Effect of iontophoresis on topical delivery of doxorubicin-loaded solid lipid nanoparticles

Journal of Biomedical Nanotechnology

Volumn 10, Issue 7, 2014, Pages 1382-1390

  Taveira, Stephânia F ^a   De Santana, Danielle C A S ^b   Araújo, Luciana M P C ^b   Marquele Oliveira, Franciane ^b   Nomizo, Auro ^b   Lopez, Renata F V ^b  

^a FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Doxorubicin; Iontophoresis; Skin Cancer; Solid Lipid Nanoparticle; Topical Drug Delivery

Indexed keywords

DERMATOLOGY; DRUG DELIVERY; ELECTROOSMOSIS; ELECTROTHERAPEUTICS; NANOPARTICLES;

DOXORUBICIN; IONTOPHORESIS; SKIN CANCERS; SOLID LIPID NANOPARTICLE (SLN); TOPICAL DRUG DELIVERIES;

ELECTROPHORESIS;

DOXORUBICIN; SOLID LIPID NANOPARTICLE; LIPID; NANOPARTICLE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; DRUG ACCUMULATION; DRUG PENETRATION; DRUG TRANSPORT; ELECTROOSMOTIC FLOW; EPIDERMIS; IONTOPHORESIS; NONHUMAN; SKIN CANCER; SKIN PENETRATION; STRATUM CORNEUM; ANIMAL; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; ELECTRODE; ELECTROOSMOSIS; HUMAN; IMPEDANCE; IN VITRO STUDY; PERMEABILITY; SKIN; SWINE; TOPICAL DRUG ADMINISTRATION; TUMOR CELL LINE; ULTRASTRUCTURE;

ADMINISTRATION, TOPICAL; ANIMALS; CELL LINE, TUMOR; DOXORUBICIN; DRUG DELIVERY SYSTEMS; ELECTRIC IMPEDANCE; ELECTRODES; ELECTROOSMOSIS; HUMANS; IN VITRO TECHNIQUES; IONTOPHORESIS; LIPIDS; NANOPARTICLES; PERMEABILITY; SKIN; SUS SCROFA;

EID: 84899085501     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2014.1834     Document Type: Article

References (46)

