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Volumn 29, Issue 5, 2014, Pages 793-803

Bone metabolism in the fetus and neonate

Author keywords

Calcium; Fetus; Gene knockout mice; Human studies; Phosphorus; Placenta; Skeletal development

Indexed keywords

CALCITONIN; CALCITRIOL; CALCIUM; CALCIUM ION; FIBROBLAST GROWTH FACTOR 23; MAGNESIUM; PARATHYROID HORMONE; PHOSPHORUS; VITAMIN D; MINERAL;

EID: 84898922295     PISSN: 0931041X     EISSN: 1432198X     Source Type: Journal    
DOI: 10.1007/s00467-013-2461-4     Document Type: Review
Times cited : (48)

References (61)
  • 1
    • 84882820914 scopus 로고    scopus 로고
    • Fetal mineral homeostasis
    • F.H. Glorieux J.M. Pettifor H. Jüppner (eds) 2 Elsevier/Academic Press San Diego
    • Kovacs CS (2011) Fetal mineral homeostasis. In: Glorieux FH, Pettifor JM, Jüppner H (eds) Pediatric bone: Biology and diseases, 2nd edn. Elsevier/Academic Press, San Diego, pp 247-275
    • (2011) Pediatric Bone: Biology and Diseases , pp. 247-275
    • Kovacs, C.S.1
  • 2
    • 81255135706 scopus 로고    scopus 로고
    • Fetus, Neonate and Infant
    • D. Feldman W.J. Pike J.S. Adams (eds) 3 Academic New York 10.1016/B978-0-12-381978-9.10035-6
    • Kovacs CS (2011) Fetus, Neonate and Infant. In: Feldman D, Pike WJ, Adams JS (eds) Vitamin D, 3rd edn. Academic, New York, pp 625-646
    • (2011) Vitamin D , pp. 625-646
    • Kovacs, C.S.1
  • 3
    • 84864253279 scopus 로고    scopus 로고
    • The role of vitamin d in pregnancy and lactation: Insights from animal models and clinical studies
    • 22483092 10.1146/annurev-nutr-071811-150742
    • Kovacs CS (2012) The role of vitamin d in pregnancy and lactation: insights from animal models and clinical studies. Annu Rev Nutr 32:97-123
    • (2012) Annu Rev Nutr , vol.32 , pp. 97-123
    • Kovacs, C.S.1
  • 5
    • 21044451621 scopus 로고    scopus 로고
    • The vitamin D receptor is not required for fetal mineral homeostasis or for the regulation of placental calcium transfer
    • 15741244 10.1152/ajpendo.00354.2004
    • Kovacs CS, Woodland ML, Fudge NJ, Friel JK (2005) The vitamin D receptor is not required for fetal mineral homeostasis or for the regulation of placental calcium transfer. Am J Physiol Endocrinol Metab 289:E133-E144
    • (2005) Am J Physiol Endocrinol Metab , vol.289
    • Kovacs, C.S.1    Woodland, M.L.2    Fudge, N.J.3    Friel, J.K.4
  • 8
    • 67650281205 scopus 로고    scopus 로고
    • Skeletal morphogenesis during embryonic development
    • 19883365 10.1615/CritRevEukarGeneExpr.v19.i3.30
    • Yang Y (2009) Skeletal morphogenesis during embryonic development. Crit Rev Eukaryot Gene Expr 19:197-218
    • (2009) Crit Rev Eukaryot Gene Expr , vol.19 , pp. 197-218
    • Yang, Y.1
  • 9
    • 77953374344 scopus 로고    scopus 로고
    • Parathyroid hormone regulates fetal-placental mineral homeostasis
    • 19968565 10.1359/jbmr.090825
    • Simmonds CS, Karsenty G, Karaplis AC, Kovacs CS (2010) Parathyroid hormone regulates fetal-placental mineral homeostasis. J Bone Miner Res 25:594-605
    • (2010) J Bone Miner Res , vol.25 , pp. 594-605
    • Simmonds, C.S.1    Karsenty, G.2    Karaplis, A.C.3    Kovacs, C.S.4
  • 10
    • 0035050109 scopus 로고    scopus 로고
    • Fetal parathyroids are not required to maintain placental calcium transport
    • 199555 11306604 10.1172/JCI11321
    • Kovacs CS, Manley NR, Moseley JM, Martin TJ, Kronenberg HM (2001) Fetal parathyroids are not required to maintain placental calcium transport. J Clin Invest 107:1007-1015
    • (2001) J Clin Invest , vol.107 , pp. 1007-1015
    • Kovacs, C.S.1    Manley, N.R.2    Moseley, J.M.3    Martin, T.J.4    Kronenberg, H.M.5
  • 11
    • 0030465408 scopus 로고    scopus 로고
    • Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptor
    • 26386 8986793 10.1073/pnas.93.26.15233
