-
1
-
-
0033817459
-
Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension
-
Lane KB, Machado RD, Pauciulo MW, Thomson JR, Phillips JA 3rd, et al. (2000) Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. Nat Genet 26: 81-84.
-
(2000)
Nat Genet
, vol.26
, pp. 81-84
-
-
Lane, K.B.1
Machado, R.D.2
Pauciulo, M.W.3
Thomson, J.R.4
Phillips III, J.A.5
-
2
-
-
0035163071
-
BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension
-
Machado RD, Pauciulo MW, Thomson JR, Lane KB, Morgan NV, et al. (2001) BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension. Am J Hum Genet 68: 92-102.
-
(2001)
Am J Hum Genet
, vol.68
, pp. 92-102
-
-
Machado, R.D.1
Pauciulo, M.W.2
Thomson, J.R.3
Lane, K.B.4
Morgan, N.V.5
-
3
-
-
32544438253
-
BMPR2 gene rearrangements account for a significant proportion of mutations in familial and idiopathic pulmonary arterial hypertension
-
Aldred MA, Vijayakrishnan J, James V, Soubrier F, Gomez-Sanchez MA, et al. (2006) BMPR2 gene rearrangements account for a significant proportion of mutations in familial and idiopathic pulmonary arterial hypertension. Hum Mutat 27: 212-213.
-
(2006)
Hum Mutat
, vol.27
, pp. 212-213
-
-
Aldred, M.A.1
Vijayakrishnan, J.2
James, V.3
Soubrier, F.4
Gomez-Sanchez, M.A.5
-
5
-
-
84988934897
-
Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression
-
Austin ED, Menon S, Hemnes AR, Robinson LR, Talati M, et al. (2011) Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression. Pulm Circ 1: 389-398.
-
(2011)
Pulm Circ
, vol.1
, pp. 389-398
-
-
Austin, E.D.1
Menon, S.2
Hemnes, A.R.3
Robinson, L.R.4
Talati, M.5
-
6
-
-
0034193390
-
BMP type II receptor is required for gastrulation and early development of mouse embryos
-
Beppu H, Kawabata M, Hamamoto T, Chytil A, Minowa O, et al. (2000) BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol 221: 249-258.
-
(2000)
Dev Biol
, vol.221
, pp. 249-258
-
-
Beppu, H.1
Kawabata, M.2
Hamamoto, T.3
Chytil, A.4
Minowa, O.5
-
7
-
-
23044504042
-
Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice
-
Song Y, Jones JE, Beppu H, Keaney JF, Jr., Loscalzo J, et al. (2005) Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice. Circulation 112: 553-562.
-
(2005)
Circulation
, vol.112
, pp. 553-562
-
-
Song, Y.1
Jones, J.E.2
Beppu, H.3
Keaney Jr., J.F.4
Loscalzo, J.5
-
8
-
-
84863279449
-
Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension
-
Johnson JA, Hemnes AR, Perrien DS, Schuster M, Robinson LJ, et al. (2011) Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol.
-
(2011)
Am J Physiol Lung Cell Mol Physiol
-
-
Johnson, J.A.1
Hemnes, A.R.2
Perrien, D.S.3
Schuster, M.4
Robinson, L.J.5
-
9
-
-
34447542025
-
Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH
-
Tada Y, Majka S, Carr M, Harral J, Crona D, et al. (2007) Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH. Am J Physiol Lung Cell Mol Physiol 292: L1556-1563.
-
(2007)
Am J Physiol Lung Cell Mol Physiol
, vol.292
-
-
Tada, Y.1
Majka, S.2
Carr, M.3
Harral, J.4
Crona, D.5
-
10
-
-
2342486700
-
Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle
-
West J, Fagan K, Steudel W, Fouty B, Lane K, et al. (2004) Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle. Circ Res 94: 1109-1114.
-
(2004)
Circ Res
, vol.94
, pp. 1109-1114
-
-
West, J.1
Fagan, K.2
Steudel, W.3
Fouty, B.4
Lane, K.5
-
11
-
-
79959329487
-
Physiologic and Molecular Consequences of Endothelial Bmpr2 Mutation
-
Majka S, Hagen M, Blackwell T, Harral J, Johnson JA, et al. (2011) Physiologic and Molecular Consequences of Endothelial Bmpr2 Mutation. Respir Res 12: 84.
