Effects of 16 weeks of treatment with tibolone on bone mass and bone mechanical and histomorphometric indices in mature ovariectomized rats with established osteopenia on a low-calcium diet

Bone

Volumn 25, Issue 3, 1999, Pages 311-319

  Yoshitake, K ^a   Yokota, K ^a   Kasugai, Y ^a   Kagawa, M ^a   Sukamoto, T ^a   Nakamura, T ^b  

^a Nippon Organon KK   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

1 hydroxyvitamin D3; 17 ethynylestradiol; Histomorphometry; Osteopenia; Ovariectomy; Tibolone

Indexed keywords

ALFACALCIDOL; ETHINYLESTRADIOL; TIBOLONE;

ANIMAL EXPERIMENT; ARTICLE; BONE ATROPHY; BONE MASS; BONE TURNOVER; CANCELLOUS BONE; CONTROLLED STUDY; CORTICAL BONE; FEMALE; MORPHOMETRICS; NONHUMAN; OSTEOPENIA; OSTEOPOROSIS; OVARIECTOMY; TRABECULAR BONE; VERTEBRA BODY;

ALKALINE PHOSPHATASE; AMINO ACIDS; ANABOLIC AGENTS; ANIMALS; BONE AND BONES; BONE DENSITY; BONE DISEASES, METABOLIC; CALCIUM; CALCIUM, DIETARY; CHOLECALCIFEROL; DENSITOMETRY, X-RAY; ETHINYL ESTRADIOL; FEMALE; NORPREGNENES; OSTEOCALCIN; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; WEIGHT-BEARING;

EID: 0032867031     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(99)00172-6     Document Type: Article

References (65)