    • Kovacs CS, Lanske B, Hunzelman JL, Guo J, Karaplis AC, Kronenberg HM (1996) Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptor. Proc Natl Acad Sci USA 93:15233-15238
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 15233-15238
    • Kovacs, C.S.1    Lanske, B.2    Hunzelman, J.L.3    Guo, J.4    Karaplis, A.C.5    Kronenberg, H.M.6
  • 12
    • 0034752132 scopus 로고    scopus 로고
    • PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP
    • 11606467 10.1210/endo.142.11.8509
    • Kovacs CS, Chafe LL, Fudge NJ, Friel JK, Manley NR (2001) PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP. Endocrinology 142:4983-4993
    • (2001) Endocrinology , vol.142 , pp. 4983-4993
    • Kovacs, C.S.1    Chafe, L.L.2    Fudge, N.J.3    Friel, J.K.4    Manley, N.R.5
  • 13
    • 0029030722 scopus 로고
    • The role of Hoxa-3 in mouse thymus and thyroid development
    • 7635047
    • Manley NR, Capecchi MR (1995) The role of Hoxa-3 in mouse thymus and thyroid development. Development 121:1989-2003
    • (1995) Development , vol.121 , pp. 1989-2003
    • Manley, N.R.1    Capecchi, M.R.2
  • 16
    • 79955647873 scopus 로고    scopus 로고
    • Vascular, cardiovascular, and neurologic actions of parathyroid-related protein
    • J. Bilezikian L.G. Raisz T.J. Martin (eds) 3 Academic New York 10.1016/B978-0-12-373884-4.00052-5
    • Riddle RC, Macica CM, Clemens TL (2008) Vascular, cardiovascular, and neurologic actions of parathyroid-related protein. In: Bilezikian JP, Raisz LG, Martin TJ (eds) Principles of bone biology, 3rd edn. Academic, New York, pp 733-748
    • (2008) Principles of Bone Biology , pp. 733-748
    • Riddle, R.C.1    Macica, C.M.2    Clemens, T.L.3
  • 17
    • 0029750190 scopus 로고    scopus 로고
    • Indian hedgehog and parathyroid hormone-related protein regulate the rate of cartilage differentiation
    • 8662546 10.1126/science.273.5275.613
    • Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, Tabin CJ (1996) Indian hedgehog and parathyroid hormone-related protein regulate the rate of cartilage differentiation. Science 273:613-622
    • (1996) Science , vol.273 , pp. 613-622
    • Vortkamp, A.1    Lee, K.2    Lanske, B.3    Segre, G.V.4    Kronenberg, H.M.5    Tabin, C.J.6
  • 21
    • 0029811142 scopus 로고    scopus 로고
    • Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation
    • 38368 8816783 10.1073/pnas.93.19.10240
    • Weir EC, Philbrick WM, Amling M, Neff LA, Baron R, Broadus AE (1996) Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation. Proc Natl Acad Sci USA 93:10240-10245
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10240-10245
    • Weir, E.C.1    Philbrick, W.M.2    Amling, M.3    Neff, L.A.4    Baron, R.5    Broadus, A.E.6
  • 22
    • 0031442990 scopus 로고    scopus 로고
    • Targeted expression of constitutively active PTH/PTHrP receptors delays endochondral bone formation and rescues PTHrP-less mice
    • 28367 9391087 10.1073/pnas.94.25.13689
    • Schipani E, Lanske B, Hunzelman J, Luz A, Kovacs CS, Lee K, Pirro A, Kronenberg HM, Jüppner H (1997) Targeted expression of constitutively active PTH/PTHrP receptors delays endochondral bone formation and rescues PTHrP-less mice. Proc Natl Acad Sci USA 94:13689-13694
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13689-13694
    • Schipani, E.1    Lanske, B.2    Hunzelman, J.3    Luz, A.4    Kovacs, C.S.5    Lee, K.6    Pirro, A.7    Kronenberg, H.M.8    Jüppner, H.9
  • 25
    • 2442713981 scopus 로고    scopus 로고
    • Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related protein
    • 15162506 10.1002/dvdy.20058
    • Rubin LP, Kovacs CS, De Paepe ME, Tsai SW, Torday JS, Kronenberg HM (2004) Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related protein. Dev Dyn 230:278-289
    • (2004) Dev Dyn , vol.230 , pp. 278-289