-
(2011)
Respir Res
, vol.12
, pp. 84
-
-
Majka, S.1
Hagen, M.2
Blackwell, T.3
Harral, J.4
Johnson, J.A.5
-
12
-
-
0035447556
-
High-dose dexamethasone accentuates nuclear factor-kappa b activation in endotoxin-treated mice
-
Sadikot RT, Jansen ED, Blackwell TR, Zoia O, Yull F, et al. (2001) High-dose dexamethasone accentuates nuclear factor-kappa b activation in endotoxin-treated mice. Am J Respir Crit Care Med 164: 873-878.
-
(2001)
Am J Respir Crit Care Med
, vol.164
, pp. 873-878
-
-
Sadikot, R.T.1
Jansen, E.D.2
Blackwell, T.R.3
Zoia, O.4
Yull, F.5
-
13
-
-
0037438457
-
Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammation
-
Sadikot RT, Han W, Everhart MB, Zoia O, Peebles RS, et al. (2003) Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammation. J Immunol 170: 1091-1098.
-
(2003)
J Immunol
, vol.170
, pp. 1091-1098
-
-
Sadikot, R.T.1
Han, W.2
Everhart, M.B.3
Zoia, O.4
Peebles, R.S.5
-
14
-
-
0037675008
-
Bioluminescent detection of endotoxin effects on HIV-1 LTR-driven transcription in vivo
-
Yull FE, Han W, Jansen ED, Everhart MB, Sadikot RT, et al. (2003) Bioluminescent detection of endotoxin effects on HIV-1 LTR-driven transcription in vivo. J Histochem Cytochem 51: 741-749.
-
(2003)
J Histochem Cytochem
, vol.51
, pp. 741-749
-
-
Yull, F.E.1
Han, W.2
Jansen, E.D.3
Everhart, M.B.4
Sadikot, R.T.5
-
15
-
-
0037085441
-
Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter
-
Korchynskyi O, ten Dijke P (2002) Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J Biol Chem 277: 4883-4891.
-
(2002)
J Biol Chem
, vol.277
, pp. 4883-4891
-
-
Korchynskyi, O.1
Ten Dijke, P.2
-
16
-
-
47949090917
-
Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors
-
Cuny GD, Yu PB, Laha JK, Xing X, Liu JF, et al. (2008) Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett 18: 4388-4392.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 4388-4392
-
-
Cuny, G.D.1
Yu, P.B.2
Laha, J.K.3
Xing, X.4
Liu, J.F.5
-
17
-
-
84863249942
-
Oxidative injury is a common consequence of BMPR2 mutations
-
Lane K, Talati M, Austin E, Hemnes A, Johnson J, et al. (2011) Oxidative injury is a common consequence of BMPR2 mutations. Pulmonary Circulation 1: 72-83.
-
(2011)
Pulmonary Circulation
, vol.1
, pp. 72-83
-
-
Lane, K.1
Talati, M.2
Austin, E.3
Hemnes, A.4
Johnson, J.5
-
18
-
-
84862112882
-
Alveolar macrophage dynamics in murine lung regeneration
-
Chamoto K, Gibney BC, Ackermann M, Lee GS, Lin M, et al. (2011) Alveolar macrophage dynamics in murine lung regeneration. J Cell Physiol.
-
(2011)
J Cell Physiol
-
-
Chamoto, K.1
Gibney, B.C.2
Ackermann, M.3
Lee, G.S.4
Lin, M.5
-
19
-
-
84864522564
-
Modern age pathology of pulmonary arterial hypertension
-
Stacher E, Graham BB, Hunt JM, Gandjeva A, Groshong SD, et al. (2012) Modern age pathology of pulmonary arterial hypertension. Am J Respir Crit Care Med 186: 261-272.
-
(2012)
Am J Respir Crit Care Med
, vol.186
, pp. 261-272
-
-
Stacher, E.1
Graham, B.B.2
Hunt, J.M.3
Gandjeva, A.4
Groshong, S.D.5
-
20
-
-
57149115142
-
Evidence for cell fusion is absent in vascular lesions associated with pulmonary arterial hypertension
-
Majka SM, Skokan M, Wheeler L, Harral J, Gladson S, et al. (2008) Evidence for cell fusion is absent in vascular lesions associated with pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol 295: L1028-1039.
