Safety and feasibility of autologous umbilical cord blood transfusion in 2 toddlers with cerebral palsy and the role of low dose granulocyte-colony stimulating factor injections

Restorative Neurology and Neuroscience

Volumn 29, Issue 1, 2011, Pages 17-22

  Papadopoulos, Konstantinos I ^a   Low, Sharon Su Shing ^b   Aw, Tar Choon ^b,c   Chantarojanasiri, Teerachai ^d  

^a Offices at Central World   (Thailand)

^b StemLife Bhd   (Malaysia)

^c MONASH UNIVERSITY   (Australia)

^d Vejthani Hospital   (Thailand)

Author keywords

Autologous cord blood stem cell transfusion; CD34+; cerebral palsy; cord blood; granulocyte colony stimulating factor; Gross Motor Function Classification System; hypoxic ischemic brain injury; neurogenesis; neuroprotection; stem cells; umbilical cord

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR;

ARTICLE; BLOOD TRANSFUSION; CASE REPORT; CEREBRAL PALSY; CHILD; DRUG SAFETY; HUMAN; LOW DRUG DOSE; MALE; MEDICAL HISTORY; PATIENT SAFETY; PRIORITY JOURNAL; TREATMENT OUTCOME; UMBILICAL CORD BLOOD;

BLOOD TRANSFUSION, AUTOLOGOUS; CEREBRAL PALSY; CHILD, PRESCHOOL; COMBINED MODALITY THERAPY; FEASIBILITY STUDIES; FETAL BLOOD; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; MALE;

EID: 79951918129     PISSN: 09226028     EISSN: 18783627     Source Type: Journal    
DOI: 10.3233/RNN-2011-0572     Document Type: Article

References (31)

