Insulin receptor substrate 1/2 (IRS1/2) regulates Wnt/β-Catenin signaling through blocking autophagic degradation of dishevelled

Journal of Biological Chemistry

Volumn 289, Issue 16, 2014, Pages 11230-11241

  Geng, Yongtao ^a,b   Ju, Yanfang ^c   Ren, Fangli ^b   Qiu, Ying ^b   Tomita, Yasuhiko ^d   Tomoeda, Miki ^d   Kishida, Mioka ^d   Wang, Yinyin ^b   Jin, Lian ^a   Su, Fuqin ^b   Wei, Chunhong ^a   Jia, Baoqing ^c   Li, Yi ^a   Chang, Zhijie ^b  

^a PEKING UNIVERSITY   (China)

^b Tsinghua University   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

^d OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROLIFERATION; INSULIN;

AUTOPHAGIC DEGRADATION; CATENIN SIGNALING; CRITICAL COMPONENT; INSULIN RECEPTORS; INSULIN SIGNALING; TUMORIGENESIS; WNT SIGNALING;

SIGNALING;

BETA CATENIN; CYCLIN D1; DISHEVELLED 2; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MYC PROTEIN; WNT PROTEIN;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; HEK293 CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MCF 7 CELL LINE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STABILITY; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UBIQUITINATION; UPREGULATION; WESTERN BLOTTING;

AUTOPHAGY; CELL PROLIFERATION; DISHEVELLED2; EMT; IRS; WNT SIGNALING; Β-CATENIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AUTOPHAGY; BETA CATENIN; CELL PROLIFERATION; CYCLIN D1; EPITHELIAL-MESENCHYMAL TRANSITION; HEK293 CELLS; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; MULTIPROTEIN COMPLEXES; PHOSPHOPROTEINS; PROTEIN STABILITY; PROTO-ONCOGENE PROTEINS C-MYC; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN; UBIQUITINATION; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84899025769     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.544999     Document Type: Article

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