1. H. Herai, T. Gratieri, J. A. Thomazine, and M. V. L. B. Bentley, and R. F. V. Lopez, Doxorubicin skin penetration from monolein-containing propylene glycol formulations. Int. J. Pharm. 329, 88 (2007).
2. G. M. Gelfuso, F. V. Figueiredo, T. Gratieri, and R. F. V. Lopez, The effects of pH and ionic strength on topical delivery of a negatively charged porphyrin (TPPS4). J. Pharm. Sci. 97, 4249 (2008).
3. P. Mikolajewska, R. F. Donnelly, M. J. Garland, D. I. J. Morrow, T. R. R. Singh, V. Iani, J. Moan, and A. Juzeniene, Microneedle pre-treatment of human skin improves 5-aminolevulinic acid (ALA) and 5-aminolevulinic acid methyl ester (MAL)-induced PpIX production for topical photodynamic therapy without increase in pain or erythema. Pharm. Res. 27, 2213 (2010).
4. L. M. P. De Campos-Araújo, J. A. Thomazine, and R. F. V. Lopez, Development of microemulsions to topically deliver 5-aminolevulinic acid in photodynamic therapy. Eur. J. Pharm. Biopharm. 75, 48 (2010).
5. D. C. A. S. De Santana, T. T. Pupo, M. G. Sauaia, R. S. Da Silva, and R. F. V. Lopez, Nitric oxide photorelease from hydrogels and from skin containing a nitro-ruthenium complex. Int. J. Pharm. 391, 21 (2010).
6. L. W. Zhang, Y. P. Fang, and J. Y. Fang, Enhancement techniques for improving 5-aminolevulinic acid delivery through the skin. Dermatol. Sin. 29, 1 (2011).
7. J. G. Souza, G. M. Gelfuso, P. S. Simão, A. C. Borges, and R. F. V. Lopez, Iontophoretic transport of zinc phthalocyanine tetrasulfonic acid as a tool to improve drug topical delivery. Anticancer. Drugs 22, 783 (2011).
8. H. L. Lu, W. J. Syu, N. Nishiyama, K. Katoaka, and P. S. Lai, Dendrimer phthalocyanine-encapsulated polymeric micelle-mediated photochemical internalization extends the efficacy of photodynamic therapy and overcomes drug-resistance in vivo. J. Control. Release 155, 458 (2011).
9. M. V. Barrera and E. Herrera, Topical chemotherapy for actinic keratosis and nonmelanoma skin cancer: Current options and future perspectives. Actas. Dermosifiliogr. 98, 556 (2007).
10. H. L. Wong, A. M. Rauth, R. Bendayan, and X. Y. Wu, In vivo evaluation of a new polymer-lipid hybrid nanoparticles (PLN) formulation of doxorubicin in a murine solid tumor model. Eur. J. Pharm. Biopharm. 65, 300 (2007).
11. S. F. Taveira, A. Nomizo, and R. F. V. Lopez, Effect of the iontophoresis of a chitosan gel on doxorubicin skin penetration and cytotoxicity. J. Control. Release 134, 35 (2009).
12. S. F. Taveira, L. M. Araújo, D. C. De Santana, A. Nomizo, L. A. De Freitas, and R. F. V. Lopez, Development of cationic solid lipid nanoparticles with factorial design-based studies for topical administration of doxorubicin. J. Biomed. Nanotechnol. 8, 219 (2012).
13. J. Liu, W. Hu, H. Chen, Q. Ni, H. Xu, and X. Yang, Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery. Int. J. Pharm. 328, 191 (2007).
14. J. Fang, C. Fang, C. Liu, and Y. Su, Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC). Eur. J. Pharm. Biopharm. 70, 633 (2008).
15. Q. Lv, A. Yu, Y. Xi, H. Li, Z. Song, J. Cui, F. Cao, and G. Zhai, Development and evaluation of penciclovir-loaded solid lipid nanoparticles for topical delivery. Int. J. Pharm. 372, 191 (2009).
16. R. H. Muller, K. Mader and S. Gohla, Solid lipid nanoparticles (SLN) for controlled drug delivery: A review of the state of the art. Eur. J. Pharm. Biopharm. 50, 161 (2000).
17. F. Marquele-Oliveira, D. C. Santana, S. F. Taveira, D. M. Vermeulen, A. R. De Oliveira, R. S. Da Silva, and R. F. Lopez, Development of nitrosyl ruthenium complex-loaded lipid carriers for topical administration: Improvement in skin stability and in nitric oxide release by visible light irradiation. J. Pharm. Biomed. Anal. 53, 843 (2010).
18. R. H. Guy, Y. N. Kalia, M. B. Delgado-Charro, V. Merino, A. López, and D. Marro, Iontophoresis: Electrorepulsion and electroosmosis. J. Control. Release 64, 129 (2000).
19. Y. N. Kalia, A. Naik, J. Garrison, and R. H. Guy, Iontophoretic drug delivery. Adv. Drug. Deliv. Rev. 56, 519 (2004).
20. M. B. Delgado-Charro, Iontophoretic drug delivery across the nail. Expert. Opin. Drug. Deliv. 9, 91 (2012).
21. K. Tomoda, H. Terashima, K. Suzuki, T. Inagi, H. Terada, and K. Makino, Enhanced transdermal delivery of indomethacin using combination of PLGA nanoparticles and iontophoresis in vivo. Colloids. Surf. B. Biointerfaces 92, 50 (2012).
22. W. Liu, M. Hu, W. Liu, C. Xue, H. Xu, and Z. L. Yang, Investigation of the carbopol gel of solid lipid nanoparticles for the transdermal iontophoretic delivery of tramcinolone acetonide acetate. Int. J. Pharm. 364, 135 (2008).