-
(2008)
Am J Physiol Lung Cell Mol Physiol
, vol.295
-
-
Majka, S.M.1
Skokan, M.2
Wheeler, L.3
Harral, J.4
Gladson, S.5
-
21
-
-
84885055633
-
Nuclear factor kappa-B is activated in the pulmonary vessels of patients with end-stage idiopathic pulmonary arterial hypertension
-
Price LC, Caramori G, Perros F, Meng C, Gambaryan N, et al. (2013) Nuclear factor kappa-B is activated in the pulmonary vessels of patients with end-stage idiopathic pulmonary arterial hypertension. PLoS One 8: e75415.
-
(2013)
PLoS One
, vol.8
-
-
Price, L.C.1
Caramori, G.2
Perros, F.3
Meng, C.4
Gambaryan, N.5
-
22
-
-
34447534205
-
Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle
-
Hagen M, Fagan K, Steudel W, Carr M, Lane K, et al. (2007) Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle. Am J Physiol Lung Cell Mol Physiol 292: L1473-1479.
-
(2007)
Am J Physiol Lung Cell Mol Physiol
, vol.292
-
-
Hagen, M.1
Fagan, K.2
Steudel, W.3
Carr, M.4
Lane, K.5
-
23
-
-
84865750840
-
Bone morphogenetic protein receptor-II regulates pulmonary artery endothelial cell barrier function
-
Burton VJ, Ciuclan LI, Holmes AM, Rodman DM, Walker C, et al. (2010) Bone morphogenetic protein receptor-II regulates pulmonary artery endothelial cell barrier function. Blood.
-
(2010)
Blood
-
-
Burton, V.J.1
Ciuclan, L.I.2
Holmes, A.M.3
Rodman, D.M.4
Walker, C.5
-
24
-
-
84863280800
-
BMP type II receptor deficiency confers resistance to growth inhibition by TGF-beta1 in pulmonary artery smooth muscle cells: Role of pro-inflammatory cytokines
-
Davies RJ, Holmes AM, Deighton J, Long L, Yang X, et al. (2012) BMP type II receptor deficiency confers resistance to growth inhibition by TGF-beta1 in pulmonary artery smooth muscle cells: role of pro-inflammatory cytokines. Am J Physiol Lung Cell Mol Physiol.
-
(2012)
Am J Physiol Lung Cell Mol Physiol
-
-
Davies, R.J.1
Holmes, A.M.2
Deighton, J.3
Long, L.4
Yang, X.5
-
25
-
-
83755183459
-
Regulation of myosin light chain function by BMP signaling controls actin cytoskeleton remodeling
-
Konstantinidis G, Moustakas A, Stournaras C (2011) Regulation of myosin light chain function by BMP signaling controls actin cytoskeleton remodeling. Cell Physiol Biochem 28: 1031-1044.
-
(2011)
Cell Physiol Biochem
, vol.28
, pp. 1031-1044
-
-
Konstantinidis, G.1
Moustakas, A.2
Stournaras, C.3
-
26
-
-
33748851390
-
Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1
-
Choi KC, Lee YS, Lim S, Choi HK, Lee CH, et al. (2006) Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1. Nat Immunol 7: 1057-1065.
-
(2006)
Nat Immunol
, vol.7
, pp. 1057-1065
-
-
Choi, K.C.1
Lee, Y.S.2
Lim, S.3
Choi, H.K.4
Lee, C.H.5
-
28
-
-
67649844313
-
Inflammation, growth factors, and pulmonary vascular remodeling
-
Hassoun PM, Mouthon L, Barbera JA, Eddahibi S, Flores SC, et al. (2009) Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol 54: S10-19.
-
(2009)
J Am Coll Cardiol
, vol.54
-
-
Hassoun, P.M.1
Mouthon, L.2
Barbera, J.A.3
Eddahibi, S.4
Flores, S.C.5
-
29
-
-
80053571093
-
Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension
-
Tamosiuniene R, Tian W, Dhillon G, Wang L, Sung YK, et al. (2011) Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension. Circ Res 109: 867-879.
-
(2011)
Circ Res
, vol.109
, pp. 867-879
-
-
Tamosiuniene, R.1
Tian, W.2
Dhillon, G.3
Wang, L.4
Sung, Y.K.5
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