    • Rubin, L.P.1    Kovacs, C.S.2    De Paepe, M.E.3    Tsai, S.W.4    Torday, J.S.5    Kronenberg, H.M.6
  • 27
    • 0036251217 scopus 로고    scopus 로고
    • Parathyroid hormone is essential for normal fetal bone formation
    • 150965 11994406 10.1172/JCI0214817
    • Miao D, He B, Karaplis AC, Goltzman D (2002) Parathyroid hormone is essential for normal fetal bone formation. J Clin Invest 109:1173-1182
    • (2002) J Clin Invest , vol.109 , pp. 1173-1182
    • Miao, D.1    He, B.2    Karaplis, A.C.3    Goltzman, D.4
  • 28
    • 0033835040 scopus 로고    scopus 로고
    • Parathyroid hormone(1-34) and parathyroid hormone-related protein(1-34) stimulate calcium release from human syncytiotrophoblast basal membranes via a common receptor
    • 10974662 10.1677/joe.0.1660689
    • Farrugia W, de Gooyer T, Rice GE, Moseley JM, Wlodek ME (2000) Parathyroid hormone(1-34) and parathyroid hormone-related protein(1-34) stimulate calcium release from human syncytiotrophoblast basal membranes via a common receptor. J Endocrinol 166:689-695
    • (2000) J Endocrinol , vol.166 , pp. 689-695
    • Farrugia, W.1    De Gooyer, T.2    Rice, G.E.3    Moseley, J.M.4    Wlodek, M.E.5
  • 29
    • 0031725947 scopus 로고    scopus 로고
    • Inactivating mutation in the human parathyroid hormone receptor type 1 gene in Blomstrand chondrodysplasia
    • 9832466 10.1210/endo.139.12.6522
    • Karaplis AC, He B, Nguyen MT, Young ID, Semeraro D, Ozawa H, Amizuka N (1998) Inactivating mutation in the human parathyroid hormone receptor type 1 gene in Blomstrand chondrodysplasia. Endocrinology 139:5255-5258
    • (1998) Endocrinology , vol.139 , pp. 5255-5258
    • Karaplis, A.C.1    He, B.2    Nguyen, M.T.3    Young, I.D.4    Semeraro, D.5    Ozawa, H.6    Amizuka, N.7
  • 30
    • 0033998745 scopus 로고    scopus 로고
    • Blomstrand osteochondrodysplasia: Three novel cases and histological evidence for heterogeneity
    • 10664159 10.1007/PL00008195
    • Oostra RJ, van der Harten JJ, Rijnders WP, Scott RJ, Young MP, Trump D (2000) Blomstrand osteochondrodysplasia: three novel cases and histological evidence for heterogeneity. Virchows Arch 436:28-35
    • (2000) Virchows Arch , vol.436 , pp. 28-35
    • Oostra, R.J.1    Van Der Harten, J.J.2    Rijnders, W.P.3    Scott, R.J.4    Young, M.P.5    Trump, D.6
  • 33
    • 0019830576 scopus 로고
    • Effect of vitamin D deficiency on skeletal development during early growth in the rat
    • 7283447 10.1016/0003-9861(81)90251-4
    • Halloran BP, De Luca HF (1981) Effect of vitamin D deficiency on skeletal development during early growth in the rat. Arch Biochem Biophys 209:7-14
    • (1981) Arch Biochem Biophys , vol.209 , pp. 7-14
    • Halloran, B.P.1    De Luca, H.F.2
  • 34
    • 0020505978 scopus 로고
    • Studies on the role of vitamin D in early skeletal development, mineralization, and growth in rats
    • 6616315 10.1007/BF02405076
    • Miller SC, Halloran BP, DeLuca HF, Jee WS (1983) Studies on the role of vitamin D in early skeletal development, mineralization, and growth in rats. Calcif Tissue Int 35:455-460
    • (1983) Calcif Tissue Int , vol.35 , pp. 455-460
    • Miller, S.C.1    Halloran, B.P.2    Deluca, H.F.3    Jee, W.S.4
  • 35
    • 0021416159 scopus 로고
    • Placental transport of calcium and phosphorus is not regulated by vitamin D
    • 6720905
    • Brommage R, DeLuca HF (1984) Placental transport of calcium and phosphorus is not regulated by vitamin D. Am J Physiol 246:F526-F529
    • (1984) Am J Physiol , vol.246
    • Brommage, R.1    Deluca, H.F.2
  • 36
    • 0024347865 scopus 로고
    • Placental transport of calcium and phosphorus in pigs
    • 2681666 10.1515/jpme.1989.17.2.127
    • Lachenmaier-Currle U, Harmeyer J (1989) Placental transport of calcium and phosphorus in pigs. J Perinat Med 17:127-136
    • (1989) J Perinat Med , vol.17 , pp. 127-136
