Measurements of total aerosol deposition in intrathoracic conducting airway replicas of children

Journal of Aerosol Science

Volumn 73, Issue , 2014, Pages 39-47

  Borojeni, Azadeh A T ^a   Noga, Michelle L ^a   Vehring, Reinhard ^a   Finlay, Warren H ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Children; Hollow replicate cast; In vitro; Total intrabronchial deposition; Tracheobronchial tree

Indexed keywords

AEROSOLS; FLOW RATE;

AEROSOL DEPOSITION; AEROSOL PARTICLE DEPOSITION; CHILDREN; EMPIRICAL CORRELATIONS; IN-VITRO; MEASUREMENTS OF; MONO-DISPERSE PARTICLES; TRACHEOBRONCHIAL TREE;

DEPOSITION;

AEROSOL; AIRFLOW; CHILD HEALTH; GRAVIMETRY; MODEL VALIDATION; PARTICLE SIZE;

ADULT; AEROSOL; AIRFLOW; AIRWAY; ARTICLE; CHILD; CHILDHOOD; FEMALE; FLOW RATE; GRAVIMETRY; HUMAN; IN VITRO STUDY; INHALATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TRACHEA; VALIDATION STUDY;

ALBERTA; CANADA;

EID: 84898945785     PISSN: 00218502     EISSN: 18791964     Source Type: Journal    
DOI: 10.1016/j.jaerosci.2014.03.005     Document Type: Article

References (52)

