NFκB signaling is essential for the lipopolysaccharide-induced increase of type 2 deiodinase in tanycytes

Endocrinology

Volumn 155, Issue 5, 2014, Pages 2000-2008

  De Vries, E M ^a   Kwakkel, J ^a   Eggels, L ^a   Kalsbeek, A ^a,c   Barrett, P ^b   Fliers, E ^a   Boelen, Anita ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ROWETT RESEARCH INSTITUTE   (United Kingdom)

^c NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHYL N' (3 PHENYLPROPYL)BENZENE 1,2 DIAMINE; DEIODINASE TYPE 2; DIAMINE; ENZYME; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; SALAZOSULFAPYRIDINE; STRESS ACTIVATED PROTEIN KINASE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARCUATE NUCLEUS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; FEMALE; HYPOTHALAMUS; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MALE; MEDIAN EMINENCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TANYCYTE; UPREGULATION;

ANIMALS; ARCUATE NUCLEUS; CELLS, CULTURED; ENDOTOXINS; ENZYME INDUCTION; EPENDYMOGLIAL CELLS; FEMALE; IODIDE PEROXIDASE; MALE; MEDIAN EMINENCE; MICE; MICE, 129 STRAIN; MIDLINE THALAMIC NUCLEI; MITOGEN-ACTIVATED PROTEIN KINASE 8; NERVE TISSUE PROTEINS; NF-KAPPA B; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA;

EID: 84899440384     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-2018     Document Type: Article

References (36)

