Association between endothelial dysfunction and frailty: The Toledo Study for Healthy Aging

Age

Volumn 36, Issue 1, 2014, Pages 495-505

  Alonso Bouzón, Cristina ^a   Carcaillon, Laure ^b   García García, Francisco J ^c   Amor Andrés, María S ^c   El Assar, Mariam ^a   Rodríguez Mañas, Leocadio ^a  

^a HOSPITAL UNIVERSITARIO DE GETAFE   (Spain)

^b CENTRE FOR RESEARCH IN EPIDEMIOLOGY AND POPULATION HEALTH   (France)

^c HOSPITAL VIRGEN DE LA SALUD   (Spain)

Author keywords

ADMA; Aging; Asymmetric dimethylarginine; Cardiovascular disease; Endothelial dysfunction; Frailty

Indexed keywords

CREATININE; N(G),N(G) DIMETHYLARGININE;

AGE; AGED; AGING; ANGOR; ANKLE BRACHIAL INDEX; ARTICLE; ATHEROSCLEROSIS; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; CLINICAL STUDY; COHORT ANALYSIS; COMORBIDITY; CONTROLLED STUDY; DIABETES MELLITUS; EDUCATIONAL STATUS; ENDOTHELIAL DYSFUNCTION; ENZYME IMMUNOASSAY; FEMALE; FRAILTY; GENDER; HEART INFARCTION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; INTERMITTENT CLAUDICATION; KIDNEY DISEASE; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; OBESITY; PROSPECTIVE STUDY; SEX DIFFERENCE; WEAKNESS;

AGED; ARGININE; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; COMORBIDITY; DEMOGRAPHY; FEMALE; FRAIL ELDERLY; GERIATRIC ASSESSMENT; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RISK FACTORS; SEX FACTORS; SPAIN;

EID: 84899053059     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-013-9576-1     Document Type: Article

References (50)

