-
1
-
-
0027370108
-
The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
-
The Diabetes Control and Complications Trial Research Group
-
The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977-86.
-
(1993)
N Engl J Med
, vol.329
, pp. 977-986
-
-
-
2
-
-
0032511583
-
Intensive bloodglucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
-
UK Prospective Diabetes Study (UKPDS) Group
-
UK Prospective Diabetes Study (UKPDS) Group. Intensive bloodglucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837-53.
-
(1998)
Lancet
, vol.352
, pp. 837-853
-
-
-
3
-
-
64649104158
-
Banting lecture: From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus
-
DeFronzo RA. Banting lecture: from the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009;58:773-95.
-
(2009)
Diabetes
, vol.58
, pp. 773-795
-
-
Defronzo, R.A.1
-
5
-
-
33845996154
-
Standards of medical care in diabetes-2007
-
The American Diabetes Association
-
The American Diabetes Association. Standards of medical care in diabetes-2007. Diabetes Care. 2007;30(Supp I):S4-41.
-
(2007)
Diabetes Care
, vol.30
, Issue.SUPPL. 1
-
-
-
7
-
-
80052362968
-
Role of sodiumglucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes
-
Abdul-Ghani MA, Norton L, Defronzo RA. Role of sodiumglucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes. Endocr Rev. 2011;32:515-31.
-
(2011)
Endocr Rev
, vol.32
, pp. 515-531
-
-
Abdul-Ghani, M.A.1
Norton, L.2
Defronzo, R.A.3
-
8
-
-
75449120532
-
Tubular reabsorption
-
Boston: Little, Brown and Company;
-
Valtin H. Tubular reabsorption. In renal function. Boston: Little, Brown and Company; 1983.
-
(1983)
Renal Function
-
-
Valtin, H.1
-
10
-
-
64749094872
-
Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose
-
Farber SJ, Berger EY, Earle DP. Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose. J Clin Invest. 1951;30:125-9.
-
(1951)
J Clin Invest
, vol.30
, pp. 125-129
-
-
Farber, S.J.1
Berger, E.Y.2
Earle, D.P.3
-
11
-
-
84255185190
-
Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat
-
Thomson SC, Rieg T, Miracle C, Mansoury H, Whaley J, Vallon V, Singh P. Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat. Am J Physiol Regul Integr Comp Physiol. 2012;302:R75-83.
-
(2012)
Am J Physiol Regul Integr Comp Physiol
, vol.302
-
-
Thomson, S.C.1
Rieg, T.2
Miracle, C.3
Mansoury, H.4
Whaley, J.5
Vallon, V.6
Singh, P.7
-
12
-
-
1842618397
-
The action of phlorizin on the excretion of glucose, xylose, sucrose, creatinine, and urea by man
-
Chassis H, Jolliffe N, Smith H. The action of phlorizin on the excretion of glucose, xylose, sucrose, creatinine, and urea by man. J Clin Invest. 1933;12:1083-9.
-
(1933)
J Clin Invest
, vol.12
, pp. 1083-1089
-
-
Chassis, H.1
Jolliffe, N.2
Smith, H.3
-
13
-
-
0015598718
-
Reevaluation of renal tubular glucose transport inhibition by phlorizin analogs
-
Vick HD, Deidrich DF. Reevaluation of renal tubular glucose transport inhibition by phlorizin analogs. Am J Physiol. 1973;224:552-7.
-
(1973)
Am J Physiol
, vol.224
, pp. 552-557
-
-
Vick, H.D.1
Deidrich, D.F.2
-
15
-
-
79953289026
-
Discovery of non-glucoside SGLT2 inhibitors
-
Li A, Zhang J, Greenberg J, Lee T, Liu J. Discovery of non-glucoside SGLT2 inhibitors. Bioorg Med Chem Lett. 2011;21:2472-5.