1. 3 and estrogen therapy on cortical bone mechanical properties in the ovariectomized rat model. Endocrinology. 137:1996;1358-1364.
2. Barengolts B.I., Gajardo H.F., Rosol T.J., et al. Effects of progesterone on postovariectomy bone loss in aged rats. J Bone Miner Res. 5:1990;1143-1147.
3. Berning B., Kuijk C.V., Kuiper J.W., Bennik H.J., Kicovic P.M., Fauser B.C. Effects of two doses of tibolone on trabecular and cortical bone loss in early postmenopausal women a two-year randomized' placebo-controlled study . Bone. 19:1996;395-399.
4. Bjarnason N.H., Bjarnason K., Haarbo J., Rosenquist C., Christiansen C. Tibolone prevention of bone loss in late postmenopausal women . J Clin Endocrinol Metab. 81:1996;2419-2422.
5. Brown J.P., Delmas P.D., Malaval L., Edouard C., Chapuy M.C., Meunier P.J. Serum bone GLA-protein a specific marker for bone formation in postmenopausal osteoporosis . Lancet. 1:1984;1091-1093.
6. Bullamore J.R., Gallagher J.C., Wilkinson R., Nordin B.E.C. Effect of age on calcium absorption. Lancet. 2:1970;535-537.
7. Cano A. Compliance to hormone replacement therapy in menopausal women controlled in a third level academic center. Maturitas. 20:1995;91-99.
8. Chachra D., Kasra M., Vanin C.M., MacLusky N.J., Casper R.F., Grynpas M.D. The effect of different hormone replacement therapy regimens on the mechanical properties of rat vertebrae. Calcif Tissue Int. 56:1995;130-134.
9. Christiansen C., Christensen M.S., Transbøl I. Bone mass in postmenopausal women after withdrawal of oestrogen/gestagen replacement therapy. Lancet. 1:1981;459-461.
10. Diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med. 94:1993;646-650.
11. Coxam V., Bowman B.M., Mecham M., Roth C.M., Miller M.A., Miller S.C. Effects of dihydrotestosterone alone and combined with estrogen on bone mineral density, bone growth, and formation rates in ovariectomized rats. Bone. 19:1996;107-114.
12. Danielsen C.C., Mosekilde L., Svenstrup B. Cortical bone mass, composition, and mechanical properties in female rats in relation to age, long-term ovariectomy, and estrogen substitution. Calcif Tissue Int. 52:1993;26-33.
13. Dempster D.W., Birchman R., Xu R., Lindsay R., Shen V. Temporal change in cancellous bone structures of rats immediately after ovariectomy. Bone. 16:1995;157-161.
14. Ederveen, A. G. H., Spanjers, C. P. M., Quaijtaal, J. H. M., and Kloosterboer, H. J. Effect of long-term treatment with tibolone (Org OD14) or 17α-ethinyl estradiol on bone mass, bone turnover and biomechanical quality of cortical and trabecular bone in mature ovariectomised rats. Osteoporosis Int in press; 1998.
15. Felson D.T., Zhang Y., Hannan M.T., Kiel D.P., Wilson P.W.F., Anderson J.J. The effect of postmenopausal estrogen therapy on bone density in elderly women. N Engl J Med. 329:1993;1141-1146.
16. 3 short- and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis . Proc Natl Acad Sci USA. 79:1982;3325-3329.
17. 3 in thyroparathyroidectomized rats. Endocrinology. 94:1974;1022-1027.
18. Genazzani A.R., Benedek-Jaszmann L.J., Hart D.M., Andolsek L., Kicovic P.M., Tax L. Org OD 14 and the endometrium. Maturitas. 13:1991;243-251.
19. Geusens P., Dequeker J., Gielen J., Schot L.P.C. Non-liner increase in vertebral density induced by a synthetic steroid (Org OD 14) in women with established osteoporosis. Maturitas. 13:1991;155-162.
20. Geusens P., Dequeker J., Nijs J., Verstraeten A., Bramm E. Prevention and treatment of osteopenia in the ovariectomized rat effect of combined therapy with estrogen, 1-alpha vitamin D, and prednisolone . Calcif Tissue Int. 48:1991;127-137.
21. Grady D., Gebretsadik T., Kerlikowske K., Ernster V., Petitti D. Hormone replacement therapy and endometrial cancer risk a meta-analysis . Obstet Gynecol. 85:1995;304-313.
22. Grodstein F., Stampfer M.J., Manson J.E., Colditz G.A., Willett W.C., Rosner B., Speizer F.E., Hennekens C.H. Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med. 335:1996;453-461.
23. Hata K., Tokuhiro H., Miura M. Precision assay of bone-type alkaline phosphatase. Jpn J Clin Chem. 23:1994;26-31.
24. Heikkinen A.M., Tuppurainen M.T., Niskanen L., Komulainen M., Penttila I., Saarikoski S. Long-term vitamin D3 supplementation may have adverse effects on serum lipids during postmenopausal hormone replacement therapy. Eur J Endocrinol. 137:1997;495-502.
25. Hodgkinson A., Aaron J.E., Horsman A., McLachlan M.S.F., Nordin B.E.C. Effect of oophorectomy and calcium deprivation on bone mass in the rat. Clin Sci Mol Med. 54:1978;439-446.
26. Kalu D.N. The ovariectomized rat model of postmenopausal bone loss. Bone Miner. 15:1991;175-192.
27. Kalu D.N., Liu C.-C., Hardin R.R., Hollis B.W. The aged rat model of ovarian hormone deficiency bone loss. Endocrinology. 124:1989;7-16.
28. Kasugai Y., Ikegami A., Matsuo K., et al. Effects of tibolone (Org OD14) treatment for 3 months on ovariectomy-induced osteopenia in 8-month-old rats on a low-calcium diet preventive testing for 3 months . Bone. 22:1998;119-124.
29. Katsumata T., Nakamura T., Ohnishi H., Sakurama T. Intermittent cyclical etidronate treatment maintains the mass' structure and the mechanical property of bone in ovariectomized rats. J Bone Miner Res. 10:1995;921-931.
30. Ke H.Z., Chen H.K., Simmons H.A., et al. Comparative effects of droloxifen, tamoxifen, and estrogen on bone, serum cholesterol, and uterine histology in the ovariectomized rat model. Bone. 20:1997;31-39.
31. Kiel D.P., Felson D.T., Anderson J.J., Wilson P.W.F., Moskowitz M.A. Hip fracture and the use of estrogens in postmenopausal women. N Engl J Med. 317:1987;1169-1174.
