Signaling of extracellular inorganic phosphate up-regulates cyclin D1 expression in proliferating chondrocytes via the Na+/Pi cotransporter Pit-1 and Raf/MEK/ERK pathway

Bone

Volumn 47, Issue 5, 2010, Pages 938-947

  Kimata, Masaaki ^a,b   Michigami, Toshimi ^a,b   Tachikawa, Kanako ^a   Okada, Tomoko ^a   Koshimizu, Takao ^a   Yamazaki, Miwa ^a   Kogo, Mikihiko ^b   Ozono, Keiichi ^c  

^a RESEARCH INSTITUTE FOR MATERNAL AND CHILD HEALTH   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Chondrocyte; Cyclin D1; Gene expression; Inorganic phosphate; Na+ Pi cotransporter

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ALKALINE PHOSPHATASE; CYCLIN D1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 2ALPHA; FOSCARNET; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATE; RAF PROTEIN; TRANSCRIPTION FACTOR PIT 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CARTILAGE CELL; CELL COUNT; CELL DIFFERENTIATION; CELL ISOLATION; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE SILENCING; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TWO DIMENSIONAL ELECTROPHORESIS; UPREGULATION; WESTERN BLOTTING;

ALKALINE PHOSPHATASE; ANIMALS; BLOTTING, WESTERN; CELL LINE; CHONDROCYTES; CYCLIN D1; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; FOSCARNET; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHATES; RAF KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE I;

EID: 77957751624     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2010.08.006     Document Type: Article

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