-
(2011)
Bioorg Med Chem Lett
, vol.21
, pp. 2472-2475
-
-
Li, A.1
Zhang, J.2
Greenberg, J.3
Lee, T.4
Liu, J.5
-
16
-
-
80052079420
-
ISIS 388626, an SGLT2 antisense drug, causes robust and sustained glucosuria in multiple species and is safe and well-tolerated
-
Bhanot S, Murray SF, Booten SL, Chakravarty K, Zanardi T, Henry S, Watts LM, Wancewicz EV, Siwkows A. ISIS 388626, an SGLT2 antisense drug, causes robust and sustained glucosuria in multiple species and is safe and well-tolerated. Diabetes. 2009;58(suppl1):A328.
-
(2009)
Diabetes
, vol.58
, Issue.SUPPL. 1
-
-
Bhanot, S.1
Murray, S.F.2
Booten, S.L.3
Chakravarty, K.4
Zanardi, T.5
Henry, S.6
Watts, L.M.7
Wancewicz, E.V.8
Siwkows, A.9
-
17
-
-
0026033325
-
Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression
-
Kahn BB, DeFronzo RA, Cushman SW, Rossetti L. Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression. J Clin Invest. 1999;87:561-70.
-
(1999)
J Clin Invest
, vol.87
, pp. 561-570
-
-
Kahn, B.B.1
Defronzo, R.A.2
Cushman, S.W.3
Rossetti, L.4
-
18
-
-
0023275573
-
Correction of hyperglycemia with phlorizin normalizes tissues sensitivity to insulin in diabetic rats
-
Rossetti L, Smith D, Shulman GI, Papachristou D, DeFronzo RA. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest. 1987;79:1510-5. (Pubitemid 17099657)
-
(1987)
Journal of Clinical Investigation
, vol.79
, Issue.5
, pp. 1510-1515
-
-
Rossetti, L.1
Smith, D.2
Shulman, G.I.3
-
19
-
-
0023571397
-
Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats
-
Rossetti L, Shulman GI, Zawalich W, DeFronzo RA. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. J Clin Invest. 1987;80:1037-44. (Pubitemid 18075639)
-
(1987)
Journal of Clinical Investigation
, vol.80
, Issue.4
, pp. 1037-1044
-
-
Rossetti, L.1
Shulman, G.I.2
Zawalich, W.3
DeFronzo, R.A.4
-
20
-
-
10744229025
-
Molecular analysis of the SGLT2 gene in patients with renal glucosuria
-
DOI 10.1097/01.ASN.0000092790.89332.D2
-
Santer R, Kinner M, Lassen CL, Schneppenheim R, Eggert P, Bald M, Brodehl J, Daschner M, Ehrich JH, Kemper M, Li Volti S, Neuhaus T, Skovby F, Swift PG, Schaub J, Klaerke D. Molecular analysis of the SGLT2 gene in patients with renal glucosuria. J Am Soc Nephrol. 2003;14:2873-82. (Pubitemid 37305650)
-
(2003)
Journal of the American Society of Nephrology
, vol.14
, Issue.11
, pp. 2873-2882
-
-
Santer, R.1
Kinner, M.2
Lassen, C.L.3
Schneppenheim, R.4
Eggert, P.5
Bald, M.6
Brodehl, J.7
Daschner, M.8
Ehrich, J.H.H.9
Kemper, M.10
Li Volti, S.11
Neuhaus, T.12
Skovby, F.13
Swift, P.G.F.14
Schaub, J.15
Klaerke, D.16
-
21
-
-
0034629266
-
+-glucose cotransporter, in neonatally streptozotocin-treated rats
-
DOI 10.1016/S0014-2999(00)00016-9, PII S0014299900000169
-
Oku A,UetaK,NawanoM,Arakawa K, Kano-Ishihara T, Matsumoto M, Saito A, Tsujihara K, Anai M, Asano T. Antidiabetic effect of T-1095, an inhibitor of Na(+)-glucose cotransporter, in neonatally streptozotocin-treated rats. Eur J Pharmacol. 2000;391:183-92. (Pubitemid 30138095)
-
(2000)
European Journal of Pharmacology
, vol.391
, Issue.1-2
, pp. 183-192
-
-
Oku, A.1
Ueta, K.2
Nawano, M.3
Arakawa, K.4
Kano-Ishihara, T.5
Matsumoto, M.6
Saito, A.7
Tsujihara, K.8
Anai, M.9
Asano, T.10
-
22
-
-
33845873376
-
Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level
-
DOI 10.1124/jpet.106.110296
-
