptor substrate in rat mature and immature enterocytes. Am J Physiol 273:G217-G226, 1997
20. Shehadeh N, Gelertner S, Blazer S, Perlamn R, Etzioni A: The importance of insulin content in infant diet: suggestion for a new infant formula. Acta Pediatr 90:93-95, 2001
21. Ziv E, Bendayan M: Intestinal absorption of peptides through the enterocytes. Microsc Res Tech 49:346-352, 2000
22. Pierce A, Risdall PC, Shaw B: Absorption of orally administered insulin by the newly born calf. J Physiol 171:203-215, 1964
23. Nordestgaard B, Aagerholm-Larsen B, Stender S: Effect of exogenous hyperinsulinemia on atherogenesis in cholesterol-fed rabbits. Diabetologia 40:512-520, 1997
24. Girard J, Perdereau D, Foufelle F, Prip-Buus C, Ferre P: Regulation of lipogenic enzyme gene expression by nutrients and hormones. FASEB J 8:36-42, 1994
25. De Feo P, Volpi E, Lucidi P, Cruciani G, Reboldi G, Siepi D, Mannarino E, Santeusanio F, Brunetti P, Bolli GB: Physiological increments in plasma insulin concentrations have selective and different effects on synthesis of hepatic proteins in normal humans. Diabetes 42:995-1002, 1993
26. Gylling H, Miettinen TA: Cholesterol absorption, synthesis and LDL metabolism in NIDDM. Diabetes Care 20:90-95, 1997
27. Miettinen TA , Tilvis RS, Kesaniemi YA: Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population. Am J Epidemiol 131:20-31, 1990
28. Shehadeh N, Khaesh-Goldberg E, Shamir R, Perlman R, Tamir A, Makhoul IR: Insulin concentration in human milk: Postpartum changes and effect of gestational age. Arch Dis Child Fetal Neonatal Ed 88:F214-F216, 2003
29. Shulman RJ: Effect of enteral administration of insulin on intestinal development and feeding tolerance in preterm infants: a pilot study. Arch Dis Child Fetal Neonatal Ed 86:F131-F133, 2002.