Nonmuscle myosin light chain kinase regulates murine asthmatic inflammation

American Journal of Respiratory Cell and Molecular Biology

Volumn 50, Issue 6, 2014, Pages 1129-1135

  Wang, Ting ^a   Moreno Vinasco, Liliana ^b   Ma, Shwu Fan ^c   Zhou, Tong ^a   Shimizu, Yuka ^a   Sammani, Saad ^b   Epshtein, Yulia ^b   Watterson, D Martin ^d   Dudek, Steven M ^b   Garcia, Joe G N ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Asthma; Endothelial permeability; Nonmuscle myosin light chain kinase; Transgenic mice

Indexed keywords

MYOSIN LIGHT CHAIN KINASE; OVALBUMIN; SMALL INTERFERING RNA;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; GENE DELETION; GENE EXPRESSION; HISTOPATHOLOGY; LUNG ENDOTHELIUM; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PNEUMONIA; RESPIRATORY TRACT ALLERGY; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; ASTHMA; CYTOKINES; ENDOTHELIAL CELLS; ENDOTHELIUM; LEUKOCYTES; LUNG; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MYOSIN-LIGHT-CHAIN KINASE; PNEUMONIA;

EID: 84899449486     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2013-0434OC     Document Type: Article

References (36)

1. Dizier MH, Besse-Schmittler C, Guilloud-Bataille M, Annesi-Maesano I, Boussaha M, Bousquet J, Charpin D, Degioanni A, Gormand F, Grimfeld A, et al. Genome screen for asthma and related phenotypes in the French EGEA study. Am J Respir Crit Care Med 2000;162:1812-1818.
2. Kurz T, Altmueller J, Strauch K, Ruschendorf F, Heinzmann A, Moffatt MF, Cookson WO, Inacio F, Nurnberg P, Stassen HH, et al. A genomewide screen on the genetics of atopy in a multiethnic European population reveals a major atopy locus on chromosome 3q21.3. Allergy 2005;60:192-199. (Pubitemid 40187473)
3. Lee YA, Wahn U, Kehrt R, Tarani L, Businco L, Gustafsson D, Andersson F, Oranje AP, Wolkertstorfer A, v Berg A, et al. A major susceptibility locus for atopic dermatitis maps to chromosome 3q21. Nat Genet 2000;26:470 -473.
4. Flores C, Ma SF, Maresso K, Ober C, Garcia JG. A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans. Genet Epidemiol 2007;31:296-305.
5. Lazar V, Garcia JG. A single human myosin light chain kinase gene (MLCK; MYLK). Genomics 1999;57:256-267.
6. Gallagher PJ, Herring BP, Griffin SA, Stull JT. Molecular characterization of a mammalian smooth muscle myosin light chain kinase. J Biol Chem 1991;266:23936-23944. (Pubitemid 21908888)
7. Garcia JG, Lazar V, Gilbert-McClain LI, Gallagher PJ, Verin AD. Myosin light chain kinase in endothelium: molecular cloning and regulation. Am J Respir Cell Mol Biol 1997;16:489-494. (Pubitemid 127498279)
8. Dudek SM, Garcia JG. Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol 2001;91:1487-1500. (Pubitemid 32900340)
9. Benayoun L, Druilhe A, Dombret MC, Aubier M, Pretolani M. Airway structural alterations selectively associated with severe asthma. Am J Respir Crit Care Med 2003;167:1360-1368. (Pubitemid 36609720)
10. Ma X, Cheng Z, Kong H, Wang Y, Unruh H, Stephens NL, Laviolette M. Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects. Am J Physiol Lung Cell Mol Physiol 2002;283:L1181-L1189. (Pubitemid 35379249)
11. Han YJ, Ma SF, Wade MS, Flores C, Garcia JG. An intronic MYLK variant associated with inflammatory lung disease regulates promoter activity of the smooth muscle myosin light chain kinase isoform. J Mol Med (Berl) 2012;90:299-308.
12. Gao L, Grant AV, Rafaels N, Stockton-Porter M, Watkins T, Gao P, Chi P, Munoz M, Watson H, Dunston G, et al. Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma. J Allergy Clin Immunol 2007;119:1111-1118. (Pubitemid 46654195)
13. Gao L, Grant A, Halder I, Brower R, Sevransky J, Maloney JP, Moss M, Shanholtz C, Yates CR, Meduri GU, et al. Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury. Am J Respir Cell Mol Biol 2006;34:487-495.
14. CSGA. A genome-wide search for asthma susceptibility loci in ethnically diverse populations. The Collaborative Study on the Genetics of Asthma (CSGA). Nat Genet 1997;15:389-392.
15. Clayburgh DR, Rosen S, Witkowski ED, Wang F, Blair S, Dudek S, Garcia JG, Alverdy JC, Turner JR. A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability. J Biol Chem 2004;279:55506-55513. (Pubitemid 40066552)
16. Kawkitinarong K, Linz-McGillem L, Birukov KG, Garcia JG. Differential regulation of human lung epithelial and endothelial barrier function by thrombin. Am J Respir Cell Mol Biol 2004;31:517 -527.