Katsuno K, Fujimori Y, Takemura Y, Hiratochi M, Itoh F, Komatsu Y, Fujikura H, Isaji M. Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level. J Pharmacol Exp Ther. 2007;320:323-30. (Pubitemid 46025747)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.320
, Issue.1
, pp. 323-330
-
-
Katsuno, K.1
Fujimori, Y.2
Takemura, Y.3
Hiratochi, M.4
Itoh, F.5
Komatsu, Y.6
Fujikura, H.7
Isaji, M.8
-
23
-
-
77149128452
-
Early clinical studies to assess safety, tolerability, pharmacokinetics and pharmacodynamics of single dose of sergliflozin, a novel inhibitor of renal glucose reabsorption in healthy volunteers and subjects with type 2 diabetes mellitus
-
Hussey E, Clark R, Amin D, Kipnes M, Semmes R, Odriscoll E, Leong J, Murphy S, Dobbins R, Nunez D. Early clinical studies to assess safety, tolerability, pharmacokinetics and pharmacodynamics of single dose of sergliflozin, a novel inhibitor of renal glucose reabsorption in healthy volunteers and subjects with type 2 diabetes mellitus. Diabetes. 2007;56(Suppl1):A189.
-
(2007)
Diabetes
, vol.56
, Issue.SUPPL. 1
-
-
Hussey, E.1
Clark, R.2
Amin, D.3
Kipnes, M.4
Semmes, R.5
Odriscoll, E.6
Leong, J.7
Murphy, S.8
Dobbins, R.9
Nunez, D.10
-
24
-
-
77149180212
-
A double-blind randomized repeat dose study to assess safety, tolerability, pharmacokineticks and pharmacodynamics of three times daily dosing of sergliflozin, a novel inhibitor of renal glucose reabsorption in healthy overweight and obese subjects
-
Hussey E, Dobbins R, Stolz R, Stockman N, Semmes R, Murray S, Nunez D. A double-blind randomized repeat dose study to assess safety, tolerability, pharmacokineticks and pharmacodynamics of three times daily dosing of sergliflozin, a novel inhibitor of renal glucose reabsorption in healthy overweight and obese subjects. Diabetes. 2007;56(Suppl1):A491.
-
(2007)
Diabetes
, vol.56
, Issue.SUPPL. 1
-
-
Hussey, E.1
Dobbins, R.2
Stolz, R.3
Stockman, N.4
Semmes, R.5
Murray, S.6
Nunez, D.7
-
25
-
-
52649083832
-
Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models
-
Fujimori Y, Katsuno K, Nakashima I, Ishikawa-Takemura Y, Fujikura H, Isaji M. Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models. J Pharmacol Exp Ther. 2008;327:268-76.
-
(2008)
J Pharmacol Exp Ther
, vol.327
, pp. 268-276
-
-
Fujimori, Y.1
Katsuno, K.2
Nakashima, I.3
Ishikawa-Takemura, Y.4
Fujikura, H.5
Isaji, M.6
-
26
-
-
79952231648
-
Remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2) reduces serum glucose in type 2 diabetes mellitus (T2DM) patients
-
Dobbins RL, Kapur A, Kapitza C, O'connor-Semmes RL, Tao W, Hussey EK. Remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2) reduces serum glucose in type 2 diabetes mellitus (T2DM) patients. Diabetes. 2009;58 suppl 1:A573.
-
(2009)
Diabetes
, vol.58
, Issue.SUPPL. 1
-
-
Dobbins, R.L.1
Kapur, A.2
Kapitza, C.3
O'Connor-Semmes, R.L.4
Tao, W.5
Hussey, E.K.6
-
27
-
-
84861095507
-
-
http://www.pharmaceutical-business-review.com/news/glaxosmith kline-discontinues- development-of-remogliflozin-090703.
-
-
-
-
28
-
-
84861099826
-
-
http://www.fda.gov/downloads/AdvisoryCommittees/Committees MeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAd visoryCommittee/ UCM262996.
-
-
-
-
29
-
-
67349275999
-
Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus
-
Komoroski B, Vachharajani N, Feng Y, Li L, Kornhauser D, Pfister M. Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus. Clin Pharm Ther. 2009;85:513.
