GM-CSF-DFF40: A novel humanized immunotoxin induces apoptosis in acute myeloid leukemia cells

Apoptosis

Volumn 18, Issue 7, 2013, Pages 882-895

  Mathew, Mrudula ^a   Zaineb, K C ^a   Verma, Rama Shanker ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY MADRAS   (India)

Author keywords

Acute myeloid leukemia (AML); Apoptosis; DNA fragmentation factor 40 (DFF40); Granulocyte macrophage colony stimulating factor (GM CSF); Immunotoxin; Targeted cancer therapy

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; CASPASE; CASPASE 3; CASPASE ACTIVATED DEOXYRIBONUCLEASE; CHIMERIC PROTEIN; COMPLEMENTARY DNA; CYTOCHROME C; DYE; FLUORESCEIN ISOTHIOCYANATE; GM CSF DFF40 FUSION PROTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYBRID PROTEIN; JC 1; LIPOCORTIN 5; PROTEIN BAX; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL KILLING; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; ESCHERICHIA COLI; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; LEUKEMIA CELL; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR CLONING; NICK END LABELING; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; PROTEIN SECRETION; STAINING;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DEOXYRIBONUCLEASES; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, LEUKEMIC; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMMUNOTOXINS; LEUKEMIA; NEOPLASM PROTEINS; PROTEIN BINDING; PROTEIN REFOLDING; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION;

EID: 84878725509     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-013-0840-8     Document Type: Article

References (23)

1. Burgess AW, Camakaris J, Metcalf D (1977) Purification and properties of colon stimulating factor from mouse lung-conditioned medium. J Biol Chem 252:1998-2003
2. Burgess AW, Metcalf D (1980) The nature and action of granulocyte-macrophage colony stimulating factors. Blood 56:947-958
3. Park LS, Waldron PE, Friend D (1989) Interleukin-3, GM-CSF, and G-CSF receptor expression on cell lines and primary leukemia cells: receptor heterogeneity and relationship to growth factor responsiveness. Blood 74:56-65
4. Miyagawa K, Chiba S, Shibuya K (1990) Frequent expression of receptors for granulocyte-macrophage colony-stimulating factor on human nonhematopoietic tumor cell lines. J Cell Physiol 143:483-487
5. Perentesis JP, Waddick KG, Bendel AE (1997) Induction of apoptosis in multidrug- resistant and radiation-resistant acute myeloid leukemia cells by a recombinant fusion toxin directed against the human granulocyte macrophage colony-stimulating factor receptor. Clin Cancer Res 3:347-355
6. Kreitman RJ, Pastan I (1997) Recombinant toxins containing human granulocyte-macrophage colony-stimulating factor and either pseudomonas exotoxin or diphtheria toxin kill gastrointestinal cancer and leukemia cells. Blood 90:252-259
7. Lappi D, Martineau D, Sarmientos P (1993) Characterization of a saporin mitotoxin specifically cytotoxic to cells bearing the granulocyte-macrophage colony-stimulating factor receptor. Growth Factors 9:31-39
8. Frankel AE, Powell BL, Hall PD, Case LD, Kreitman RJ (2002) Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia. Clin Cancer Res 8:1004-1013
9. Mathew M, Verma RS (2009) Humanized immunotoxins: a new generation of immunotoxins for targeted cancer therapy. Cancer Sci 100:1359-1365
10. Stahnke B, Thepen T, Stocker M (2008) Granzyme B-H22(scFv), a human immunotoxin targeting CD64 in acute myeloid leukemia of monocytic subtypes. Mol Cancer Ther 7:2924-2932
11. Antignani A, Youle RJ (2005) A chimeric protein induces tumor cell apoptosis by delivering the human Bcl-2 family BH3-only protein Bad. Biochemistry 44:4074-4082
12. Zhang JH, Xu M (2000) DNA fragmentation in apoptosis. Cell Res 10:205-211
13. Liu X, Zou H, Widlak P, Garrard W, Wang X (1999) Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). J Biol Chem 274:13836-13840
14. Ben-Yehudah A, Aqeilan R, Robashkevich D, Lorberboum-Galski H (2003) Using apoptosis for targeted cancer therapy by a new gonadotropin releasing hormone-DNA fragmentation factor 40 chimeric protein. Clin Cancer Res 9:1179-1190
15. Tsumoto K, Umetsu M, Kumagai I (2004) Role of arginine in protein refolding, solubilization and purification. Biotechnol Prog 20:1301-1308
16. Kurata H, Arai T, Yokota T, Arai K (1995) Differential expression of granulocyte-macrophage colony-stimulating factor and IL-3 receptor subunits on human CD34 + cells and leukemic cell lines. J Allergy Clin Immunol 96:1083-1099
17. Heaney ML, Vera JC, Raines MA, Golde DW (1995) Membrane-associated and soluble granulocyte/macrophage-colony-stimulating factor receptor alpha subunits are independently regulated in HL-60 cells. Proc Natl Acad Sci USA 92:2365-2369
18. Saraste A, Pulkki K (2000) Morphologic and biochemical hallmarks of apoptosis. Cardiovasc Res 45:528-537
19. Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi X-G, Youle RJ (1997) Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol 139:1281-1292
20. Wetzler M, Byrd JC, Bloomfield CD (2010) Acute and chronic myeloid leukemia. In: Longo D (ed) Harrison's hematology and oncology. McGraw-Hill, New York, pp 166-181
21. Pulte D, Gondos A, Brenner H (2010) Expected long-term survival of patients diagnosed with acute myeloblastic leukemia during 2006-2010. Ann Oncol 21:335-341
22. MacFarlane M, Williams AC (2004) Apoptosis and disease: a life or death decision. EMBO Rep 5:674-678
23. Testa U, Riccioni R (2007) Deregulation of apoptosis in acute myeloid leukemia. Haematologica 92:81-94