1. ACCF/AHA (2011) Focused update of the guideline for the management of patients with peripheral artery disease (Updating the 2005 Guideline): a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines (2011). Circulation 124(18):2020-2045. doi:10.1161/CIR.0b013e31822e80c3
2. Achan V, Broadhead M, Malaki M, Whitley G, Leiper J, MacAllister R, Vallance P (2003) Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase. Arterioscler Thromb Vasc Biol 23(8):1455-1459. doi:10.1161/01.ATV.0000081742.92006.5901.ATV] (Pubitemid 36994536)
3. Angulo J, Vallejo S, El Assar M, Garcia-Septiem J, Sanchez- Ferrer CF, Rodriguez-Manas L (2012) Age-related differences in the effects of alpha and gamma peroxisome proliferator-activated receptor subtype agonists on endothelial vasodilation in human microvessels. Exp Gerontol. doi:10.1016/j.exger.2012.06. 014
4. Barzilay JI, Blaum C, Moore T, Xue QL, Hirsch CH, Walston JD, Fried LP (2007) Insulin resistance and inflammation as precursors of frailty: the Cardiovascular Health Study. Arch Intern Med 167(7):635-641. doi:10.1001/archinte.167.7.635 (Pubitemid 46598454)
5. Beltowski J, Kedra A (2006) Asymmetric dimethylarginine (ADMA) as a target for pharmacotherapy. Pharmacol Rep 58(2):159-178
6. Bergman H, Ferrucci L, Guralnik J, Hogan DB, Hummel S, Karunananthan S, Wolfson C (2007) Frailty: an emerging research and clinical paradigm -issues and controversies. J Gerontol A Biol Sci Med Sci 62(7):731-737 (Pubitemid 350143604)
7. Berni A, Giuliani A, Tartaglia F, Tromba L, Sgueglia M, Blasi S, Russo G (2011) Effect of vascular risk factors on increase in carotid and femoral intima-media thickness: identification of a risk scale. Atheroscler 216(1):109-114. doi:10.1016/j.atherosclerosis.2011.01.034
8. Carcaillon L, Blanco C, Alonso-Bouzon C, Alfaro-Acha A, Garcia-Garcia FJ, Rodriguez-Manas L (2012a) Sex differences in the association between serum levels of testosterone and frailty in an elderly population: the Toledo Study for Healthy Aging. PLoS One 7(3):e32401. doi:10.1371/journal.pone
9. Carcaillon L, Garcia-Garcia FJ, Tresguerres JA, Gutierrez Avila G, Kireev R, Rodriguez-Manas L (2012b) Higher levels of endogenous estradiol are associated with frailty in postmenopausal women from the Toledo Study for Healthy Aging. J Clin Endocrinol Metab. doi:10.1210/jc.2012-1271
10. Cooke JP (2005) ADMA: its role in vascular disease. Vasc Med 10(Suppl 1):S11-17
11. Chen XM, Xia J, Zhou T, Yuan Q, Zhang WF, Hu CP, Li YJ, Jiang JL (2013) Involvement of DDAH/ADMA pathway in the pathogenesis of rheumatoid arthritis in rats. Int Immunopharmacol 16(2):322-331. doi:10.1016/j.intimp.2013.04
12. Chin APMJ, Dekker JM, Feskens EJ, Schouten EG, Kromhout D (1999) How to select a frail elderly population? A comparison of three working definitions. J Clin Epidemiol 52(11):1015-1021 (Pubitemid 29469803)
13. Dogru T, Genc H, Tapan S, Ercin CN, Ors F, Aslan F, Kara M, Sertoglu E, Bagci S, Kurt I, Sonmez A (2012) Elevated asymmetric dimethylarginine in plasma: an early marker for endothelial dysfunction in non-alcoholic fatty liver disease? Diabetes Res Clin Pract 96(1):47-52. doi:10.1016/j.diabres
14. El Assar M, Angulo J, Vallejo S, Peiro C, Sanchez-Ferrer CF, Rodriguez-Manas L (2012) Mechanisms involved in the aging-induced vascular dysfunction. Front Physiol 3:132. doi:10.3389/fphys.2012.00132
15. Espelt A, Goday A, Franch J, Borrell C (2012) Validity of self-reported diabetes in health interview surveys for measuring social inequalities in the prevalence of diabetes. J Epidemiol Community Health 66(7):e15. doi:10.1136/jech.2010.112698
16. Espinola-Klein C, Rupprecht HJ, Bickel C, Lackner K, Savvidis S, Messow CM, Munzel T, Blankenberg S (2008) Different calculations of ankle-brachial index and their impact on cardiovascular risk prediction. Circulation 118(9):961-967. doi:10.1161/CIRCULATIONAHA.107.763227
17. Espinoza SE, Jung I, Hazuda H (2010) Lower frailty incidence in older Mexican Americans than in older European Americans: the San Antonio Longitudinal Study of Aging. J Am Geriatr Soc 58(11):2142-2148. doi:10.1111/j.1532-5415. 2010.03153.x
18. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA (2001) Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56(3):M146-156 (Pubitemid 32187141)