1. Becquemin M.H., Bertholon J.F., Bouchikhi A., Malarbet J.L., Roy M. Oronasal ventilation partitioning in adults and children. Effect on aerosol deposition in airways. Radiation Protection Dosimetry Nuclear Technology Publishing 1999, 81:221-228.
2. Becquemin M.H., Yu C.P., Roy M., Bouchikhi A. Total deposition of inhaled particles related to age. Comparison with age-dependent model calculations. Radiation Protection Dosimetry Nuclear Technology Publishing 1991, 38:23-28.
3. Chan T.L., Lippmann M. Experimental measurements and empirical modeling of the regional deposition of inhaled particles in human. American Industrial Hygiene Association Journal 1980, 41:399-459.
4. Cheng Y.S., Fu C.S., Yazzie D., Zhou Y. Respiratory deposition patterns of salbutamol pMDI with CFC and HFA-134a formulations in a human airway replica. Journal of Aerosol Medicine 2001, 14:255-266.
5. Cheng Y.S., Zhou Y., Chen B.T. Particle deposition in a cast of human oral airways. Aerosol Science and Technology 1999, 31:286-300.
6. Chernick, V., Boat, T.F., Wilmott, R.W., & Bush, A. (2006). Kendig[U+05F3]s Disorders of the Respiratory Tract in Children (Disorders of the Respiratory Tract in Children) (seventh edition). Saunders: Amsterdam, NL.
7. Delvadia R.R., Longest P.W., Grein E., Byron P.R. In vitro tests for aerosol deposition. I. Scaling a physical model of the upper airways to predict drug deposition variation in normal humans. Journal of Aerosol Medicine and Pulmonary Drug Delivery 2012, 25:32-40.
8. Dozor A.J., Amin N. Primary Pediatric Pulmonology 2002, Blackwell Publishing, Hoboken, NJ.
9. Finlay W.H. The Mechanics of Inhaled Pharmaceutical Aerosols. An Introduction 2001, Academic Press, Amsterdam, NL.
10. Golshahi L., Noga M.L., Finlay W.H. Deposition of inhaled micrometer-sized particles in oropharyngeal airway replicas of children at constant flow rates. Journal of Aerosol Science 2012, 49:21-31.
11. Golshahi L., Noga M.L., Thompson R.B., Finlay W.H. In vitro deposition measurement of inhaled micrometer-sized particles in extrathoracic airways of children and adolescents during nose breathing. Journal of Aerosol Science 2011, 42:474-488.
12. Grgic B., Finlay W.H., Burnell P.K.P., Heenan A.F. In vitro intersubject and intrasubject deposition measurements in realistic mouth-throat geometries. Journal of Aerosol Science 2004, 35:1025-1040.
13. Grgic B., Finlay W.H., Heenan A.F. Regional aerosol deposition and flow measurements in an idealized mouth and throat geometries. Journal of Aerosol Science 2004, 35:21-32.
14. Gurman J.L., Lioy P.J., Lippmann M., Schlesinger R.B. Particle deposition in replicate casts of the human upper tracheobronchial tree under constant and cyclic inspiratory flow. II. Empirical model. Aerosol Science and Technology 1984, 3:253-257.
15. Gurman J.L., Lippmann M., Schlesinger R.B. Particle deposition in replicate casts of the human upper tracheobronchial tree under constant and cyclic inspiratory flow. I. Experimental. Aerosol Science and Technology 1984, 3:245-252.
16. Heenan A.F., Finlay W.H., Grgic B., Pollard A., Burnell P.K.P. An investigation of the relationship between the flow field and regional deposition in realistic extra-thoracic airways. Journal of Aerosol Science 2004, 35:1013-1023.
17. Hofmann W. Mathematical model for the postnatal growth of the human lung. Respiration Physiology 1982, 49:115-129.
18. Hofmann W., Martonen T.B., Graham R.C. Predicted deposition of nonhygroscopic aerosols in the human lung as a function of subject age. Journal of Aerosol Medicine 1989, 2:49-68.
19. ICRP (1994). International Commission on Radiological Protection (ICRP) Publication 66. Human Respiratory Tract Model for Radiological Protection. Pergamon Press: Oxford.
20. Inthavong K., Choi L.-T., Tu J., Ding S., Thien F. Micron particle deposition in a tracheobronchial airway model under different breathing conditions. Medical Engineering and Physics 2010, 32:1198-1212.
21. Inthavong K., Tu J., Ye Y., Ding S., Subic A., Thien F. Effects of airway obstruction induced by asthma attack on particle deposition. Journal of Aerosol Science 2010, 41:587-601.
22. Kelly J.T., Asgharian B., Kimbell J.S., Wong B.A. Particle deposition in human nasal airway replicas manufactured by different methods. Part I. Inertial regime particles. Aerosol Science and Technology 2004, 38:1063-1071.
23. Lambert A.R., O[U+05F3]Shaughnessy P.T., Tawhai M.H., Hoffman E.A., Lin C.-L. Regional deposition of particles in an image-based airway model. Large-eddy simulation and left-right lung ventilation asymmetry. Journal of Aerosol Science and Technology 2011, 45:11-25.
24. Lin T.C., Breysse P.N., Laube B.L., Swift D.L. Mouthpiece diameter affects deposition efficiency in cast models of the human oral airways. Journal of Aerosol Science 2001, 14:335-341.