1. Boelen A, Kwakkel J, Fliers E. Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection. Endocr Rev. 2011;32:670-693.
2. Docter R, Krenning EP, de JM, Hennemann G. The sick euthyroid syndrome: changes in thyroid hormone serum parameters and hormone metabolism. Clin Endocrinol (Oxf). 1993;39:499-518. (Pubitemid 23323946
3. Fliers E, Guldenaar SE, Wiersinga WM, Swaab DF. Decreased hypothalamic thyrotropin-releasing hormone gene expression in patients with nonthyroidal illness. J Clin Endocrinol Metab. 1997;82: 4032-4036. (Pubitemid 27525507
4. Crantz FR, Silva JE, Larsen PR. An analysis of the sources and quantity of 3,5,3'-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum. Endocrinology. 1982; 110:367-375. (Pubitemid 12162924
5. Tu HM, Kim SW, Salvatore D, et al. Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone. Endocrinology. 1997;138:3359-3368. (Pubitemid 27345689
6. Alkemade A, Friesema EC, Unmehopa UA, et al. Neuroanatomical pathways for thyroid hormone feedback in the human hypothalamus. J Clin Endocrinol Metab. 2005;90:4322-4334. (Pubitemid 41058215
7. Boelen A, Kwakkel J, Thijssen-Timmer DC, Alkemade A, Fliers E, Wiersinga WM. Simultaneous changes in central and peripheral components of the hypothalamus-pituitary-thyroid axis in lipopolysaccharide- induced acute illness in mice. J Endocrinol. 2004;182: 315-323. (Pubitemid 39199015
8. Fekete C, Gereben B, Doleschall M, et al. Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome. Endocrinology. 2004;145:1649-1655. (Pubitemid 38402371
9. Fekete C, Sarkar S, Christoffolete MA, Emerson CH, Bianco AC, Lechan RM. Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels. Brain Res. 2005;1056:97-99. (Pubitemid 41219362
10. Sánchez E, Singru PS, Fekete C, Lechan RM. Induction of type 2 iodothyronine deiodinase in the mediobasal hypothalamus by bacterial lipopolysaccharide: role of corticosterone. Endocrinology. 2008;149:2484-2493. (Pubitemid 351574522
11. Freitas BC, Gereben B, Castillo M, et al. Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells. J Clin Invest. 2010;120:2206- 2217.
12. Boelen A, Kwakkel J, Chassande O, Fliers E. Thyroid hormone receptor ß mediates acute illness-induced alterations in central thyroid hormone metabolism. J Neuroendocrinol. 2009;21:465-472.
13. Lamirand A, Ramaugé M, Pierre M, Courtin F. Bacterial lipopolysaccharide induces type 2 deiodinase in cultured rat astrocytes. J Endocrinol. 2011;208:183-192.
14. Zeöld A, Doleschall M, Haffner MC, et al. Characterization of the nuclear factor-κ B responsiveness of the human dio2 gene. Endocrinology. 2006;147:4419-4429. (Pubitemid 44268393
15. Sabio G, Cavanagh-Kyros J, et al. Role of the hypothalamic-pituitary- thyroid axis in metabolic regulation by JNK1. Genes, Development. 2010;24:256-264.
16. Kwakkel J, Wiersinga WM, Boelen A. Differential involvement of nuclear factor-κB and activator protein-1 pathways in the interleukin- 1ß-mediated decrease of deiodinase type 1 and thyroid hormone receptor ß1 mRNA. J Endocrinol. 2006;189:37-44. (Pubitemid 43670699
17. Kwakkel J, Chassande O, van Beeren HC, Fliers E, Wiersinga WM, Boelen A. Thyroid hormone receptor α modulates lipopolysaccha ride-induced changes in peripheral thyroid hormone metabolism. Endocrinology. 2010;151:1959-1969.
18. Wiersinga WM, Chopra IJ. Radioimmunoassays of thyroxine-(T4), 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (reverse T3, Rt3), and 3,3'-diiodothyronine (T2). Methods Enzymol. 1982;84: 272-303.
19. 2 production and induces cell plasticity. J Neurosci. 2003;23:10622- 10632. (Pubitemid 37485276
20. Chauvet N, Parmentier ML, Alonso G. Transected axons of adult hypothalamo-neurohypophysial neurons regenerate along tanycytic processes. J Neurosci Res. 1995;41:129-144.
21. Chauvet N, Prieto M, Alonso G. Tanycytes present in the adult rat mediobasal hypothalamus support the regeneration of monoaminergic axons. Exp Neurol. 1998;151:1-13. (Pubitemid 28223851
22. Akmayev IG, Popov AP. Morphological aspects of the hypothalamic- hypophyseal system. VII. The tanycytes: their relation to the hypophyseal adrenocorticotrophic function. An ultrastructural study. Cell Tissue Res. 1977;180:263-282. (Pubitemid 8102833
23. Sánchez E, Singru PS, Wittmann G, Nouriel SS, Barrett P, Fekete C, LechanRM.Contribution ofTNF-α and nuclear factor-κBsignaling to type 2 iodothyronine deiodinase activation in the mediobasal hypothalamus after lipopolysaccharide administration. Endocrinology. 2010;151:3827-3835.
24. Boelen A, Kwakkel J, Wiersinga WM, Fliers E. Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake. J Endocrinol. 2006;191: 707-714. (Pubitemid 46210295
25. Boelen A, Kwakkel J, Wieland CW, St Germain DL, Fliers E, Hernandez A. Impaired bacterial clearance in type 3 deiodinase-deficient mice infected with Streptococcus pneumoniae. Endocrinology. 2009;150:1984-1990.
26. Diano S, Naftolin F, Goglia F, Horvath TL. Fasting-induced increase in type II iodothyronine deiodinase activity and messenger ribonucleic acid levels is not reversed by thyroxine in the rat hypothalamus. Endocrinology. 1998;139:2879-2884. (Pubitemid 28512399
27. Kameda Y, Arai Y, Nishimaki T. Ultrastructural localization of vimentin immunoreactivity and gene expression in tanycytes and their alterations in hamsters kept under different photoperiods. Cell Tissue Res. 2003;314:251-262. (Pubitemid 37452691
28. Fekete C, Mihály E, Herscovici S, et al. DARPP-32 and CREB are present in type 2 iodothyronine deiodinase-producing tanycytes: implications for the regulation of type 2 deiodinase activity. Brain Res. 2000;862:154-161. (Pubitemid 30229781
29. Barrett P, Ivanova E, Graham ES, et al. Photoperiodic regulation of cellular retinol binding protein, CRBP1 [corrected] and nestin in tanycytes of the third ventricle ependymal layer of the Siberian hamster. J Endocrinol. 2006;191:687-698. (Pubitemid 46210293
30. Wahl C, Liptay S, Adler G, Schmid RM. Sulfasalazine: a potent and specific inhibitor of nuclear factor κ B. J Clin Invest. 1998;101: 1163-1174. (Pubitemid 28125296
31. Shin HM, Kim MH, Kim BH, et al. Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-κB without affecting IκB degradation. FEBS Lett. 2004;571:50-54. (Pubitemid 38992922
32. Zhong H, May MJ, Jimi E, Ghosh S. The phosphorylation status of nuclear NF-κ B determines its association with CBP/p300 or HDAC-1. Mol Cell. 2002;9:625-636. (Pubitemid 34273792
33. Ghosh S, Karin M. Missing pieces in the NF-κB puzzle. Cell. 2002; 109:S81-S96.
34. Huang TT, Kudo N, Yoshida M, Miyamoto S. A nuclear export signal in the N-terminal regulatory domain of IκBα controls cytoplasmic localization of inactive NF-κB/IκBα complexes. Proc Natl Acad Sci USA. 2000;97:1014-1019. (Pubitemid 30080804
35. Malek S, Huang DB, Huxford T, Ghosh S, Ghosh G. X-ray crystal structure of an IκBß x NF-κB p65 homodimer complex J BiolChem. 2003;278:23094-23100. (Pubitemid 36830375
36. Yu J, Koenig RJ. Regulation of hepatocyte thyroxine 5'-deiodinase by T3 and nuclear receptor coactivators as a model of the sick euthyroid syndrome. J Biol Chem. 2000;275:38296-38301. March 17, 2014