Increased ratio of FoxP3+ regulatory T cells/CD3+ T cells in skin lesions in drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms

Clinical and Experimental Dermatology

Volumn 39, Issue 3, 2014, Pages 284-291

  Morito, H ^a   Ogawa, K ^a   Fukumoto, T ^a   Kobayashi, N ^a   Morii, T ^a   Kasai, T ^a   Nonomura, A ^a   Kishimoto, T ^a   Asada, H ^a  

^a NARA MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN;

ADOLESCENT; ADULT; AGED; ARTICLE; CD3+ T LYMPHOCYTE; CELL INFILTRATION; CLINICAL ARTICLE; DISEASE ASSOCIATION; DRESS SYNDROME; FEMALE; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MACULOPAPULAR RASH; MALE; MIDDLE AGED; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SKIN BIOPSY; SKIN DEFECT; TARGET ORGAN; DRUG ERUPTION; EOSINOPHILIA; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGY; METABOLISM; PATHOLOGY; RASH; YOUNG ADULT; ACUTE DISEASE; ACUTE GRAFT VERSUS HOST DISEASE; CELL VACUOLE; CHILD; DEGENERATION; DERMATITIS; EOSINOPHIL; HISTOPATHOLOGY; HUMAN TISSUE; IMMUNOPATHOGENESIS; LYMPHOCYTE COUNT; LYMPHOCYTIC INFILTRATION; SKIN INFILTRATE;

ADOLESCENT; ADULT; AGED; DRUG ERUPTIONS; EOSINOPHILIA; EXANTHEMA; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; T-LYMPHOCYTES, REGULATORY; YOUNG ADULT;

EID: 84899013367     PISSN: 03076938     EISSN: 13652230     Source Type: Journal    
DOI: 10.1111/ced.12246     Document Type: Article

References (21)

1. Solensky R,. Drug hypersensitivity. Med Clin North Am 2006; 90: 233-60. (Pubitemid 41682039)
2. Descamps V, Bouscarat F, Laglenne S, et al,. Human herpesvirus 6 infection associated with anticonvulsant hypersensitivity syndrome and reactive haemophagocytic syndrome. Br J Dermatol 1997; 137: 605-8. (Pubitemid 27469515)
3. Tohyama M, Yahata Y, Yasukawa M, et al,. Severe hypersensitivity syndrome due to sulfasalazine associated with reactivation of human herpesvirus 6. Arch Dermatol 1998; 134: 1113-17. (Pubitemid 28432326)
4. Suzuki Y, Inagi R, Aono T, et al,. Human herpesvirus 6 infection as a risk factor for the development of severe drug-induced hypersensitivity syndrome. Arch Dermatol 1998; 134: 1108-12. (Pubitemid 28432325)
5. Kano Y, Inaoka M, Shiohara T,. Association between anticonvulsant hypersensitivity syndrome and human herpesvirus 6 reactivation and hypogammaglobulinemia. Arch Dermatol 2004; 140: 183-8. (Pubitemid 38500330)
6. Brown RJ, Rother KI, Artman H, et al,. Minocycline-induced drug hypersensitivity syndrome followed by multiple autoimmune sequelae. Arch Dermatol 2009; 145: 63-6.
7. Chiou CC, Chung WH, Hung SI, et al,. Fulminant type1 diabetes mellitus caused by drug hypersensitivity syndrome with human herpesvirus 6 infection. J Am Acad Dermatol 2006; 54: S14-17.
8. Yoshikawa T, Asano Y, Ihira M, et al,. Human herpesvirus 6 viremia in bone marrow transplant recipients: clinical features and risk factors. J Infect Dis 2002; 185: 847-53. (Pubitemid 34274426)
9. Kitamura K, Asada H, Iida H, et al,. Relationship among human herpesvirus 6 reactivation, serum interleukin 10 levels, and rash/graft-versus-host disease after allogeneic stem cell transplantation. J Am Acad Dermatol 2008; 58: 802-9.
10. Ferrara JL, Levine JE, Reddy P, Holler E,. Graft-versus-host disease. Lancet 2009; 373: 1550-61.
11. Bradley DS, Jennette JC, Cohen PL, Eisenberg RA,. Chronic graft versus host disease-associated autoimmune manifestations are independently regulated by different MHC class II loci. J Immunol 1994; 152: 1960-9. (Pubitemid 24075730)
12. Shiohara T, Iijima M, Ikezawa Z, Hashimoto K,. The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations. Br J Dermatol 2007; 156: 1083-4. (Pubitemid 46642847)
13. Kardaun SH, Sidoroff A, Valeyrie-Allanore L, et al,. Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? Br J Dermatol 2007; 156: 609-11.
14. Lerner KG, Kao GF, Storb R, et al,. Histopathology of graft-vs.-host reaction (GvHR) in human recipients of marrow from HL-A-matched sibling donors. Transplant Proc 1974; 6: 367-71.
15. Horn TD,. Acute cutaneous eruptions after marrow ablation: roses by other names? J Cutan Pathol 1994; 21: 385-92. (Pubitemid 24354611)
16. Tanaka N, Kimura H, Iida K, et al,. Quantitative analysis of cytomegalovirus load using a realtime PCR assay. J Med Virol 2000; 60: 455-62. (Pubitemid 30127318)
17. Fondi C, Nozzoli C, Benemei S, et al,. Increase in FOXP3+ regulatory T cells in GVHD skin biopsies is associated with lower disease severity and treatment response. Biol Blood Marrow Transplant 2009; 15: 938-47.
18. Wu KN, Emmons RV, Lisanti MP, et al,. Foxp3-expressing T regulatory cells and mast cells in acute graft-versus-host disease of the skin. Cell Cycle 2009; 8: 3593-7.
19. Takahashi R, Kano Y, Yamazaki Y, et al,. Defective regulatory T cells in patients with severe drug eruptions: timing of the dysfunction is associated with the pathological phenotype and outcome. J Immunol 2009; 182: 8071-9.
20. Hori S, Nomura T, Sakaguchi S,. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-61. (Pubitemid 36222930)
21. Ozdemir C, Akdis M, Akdis CA,. T regulatory cells and their counterparts: masters of immune regulation. Clin Exp Allergy 2009; 39: 626-39.