Low-flow mediated constriction: The yin to FMD's yang?

Expert Review of Cardiovascular Therapy

Volumn 12, Issue 5, 2014, Pages 557-564

  Humphreys, Ruth E ^a   Green, Daniel J ^a,b   Cable, N Timothy ^a,c   Thijssen, Dick H J ^a,d   Dawson, Ellen A ^a  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c ASPIRE Academy for Sports Excellence   (Qatar)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

cardiovascular prognosis; cardiovascular risk; composite end point; endothelial function; flow mediated dilation; low flow mediated constriction

Indexed keywords

ARTERY CONSTRICTION; ARTERY ENDOTHELIUM; ARTICLE; BLOOD FLOW; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CORONARY ARTERY DILATATION; ENDOTHELIAL DYSFUNCTION; FLOW MEDIATED DILATION; HUMAN; LOW FLOW MEDIATED CONSTRICTION; PREDICTIVE VALUE; PREVALENCE; PROGNOSIS; RADIAL ARTERY; RISK FACTOR; SENSITIVITY AND SPECIFICITY; CARDIOVASCULAR DISEASES; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; VASODILATATION;

CARDIOVASCULAR DISEASES; ENDOTHELIUM, VASCULAR; HUMANS; PREDICTIVE VALUE OF TESTS; RISK FACTORS; SENSITIVITY AND SPECIFICITY; VASOCONSTRICTION; VASODILATION;

EID: 84899120781     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/14779072.2014.909728     Document Type: Article

References (60)

