Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: A new class of potent and selective acetylcholinesterase inhibitors

Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2003, Pages 1144-1152

  Barreiro, Eliezer J ^a   Camara, Celso A ^a   Verli, Hugo ^a   Brazil Más, Leonora ^a   Castro, Newton G ^a   Cintra, Wagner M ^a   Aracava, Yasco ^a   Rodrigues, Carlos R ^a   Fraga, Carlos A M ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHENYL 5,6,7,8 TETRAHYDRO 2H PYRAZOLO[3,4 B]QUINOLIN 4 AMINE; 3 METHYL 1 PHENYL 1,5,6,7 TETRAHYDROCYCLOPENTA[B]PYRAZOLO[3,4 E]PYRIDIN 8 AMINE; 3 METHYL 1 PHENYL 1,5,6,7 TETRAHYDROCYCLOPENTA[B]PYRAZOLO[4,3 E]PYRIDIN 4 AMINE; 3 METHYL 1 PHENYL 1,6,7,8 TETRAHYDROCYCLOPENTA[B]PYRAZOLO[4,3 G][1,8]NAPHTHYRIDIN 5 AMINE; 3 METHYL 1 PHENYL 5,6,7,8 TETRAHYDRO 1H PYRAZOLO[3,4 B]QUINOLIN 4 AMINE; 3 METHYL 1 PHENYL 5,6,7,8 TETRAHYDRO 1H PYRAZOLO[4,3 B]QUINOLIN 9 AMINE; 3 METHYL 1 PHENYL 6,7,8,9 TETRAHYDRO 1H BENZO[B]PYRAZOLO[4,3 G][1,8]NAPHTHYRIDIN 5 AMINE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; NAPHTHYRIDINE DERIVATIVE; PYRAZOLO[3,4 B]NAPTHYRIDINE; PYRAZOLO[4,3 D]PYRIDINE; PYRIDINE DERIVATIVE; TACRINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE FLUIDITY; CHOLINESTERASE INHIBITION; COLORIMETRY; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; FETUS; IN VITRO STUDY; MOLECULAR DYNAMICS; NEUROTOXICITY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TORPEDO CALIFORNICA; X RAY CRYSTALLOGRAPHY;

ACETYLCHOLINESTERASE; ANIMALS; BUTYRYLCHOLINESTERASE; CELLS, CULTURED; CEREBRAL CORTEX; CHOLINESTERASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; NAPHTHYRIDINES; NEUROPROTECTIVE AGENTS; PYRAZOLES; PYRIDINES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; TORPEDO;

EID: 0345616432     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020391n     Document Type: Article

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