32. Lindsay R., Tohme J.F. Estrogen treatment of patients with established postmenopausal osteoporosis. Obstet Gynecol. 76:1990;290-295.
33. Markiewicz L., Gurpide E. In vitro evaluation of estrogenic, estrogen antagonistic and progestagenic effects of a steroidal drug (Org OD-14) and its metabolites on human endometrium. J Steroid Biochem. 35:1990;535-541.
34. Mason R.A., Morris H.A. Effects of dihydrotestosterone on bone biochemical markers in sham and oophorectomized rats. J Bone Miner Res. 12:1997;1431-1437.
35. 3, and etidronate on bone. Bone. 8:1987;91-94.
36. Meyer-Sabellek W. Review alkaline phosphatase laboratory and clinical implications. J Chromatogr. 429:1988;419-444.
37. Milner M.H., Sinnott M.M., Cooke T.M., Kelly A., McGill T., Harrison R.F. A 2-year study of lipid and lipoprotein changes in postmenopausal women with tibolone and estrogen-progestin. Obstet Gynecol. 87:1996;593-599.
38. Morris H.A., Porter S.J., Durbridge T.C., Moore R.J., Need A.G., Nordin B.E.C. Effects of oophorectomy on biochemical and bone variables in the rat. Bone Miner. 18:1992;133-142.
39. Mosekilde L., Danielsen C.C., Knudsen U.B. The effect of aging and ovariectomy on the vertebral bone mass and biomechanical properties of mature rats. Bone. 14:1993;1-6.
40. Nagae Y., Miyamoto M., Miyamoto H. Effect of estrogen replacement on liver function in ovariectomized rats. J Toxicol Sci. 16:1991;87-100.
41. Nikolov Y.T., Dimitrov O.A., Kabaivanova S.D., Moskova V.V., Ivanova V.L. Effect of estradiol on the protein synthesis in the female rat liver in vitro. Acta Physiol Pharmacol Bulg. 13:1987;46-51.
42. 3 on osteoporosis induced by immobilization combined with ovariectomy in rats. Bone. 8:1987;351-355.
43. Otawara Y., Sakaguchi C., Hosoya N., Kuwada M., Katayama K., Ishiguro S., Moriuchi S. Determination of vitamin K-dependent calcium binding protein level in rat bone using radioimmunoassay and high-performance liquid chromatography. Vitamins. 56:1982;531-535.
44. Parfitt A.M., Drezner M.K., Glorieux F.H., et al. Bone histomorphometry standardization of nomenclature, symbols, and Units . J Bone Miner Res. 2:1987;595-610.
45. Parfitt A.M., Mathews C.H.E., Villanueva A.R., Kleerekoper M., Frame B., Rao D.S. Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. J Clin Invest. 72:1983;1396-1409.
46. Price P.A., Baukol S.A. 1,25-dihydroxyvitamin D3 increases serum levels of the vitamin K-dependent bone protein. Biochem Biophys Res Commun. 99:1981;928-935.
47. Riggs B.L., Melton L.J. III. Involutional osteoporosis. N Engl J Med. 314:1986;1676-1686.
48. Roux C., Kolta S., Chappard C., Morieux C., Dougados M., de Vernejoul M.C. Bone effects of dydrogesterone in ovariectomized rats a biologic, histomorphometric, and densitometric study . Bone. 19:1996;463-468.
49. Rymer J., Chapman M.G., Fogelman I. Effect of tibolone on postmenopausal bone loss. Osteoporosis Int. 4:1994;314-319.
50. Sandker G.W., Vos R.M.E., Delbressine L.P.C., Slooff M.J.H., Meijer D.K.F., Groothuis G.M.M. Metabolism of three pharmacologically active drugs in isolated human and rat hepatocytes analysis of interspecies variability and comparison with metabolism in vivo . Xenobiotica. 24:1994;143-155.
51. Shen V., Birchman R., Xu R., Lindsay R., Dempster D.W. Short-term changes in histomorphometric and biochemical turnover markers and bone mineral density in estrogen- and/or dietary calcium-deficient rats. Bone. 16:1995;149-156.
52. Silver J., Naveh-Many T., Mayer H., Schmelzer H.J., Popovtzer M.M. Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat. J Clin Invest. 78:1986;1296-1301.
53. Tang B., Markiewicz L., Kloosterboer H.J., Gurpide E. Human endometrial 3β-hydroxysteroid dehydrogenase/isomerase can locally reduce intrinsic estrogenic/progestagenic activity ratios of a steroidal drug (Org OD 14). J Steroid Biochem Mol Biol. 45:1993;345-351.
54. Tax L., Goorissen E.M., Kicovic P.M. Clinical profile of Org OD 14. Maturitas Suppl. 1:1987;3-13.
55. Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. JAMA. 273:1995;199-208.
56. Tsukahara H., Miura M., Tsuchida S., Hata I., Hata K., Yamamoto K., Ishii Y., Muramatsu I., Sudo M. Effect of nitric oxide synthase inhibitors on bone metabolism in growing rats. Am J Physiol. 270:1996;E840-E845.
57. 3 (ED-71), increases bone mass by stimulating the bone formation in normal and ovariectomized rats. Calcif Tissue Int. 54:1994;142-149.
58. Tsutsumi N., Kawashima K., Nagata H., et al. Effects of KCA-098 on bone metabolism comparison with those of ipriflavone . Jpn J Pharmacol. 65:1994;343-349.
59. Turner R.T., Evans G.L., Wakley G.K. Mechanism of action of estrogen on cancellous bone balance in tibiae of ovariectomized growing rats inhibition of indices of formation and resorption . J Bone Miner Res. 8:1993;359-366.
60. van der Vies J. Pharmacological studies with (7α, 17α)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one (Org OD 14). Maturitas Suppl. 1:1987;15-24.
61. de Visser J., Coert A., Feenstra H., van der Vies J. Endocrinological studies with (7α, 17α)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one (Org OD 14). Arzneimittelforschung. 34:1984;1010-1017.
62. Wronski T.J., Cintrón M., Doherty A.L., Dann L.M. Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats. Endocrinology. 123:1988;681-686.
63. Wronski T.J., Dann L.M., Horner S.L. Time course of vertebral osteopenia in ovariectomized rats. Bone. 10:1989;295-301.
64. Wronski T.J., Dann L.M., Scott K.S., Cintrón M. Long-term effects of ovariectomy and aging on the rat skeleton. Caicif Tissue Int. 45:1989;360-366.
65. Wronski T.J., Yen C.-F. The ovariectomized rat as an animal model for postmenopausal bone loss. Cell Materials Suppl. 1:1991;69-74.