    • Lachenmaier-Currle, U.1    Harmeyer, J.2
  • 38
    • 0018170182 scopus 로고
    • Intestinal and placental calcium-binding proteins in vitamin D-deprived or -supplemented rats
    • 739838 10.1016/0024-3205(78)90370-3
    • Marche P, Delorme A, Cuisinier-Gleizes P (1978) Intestinal and placental calcium-binding proteins in vitamin D-deprived or -supplemented rats. Life Sci 23:2555-2561
    • (1978) Life Sci , vol.23 , pp. 2555-2561
    • Marche, P.1    Delorme, A.2    Cuisinier-Gleizes, P.3
  • 40
    • 0035912707 scopus 로고    scopus 로고
    • Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: Evidence for skeletal, reproductive, and immune dysfunction
    • 34697 11416220 10.1073/pnas.131029498
    • Panda DK, Miao D, Tremblay ML, Sirois J, Farookhi R, Hendy GN, Goltzman D (2001) Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. Proc Natl Acad Sci USA 98:7498-7503
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7498-7503
    • Panda, D.K.1    Miao, D.2    Tremblay, M.L.3    Sirois, J.4    Farookhi, R.5    Hendy, G.N.6    Goltzman, D.7
  • 41
    • 0034984919 scopus 로고    scopus 로고
    • Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets
    • 11416036
    • Dardenne O, Prud'homme J, Arabian A, Glorieux FH, St-Arnaud R (2001) Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets. Endocrinology 142:3135-3141
    • (2001) Endocrinology , vol.142 , pp. 3135-3141
    • Dardenne, O.1    Prud'Homme, J.2    Arabian, A.3    Glorieux, F.H.4    St-Arnaud, R.5
  • 42
    • 0000524953 scopus 로고    scopus 로고
    • Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice
    • 9751523
    • Li YC, Amling M, Pirro AE, Priemel M, Meuse J, Baron R, Delling G, Demay MB (1998) Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology 139:4391-4396
    • (1998) Endocrinology , vol.139 , pp. 4391-4396
    • Li, Y.C.1    Amling, M.2    Pirro, A.E.3    Priemel, M.4    Meuse, J.5    Baron, R.6    Delling, G.7    Demay, M.B.8
  • 43
    • 0030610422 scopus 로고    scopus 로고
    • Targeted ablation of the vitamin D receptor: An animal model of vitamin D dependent rickets type II with alopecia
    • 23277 9275211 10.1073/pnas.94.18.9831
    • Li YC, Pirro AE, Amling M, Delling G, Baron R, Bronson R, Demay MB (1997) Targeted ablation of the vitamin D receptor: an animal model of vitamin D dependent rickets type II with alopecia. Proc Natl Acad Sci USA 94:9831-9835
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9831-9835
    • Li, Y.C.1    Pirro, A.E.2    Amling, M.3    Delling, G.4    Baron, R.5    Bronson, R.6    Demay, M.B.7
  • 44
    • 0033303655 scopus 로고    scopus 로고
    • Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: Formal histomorphometric and biomechanical analyses
    • 10537122
    • Amling M, Priemel M, Holzmann T, Chapin K, Rueger JM, Baron R, Demay MB (1999) Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology 140:4982-4987
    • (1999) Endocrinology , vol.140 , pp. 4982-4987
    • Amling, M.1    Priemel, M.2    Holzmann, T.3    Chapin, K.4    Rueger, J.M.5    Baron, R.6    Demay, M.B.7
  • 45
    • 0012884005 scopus 로고    scopus 로고
    • Rescue of the pseudo-vitamin D deficiency rickets phenotype of CYP27B1-deficient mice by treatment with 1,25-dihydroxyvitamin D3: Biochemical, histomorphometric, and biomechanical analyses
    • 12674324 10.1359/jbmr.2003.18.4.637
    • Dardenne O, Prudhomme J, Hacking SA, Glorieux FH, St-Arnaud R (2003) Rescue of the pseudo-vitamin D deficiency rickets phenotype of CYP27B1-deficient mice by treatment with 1,25-dihydroxyvitamin D3: biochemical, histomorphometric, and biomechanical analyses. J Bone Miner Res 18:637-643
    • (2003) J Bone Miner Res , vol.18 , pp. 637-643
    • Dardenne, O.1    Prudhomme, J.2    Hacking, S.A.3    Glorieux, F.H.4    St-Arnaud, R.5
  • 47