23. S. Nicoli, P. Santi, P. Couvreur, G. Couarraze, P. Colombo, and E. Fattal, Design of tiptorelin loaded nanospheres for transdermal iontophoretic administration. Int. J. Pharm. 214, 31 (2001).
24. M. R. Gasco, Method for producing solid lipid microspheres having a narrow size distribution, US Patent No. 188837 (1993).
25. FDA, Guidance for Industry - Bioanalytical Method Validation (2001), pp. 1-11.
26. P. Glikfeld, C. Cullander, R. S. Hinz, and R. H. Guy, A new system for in vitro studies of iontophoresis. Pharm. Res. 5, 443 (1988).
27. P. G. Green, R. S. Hinz, C. Cullander, G. Yamane, and R. H. Guy, Iontophoretic delivery of amino acids and amino acid derivatives across the skin in vitro. Pharm. Res. 8, 1113 (1991).
28. Y. B. Schuets, A. Naik, R. H. Guy, E. Vuaridel, and Y. N. Kalia, Transdermal iontophoretic delivery of triptorelin in vitro. J. Pharm. Sci. 94, 2175 (2005).
29. S. Mitragotri, J. Farrell, H. Tang, T. Terahara, J. Kost, and R. Langer, Determination of threshold energy dose for ultrasound-induced transdermal drug transport. J. Control. Release 63, 41 (2000).
30. J. E. Seto, B. E. Polat, R. F. V. Lopez, D. Blankschtein, and R. Langer, Effects of ultrasound and sodium lauryl sulfate on the transdermal delivery of hydrophilic permeants: Comparative in vitro studies with full-thickness and split-thickness pig and human skin. J. Control. Release 145, 26 (2010).
31. M. H. Gaber, M. M. Ghannam, S. A. Ali, and W. A. Khalil, Interaction of doxorubicin with phospholipid monolayer and liposomes. Biophys. Chem. 70, 229 (1998).
32. D. Marro, Y. N. Kalia, M. B. Delgado-Charro, and R. H. Guy, Contributions of electromigration and electroosmosis to iontophoretic drug delivery. Pharm. Res. 18, 1701 (2001).
33. M. B. Delgado-Charro and R. H. Guy, Characterization of convective solvent flow during iontophoresis. Pharm. Res. 11, 929 (1994).
34. M. Schäfer-Korting, W. Mehnert, and H. Korting, Lipid nanoparticles for improved topical application of drugs for skin diseases. Adv. Drug. Deliv. Rev. 59, 427 (2007).
35. R. H. Muller, R. D. Petersen, A. Hommoss, and J. Pardeike, Nanostructured lipid carriers (NLC) in cosmetic dermal products. Adv. Drug. Deliv. Rev. 59, 522 (2007).
36. W. Mehnert and K. Mäder, Solid lipid nanoparticles: Production, characterization and applications. Adv. Drug. Deliv. Rev. 47, 165 (2001).
37. S. N. Murthy, Y. L. Zhao, S. W. Hui, and A. Sen, Synergistic effect of anionic lipid enhancer and electroosmosis for transcutaneous delivery of insulin. Int. J. Pharm. 326, 1 (2006).
38. E. Pereverzeva, I. Treschalin, D. Bodyagin, O. Maksimenko, K. Langer, S. Dreis, B. Asmussen, J. Kreuter, and S. Gelperina, Influence of the formulation on the tolerance profile of nanoparticle-bound doxorubicin in healthy rats: focus on cardio- and testicular toxicity. Int. J. Pharm. 337, 346 (2007).
39. Y. Matsumura, T. Hamaguchi, T. Ura, K. Muro, Y. Yamada, Y. Shimada, K. Shirao, T. Okusaka, H. Ueno, M. Ikeda, and N. Watanabe, Phase I clinical trial and pharmacokinetic evaluation of NK911 a micelle-encapsulated doxorubicin. Br. J. Cancer. 91, 1775 (2004).
40. J. L. Raoul, D. Heresbach, J. F. Bretagne, D. Bentue Ferrer, R. Buvauferrier, P. Bourguet, M. Messner, and M. Gosselin, Chemoembolization of hepatocellular carcinomas: a study of the biodistribution and pharamcokinetics of doxorubicin. Cancer 70, 585 (1992).
41. H. L. Wong, R. Bendayan, A. M. Rauth, Y. Li, and X. Y. Wu, Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles. Adv. Drug Deliv. Reviews 59, 491 (2007).
42. Y. Z. Zhao, C. Z. Sun, C. T. Lu, D. D. Dai, H. F. Lv, Y. Wu, C. W. Wan, L. J. Chen, M. Lin, and X. K.-Li, Characterization and antitumor activity of chemical conjugation of doxorubicin in polymeric micelles (DOX-P) in vitro. Cancer Lett. 311, 187 (2011).
43. S. Kunjachan, A. Blauz, D. Möckel, B. Theek, F. Kiessling, T. Etrych, K. Ulbrich, L. Van Bloois, F. Storm, G. Bartosz, B. Rychlik, and T. Lammers, Overcoming cellular multidrug resistance using classical nanomedicine formulations. Eur. J. Pharm. Sci. 45, 421 (2012).
44. Y. P. Fang, Y. K. Lin, Y. H. Su, and J. Y. Fang, Tryptanthrin-loaded nanoparticles for delivery into cultured human breast cancer cells, MCF7: The effects of solid lipid/liquid lipid ratios in the inner core. Chem. Pharm. Bull. 59, 266 (2011).
45. C. He, Y. Hu, L. Yin, C. Tang, and C. Yin, Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. Biomaterials 31, 3657 (2010).
46. T. Kaasgaard and T. L. Andresen, Liposomal cancer therapy: Exploiting tumor characteristics. Expert. Opin. Drug. Deliv. 7, 225 (2010).