25. Liu Y., Matida E.A., Gu J., Johnson M.R. Numerical simulation of aerosol deposition in a 3-D human nasal cavity using RANS, RANS/EIM, and LES. Journal of Aerosol Science 2007, 38:683-700.
26. Luo H.Y., Liu Y. Particle deposition in a CT-scanned human lung airway. Journal of Biomechanics 2009, 42:1869-1876.
27. Mallepree, T., & Bergers, D. (2009). Complex anatomies in medical rapid prototyping. In: ICBME 2008 (Vol. 23), pp. 1866-1869.
28. Martonen, T.B., & Lowe, J. (1982). Assessment of Aerosol Deposition Patterns in Human Respiratory Tract Casts (Vol. 1). Ann Arbor Science Publishers: Ann Arbor, MI.
29. Oldham M.J., Mannix R.C., Phalen R.F. Deposition of monodisperse particles in hollow models representing adult and child-size tracheobronchial airways. Health Physics 1997, 72:827-834.
30. Phalen R.F., Oldham M.J., Kleinman M.T., Crocker T.T. Tracheobronchial deposition predictions for infants, children and adolescents. Annals of Occupational Hygiene 1988, 32:11-21.
31. Rosenthal M., Bush A. Ventilatory variables in normal children during rest and exercise. European Respiratory Journal 2000, 16:1075-1083.
32. Rusconi F., Castagneto M., Porta N., Gagliardi L., Leo G., Pellegatta A., Razon S., Braga M. Reference values for respiratory rate in the first 3 years of life. Journal of the American Academy of Pediatrics 1994, 94:350-355.
33. Schiller-Scotland C.F., Hlawa R., Gebhart J. Experimental data for total deposition in the respiratory tract of children. Toxicology Letters 1994, 72:137-144.
34. Schiller-Scotland C.F., Hlawa R., Gebhart J., Heyder J., Roth C., Wonne R. Particle deposition in the respiratory tract of children during spontaneous and controlled mouth breathing. American Industrial Hygiene Association Journal 1994, 38:117-125.
35. Schlesinger R.B., Bohning D.E., Chan T.L., Lippmann M. Particle deposition in a hollow cast of the human tracheobronchial tree. Journal of Aerosol Science 1977, 8:429-445.
36. Schlesinger, R.B., Cohen, V.R., & Lippmann, M. (1974). Studies of intrabronchial particle deposition using hollow bronchial casts. In: Experimental Lung Cancer: Carcinogenesis and Bioassays. International Symposium Held at the Battelle Seattle Research Center, pp. 116-127.
37. Schlesinger R.B., Gurman J.L., Lippmann M. Particle deposition within bronchial airways: Comparisons using constant and cyclic inspiratory flows. Annals of Occupational Hygiene 1982, 26:47-64.
38. Schlesinger R.B., Lippmann M. Particle deposition in casts of the human upper tracheobronchial tree. American Industrial Hygiene Association Journal 1972, 33:237-251.
39. Schlesinger R.B., Lippmann M. Particle deposition in the trachea: In vivo and in hollow casts. Thorax 1976, 31:678-684.
40. Schlesinger R.B., Lippmann M. Selective particle deposition and bronchogenic carcinoma. Environmental Research 1978, 15:424-431.
41. Smith S.M., Cheng Y.S., Yeh H.C. Deposition of ultrafine particles in human tracheobronchial airways of adults and children. Inhalation Toxicology 2001, 35:697-709.
42. Storey-Bishoff J., Noga M., Finlay W. Deposition of micrometer-sized aerosol particles in infant nasal airway replicas. Journal of Aerosol Science 2008, 39:1055-1065.
43. Su W.C., Cheng Y.S. Deposition of fiber in a human airway replica. Journal of Aerosol Science 2006, 37:1429-1441.
44. Verbanck S., Kalsi H.S., Biddiscombe M.F., Agnihotri V., Belkassem B., Lacor C., Usmani O.S. Inspiratory and expiratory aerosol deposition in the upper airway. Inhalation Toxicology 2011, 23:104-111.
45. Xi J., Si X., Kim J.W., Berlinski A. Simulation of airflow and aerosol deposition in the nasal cavity of a 5-year-old child. Journal of Aerosol Science 2011, 42:156-173.
46. Xu G.B., Yu C.P. Effects of age on deposition of inhaled aerosols in the human lung. Aerosol Science and Technology 1986, 5:349-357.
47. Yamada Y., Koizumi A., Fukuda S., Inaba J., Cheng Y.S., Yeh H.C. Deposition of ultrafine monodisperse particles in a human tracheobronchial cast. Annals of Occupational Hygiene 1994, 38:91-100.
48. Zhang Y., Finlay W.H. Experimental measurements of particle deposition in three proximal lung bifurcation models with an idealized mouth-throat. Journal of Aerosol Medicine 2005, 18:460-473.
49. Zhang Y., Finlay W.H. Measurement of the effect of cartilaginous rings on particle deposition in a proximal lung bifurcation model. Aerosol Science and Technology 2005, 39:394-399.
50. Zhou Y., Cheng Y.S. Particle deposition in a cast of human tracheobronchial airways. Aerosol Science and Technology 2005, 39:492-500.
51. Zhou Y., Guo M., Xi J., Irshad H., Cheng Y.S. Nasal deposition in infants and children. Journal of Aerosol Medicine and Pulmonary Drug Delivery 2013, 26:1-7.
52. Zhou Y., Xi J., Simpson J., Irshad H., Cheng Y.S. Aerosol deposition in a nasopharyngolaryngeal replica of a 5-year-old child. Journal of Aerosol Science and Technology 2013, 47:275-282.