19. Garcia-Garcia FJ, Gutierrez Avila G, Alfaro-Acha A, Amor Andres MS, De Los Angeles De La Torre Lanza M, Escribano Aparicio MV, Humanes Aparicio S, Larrion Zugasti JL, Gomez-Serranillo Reus M, Rodriguez- Artalejo F, Rodriguez-Manas L (2011) The prevalence of frailty syndrome in an older population from Spain. The Toledo Study for Healthy Aging. J Nutr Health Aging 15(10):852-856
20. Garcia Garcia FJ, Sanchez Ayala MI, Perez Martin A, Martin Correa E, Marsal Alonso C, Rodriguez Ferrer G, Garcia Colmenero C, Romero Rizos L, Rodriguez Barqueroa MJ, Gutierrez Avila G (2001) The prevalence of dementia and its main subtypes in subjects older than 65 years: impact of occupation and education. The Toledo Study. Med Clin (Barc) 116(11):401-407 (Pubitemid 33622015)
21. Gill TM, Gahbauer EA, Allore HG, Han L (2006) Transitions between frailty states among community-living older persons. Arch Intern Med 166(4):418-423. doi:10.1001/.418
22. Hirsch AT, Haskal ZJ, Hertzer NR, Bakal CW, Creager MA, Halperin JL, Hiratzka LF, Murphy WR, Olin JW, Puschett JB, Rosenfield KA, Sacks D, Stanley JC, Taylor LM Jr, White CJ, White J, White RA, Antman EM, Smith SC Jr, Adams CD, Anderson JL, Faxon DP, Fuster V, Gibbons RJ, Hunt SA, Jacobs AK, Nishimura R, Ornato JP, Page RL, Riegel B (2006) ACC/AHA 2005 guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): executive summary a collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for VascularMedicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease) endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease Foundation. J Am Coll Cardiol 47(6):1239-1312. doi:10.1016/j.jacc.2005.10.009
23. Hsu CP, Lin SJ, Chung MY, Lu TM (2012) Asymmetric dimethylarginine predicts clinical outcomes in ischemic chronic heart failure. Atherosclerosis 225(2):504-510. doi:10.1016/j.atherosclerosis.2012.09
24. Ito A, Tsao PS, Adimoolam S, Kimoto M, Ogawa T, Cooke JP (1999) Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 99(24):3092-3095 (Pubitemid 29289071)
25. Kielstein JT, Bode-Boger SM, Frolich JC, Ritz E, Haller H, Fliser D (2003) Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects. Circulation 107(14):1891-1895. doi:10.1161/01.CIR.0000060496. 23144.A701 (Pubitemid 36444130)
26. Lim S, Hong J, Liu CT, Hivert MF, White CC, Murabito JM, O'Donnell CJ, Dupuis J, Florez JC, Meigs JB (2013) Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study. Atheroscler 229(1):149-154. doi:10.1016/j.atherosclerosis.2013.03.037
27. Meinitzer A, Seelhorst U, Wellnitz B, Halwachs-Baumann G, Boehm BO, Winkelmann BR, Marz W (2007) Asymmetrical dimethylarginine independently predicts total and cardiovascular mortality in individuals with angiographic coronary artery disease (the Ludwigshafen Risk and Cardiovascular Health study). Clin Chem 53(2):273-283. doi:10.1373/clinchem.2006.076711 (Pubitemid 46338272)
28. Mulero J, Zafrilla P, Martinez-Cacha A (2011) Oxidative stress, frailty and cognitive decline. J Nutr Health Aging 15(9):756-760
29. Najjar SS, Scuteri A, Lakatta EG (2005) Arterial aging: is it an immutable cardiovascular risk factor? Hypertension 46(3):454-462. doi:10.1161/01.HYP.0000177474.06749.98 (Pubitemid 41376818)
30. Newman AB, Gottdiener JS, McBurnie MA, Hirsch CH, Kop WJ, Tracy R, Walston JD, Fried LP (2001) Associations of subclinical cardiovascular disease with frailty. J Gerontol A Biol Sci Med Sci 56(3):M158-166 (Pubitemid 32187142)
31. Newman AB, Simonsick EM, Naydeck BL, Boudreau RM, Kritchevsky SB, Nevitt MC, Pahor M, Satterfield S, Brach JS, Studenski SA, Harris TB (2006) Association of longdistance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability. JAMA 295(17):2018-2026. doi:10.1001/jama.295.17.2018 (Pubitemid 44794004)
32. Perticone F, Sciacqua A, Maio R, Perticone M, Maas R, Boger RH, Tripepi G, Sesti G, Zoccali C (2005) Asymmetric dimethylarginine, L-arginine, and endothelial dysfunction in essential hypertension. J Am Coll Cardiol 46(3):518-523. doi:10.1016/j.jacc.2005.04.040 (Pubitemid 41040296)
33. Phan HM, Alpert JS, Fain M (2008) Frailty, inflammation, and cardiovascular disease: evidence of a connection. Am J Geriatr Cardiol 17(2):101-107
34. Purser JL, Kuchibhatla MN, Fillenbaum GG, Harding T, Peterson ED, Alexander KP (2006) Identifying frailty in hospitalized older adults with significant coronary artery disease. J Am Geriatr Soc 54(11):1674- 1681. doi:10.1111/j.1532-5415.2006.00914.x
