Effects of extracellular phosphate on gene expression in murine osteoblasts

Calcified Tissue International

Volumn 94, Issue 5, 2014, Pages 474-483

  Rendenbach, C ^a   Yorgan, T A ^a   Heckt, T ^a   Otto, B ^a   Baldauf, C ^a   Jeschke, A ^a   Streichert, T ^a   David, J P ^a   Amling, M ^a   Schinke, T ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Fgf23; Hyperphosphatemia; Osteomalacia; Pyrophosphate

Indexed keywords

ALKALINE PHOSPHATASE; CXCL11 CHEMOKINE; DENTIN MATRIX PROTEIN 1; DICKKOPF 1 PROTEIN; FIBROBLAST GROWTH FACTOR 23; INTERLEUKIN 6; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHATE; PHOSPHATE REGULATING NEUTRAL ENDOPEPTIDASE; PHOSPHATE TRANSPORTER; PROTEIN; PROTEIN ANK; PROTEIN BGLAP; PROTEIN ENPP1; PROTEIN IBSP; PROTEIN SLC20A1; SCLEROSTIN; SHORT HAIRPIN RNA; SODIUM DIHYDROGEN PHOSPHATE; TRANSCRIPTION FACTOR FRA 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL TYPE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC CODE; HUMAN CELL CULTURE; HYPERPHOSPHATEMIA; HYPOPHOSPHATEMIC RICKETS; IMMEDIATE EARLY GENE; MINERALIZATION; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLASTOGENESIS; OSTEOMALACIA; PHENOTYPE; PHOSPHATE METABOLISM; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; ANIMAL; BONE MINERALIZATION; C57BL MOUSE; DNA MICROARRAY; GENE EXPRESSION REGULATION; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; CALCIFICATION, PHYSIOLOGIC; GENE EXPRESSION REGULATION; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOBLASTS; PHOSPHATES; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84898917805     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-013-9831-6     Document Type: Article

References (49)

