Endogenous endothelial progenitor cells participate in neovascularization via CXCR4/SDF-1 axis and improve outcome after stroke

CNS Neuroscience and Therapeutics

Volumn 20, Issue 5, 2014, Pages 460-468

  Mao, Ling ^a   Huang, Ming ^a,b   Chen, Sheng Cai ^a   Li, Ya Nan ^a   Xia, Yuan Peng ^a   He, Quan Wei ^a   Wang, Meng Die ^a   Huang, Yan ^a   Zheng, Long ^b   Hu, Bo ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUBEI UNIVERSITY FOR NATIONALITIES   (China)

Author keywords

CXCR4; EPCs; Neovascularization; Stroke

Indexed keywords

CD34 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; GLIAL FIBRILLARY ACIDIC PROTEIN; LAMININ; PLERIXAFOR; STROMAL CELL DERIVED FACTOR 1; VASCULOTROPIN RECEPTOR 2; VON WILLEBRAND FACTOR; ANGIOGENESIS INHIBITOR; CXCL12 PROTEIN, RAT; CXCR4 PROTEIN, RAT; HETEROCYCLIC COMPOUND;

ADULT; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; CAPILLARY DENSITY; CEREBROVASCULAR ACCIDENT; COGNITION; CONTROLLED STUDY; DISEASE SEVERITY; ENDOTHELIAL PROGENITOR CELL; GLIA CELL; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PROTEIN EXPRESSION; RAT; TASK PERFORMANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; BRAIN CIRCULATION; BRAIN ISCHEMIA; CAPILLARY; CEREBRAL ARTERY DISEASE; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SEVERITY OF ILLNESS INDEX; SPRAGUE DAWLEY RAT; STROKE; VASCULARIZATION;

ANGIOGENESIS INHIBITORS; ANIMALS; BRAIN; BRAIN ISCHEMIA; CAPILLARIES; CEREBROVASCULAR CIRCULATION; CHEMOKINE CXCL12; DISEASE MODELS, ANIMAL; ENDOTHELIAL PROGENITOR CELLS; HETEROCYCLIC COMPOUNDS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; RATS, SPRAGUE-DAWLEY; RECEPTORS, CXCR4; SEVERITY OF ILLNESS INDEX; STROKE;

EID: 84899061596     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12238     Document Type: Article

References (26)