1. Alwan A. Global status report on noncommunicable diseases 2010. WHO; Geneva, Switzerland: 2011. p. 176
2. Quyyumi AA. Prognostic value of endothelial function. Am J Cardiol 2003; 91(12A):19H-24H
3. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288(5789):373-6
4. Cooke JP, Tsao PS. Is NO an endogenous antiatherogenic molecule? Arterioscler Throm 1994;14(5):653-5
5. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43(2): 109-42
6. Myers J, Prakash M, Froelicher V, et al. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med 2002;346(11):793-801
7. Heran BS, Chen JM, Ebrahim S, et al. Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev 2011(7):CD001800
8. Naghavi M, Libby P, Falk E, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I. Circulation 2003;108(14):1664-72
9. de Simone G, Roman MJ, Koren MJ, et al. Stroke volume/pulse pressure ratio and cardiovascular risk in arterial hypertension. Hypertension 1999;33(3):800-5
10. Ben-Shlomo Y, Spears M, Boustred C, et al. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. J Am Coll Cardiol 2013
11. Wang TJ, Gona P, Larson MG, et al. Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med 2006;355(25):2631-9
12. Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340(8828): 1111-15
13. Corretti MC, Anderson TJ, Benjamin EJ, et al. Guidelines for the ultrasound assessment of endothelial-dependent flowmediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002;39(2):257-65
14. Thijssen DH, Black MA, Pyke KE, et al. Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. Am J Physiol Heart Circ Physiol 2011;300(1):H2-12
15. Green DJ, Dawson EA, Groenewoud HM, et al. Is flow-mediated dilation nitric oxide mediated?: a meta-analysis. Hypertension 2014;63(2):376-82
16. Joannides R, Haefeli WE, Linder L, et al. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 1995;91(5):1314-19
17. Green DJ, Maiorana A, O'Driscoll G, Taylor R. Effect of exercise training on endothelium-derived nitric oxide function in humans. J Physiol 2004;561(Pt 1):1-25
18. Hambrecht R, Adams V, Erbs S, et al. Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation 2003;107(25):3152-8
19. Maiorana A, O'Driscoll G, Cheetham C, et al. The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes. J Am Coll Cardiol 2001;38(3):860-6
20. Watts K, Beye P, Siafarikas A, et al. Exercise training normalizes vascular dysfunction and improves central adiposity in obese adolescents. J Am Coll Cardiol 2004;43(10):1823-7
21. Green DJ, Jones H, Thijssen D, et al. Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter? Hypertension 2011;57(3):363-9
22. Ras RT, Streppel MT, Draijer R, Zock PL. Flow-mediated dilation and cardiovascular risk prediction: a systematic review with meta-analysis. Int J Cardiol 2013;168(1): 344-51
23. Celermajer DS, Sorensen KE, Georgakopoulos D, et al. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation 1993;88(5 Pt 1): 2149-55
24. Clarkson P, Celermajer DS, Donald AE, et al. Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low density lipoprotein cholesterol levels. J Am Coll Cardiol 1996;28(3):573-9
25. Levenson J, Simon A, Pithois-Merli I. Brachial arterial changes in response to wrist occlusion in normotensive and hypertensive men. Am J Physiol 1987;253(2 Pt 2): H217-24
26. Anderson EA, Mark AL. Flow-mediated and reflex changes in large peripheral artery tone in humans. Circulation 1989;79(1):93-100
27. Levenson J, Pessana F, Gariepy J, et al. Gender differences in wall shear-mediated brachial artery vasoconstriction and vasodilation. J Am Coll Cardiol 2001;38(6): 1668-74
28. Megnien JL, Simon A, Andriani A, et al. Cholesterol lowering therapy inhibits the low-flow mediated vasoconstriction of the brachial artery in hypercholesterolaemic subjects. Br J Clin Pharmacol 1996;42(2): 187-93
29. Mullen MJ, Kharbanda RK, Cross J, et al. Heterogenous nature of flow-mediated dilatation in human conduit arteries in vivo: relevance to endothelial dysfunction in hypercholesterolemia. Circ Res 2001;88(2): 145-51
30. Spieker LE, Luscher TF, Noll G. ET A receptors mediate vasoconstriction of large conduit arteries during reduced flow in humans. J Cardiovasc Pharmacol 2003; 42(3):315-18
31. Gori T, Dragoni S, Lisi M, et al. Conduit artery constriction mediated by low flow a novel noninvasive method for the assessment of vascular function. J Am Coll Cardiol 2008;51(20):1953-8
32. Gori T, Parker JD, Munzel T. Flow-mediated constriction: further insight into a new measure of vascular function. Eur Heart J 2011;32(7):784-7
33. Charakida M, de Groot E, Loukogeorgakis SP, et al. Variability and reproducibility of flow-mediated dilatation in a multicentre clinical trial. Eur Heart J 2013;34(45):3501-7
34. Ghiadoni L, Faita F, Salvetti M, et al. Assessment of flow-mediated dilation reproducibility: a nationwide multicenter study. J Hypertens 2012;30(7):1399-405
