Inhibition of calcineurin abrogates while inhibition of mTOR promotes regulatory T cell expansion and graft-versus-host disease protection by IL-2 in allogeneic bone marrow transplantation

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Satake, Atsushi ^a,b   Schmidt, Amanda M ^a   Nomura, Shosaku ^b   Kambayashi, Taku ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; INTERLEUKIN 2; RAPAMYCIN; T LYMPHOCYTE RECEPTOR;

ACUTE GRAFT VERSUS HOST DISEASE; ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL EXPANSION; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG POTENTIATION; GRAFT RECIPIENT; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PROTECTION; REGULATORY T LYMPHOCYTE;

ANIMALS; BONE MARROW TRANSPLANTATION; CALCINEURIN; CYCLOSPORINE; GRAFT VS HOST DISEASE; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MELANOMA, EXPERIMENTAL; MICE; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, REGULATORY; TISSUE DONORS; TOR SERINE-THREONINE KINASES; TRANSPLANTATION, HOMOLOGOUS;

EID: 84899105427     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092888     Document Type: Article

References (27)

1. Sakaguchi S, Yamaguchi T, Nomura T, Ono M (2008) Regulatory T cells and immune tolerance. Cell 133: 775-787. (Pubitemid 351707693)
2. Josefowicz SZ, Rudensky A, Sakaguchi S, Yamaguchi T, Nomura T, et al. (2009) Control of regulatory T cell lineage commitment and maintenance Regulatory T cells and immune tolerance. Immunity 30: 616-625.
3. Fontenot JD, Gavin MA, Rudensky AY (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4: 330-336. (Pubitemid 36432314)
4. Joffre O, Santolaria T, Calise D, Al Saati T, Hudrisier D, et al. (2008) Prevention of acute and chronic allograft rejection with CD4 +CD25+Foxp3+ regulatory T lymphocytes. Nat Med 14: 88-92.
5. Edinger M, Hoffmann P, Ermann J, Drago K, Fathman CG, et al. (2003) CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med 9: 1144-1150. (Pubitemid 37173698)
6. Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S (2002) Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med 196: 389-399. (Pubitemid 34875667)
7. Setoguchi R, Hori S, Takahashi T, Sakaguchi S (2005) Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med 201: 723-735. (Pubitemid 40395118)
8. Gavin MA, Clarke SR, Negrou E, Gallegos A, Rudensky A (2002) Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol 3: 33-41. (Pubitemid 34065615)
9. Bhandoola A, Tai X, Eckhaus M, Auchincloss H, Mason K, et al. (2002) Peripheral expression of self-MHC-II influences the reactivity and self-tolerance of mature CD4(+) T cells: evidence from a lymphopenic T cell model. Immunity 17: 425-436. (Pubitemid 35223532)
10. Zou T, Caton AJ, Koretzky GA, Kambayashi T (2010) Dendritic cells induce regulatory T cell proliferation through antigen-dependent and -independent interactions. J Immunol 185: 2790-2799.
11. Swee LK, Bosco N, Malissen B, Ceredig R, Rolink A (2009) Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment. Blood 113: 6277-6287.
12. Satake A, Schmidt AM, Archambault A, Leichner TM, Wu GF, et al. (2013) Differential targeting of IL-2 and T cell receptor signaling pathways selectively expands regulatory T cells while inhibiting conventional T cells. J Autoimmun 44: 13-20.
13. Cooke KR, Kobzik L, Martin TR, Brewer J, Delmonte J Jr, et al. (1996) An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood 88: 3230-3239. (Pubitemid 26357409)
14. Sawamukai N, Satake A, Schmidt AM, Lamborn IT, Ojha P, et al. (2012) Cell-autonomous role of TGFbeta and IL-2 receptors in CD4 (+) and CD8(+) inducible regulatory T-cell generation during GVHD. Blood 119: 5575-5583.
15. Robb RJ, Lineburg KE, Kuns RD, Wilson YA, Raffelt NC, et al. (2012) Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation. Blood 119: 5898-5908.
16. Beres AJ, Haribhai D, Chadwick AC, Gonyo PJ, Williams CB, et al. (2012) CD8+ Foxp3+ regulatory T cells are induced during graft-versus-host disease and mitigate disease severity. J Immunol 189: 464-474.
17. Shin HJ, Baker J, Leveson-Gower DB, Smith AT, Sega EI, et al. (2011) Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells. Blood 118: 2342-2350.
18. Zou T, Satake A, Ojha P, Kambayashi T (2011) Cellular therapies supplement: the role of granulocyte macrophage colony-stimulating factor and dendritic cells in regulatory T-cell homeostasis and expansion. Transfusion 51 Suppl 4: 160S-168S.
19. Wang Y, Camirand G, Lin Y, Froicu M, Deng S, et al. (2011) Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice. J Immunol 186: 2809-2818.
20. Zeiser R, Leveson-Gower DB, Zambricki EA, Kambham N, Beilhack A, et al. (2008) Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+T cells. Blood 111: 453-462.
21. Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY (2005) A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 6: 1142-1151. (Pubitemid 41541792)
22. D'Cruz LM, Klein L (2005) Development and function of agonist-induced CD25+Foxp3 + regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol 6: 1152-1159. (Pubitemid 41541793)
23. Zeiser R, Nguyen VH, Beilhack A, Buess M, Schulz S, et al. (2006) Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood 108: 390-399. (Pubitemid 43990654)
24. Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, et al. (2006) FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126: 375-387. (Pubitemid 44092960)
25. Matsuoka K, Kim HT, McDonough S, Bascug G, Warshauer B, et al. (2010) Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation. J Clin Invest 120: 1479-1493.
26. Sakoda Y, Hashimoto D, Asakura S, Takeuchi K, Harada M, et al. (2007) Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease. Blood 109: 1756-1764. (Pubitemid 46239612)
27. Koreth J, Matsuoka K, Kim HT, McDonough SM, Bindra B, et al. (2011) Interleukin-2 and regulatory T cells in graft-versus-host disease. N Engl J Med 365: 2055-2066.