35. Rentoukas E, Tsarouhas K, Kaplanis I, Korou E, Nikolaou M, Marathonitis G, Kokkinou S, Haliassos A, Mamalaki A, Kouretas D, Tsitsimpikou C (2012) Connection between telomerase activity in PBMC and markers of inflammation and endothelial dysfunction in patients with metabolic syndrome. PLoS One 7(4):e35739. doi:10.1371/journal.pone
36. Rodriguez-Mañas L, El-AssarM, Vallejo S, Lopez-Doriga P, Solis J, Petidier R, Montes M, Nevado J, Castro M, Gomez- Guerrero C, Peiro C, Sanchez-Ferrer CF (2009) Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation.Aging Cell 8(3):226-238. doi:10.1111/j.1474-9726.2009.00466.x
37. Rodriguez-Mañas L, Feart C, Mann G, Vina J, Chatterji S, Chodzko-Zajko W, Gonzalez-Colaco Harmand M, Bergman H, Carcaillon L, Nicholson C, Scuteri A, Sinclair A, Pelaez M, Van der Cammen T, Beland F, Bickenbach J, Delamarche P, Ferrucci L, Fried LP, Gutierrez-Robledo LM, Rockwood K, Rodriguez Artalejo F, Serviddio G, Vega E (2012) Searching for an operational definition of frailty: A Delphi method based consensus statement.The frailty operative definition-consensus conference project. J Gerontol A Biol Sci Med Sci. doi:10.1093/gerona/gls119
38. Santos-Eggimann B, Cuenoud P, Spagnoli J, Junod J (2009) Prevalence of frailty in middle-aged and older communitydwelling Europeans living in 10 countries. J Gerontol A Biol Sci Med Sci 64(6):675-681. doi:10.1093/gerona/ glp012
39. Schuit AJ, Schouten EG, Westerterp KR, Saris WH (1997) Validity of the Physical Activity Scale for the Elderly (PASE): according to energy expenditure assessed by the doubly labeled water method. J Clin Epidemiol 50(5):541-546 (Pubitemid 27270203)
40. Schulze F, Maas R, Freese R, Schwedhelm E, Silberhorn E, Boger RH (2005) Determination of a reference value for N(G), N(G)-dimethyl-L-arginine in 500 subjects. Eur J Clin Invest 35(10):622-626. doi:10.1111/j.1365-2362.2005.01561.x (Pubitemid 41406726)
41. Schulze F, Wesemann R, Schwedhelm E, Sydow K, Albsmeier J, Cooke JP, Boger RH (2004) Determination of asymmetric dimethylarginine (ADMA) using a novel ELISA assay. Clin Chem Lab Med 42(12):1377- 1383. doi:10.1515/CCLM.2004. 257
42. Sibal L, Agarwal SC, Home PD, Boger RH (2010) The role of asymmetric dimethylarginine (ADMA) in endothelial dysfunction and cardiovascular disease. Curr Cardiol Rev 6(2):82-90. doi:10.2174/157340310791162659
43. Sitia S, Tomasoni L, Atzeni F, Ambrosio G, Cordiano C, Catapano A, Tramontana S, Perticone F, Naccarato P, Camici P, Picano E, Cortigiani L, BevilacquaM, Milazzo L, CusiD, Barlassina C, Sarzi-Puttini P, Turiel M (2010) From endothelial dysfunction to atherosclerosis. Autoimmun Rev 9(12):830-834. doi:10.1016/j.autrev.2010.07.016
44. Stuhlinger MC, Oka RK, Graf EE, Schmolzer I, Upson BM, Kapoor O, Szuba A, Malinow MR, Wascher TC, Pachinger O, Cooke JP (2003) Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine. Circulation 108(8):933-938. doi:10.1161/01.CIR.0000085067.55901.8901 (Pubitemid 37048221)
45. Teerlink T (2005) ADMA metabolism and clearance. Vasc Med 10(Suppl 1):S73-81
46. Walston J, Hadley EC, Ferrucci L, Guralnik JM, Newman AB, Studenski SA, Ershler WB, Harris T, Fried LP (2006) Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc 54(6):991-1001. doi:10.1111/j.1532-5415.2006.00745.x (Pubitemid 43847040)
47. Walston J, McBurnie MA, Newman A, Tracy RP, Kop WJ, Hirsch CH, Gottdiener J, Fried LP (2002) Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results fromthe Cardiovascular Health Study. Arch Intern Med 162(20):2333-2341 (Pubitemid 35332516)
48. Woods NF, LaCroix AZ, Gray SL, Aragaki A, Cochrane BB, Brunner RL, Masaki K, Murray A, Newman AB (2005) Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study. J Am Geriatr Soc 53(8):1321-1330. doi:10.1111/j.1532-5415.2005.53405.x (Pubitemid 41602477)
49. Xiao S, Wagner L, Schmidt RJ, Baylis C (2001) Circulating endothelial nitric oxide synthase inhibitory factor in some patients with chronic renal disease. Kidney Int 59(4):1466-1472. doi:10.1046/j.1523-1755.2001.0590041466.x (Pubitemid 32281236)
50. Zhang L, Buzkova P, Wassel CL, Roman MJ, North KE, Crawford DC, Boston J, Brown-Gentry KD, Cole SA, Deelman E, Goodloe R, Wilson S, Heiss G, Jenny NS, Jorgensen NW, Matise TC, McClellan BE Jr, Nato AQ Jr, Ritchie MD, Franceschini N, Kao WH (2013) Lack of associations of ten candidate coronary heart disease risk genetic variants and subclinical atherosclerosis in four U.S. populations: the Population Architecture using Genomics and Epidemiology (PAGE) study. Atheroscler 228(2):390-399. doi:10.1016/j.atherosclerosis.2013.02.038