-
1
-
-
84860241870
-
A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate
-
Bruce J.Y., et al. A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate. Investig. New Drugs 2012, 30(2):794-802.
-
(2012)
Investig. New Drugs
, vol.30
, Issue.2
, pp. 794-802
-
-
Bruce, J.Y.1
-
2
-
-
84855801712
-
A phase II study of 2-methoxyestradiol (2ME2) nanocrystal(R) dispersion (NCD) in patients with taxane-refractory, metastatic castrate-resistant prostate cancer (CRPC)
-
Harrison M.R., et al. A phase II study of 2-methoxyestradiol (2ME2) nanocrystal(R) dispersion (NCD) in patients with taxane-refractory, metastatic castrate-resistant prostate cancer (CRPC). Investig. New Drugs 2011, 29(6):1465-1474.
-
(2011)
Investig. New Drugs
, vol.29
, Issue.6
, pp. 1465-1474
-
-
Harrison, M.R.1
-
3
-
-
79960900243
-
A prospective phase II study of 2-methoxyestradiol administered in combination with bevacizumab in patients with metastatic carcinoid tumors
-
Kulke M.H., et al. A prospective phase II study of 2-methoxyestradiol administered in combination with bevacizumab in patients with metastatic carcinoid tumors. Cancer Chemother. Pharmacol. 2011, 68(2):293-300.
-
(2011)
Cancer Chemother. Pharmacol.
, vol.68
, Issue.2
, pp. 293-300
-
-
Kulke, M.H.1
-
4
-
-
69249212263
-
Activity of 2 methoxyestradiol (Panzem NCD) in advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: a Hoosier Oncology Group trial
-
Matei D., et al. Activity of 2 methoxyestradiol (Panzem NCD) in advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: a Hoosier Oncology Group trial. Gynecol. Oncol. 2009, 115(1):90-96.
-
(2009)
Gynecol. Oncol.
, vol.115
, Issue.1
, pp. 90-96
-
-
Matei, D.1
-
5
-
-
10744231706
-
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
-
Mabjeesh N.J., et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 2003, 3(4):363-375.
-
(2003)
Cancer Cell
, vol.3
, Issue.4
, pp. 363-375
-
-
Mabjeesh, N.J.1
-
6
-
-
56449110050
-
An angiogenesis inhibitor, 2-methoxyestradiol, involutes rat collagen-induced arthritis and suppresses gene expression of synovial vascular endothelial growth factor and basic fibroblast growth factor
-
Brahn E., et al. An angiogenesis inhibitor, 2-methoxyestradiol, involutes rat collagen-induced arthritis and suppresses gene expression of synovial vascular endothelial growth factor and basic fibroblast growth factor. J. Rheumatol. 2008, 35(11):2119-2128.
-
(2008)
J. Rheumatol.
, vol.35
, Issue.11
, pp. 2119-2128
-
-
Brahn, E.1
-
7
-
-
79958765066
-
Role of 2-methoxyestradiol as inhibitor of arthritis and osteoporosis in a model of postmenopausal rheumatoid arthritis
-
Stubelius A., et al. Role of 2-methoxyestradiol as inhibitor of arthritis and osteoporosis in a model of postmenopausal rheumatoid arthritis. Clin. Immunol. 2011, 140(1):37-46.
-
(2011)
Clin. Immunol.
, vol.140
, Issue.1
, pp. 37-46
-
-
Stubelius, A.1
-
8
-
-
84871370448
-
2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation
-
Duncan G.S., et al. 2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation. Proc. Natl. Acad. Sci. U. S. A. 2012, 109(51):21034-21039.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, Issue.51
, pp. 21034-21039
-
-
Duncan, G.S.1
-
9
-
-
0037342558
-
Oestrogen receptor specificity in oestradiol-mediated effects on B lymphopoiesis and immunoglobulin production in male mice
-
Erlandsson M.C., et al. Oestrogen receptor specificity in oestradiol-mediated effects on B lymphopoiesis and immunoglobulin production in male mice. Immunology 2003, 108(3):346-351.
-
(2003)
Immunology
, vol.108
, Issue.3
, pp. 346-351
-
-
Erlandsson, M.C.1
-
10
-
-
0020696063
-
Enhancement of tumor metastasis and suppression of natural killer cell activity by beta-estradiol treatment
-
Hanna N., Schneider M. Enhancement of tumor metastasis and suppression of natural killer cell activity by beta-estradiol treatment. J. Immunol. 1983, 130(2):974-980.