35. Spiro JR, Digby JE, Ghimire G, et al. Brachial artery low-flow-mediated constriction is increased early after coronary intervention and reduces during recovery after acute coronary syndrome: characterization of a recently described index of vascular function. Eur Heart J 2011; 32(7):856-66
36. Dawson EA, Alkarmi A, Thijssen DH, et al. Low-flow mediated constriction is endothelium-dependent: effects of exercise training after radial artery catheterization. Circ Cardiovasc Interv 2012;5(5):713-19
37. Thijssen DH, Rongen GA, Smits P, Hopman MT. Physical (in)activity and endothelium-derived constricting factors: overlooked adaptations. J Physiol 2008; 586(2):319-24
38. Thijssen DH, Dawson EA, Black MA, et al. Heterogeneity in conduit artery function in humans: impact of arterial size. Am J Physiol Heart Circ Physiol 2008;295(5): H1927-34
39. Thijssen DH, Willems L, van den Munckhof I, et al. Impact of wall thickness on conduit artery function in humans: is there a "Folkow" effect? Atherosclerosis 2011;217(2):415-19
40. Filitti V, Giral P, Simon A, et al. Enhanced constriction of the peripheral large artery in response to acute induction of a low-flow state in human hypercholesterolemia. Arterioscler Thromb 1991;11(1):161-6
41. Stadler RW, Ibrahim SF, Lees RS. Measurement of the time course of peripheral vasoactivity: results in cigarette smokers. Atherosclerosis 1998;138(1): 197-205
42. Thijssen DH, van Bemmel MM, Bullens LM, et al. The impact of baseline diameter on flow-mediated dilation differs in young and older humans. Am J Physiol Heart Circ Physiol 2008;295(4): H1594-8
43. Weissgerber TL, Davies GA, Tschakovsky ME. Low flow-mediated constriction occurs in the radial but not the brachial artery in healthy pregnant and nonpregnant women. J Appl Physiol 2010; 108(5):1097-105
44. Gori T, Grotti S, Dragoni S, et al. Assessment of vascular function: flow-mediated constriction complements the information of flow-mediated dilatation. Heart 2010;96(2):141-7
45. Gori T, Muxel S, Damaske A, et al. Endothelial function assessment: flow-mediated dilation and constriction provide different and complementary information on the presence of coronary artery disease. Eur Heart J 2012;33(3): 363-71
46. Anderson TJ, Uehata A, Gerhard MD, et al. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol 1995;26(5): 1235-41
47. Takase B, Uehata A, Akima T, et al. Endothelium-dependent flow-mediated vasodilation in coronary and brachial arteries in suspected coronary artery disease. Am J Cardiol 1998;82(12):1535-9.A7-8
48. Harrison M, Parkhurst K, Tarumi T, et al. Low flow-mediated constriction: prevalence, impact and physiological determinant. Clin Physiol Funct Imaging 2011;31(5):394-8
49. Rakobowchuk M, Harris E, Taylor A, et al. Heavy and moderate interval exercise training alters low-flow-mediated constriction but does not increase circulating progenitor cells in healthy humans. Exp Physiol 2012;97(3):375-85
50. Rakobowchuk M, Parsloe ER, Gibbins SE, et al. Prolonged low flow reduces reactive hyperemia and augments low flow mediated constriction in the brachial artery independent of the menstrual cycle. PLoS One 2013;8(2):e55385
51. Dørup I, Skajaa K, Sørensen KE. Normal pregnancy is associated with enhanced endothelium-dependent flow-mediated vasodilation. Am J Physiol 1999;276(3): H821-H5
52. Sianos G, Morel MA, Kappetein AP, et al. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. Euro Intervention 2005;1(2):219-27
53. Kaku B, Mizuno S, Ohsato K, et al. The correlation between coronary stenosis index and flow-mediated dilation of the brachial artery. Jpn Circ J 1998;62(6):425-30
54. Green DJ. Exercise training as vascular medicine: direct impacts on the vasculature in humans. Exerc Sport Sci Rev 2009;37(4): 196-202
55. Mora S, Cook N, Buring JE, et al. Physical activity and reduced risk of cardiovascular events: potential mediating mechanisms. Circulation 2007;116(19):2110-18
56. Maiorana AJ, Naylor LH, Exterkate A, et al. The impact of exercise training on conduit artery wall thickness and remodeling in chronic heart failure patients. Hypertension 2011;57(1):56-62
57. Swift DL, Earnest CP, Blair SN, Church TS. The effect of different doses of aerobic exercise training on endothelial function in postmenopausal women with elevated blood pressure: results from the DREW study. Br J Sports Med 2012; 46(10):753-8
58. Tinken TM, Thijssen DH, Black MA, et al. Time course of change in vasodilator function and capacity in response to exercise training in humans. J Physiol 2008; 586(Pt 20):5003-12
59. Dawson EA, Rathore S, Cable NT, et al. Impact of introducer sheath coating on endothelial function in humans after transradial coronary procedures. Circ Cardiovasc Interv 2010;3(2):148-56
60. Atkinson G, Batterham AM, Thijssen DH, Green DJ. A new approach to improve the specificity of flow-mediated dilation for indicating endothelial function in cardiovascular research. J Hypertens 2013; 31(2):287-91