1. Bergwitz C, Juppner H (2012) FGF23 and syndromes of abnormal renal phosphate handling. Adv Exp Med Biol 728:41-64
2. Chong WH, Molinolo AA, Chen CC, Collins MT (2011) Tumor-induced osteomalacia. Endocr Relat Cancer 18:R53-R77
3. ADHR Consortium (2000) Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet 26:345-348
4. Benet-Pagès A, Orlik P, Strom TM, Lorenz-Depiereux B (2005) An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. Hum Mol Genet 14:385-390
5. Shimada T, Kakitani M, Yamazaki Y, Hasegawa H, Takeuchi Y, Fujita T, Fukumoto S, Tomizuka K, Yamashita T (2004) Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest 113:561-568
6. Sitara D, Razzaque MS, Hesse M, Yoganathan S, Taguchi T, Erben RG, Juppner H, Lanske B (2004) Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol 23:421-432
7. Mansfield K, Rajpurohit R, Shapiro IM (1999) Extracellular phosphate ions cause apoptosis of terminally differentiated epiphyseal chondrocytes. J Cell Physiol 179:276-286
8. Teixeira CC, Mansfield K, Hertkorn C, Ischiropoulos H, Shapiro IM (2001) Phosphate-induced chondrocyte apoptosis is linked to nitric oxide generation. Am J Physiol Cell Physiol 281:C833-C839
9. Miedlich SU, Zalutskaya A, Zhu ED, Demay MB (2010) Phosphate-induced apoptosis of hypertrophic chondrocytes is associated with a decrease in mitochondrial membrane potential and is dependent upon Erk1/2 phosphorylation. J Biol Chem 285:18270-18275
10. Ohnishi M, Razzaque MS (2010) Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging. FASEB J 24:3562-3571
11. Liu S, Zhou J, Tang W, Jiang X, Rowe DW, Quarles LD (2006) Pathogenic role of Fgf23 in Hyp mice. Am J Physiol Endocrinol Metab 291:E38-E49
12. Sitara D, Kim S, Razzaque MS, Bergwitz C, Taguchi T, Schuler C, Erben RG, Lanske B (2008) Genetic evidence of serum phosphate-independent functions of FGF-23 on bone. PLoS Genet 4:e1000154
13. Chang SH, Yu KN, Lee YS, An GH, Beck GR Jr, Colburn NH, Lee KH, Cho MH (2006) Elevated inorganic phosphate stimulates Akt-ERK1/2-Mnk1 signaling in human lung cells. Am J Respir Cell Mol Biol 35:528-539
14. Julien M, Magne D, Masson M, Rolli-Derkinderen M, Chassande O, Cario-Toumaniantz C, Cherel Y, Weiss P, Guicheux J (2007) Phosphate stimulates matrix Gla protein expression in chondrocytes through the extracellular signal regulated kinase signaling pathway. Endocrinology 148:530-537
15. Wittrant Y, Bourgine A, Khoshniat S, Alliot-Licht B, Masson M, Gatius M, Rouillon T, Weiss P, Beck L, Guicheux J (2009) Inorganic phosphate regulates Glvr-1 and -2 expression: role of calcium and ERK1/2. Biochem Biophys Res Commun 381:259-263
16. +/Pi cotransporter Pit-1 and Raf/MEK/ERK pathway. Bone 47:938-947
17. Yamazaki M, Ozono K, Okada T, Tachikawa K, Kondou H, Ohata Y, Michigami T (2010) Both FGF23 and extracellular phosphate activate Raf/MEK/ERK pathway via FGF receptors in HEK293 cells. J Cell Biochem 111:1210-1221
18. Khoshniat S, Bourgine A, Julien M, Weiss P, Guicheux J, Beck L (2011) The emergence of phosphate as a specific signaling molecule in bone and other cell types in mammals. Cell Mol Life Sci 68:205-218
19. Kanatani M, Sugimoto T, Kano J, Chihara K (2002) IGF-I mediates the stimulatory effect of high phosphate concentration on osteoblastic cell proliferation. J Cell Physiol 190:306-312
20. Beck GR Jr, Knecht N (2003) Osteopontin regulation by inorganic phosphate is ERK1/2-, protein kinase C-, and proteasome-dependent. J Biol Chem 278:41921-41929
21. Conrads KA, Yi M, Simpson KA, Lucas DA, Camalier CE, Yu LR, Veenstra TD, Stephens RM, Conrads TP, Beck GR Jr (2005) A combined proteome and microarray investigation of inorganic phosphate-induced pre-osteoblast cells. Mol Cell Proteomics 4:1284-1296
22. Naviglio S, Spina A, Chiosi E, Fusco A, Illiano F, Pagano M, Romano M, Senatore G, Sorrentino A, Sorvillo L, Illiano G (2006) Inorganic phosphate inhibits growth of human osteosarcoma U2OS cells via adenylate cyclase/cAMP pathway. J Cell Biochem 98:1584-1596
23. Yoshiko Y, Candeliere GA, Maeda N, Aubin JE (2007) Osteoblast autonomous Pi regulation via Pit1 plays a role in bone mineralization. Mol Cell Biol 27:4465-4474
24. Jochum W, David JP, Elliott C, Wutz A, Plenk H Jr, Matsuo K, Wagner EF (2000) Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. Nat Med 6:980-984
25. Eferl R, Hoebertz A, Schilling AF, Rath M, Karreth F, Kenner L, Amling M, Wagner EF (2004) The Fos-related antigen Fra-1 is an activator of bone matrix formation. EMBO J 23:2789-2799
