Particle deposition in a CT-scanned human lung airway

Journal of Biomechanics

Volumn 42, Issue 12, 2009, Pages 1869-1876

  Luo, H Y ^a   Liu, Y ^a  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Human lung model; Numerical simulation; Particle deposition; Turbulent flow

Indexed keywords

DEPOSITION EFFICIENCIES; HUMAN LUNG; HUMAN LUNG MODEL; INLET VELOCITY PROFILE; LOW REYNOLDS NUMBER; NUMERICAL SIMULATION; PARTICLE DEPOSITION; PARTICLE DEPOSITION PATTERNS; PARTICLE DEPOSITIONS; STOKES NUMBER; TURBULENT MODELS;

BIOLOGICAL ORGANS; COMPUTER SIMULATION LANGUAGES; COMPUTERIZED TOMOGRAPHY; FLOW SIMULATION; REYNOLDS NUMBER; SIMULATORS; TURBULENCE MODELS; TURBULENT FLOW;

DEPOSITION;

ADULT; AIRWAY; ARTICLE; BIOLOGICAL MODEL; BRONCHUS; CASE REPORT; CHINESE; COMPUTER ASSISTED TOMOGRAPHY; FLOW RATE; HUMAN; LARYNX; LUNG; MALE; PARTICLE SIZE; PRIORITY JOURNAL; RESPIRATORY AIRFLOW; SIMULATION; TRACHEA;

BRONCHI; HUMANS; LUNG; MALE; MIDDLE AGED; PARTICLE SIZE; PARTICULATE MATTER; PULMONARY VENTILATION; RESPIRATORY MECHANICS; TOMOGRAPHY, X-RAY COMPUTED; TRACHEA;

EID: 68149148165     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2009.05.004     Document Type: Article

References (26)

1. Balashazy I., Hofmann W., and Heistracher T. Computation of local enhancement factors for the quantification of particle deposition patterns in airway dividers. Journal of Aerosol Science 30 (1999) 185-203
2. Comer J.K., Kleinstreuer C., Hyun S., and Kim C.S. Aerosol transport and deposition in sequentially bifurcating airways. ASME Journal of Biomechanical Engineering 122 (2000) 152-158
3. Comer J.K., Kleinstreuer C., and Kim C.S. Flow structures and particle deposition patterns in double-bifurcation airway models. Part 2. Aerosol transport and deposition. Journal of Fluid Mechanics 435 (2001) 55-80
4. De Backer J.W., Vanderveken O.M., Vos W.G., Devolder A., Verhulst S.L., Verbraecken J.A., Parizel P.M., Braem M.J., Van de Heyning P.H., and De Backer W.A. Functional imaging using computational fluid dynamics to predict treatment success of mandibular advancement devices in sleep-disordered breathing. Journal of Biomechanics 40 (2007) 3708-3714
5. Ertbruggen C.V., Hirsch C., and Paiva M. Anatomically based three-dimensional model of airways to simulate flow and particle transport using computational fluid dynamics. Journal of Applied Physiology 98 (2005) 970-980
6. Farkas A., and Balashazy I. Simulation of the effect of local obstructions and blockage on airflow and aerosol deposition in central human airways. Journal of Aerosol Science 38 (2007) 865-884
7. Heistracher T., and Hofmman W. Flow and deposition patterns in successive airway dividers. Annals of Occupational Hygiene 41 (1997) 537-542
8. Hickey A.J. Inhalation Aerosols: Physical and Biological Basis for Therapy. second ed. (2007), Informa Healthcare, New York
9. Horsfield K., Dart G., Olson D.E., Filley G.F., and Cumming G. Models of the human bronchial tree. Journal of Applied Physiology 31 (1971) 207-217
10. Johnson J.R., and Schroter R.C. Deposition of particles in model airways. Journal of Applied Physiology 47 (1979) 947-953
11. Kim C.S., and Iglesias A.J. Deposition of inhaled particles in bifurcating airway models. I. Inspiratory deposition. Journal of Aerosol Medicine 2 (1989) 1-14
12. Lee J.W., Goo I.H., and Chung M.K. Characteristics of inertial deposition in a double bifurcation. Journal of Aerosol Science 27 (1996) 119-138
13. Li Z., Kleinstreuer C., and Zhang Z. Simulation of airflow fields and microparticle deposition in realitic human lung airway models. Part I: airflow patterns. European Journal of Mechanics B/Fluids 26 (2007) 650-668
14. Lin C.L., Tawhai M.H., McLennan G., and Hoffman E.A. Characteristics of the turbulent laryngeal jet and its effect on airflow in the human intra-thoracic airways. Respiratory Physiology & Neurobiology 157 (2007) 295-309
15. Liu Y., So R.M.C., and Zhang C.H. Modeling the bifurcating flow in a human lung airway. Journal of Biomechanics 35 (2002) 477-485
16. Liu Y., So R.M.C., and Zhang C.H. Modeling the bifurcating flow in an asymmetric human lung airway. Journal of Biomechanics 36 (2003) 951-959
17. Longest W.P., and Vinchurkar S. Validating CFD predictions of respiratory aerosol deposition: effects of upstream transition and turbulence. Journal of Biomechanics 40 (2007) 305-316
18. Luo H.Y., Liu Y., and Yang X.L. Particle deposition in obstructed airways. Journal of Biomechanics 40 (2007) 3096-3104
19. Luo H.Y., and Liu Y. Modeling the Bifurcating Flow in a CT-Scanned Human Lung Airway. Journal of Biomechanics 41 (2008) 2681-2688
20. Rochefort L., Vial L., Fodil R., Mai{dotless}tre X., Louis B., Isabey D., Caillibotte G., Thiriet M., Bittoun J., Durand E., and Sbirlea-Apiou G. In vitro validation of computational fluid dynamic simulation in human proximal airways with hyperpolarized 3He magnetic resonance phase-contrast velocimetry. Journal of Applied Physiology 102 (2007) 2012-2023
21. Weibel E.R. Morphometry of the Human Lung (1963), Academic Press, Springer, New York
22. Wilcox D.C. Turbulence Modeling for CFD (1998), California DCW Industries Inc.
23. Zhang Z., and Kleinstreuer C. Effect of particle inlet distribution on deposition in a triple bifurcation lung airway model. Journal of Aerosol Medicine 14 (2001) 13-29
24. Zhang Z., Kleinstreuer C., and Kim C.S. Cyclic micron-size particle inhalation and deposition in a triple bifurcation lung airway model. Journal of Aerosol Science 33 (2002) 257-281
25. Zhang Z., and Kleinstreuer C. Low-Reynolds-Number turbulent flows in locally constricted conduits: a comparison study. AIAA Journal 41 (2003) 831-837
26. Zhang Z., and Kleinstreuer C. Airflow structures and nano-particle deposition in a human upper airway model. Journal of Computational Physics 198 (2004) 178-210