Structure-activity relationships of pyrazole derivatives as potential therapeutics for immune thrombocytopenias

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 9, 2014, Pages 2739-2752

  Purohit, Meena K ^a,b   Chakka, Sai Kumar ^a   Scovell, Iain ^c   Neschadim, Anton ^c   Bello, Angelica M ^a,f   Salum, Noruê ^a,d   Katsman, Yulia ^c   Bareau, Madeleine C ^c   Branch, Donald R ^c   Kotra, Lakshmi P ^a,e,f  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

^c CANADIAN BLOOD SERVICES   (Canada)

^d FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^e UNIVERSITY HEALTH NETWORK   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

Author keywords

Immune thrombocytopenia; Phagocytosis inhibitors; Pyrazole derivatives; Structure activity relationship

Indexed keywords

1 (CYCLOHEXYLMETHYL) 3 METHYL 5 [(3 METHYL 1 PHENYL 1H PYRAZOL 5 YL]METHOXY) 1H PYRAZOLE; 1 BENZYL 3 METHYL 5 [(3 METHYL 1 PHENYL 1H PYRAZOL 5 YLOXY]METHYL) 1H PYRAZOLE; 1 CYCLOPENTYL 3 METHYL 5 [(3 METHYL 1 PHENYL 1H PYRAZOL 5 YL)METHOXY] 1H PYRAZOLE; 1,2 BIS(3 METHYL 1 PHENYL 1H PYRAZOL 5 YL)ETHANE; 1,2 BIS(3 METHYL 1 PHENYL 1H PYRAZOL 5 YLOXY)ETHANE; 2 [3 METHYL 5 [(3 METHYL 1 PHENYL 1H PYRAZOL 5 YL)METHOXY] 1H PYRAZOL 1 YL]ACETIC ACID; 2 [3 METHYL 5 [(3 METHYL 1 PHENYL 1H PYRAZOL 5 YL)METHOXY] 1H PYRAZOL 1 YL]ETHANAMINE; 3 METHYL 1 [(3 METHYL 1 PHENYL 1H PYRAZOL 5 YL)METHYL] 1H PYRAZOL 5 OL; 3 METHYL 5 (3 METHYL 1 PHENYL 1H PYRAZOL 5 YLOXY) 1 PHENYL 1H PYRAZOL 4 AMINE; 3 METHYL 5 [(3 METHYL 1 PHENYL 1H PYRAZOL 5 YL]METHOXY) 1 PHENYL 1H PYRAZOLE; 3 METHYL 5 [(3 METHYL 1H PYRAZOL 5 YLOXY)METHYL] 1 PHENYL 1H PYRAZOLE; 3 METHYL 5 [[[3 METHYL 1 (4 NITROPHENYL) 1H PYRAZOL 5 YL]OXY]METHYL] 1 PHENYL 1H PYRAZOLE; 5 [(1 BENZYLPYRROLIDIN 2 YL)METHOXY] 3 METHYL 1 PHENYL 1H PYRAZOLE; BIS[(3 METHYL 1 PHENYL 1H PYRAZOL 5 YL]METHYL)AMINE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ANTIBODY; PYRAZOLE;

ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; ERYTHROCYTE; HUMAN; HUMAN CELL; IC 50; IDIOPATHIC THROMBOCYTOPENIC PURPURA; MACROPHAGE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHAGOCYTOSIS; STRUCTURE ACTIVITY RELATION; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; IMMUNOLOGY; MONONUCLEAR CELL; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC;

ANTIBODIES; ERYTHROCYTES; HUMANS; LEUKOCYTES, MONONUCLEAR; PHAGOCYTOSIS; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84899432212     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.03.016     Document Type: Article

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