26. Julien M, Khoshniat S, Lacreusette A, Gatius M, Bozec A, Wagner EF, Wittrant Y, Masson M, Weiss P, Beck L, Magne D, Guicheux J (2009) Phosphate-dependent regulation of MGP in osteoblasts: role of ERK1/2 and Fra-1. J Bone Miner Res 24:1856-1868
27. Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G (1997) Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386:78-81
28. Khoshniat S, Bourgine A, Julien M, Petit M, Pilet P, Rouillon T, Masson M, Gatius M, Weiss P, Guicheux J, Beck L (2011) Phosphate-dependent stimulation of MGP and OPN expression in osteoblasts via the ERK1/2 pathway is modulated by calcium. Bone 48:894-902
29. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
30. Sudo H, Kodama HA, Amagai Y, Yamamoto S, Kasai S (1983) In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J Cell Biol 96:191-198
31. Bergwitz C, Juppner H (2010) Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23. Annu Rev Med 61:91-104
32. Bergwitz C, Juppner H (2009) Disorders of phosphate homeostasis and tissue mineralisation. Endocr Dev 16:133-156
33. Ecarot B, Glorieux FH, Desbarats M, Travers R, Labelle L (1992) Defective bone formation by Hyp mouse bone cells transplanted into normal mice: evidence in favor of an intrinsic osteoblast defect. J Bone Miner Res 7:215-220
34. Xiao G, Wang D, Benson MD, Karsenty G, Franceschi RT (1998) Role of the alpha2-integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor. J Biol Chem 273:32988-32994
35. Seitz S, Rendenbach C, Barvencik F, Streichert T, Jeschke A, Schulze J, Amling M, Schinke T (2013) Retinol deprivation partially rescues the skeletal mineralization defects of Phex-deficient Hyp mice. Bone 53:231-238
36. Bergwitz C, Juppner H (2011) Phosphate sensing. Adv Chronic Kidney Dis 18:132-144
37. Ho AM, Johnson MD, Kingsley DM (2000) Role of the mouse ank gene in control of tissue calcification and arthritis. Science 289:265-270
38. Pendleton A, Johnson MD, Hughes A, Gurley KA, Ho AM, Doherty M, Dixey J, Gillet P, Loeuille D, McGrath R, Reginato A, Shiang R, Wright G, Netter P, Williams C, Kingsley DM (2002) Mutations in ANKH cause chondrocalcinosis. Am J Hum Genet 71:933-940
39. Okawa A, Nakamura I, Goto S, Moriya H, Nakamura Y, Ikegawa S (1998) Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet 19:271-273
40. Nakamura I, Ikegawa S, Okawa A, Okuda S, Koshizuka Y, Kawaguchi H, Nakamura K, Koyama T, Goto S, Toguchida J, Matsushita M, Ochi T, Takaoka K, Nakamura Y (1999) Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL). Hum Genet 104:492-497
41. Rutsch F, Ruf N, Vaingankar S, Toliat MR, Suk A, Hohne W, Schauer G, Lehmann M, Roscioli T, Schnabel D, Epplen JT, Knisely A, Superti-Furga A, McGill J, Filippone M, Sinaiko AR, Vallance H, Hinrichs B, Smith W, Ferre M, Terkeltaub R, Nurnberg P (2003) Mutations in ENPP1 are associated with "idiopathic" infantile arterial calcification. Nat Genet 34:379-381
42. Fleisch H, Bisaz S (1962) Mechanism of calcification: inhibitory role of pyrophosphate. Nature 195:911
43. Terkeltaub RA (2001) Inorganic pyrophosphate generation and disposition in pathophysiology. Am J Physiol Cell Physiol 281:C1-C11
44. Hessle L, Johnson KA, Anderson HC, Narisawa S, Sali A, Goding JW, Terkeltaub R, Millan JL (2002) Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proc Natl Acad Sci USA 99:9445-9449
45. Harmey D, Hessle L, Narisawa S, Johnson KA, Terkeltaub R, Millan JL (2004) Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders. Am J Pathol 164:1199-1209
46. Saier MH Jr (2000) A functional-phylogenetic classification system for transmembrane solute transporters. Microbiol Mol Biol Rev 64:354-411
47. Beck L, Leroy C, Salaun C, Margall-Ducos G, Desdouets C, Friedlander G (2009) Identification of a novel function of PiT1 critical for cell proliferation and independent of its phosphate transport activity. J Biol Chem 284:31363-31374
48. Beck L, Leroy C, Beck-Cormier S, Forand A, Salaun C, Paris N, Bernier A, Urena-Torres P, Prie D, Ollero M, Coulombel L, Friedlander G (2010) The phosphate transporter PiT1 (Slc20a1) revealed as a new essential gene for mouse liver development. PLoS One 5:e9148
49. Festing MH, Speer MY, Yang HY, Giachelli CM (2009) Generation of mouse conditional and null alleles of the type III sodium-dependent phosphate cotransporter PiT-1. Genesis 47:858-863