-
(1983)
J. Immunol.
, vol.130
, Issue.2
, pp. 974-980
-
-
Hanna, N.1
Schneider, M.2
-
11
-
-
0027937803
-
Estrogen induces suppression of natural killer cell cytotoxicity and augmentation of polyclonal B-cell activation
-
Nilsson N., Carlsten H. Estrogen induces suppression of natural killer cell cytotoxicity and augmentation of polyclonal B-cell activation. Cell. Immunol. 1994, 158(1):131-139.
-
(1994)
Cell. Immunol.
, vol.158
, Issue.1
, pp. 131-139
-
-
Nilsson, N.1
Carlsten, H.2
-
12
-
-
0021288484
-
In vivo effect of progesteron and estrogen on thymus mass and T-cell functions in female mice
-
Marotti T., et al. In vivo effect of progesteron and estrogen on thymus mass and T-cell functions in female mice. Horm. Metab. Res. 1984, 16(4):201-203.
-
(1984)
Horm. Metab. Res.
, vol.16
, Issue.4
, pp. 201-203
-
-
Marotti, T.1
-
13
-
-
79951580018
-
Estrogens in rheumatoid arthritis; the immune system and bone
-
Islander U., et al. Estrogens in rheumatoid arthritis; the immune system and bone. Mol. Cell. Endocrinol. 2011, 335(1):14-29.
-
(2011)
Mol. Cell. Endocrinol.
, vol.335
, Issue.1
, pp. 14-29
-
-
Islander, U.1
-
14
-
-
34547792318
-
The complex role of estrogens in inflammation
-
Straub R.H. The complex role of estrogens in inflammation. Endocr. Rev. 2007, 28(5):521-574.
-
(2007)
Endocr. Rev.
, vol.28
, Issue.5
, pp. 521-574
-
-
Straub, R.H.1
-
15
-
-
0037370558
-
Dose-response effects of 2-methoxyestradiol on estrogen target tissues in the ovariectomized rat
-
Sibonga J.D., et al. Dose-response effects of 2-methoxyestradiol on estrogen target tissues in the ovariectomized rat. Endocrinology 2003, 144(3):785-792.
-
(2003)
Endocrinology
, vol.144
, Issue.3
, pp. 785-792
-
-
Sibonga, J.D.1
-
16
-
-
45749098246
-
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with preeclampsia
-
Kanasaki K., et al. Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with preeclampsia. Nature 2008, 453(7198):1117-1121.
-
(2008)
Nature
, vol.453
, Issue.7198
, pp. 1117-1121
-
-
Kanasaki, K.1
-
17
-
-
84868153248
-
Low 2-methoxyestradiol levels at the first trimester of pregnancy are associated with the development of preeclampsia
-
Perez-Sepulveda A., et al. Low 2-methoxyestradiol levels at the first trimester of pregnancy are associated with the development of preeclampsia. Prenat. Diagn. 2012, 32(11):1053-1058.
-
(2012)
Prenat. Diagn.
, vol.32
, Issue.11
, pp. 1053-1058
-
-
Perez-Sepulveda, A.1
-
18
-
-
84873060035
-
Aberrant synthesis, metabolism, and plasma accumulation of circulating estrogens and estrogen metabolites in preeclampsia implications for vascular dysfunction
-
Jobe S.O., Tyler C.T., Magness R.R. Aberrant synthesis, metabolism, and plasma accumulation of circulating estrogens and estrogen metabolites in preeclampsia implications for vascular dysfunction. Hypertension 2013, 61(2):480-487.
-
(2013)
Hypertension
, vol.61
, Issue.2
, pp. 480-487
-
-
Jobe, S.O.1
Tyler, C.T.2
Magness, R.R.3
-
19
-
-
84862506292
-
Sexual dimorphisms in the immune system of catechol-O-methyltransferase knockout mice
-
Stubelius A., et al. Sexual dimorphisms in the immune system of catechol-O-methyltransferase knockout mice. Immunobiology 2012, 217(8):751-760.
-
(2012)
Immunobiology
, vol.217
, Issue.8
, pp. 751-760
-
-
Stubelius, A.1
-
20
-
-
0036645421
-
2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta
-
LaVallee T.M., et al. 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta. Cancer Res. 2002, 62(13):3691-3697.
-
(2002)
Cancer Res.