    • 0022602510 scopus 로고
    • Nutritional deficiencies in the neonate
    • 3514049
    • Pereira GR, Zucker AH (1986) Nutritional deficiencies in the neonate. Clin Perinatol 13:175-189
    • (1986) Clin Perinatol , vol.13 , pp. 175-189
    • Pereira, G.R.1    Zucker, A.H.2
  • 48
    • 62649135299 scopus 로고    scopus 로고
    • Incidence and prevalence of nutritional and hereditary rickets in southern Denmark
    • 19095780 10.1530/EJE-08-0818
    • Beck-Nielsen SS, Brock-Jacobsen B, Gram J, Brixen K, Jensen TK (2009) Incidence and prevalence of nutritional and hereditary rickets in southern Denmark. Eur J Endocrinol 160:491-497
    • (2009) Eur J Endocrinol , vol.160 , pp. 491-497
    • Beck-Nielsen, S.S.1    Brock-Jacobsen, B.2    Gram, J.3    Brixen, K.4    Jensen, T.K.5
  • 51
    • 0014422111 scopus 로고
    • Maternal malabsorption presenting as congenital rickets
    • 4171742 10.1016/S0140-6736(68)91408-6
    • Begum R, Coutinho ML, Dormandy TL, Yudkin S (1968) Maternal malabsorption presenting as congenital rickets. Lancet 1:1048-1052
    • (1968) Lancet , vol.1 , pp. 1048-1052
    • Begum, R.1    Coutinho, M.L.2    Dormandy, T.L.3    Yudkin, S.4
  • 52
    • 0020567901 scopus 로고
    • Mineral content of the forearms of babies born to Asian and white mothers
    • 10.1136/bmj.286.6373.1233
    • Congdon P, Horsman A, Kirby PA, Dibble J, Bashir T (1983) Mineral content of the forearms of babies born to Asian and white mothers. Br Med J (Clin Res Ed) 286:1233-1235
    • (1983) Br Med J (Clin Res Ed) , vol.286 , pp. 1233-1235
    • Congdon, P.1    Horsman, A.2    Kirby, P.A.3    Dibble, J.4    Bashir, T.5
  • 53
    • 0017255054 scopus 로고
    • Congenital hyperparathyroidism and vitamin D deficiency secondary to maternal hypoparathyroidism
    • 179272 10.1111/j.1651-2227.1976.tb04901.x
    • Sann L, David L, Thomas A, Frederich A, Chapuy MC, Francois R (1976) Congenital hyperparathyroidism and vitamin D deficiency secondary to maternal hypoparathyroidism. Acta Paediatr Scand 65:381-385
    • (1976) Acta Paediatr Scand , vol.65 , pp. 381-385
    • Sann, L.1    David, L.2    Thomas, A.3    Frederich, A.4    Chapuy, M.C.5    Francois, R.6
  • 56
    • 79961228421 scopus 로고    scopus 로고
    • Vitamin D supplementation during pregnancy: Double blind, randomized clinical trial of safety and effectiveness
    • 3183324 21706518 10.1002/jbmr.463
    • Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL (2011) Vitamin D supplementation during pregnancy: double blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 26:2341-2357
    • (2011) J Bone Miner Res , vol.26 , pp. 2341-2357
    • Hollis, B.W.1    Johnson, D.2    Hulsey, T.C.3    Ebeling, M.4    Wagner, C.L.5
  • 57
    • 33644830265 scopus 로고    scopus 로고
    • Maternal 25-hydroxyvitamin D and parathyroid hormone concentrations and offspring birth size
    • 16352684 10.1210/jc.2005-1479
    • Morley R, Carlin JB, Pasco JA, Wark JD (2006) Maternal 25-hydroxyvitamin D and parathyroid hormone concentrations and offspring birth size. J Clin Endocrinol Metab 91:906-912
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 906-912
    • Morley, R.1    Carlin, J.B.2    Pasco, J.A.3    Wark, J.D.4
  • 61
    • 84884023229 scopus 로고    scopus 로고
    • Fetal control of calcium and phosphate homeostasis - Lessons from mouse models
    • R.V. Thakker M. Whyte J.A. Eisman T. Igarashi (eds) Academic Press/Elsevier San Diego
    • Kovacs CS (2012) Fetal control of calcium and phosphate homeostasis - lessons from mouse models. In: Thakker RV, Whyte MP, Eisman JA, Igarashi T (eds) Genetics of bone biology and skeletal disease. Academic Press/Elsevier, San Diego, pp 205-220
    • (2012) Genetics of Bone Biology and Skeletal Disease , pp. 205-220
    • Kovacs, C.S.1


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