1. Andersen, G.L., Irgens, L.M., Haagaas, I., Skranes, J.S., Meberg, A.E. & Vik, T. (2008). Cerebral palsy in Norway: prevalence, subtypes and severity. Eur J Paediatr Neurol, 12(1), 4-13. (Pubitemid 350251848)
2. Arien-Zakay, H., Lecht, S., Bercu, M.M. et al. (2009). Neuroprotection by cord blood neural progenitors involves antioxidants, neurotrophic and angiogenic factors. Exp Neurol, 216(1), 83-94.
3. Bachstetter, A.D., Pabon, M.M., Cole, M.J. et al. (2008). Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain. BMC Neurosci, 14, 9, 22. (Pubitemid 351423981)
4. Bax, M., Goldstein, M., Rosenbarum, P., et al. (2005). Proposed definition and classification of cerebral palsy. Dev Med Child Neurol, 47(8), 571-576. (Pubitemid 41131619)
5. Cavallaro, A.M., Lilleby, K.,Majolino, I. et al. (2000). Three to six year follow-up of normal donors who received recombinant human granulocyte colony-stimulating factor. Bone Marrow Transplant, 25(1), 85-89. (Pubitemid 30093161)
6. Chen, N., Hudson, J.E.,Walczak, P. et al. (2005). Human umbilical cord blood progenitors: the potential of these hematopoietic cells to become neural. Stem Cells, 23(10), 1560-1570. (Pubitemid 41741005)
7. Collet, J.P., Vanasse, M., Marois, P. et al. (2001). Hyperbaric oxygen for children with cerebral palsy: a randomised multicentre trial. HBO-CP Research Group. Lancet, 357(9256), 582-586. (Pubitemid 32179610)
8. Frampton, J.E., Lee, C.R. & Faulds, D. (1994). Filgrastim. A review of its pharmacological properties and therapeutic efficacy in neutropenia. Drugs, 48(5),731-760. (Pubitemid 24304423)
9. Harris, D.T. (2009). Non-haematological uses of cord blood stem cells. Br J Haematol, 147(2), 177-184.
10. Herranz, A.S., Gonzalo-Gobernado, R., Reimers, D. et al. (2009). Applications of Human Umbilical Cord Blood Cells in Central Nervous System Regeneration. Curr Stem Cell Res Ther. Oct 7. (Epub ahead of print). http://articles.latimes.com/2008/apr/07/health/hecpalsy7 (accessed February 2010) http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5303a4.htm (accessed February 2010) http://www.foxnews.com/video/index.html?playerId=011008 &streamingFormat=FLASH&referralObject=11461523& referreferralPlaylistId=playlist (accessed February 2010).
11. Klocke, R., Kuhlmann, M.T., Scobioala, S., Schäbitz, W.R. & Nikol, S. (2008). Granulocyte colony-stimulating factor (G-CSF) for cardio- and cerebrovascular regenerative applications. Curr Med Chem, 15(10), 968-977. (Pubitemid 351736399)
12. Luo, J., Zhang, H.T., Jiang, X.D., Xue, S. & Ke, Y.Q. (2009). Combination of bone marrow stromal cell transplantation with mobilization by granulocyte-colony stimulating factor promotes functional recovery after spinal cord transection. Acta Neurochir (Wien), 151(11), 1483-1492.
13. Maurer, M.H., Schäbitz, W.R. & Schneider, A. (2008). Old friends in new constellations-the hematopoetic growth factors G-CSF, GM-CSF, and EPO for the treatment of neurological diseases. Curr Med Chem, 15(14), 1407-1011.
14. Meier, C., Middelanis, J., Wasielewski, B. et al. (2006). Spastic paresis after perinatal brain damage in rats is reduced by human cord blood mononuclear cells. Pediatr Res, 59(2), 244-249. (Pubitemid 43840996)
15. Mezey, E., Key, S., Vogelsang, G., Szalayova, I., Lange, G.D. & Crain, B. (2003). Transplanted bone marrow generates new neurons in human brains. Proc Natl Acad Sci U S A, 100(3), 1364-1369. (Pubitemid 36184007)
16. Nishio, Y., Koda, M., Kamada, T. et al. (2007). Granulocyte colony-stimulating factor attenuates neuronal death and promotes functional recovery after spinal cord injury in mice. J Neuropathol Exp Neurol, 66(8), 724-731. (Pubitemid 47344251)
17. Palisano, R.J., Cameron, D., Rosenbaum, P.L.,Walter, S.D. & Russell, D. (2006). Stability of the gross motor function classification system. Dev Med Child Neurol, 48(6), 424-428. (Pubitemid 43740901)
18. Palisano, R.J., Hanna, S.E., Rosenbaum, P.L. & Tieman, B. (2009). Probability ofwalking, wheeledmobility, and assisted mobility in children and adolescents with cerebral palsy. Dev Med Child Neurol, Aug 27. (Epub ahead of print)
19. Palisano, R., Rosenbaum, P., Walter, S., Russell, D., Wood, E. & Galuppi, B. (1997). Development and reliability of a system to classify gross motor function in children with cerebral palsy. Dev Med Child Neurol, 39(4), 214-223. (Pubitemid 27226331)
20. Pan, H.C., Wu, H.T., Cheng, F.C., Chen, C.H., Sheu, M.L. & Chen, C.J. (2009). Potentiation of angiogenesis and regeneration by G-CSF after sciatic nerve crush injury. Biochem Biophys Res Commun, 382(1), 177-182.
21. Papadopoulos, K.I., Chanthachorn, S., Paisan, M.& Unkarunwong, A. (2008). Safety and Feasibility of Autologous Umbilical Cord Blod Stem Cell Intravenous Infusion in a toddler with Spastic Diplegia/Cerebral Palsy: a Case Report (abstract). 22nd Annual Royal College of Obstetrics and Gynaecology, Chonburi, Thailand.
22. Pulsipher, M.A., Nagler, A., Iannone, R. & Nelson, R.M. (2006). Weighing the risks of G-CSF administration, leukopheresis, and standard marrow harvest: ethical and safety considerations for normal pediatric hematopoietic cell donors. Pediatr Blood Cancer, 46(4), 422-433. (Pubitemid 43334647)
23. Ro, L.S., Chen, S.R., Chao, P.K., Lee, Y.L. & Lu, K.T. (2009). The Potential Application of Granulocyte Colony Stimulating Factor Therapy on Neuropathic Pain. Chang Gung Med J, 32(3), 235-346.
24. Schneider, A., Krüger C., Steigleder, T. et al. (2005). The hematopoietic factor G-CSF is a neuronal ligand that counter-acts programmed cell death and drives neurogenesis. J Clin Invest, 115(8), 2083-2098. (Pubitemid 41134150)
25. Schäbitz, W.R., Krüger, C., Pitzer, C. et al. (2008). A neuro-protective function for the hematopoietic protein granulocytemacrophage colony stimulating factor (GM-CSF). J Cereb Blood Flow Metab, 28(1), 29-43.
26. Serefhanoglu, S., Goker, H., Buyukasik, Y., Buyukasik, Y. & Ozcebe, O.I. (2009). Changes in vascular endothelial growth factor, angiopoietins, and Tie-2 levels with G-CSF stimulation in healthy donors. Ann Hematol, 88(7), 667-671.
27. Sevimli, S., Diederich, K., Strecker, J.K. et al. (2009). Endogenous brain protection by granulocyte-colony stimulating factor after ischemic stroke. Exp Neurol, 217(2), 328-335.
28. Shyu, W.C., Lin, S.Z., Lee, C.C., Liu, D.D. & Li, H. (2006). Granulocyte colony-stimulating factor for acute ischemic stroke: a randomized controlled trial. CMAJ, 174(7), 927-933.
29. Tigue, C.C., McKoy, J.M., Evens, A.M., Trifilio, S.M., Tallman, M.S. & Bennett, C.L. (2007). Granulocyte-colony stimulating factor administration to healthy individuals and persons with chronic neutropenia or cancer: an overview of safety considerations from the Research on Adverse Drug Events and Reports project. Bone Marrow Transplant, 40(3), 185-192. (Pubitemid 47108460)
30. Toth, Z.E., Leker, R.R., Shahar, T. et al. (2008). The combination of granulocyte colony-stimulating factor and stem cell factor significantly increases the number of bone marrow-derived endothelial cells in brains ofmice following cerebral ischemia. Blood, 111(12), 5544-5552.
31. Welte, K., Platzer, E., Lu, L. et al. (1985). Purification and biochemical characterization of human pluripotent hematopoietic colony-stimulating factor. Proc Natl Acad Sci USA, 82(5), 1526-1530. (Pubitemid 15120576)