1. Liman TG, Endres M. New vessels after stroke: Postischemic neovascularization and regeneration. Cerebrovasc Dis 2012;33:492-499.
2. Xiong Y, Mahmood A, Chopp M. Angiogenesis, neurogenesis and brain recovery of function following injury. Curr Opin Investig Drugs 2010;11:298-308.
3. Abe K, Yamashita T, Takizawa S, Kuroda S, Kinouchi H, Kawahara N. Stem cell therapy for cerebral ischemia: From basic science to clinical applications. J Cereb Blood Flow Metab 2012;32:1317-1331.
4. Jujo K, Hamada H, Iwakura A, et al. Cxcr4 blockade augments bone marrow progenitor cell recruitment to the neovasculature and reduces mortality after myocardial infarction. Proc Natl Acad Sci U S A 2010;107:11008-11013.
5. Oh IY, Yoon CH, Hur J, et al. Involvement of e-selectin in recruitment of endothelial progenitor cells and angiogenesis in ischemic muscle. Blood 2007;110:3891-3899.
6. Fan Y, Shen F, Frenzel T, et al. Endothelial progenitor cell transplantation improves long-term stroke outcome in mice. Ann Neurol 2009;67:488-497.
7. Chen J, Xiao X, Chen S, et al. Angiotensin-converting enzyme 2 priming enhances the function of endothelial progenitor cells and their therapeutic efficacy novelty and significance. Hypertension 2013;61:681-689.
8. Bogoslovsky T, Spatz M, Chaudhry A, et al. Stromal-derived factor-1α correlates with circulating endothelial progenitor cells and with acute lesion volume in stroke patients. Stroke 2011;42:618-625.
9. Walter DH, Haendeler J, Reinhold J, et al. Impaired cxcr4 signaling contributes to the reduced neovascularization capacity of endothelial progenitor cells from patients with coronary artery disease. Circ Res 2005;97:1142-1151.
10. Jujo K, Ii M, Sekiguchi H, et al. Cxc-chemokine receptor 4 antagonist amd3100 promotes cardiac functional recovery after ischemia/reperfusion injury via endothelial nitric oxide synthase-dependent mechanism clinical perspective. Circulation 2013;127:63-73.
11. He Y, Hua Y, Liu W, Hu H, Keep RF, Xi G. Effects of cerebral ischemia on neuronal hemoglobin. J Cereb Blood Flow Metab 2009;29:596-605.
12. Hu X, Li P, Guo Y, et al. Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke 2012;43:3063-3070.
13. Zhang L, Zhang ZG, Zhang R, et al. Adjuvant treatment with a glycoprotein iib/iiia receptor inhibitor increases the therapeutic window for low-dose tissue plasminogen activator administration in a rat model of embolic stroke. Circulation 2003;107:2837-2843.
14. Li Y, Chopp M, Chen J, et al. Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice. J Cereb Blood Flow Metab 2000;20:1311-1319.
15. Chen J, Chen J, Chen S, et al. Transfusion of cxcr4-primed endothelial progenitor cells reduces cerebral ischemic damage and promotes repair in db/db diabetic mice. PLoS ONE 2012;7:e50105.
16. Zhao YH, Yuan B, Chen J, et al. Endothelial progenitor cells: Therapeutic perspective for ischemic stroke. CNS Neurosci Ther 2013;19:67-75.
17. Ergul A, Alhusban A, Fagan SC. Angiogenesis a harmonized target for recovery after stroke. Stroke 2012;43:2270-2274.
18. Krupinski J, Kaluza J, Kumar P, Wang M, Kumar S. Prognostic value of blood vessel density in ischaemic stroke. Lancet 1993;342:742.
19. Krupinski J, Issa R, Bujny T, et al. A putative role for platelet-derived growth factor in angiogenesis and neuroprotection after ischemic stroke in humans. Stroke 1997;28:564-573.
20. Li Y, Xia Y, Wang Y, et al. Sonic hedgehog (shh) regulates the expression of angiogenic growth factors in oxygen-glucose-deprived astrocytes by mediating the nuclear receptor nr2f2. Mol Neurobiol 2013;47:967-975.
21. Simon-Assmann P, Orend G, Mammadova-Bach E, Spenlé C, Lefebvre O. Role of laminins in physiological and pathological angiogenesis. Int J Dev Biol 2011;55:455-465.
22. Bogoslovsky T, Chaudhry A, Latour L, et al. Endothelial progenitor cells correlate with lesion volume and growth in acute stroke. Neurology 2010;75:2059-2062.
23. Aiuti A, Webb IJ, Bleul C, Springer T, Gutierrez-Ramos JC. The chemokine sdf-1 is a chemoattractant for human cd34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of cd34+ progenitors to peripheral blood. J Exp Med 1997;185:111-120.
24. Theiss HD, Vallaster M, Rischpler C, et al. Dual stem cell therapy after myocardial infarction acts specifically by enhanced homing via the sdf-1/cxcr4 axis. Stem Cell Res 2011;7:244-255.
25. Huang J, Li Y, Tang Y, Tang G, Yang GY, Wang Y. Cxcr4 antagonist amd3100 protects blood-brain barrier integrity and reduces inflammatory response after focal ischemia in mice. Stroke 2013;44:190-197.
26. Tran PB, Ren D, Veldhouse TJ, Miller RJ. Chemokine receptors are expressed widely by embryonic and adult neural progenitor cells. J Neurosci Res 2004;76:20-34.