, vol.62
, Issue.13
, pp. 3691-3697
-
-
LaVallee, T.M.1
-
21
-
-
16344381892
-
2-Methoxyestradiol is an estrogen receptor agonist that supports tumor growth in murine xenograft models of breast cancer
-
Sutherland T.E., et al. 2-Methoxyestradiol is an estrogen receptor agonist that supports tumor growth in murine xenograft models of breast cancer. Clin. Cancer Res. 2005, 11(5):1722-1732.
-
(2005)
Clin. Cancer Res.
, vol.11
, Issue.5
, pp. 1722-1732
-
-
Sutherland, T.E.1
-
22
-
-
0031036011
-
Suppression of type II collagen-induced arthritis by the endogenous estrogen metabolite 2-methoxyestradiol
-
Josefsson E., Tarkowski A. Suppression of type II collagen-induced arthritis by the endogenous estrogen metabolite 2-methoxyestradiol. Arthritis Rheum. 1997, 40(1):154-163.
-
(1997)
Arthritis Rheum.
, vol.40
, Issue.1
, pp. 154-163
-
-
Josefsson, E.1
Tarkowski, A.2
-
23
-
-
18544375627
-
Estrogen receptor specificity for the effects of estrogen in ovariectomized mice
-
Lindberg M.K., et al. Estrogen receptor specificity for the effects of estrogen in ovariectomized mice. J. Endocrinol. 2002, 174(2):167-178.
-
(2002)
J. Endocrinol.
, vol.174
, Issue.2
, pp. 167-178
-
-
Lindberg, M.K.1
-
24
-
-
3042712865
-
Tissue- and time-dependent estrogen receptor activation in estrogen reporter mice
-
Lemmen J.G., et al. Tissue- and time-dependent estrogen receptor activation in estrogen reporter mice. J. Mol. Endocrinol. 2004, 32(3):689-701.
-
(2004)
J. Mol. Endocrinol.
, vol.32
, Issue.3
, pp. 689-701
-
-
Lemmen, J.G.1
-
25
-
-
34548108398
-
The endogenous estradiol metabolite 2-methoxyestradiol reduces atherosclerotic lesion formation in female apolipoprotein E-deficient mice
-
Bourghardt J., et al. The endogenous estradiol metabolite 2-methoxyestradiol reduces atherosclerotic lesion formation in female apolipoprotein E-deficient mice. Endocrinology 2007, 148(9):4128-4132.
-
(2007)
Endocrinology
, vol.148
, Issue.9
, pp. 4128-4132
-
-
Bourghardt, J.1
-
26
-
-
31144449386
-
CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity
-
Hayakawa Y., Smyth M.J. CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity. J. Immunol. 2006, 176(3):1517-1524.
-
(2006)
J. Immunol.
, vol.176
, Issue.3
, pp. 1517-1524
-
-
Hayakawa, Y.1
Smyth, M.J.2
-
27
-
-
59049094662
-
Adaptive immune features of natural killer cells
-
Sun J.C., Beilke J.N., Lanier L.L. Adaptive immune features of natural killer cells. Nature 2009, 457(7229):557-561.
-
(2009)
Nature
, vol.457
, Issue.7229
, pp. 557-561
-
-
Sun, J.C.1
Beilke, J.N.2
Lanier, L.L.3
-
28
-
-
0030667676
-
Molecular basis of agonism and antagonism in the oestrogen receptor
-
Brzozowski A.M., et al. Molecular basis of agonism and antagonism in the oestrogen receptor. Nature 1997, 389(6652):753-758.
-
(1997)
Nature
, vol.389
, Issue.6652
, pp. 753-758
-
-
Brzozowski, A.M.1
-
29
-
-
18944381947
-
Structural basis for an unexpected mode of SERM-mediated ER antagonism
-
Wu Y.L., et al. Structural basis for an unexpected mode of SERM-mediated ER antagonism. Mol. Cell 2005, 18(4):413-424.
-
(2005)
Mol. Cell
, vol.18
, Issue.4
, pp. 413-424
-
-
Wu, Y.L.1
-
30
-
-
70349759531
-
Estrone/17beta-estradiol conversion to, and tumor necrosis factor inhibition by, estrogen metabolites in synovial cells of patients with rheumatoid arthritis and patients with osteoarthritis
-
Schmidt M., et al. Estrone/17beta-estradiol conversion to, and tumor necrosis factor inhibition by, estrogen metabolites in synovial cells of patients with rheumatoid arthritis and patients with osteoarthritis. Arthritis Rheum. 2009, 60(10):2913-2922.
