Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 16, 2014, Pages 5884-5889

  Ng, Ashley P ^a,b   Kauppi, Maria ^a,b   Metcalf, Donald ^a,b   Hyland, Craig D ^a   Josefsson, Emma C ^a,b   Lebois, Marion ^a   Zhang, Jian Guo ^a,b   Baldwin, Tracey M ^a   Di Rago, Ladina ^a   Hilton, Douglas J ^a,b   Alexander, Warren S ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Bone marrow; Essential thrombocythemia

Indexed keywords

CD34 ANTIGEN; MPL PROTEIN; ONCOPROTEIN; THROMBOPOIETIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLAST CELL; CONTROLLED STUDY; EMBRYONIC STEM CELL; EOSINOPHIL; GENE EXPRESSION; GENE EXPRESSION PROFILING; HEMATOCRIT; LEUKOCYTE COUNT; LYMPHOCYTE; MEGAKARYOBLAST; MEGAKARYOCYTE; MONOCYTE; MOUSE; MYELOID PROGENITOR CELL; MYELOPROLIFERATIVE DISORDER; MYELOPROLIFERATIVE NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; THROMBOCYTE; THROMBOCYTE COUNT; THROMBOCYTOPOIESIS; THROMBOCYTOSIS; TRANSGENIC MOUSE; VIRUS ONCOGENE;

BONE MARROW; ESSENTIAL THROMBOCYTHEMIA;

ANIMALS; ANTIGENS, CD34; BLOOD PLATELETS; CELL COMPARTMENTATION; CELL PROLIFERATION; CLONE CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC LOCI; HEMATOPOIETIC STEM CELLS; INTEGRASES; MEGAKARYOCYTES; MICE; MODELS, BIOLOGICAL; MYELOID CELLS; RECEPTORS, THROMBOPOIETIN; THROMBOCYTOSIS; THROMBOPOIESIS; THROMBOPOIETIN; TRANSCRIPTION, GENETIC;

EID: 84899095747     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1404354111     Document Type: Article

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