17. Garcia JG, Verin AD, Herenyiova M, English D. Adherent neutrophils activate endothelial myosin light chain kinase: role in transendothelial migration. J Appl Physiol 1998;84:1817 -1821.
18. Clayburgh DR, Barrett TA, Tang Y, Meddings JB, Van Eldik LJ, Watterson DM, Clarke LL, Mrsny RJ, Turner JR. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. J Clin Invest 2005;115:2702-2715. (Pubitemid 41434398)
19. Mirzapoiazova T, Moitra J, Moreno-Vinasco L, Sammani S, Turner JR, Chiang ET, Evenoski C, Wang T, Singleton PA, Huang Y, et al. Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury. Am J Respir Cell Mol Biol 2011;44:40-52.
20. Petrache I, Verin AD, Crow MT, Birukova A, Liu F, Garcia JG. Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction. Am J Physiol Lung Cell Mol Physiol 2001;280:L1168-L1178.
21. Lee KS, Park SJ, Kim SR, Min KH, Jin SM, Puri KD, Lee YC. Phosphoinositide 3-kinase-delta inhibitor reduces vascular permeability in a murine model of asthma. J Allergy Clin Immunol 2006;118:403-409. (Pubitemid 44142718)
22. Rossi JL, Velentza AV, Steinhorn DM, Watterson DM, Wainwright MS. MLCK210 gene knockout or kinase inhibition preserves lung function following endotoxin-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol 2007;292:L1327-L1334. (Pubitemid 47077349)
23. Wainwright MS, Rossi J, Schavocky J, Crawford S, Steinhorn D, Velentza AV, Zasadzki M, Shirinsky V, Jia Y, Haiech J, et al. Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment. Proc Natl Acad Sci USA 2003;100:6233 -6238.
24. Moitra J, Evenoski C, Sammani S, Wadgaonkar R, Turner JR, Ma SF, Garcia JG. A transgenic mouse with vascular endothelial overexpression of the non-muscle myosin light chain kinase-2 isoform is susceptible to inflammatory lung injury: role of sexual dimorphism and age. Transl Res 2008;151:141-153. (Pubitemid 351221439)
25. Wang T, Moreno-Vinasco L, Huang Y, Lang GD, Linares JD, Goonewardena SN, Grabavoy A, Samet JM, Geyh AS, Breysse PN, et al. Murine lung responses to ambient particulate matter: genomic analysis and influence on airway hyperresponsiveness. Environ Health Perspect 2008;116:1500-1508.
26. Tong J, Bandulwala HS, Clay BS, Anders RA, Shilling RA, Balachandran DD, Chen B, Weinstock JV, Solway J, Hamann KJ, et al. Fas-positive T cells regulate the resolution of airway inflammation in a murinemodel of asthma. J Exp Med 2006;203:1173-1184. (Pubitemid 43736588)
27. Walter MJ, Morton JD, Kajiwara N, Agapov E, Holtzman MJ. Viral induction of a chronic asthma phenotype and genetic segregation from the acute response. J Clin Invest 2002;110:165-175. (Pubitemid 34787353)
28. El-Ekiaby A, Brianas L, Skowronski ME, Coreno AJ, Galan G, Kaeberlein FJ, Seitz RE, Villaba KD, Dickey-White H, McFadden ER Jr. Impact of race on the severity of acute episodes of asthma and adrenergic responsiveness. Am J Respir Crit Care Med 2006;174:508- 513.
29. Lester LA, Rich SS, Blumenthal MN, Togias A, Murphy S, Malveaux F, Miller ME, Dunston GM, Solway J, Wolf RL, et al. Ethnic differences in asthma and associated phenotypes: collaborative study on the genetics of asthma. J Allergy Clin Immunol 2001;108:357-362. (Pubitemid 32881055)
30. Meyer NJ, Garcia JG. Wading into the genomic pool to unravel acute lung injury genetics. Proc Am Thorac Soc 2007;4:69-76. (Pubitemid 46067565)
31. Hogan SP, Mould AW, Young JM, Rothenberg ME, Ramsay AJ, Matthaei K, Young IG, Foster PS. Cellular and molecular regulation of eosinophil trafficking to the lung. Immunol Cell Biol 1998;76:454- 460.
32. Conroy DM, Williams TJ. Eotaxin and the attraction of eosinophils to the asthmatic lung. Respir Res 2001;2:150-156. (Pubitemid 34187921)
33. Holgate ST, Polosa R. The mechanisms, diagnosis, and management of severe asthma in adults. Lancet 2006;368:780-793. (Pubitemid 44279056)
34. McDonald DM. Angiogenesis and remodeling of airway vasculature in chronic inflammation. Am J Respir Crit Care Med 2001;164:S39-S45.
35. Jeffery PK. Remodeling in asthma and chronic obstructive lung disease. Am J Respir Crit Care Med 2001;164:S28-S38.
36. Harlan JM, Winn RK. Leukocyte-endothelial interactions: clinical trials of anti-adhesion therapy. Crit Care Med 2002;30(5 Suppl):S214-S219. (Pubitemid 34507993)