-
(2009)
Arthritis Rheum.
, vol.60
, Issue.10
, pp. 2913-2922
-
-
Schmidt, M.1
-
31
-
-
21444459241
-
Estradiol metabolites attenuate renal and cardiovascular injury induced by chronic nitric oxide synthase inhibition
-
Tofovic S.P., et al. Estradiol metabolites attenuate renal and cardiovascular injury induced by chronic nitric oxide synthase inhibition. J. Cardiovasc. Pharmacol. 2005, 46(1):25-35.
-
(2005)
J. Cardiovasc. Pharmacol.
, vol.46
, Issue.1
, pp. 25-35
-
-
Tofovic, S.P.1
-
32
-
-
84887126579
-
2-Methoxyestradiol in the human corpus luteum throughout the luteal phase and its influence on lutein cell steroidogenesis and angiogenic activity
-
(e1)
-
Kohen P., et al. 2-Methoxyestradiol in the human corpus luteum throughout the luteal phase and its influence on lutein cell steroidogenesis and angiogenic activity. Fertil. Steril. 2013, 100(5):1397-1404. (e1).
-
(2013)
Fertil. Steril.
, vol.100
, Issue.5
, pp. 1397-1404
-
-
Kohen, P.1
-
33
-
-
0037125379
-
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial
-
Rossouw J.E., et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002, 288(3):321-333.
-
(2002)
JAMA
, vol.288
, Issue.3
, pp. 321-333
-
-
Rossouw, J.E.1
-
34
-
-
0037434618
-
Selective estrogen-receptor modulators - mechanisms of action and application to clinical practice
-
Riggs B.L., Hartmann L.C. Selective estrogen-receptor modulators - mechanisms of action and application to clinical practice. N. Engl. J. Med. 2003, 348(7):618-629.
-
(2003)
N. Engl. J. Med.
, vol.348
, Issue.7
, pp. 618-629
-
-
Riggs, B.L.1
Hartmann, L.C.2
-
35
-
-
13844293153
-
Raloxifene- and estradiol-mediated effects on uterus, bone and B lymphocytes in mice
-
Erlandsson M.C., et al. Raloxifene- and estradiol-mediated effects on uterus, bone and B lymphocytes in mice. J. Endocrinol. 2002, 175(2):319-327.
-
(2002)
J. Endocrinol.
, vol.175
, Issue.2
, pp. 319-327
-
-
Erlandsson, M.C.1
-
36
-
-
1642319678
-
Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents
-
Ireson C.R., et al. Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents. Br. J. Cancer 2004, 90(4):932-937.
-
(2004)
Br. J. Cancer
, vol.90
, Issue.4
, pp. 932-937
-
-
Ireson, C.R.1
-
37
-
-
33749320658
-
Estrogens, enzyme variants, and breast cancer: a risk model
-
Crooke P.S., et al. Estrogens, enzyme variants, and breast cancer: a risk model. Cancer Epidemiol. Biomarkers Prev. 2006, 15(9):1620-1629.
-
(2006)
Cancer Epidemiol. Biomarkers Prev.
, vol.15
, Issue.9
, pp. 1620-1629
-
-
Crooke, P.S.1
-
38
-
-
0038407728
-
Methoxyestrogens exert feedback inhibition on cytochrome P450 1A1 and 1B1
-
Dawling S., Roodi N., Parl F.F. Methoxyestrogens exert feedback inhibition on cytochrome P450 1A1 and 1B1. Cancer Res. 2003, 63(12):3127-3132.
-
(2003)
Cancer Res.
, vol.63
, Issue.12
, pp. 3127-3132
-
-
Dawling, S.1
Roodi, N.2
Parl, F.F.3
-
39
-
-
0030030930
-
Metabolic deglucuronidation and demethylation of estrogen conjugates as a source of parent estrogens and catecholestrogen metabolites in Syrian hamster kidney, a target organ of estrogen-induced tumorigenesis
-
Zhu B.T., et al. Metabolic deglucuronidation and demethylation of estrogen conjugates as a source of parent estrogens and catecholestrogen metabolites in Syrian hamster kidney, a target organ of estrogen-induced tumorigenesis. Toxicol. Appl. Pharmacol. 1996, 136(1):186-193.
-
(1996)
Toxicol. Appl. Pharmacol.
, vol.136
, Issue.1
, pp. 186-193
-
-
Zhu, B.T.1
|