-
(2009)
Clin Pharm Ther
, vol.85
, pp. 513
-
-
Komoroski, B.1
Vachharajani, N.2
Feng, Y.3
Li, L.4
Kornhauser, D.5
Pfister, M.6
-
30
-
-
76749111151
-
In vitro characterization and pharmacokinetics of dapagliflozin (BMS-512148), a potent sodium-glucose cotransporter type II inhibitor, in animals and humans
-
Obermeier M, Yao M, Khanna A, Koplowitz B, Zhu M, Li W, Komoroski B, Kasichayanula S, Discenza L, Washburn W, Meng W, Ellsworth BA, Whaley JM, Humphreys WG. In vitro characterization and pharmacokinetics of dapagliflozin (BMS-512148), a potent sodium-glucose cotransporter type II inhibitor, in animals and humans. Am Soc Pharmacol Exp Therapeut. 2010;38:405-14.
-
(2010)
Am Soc Pharmacol Exp Therapeut
, vol.38
, pp. 405-414
-
-
Obermeier, M.1
Yao, M.2
Khanna, A.3
Koplowitz, B.4
Zhu, M.5
Li, W.6
Komoroski, B.7
Kasichayanula, S.8
Discenza, L.9
Washburn, W.10
Meng, W.11
Ellsworth, B.A.12
Whaley, J.M.13
Humphreys, W.G.14
-
31
-
-
65349196064
-
Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
-
List J, Woo V, Morales E, Tang W, Fiedorek FT. Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes. Diabetes Care. 2009;32:650-7.
-
(2009)
Diabetes Care
, vol.32
, pp. 650-657
-
-
List, J.1
Woo, V.2
Morales, E.3
Tang, W.4
Fiedorek, F.T.5
-
32
-
-
77956921439
-
Dapagliflozin monotherapy in T2DM patients with inadequate glycemic control by diet and exercise: A randomized, double-blind, placebo-controlled, multicenter phase III trial
-
Ferrannini E, Ramos SJ, Tang W, Salsali A, List JF. Dapagliflozin monotherapy in T2DM patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, multicenter phase III trial. Diabetes Care. 2010;33:2217-24.
-
(2010)
Diabetes Care
, vol.33
, pp. 2217-2224
-
-
Ferrannini, E.1
Ramos, S.J.2
Tang, W.3
Salsali, A.4
List, J.F.5
-
33
-
-
69549095914
-
A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers. Applicability of a novel insulin-independent treatment
-
Wilding JPH, Norwood P, Tjoen C, Bastien A, List JF, Fiedorek FT. A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers. Applicability of a novel insulin-independent treatment. Diabetes Care. 2009;32:1656-62.
-
(2009)
Diabetes Care
, vol.32
, pp. 1656-1662
-
-
Wilding, J.P.H.1
Norwood, P.2
Tjoen, C.3
Bastien, A.4
List, J.F.5
Fiedorek, F.T.6
-
34
-
-
77953181310
-
Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: Effects on glycaemic control and body weight
-
Zhang L, Feng Y, List J, Kasichayanula S, Pfister M. Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: effects on glycaemic control and body weight. Diabetes Obes Metabol. 2010;12:510-6.
-
(2010)
Diabetes Obes Metabol
, vol.12
, pp. 510-516
-
-
Zhang, L.1
Feng, Y.2
List, J.3
Kasichayanula, S.4
Pfister, M.5
-
35
-
-
80155124676
-
Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: A randomized, 52-week, double-blind, active-controlled noninferiority trial
-
Nauck MA, Del Prato S, Meier JJ, Durán-García S, Rohwedder K, Elze M, Parikh SJ. Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial. Diabetes Care. 2011;34:2015-22.
-
(2011)
Diabetes Care
, vol.34
, pp. 2015-2022
-
-
Nauck, M.A.1
Del Prato, S.2
Meier, J.J.3
Durán-García, S.4
Rohwedder, K.5
Elze, M.6
Parikh, S.J.7
-
36
-
-
84861095547
-
Sustained efficacy of dapagliflozin when added to metformin in type 2 diabetes inadequately controlled by metformin monotherapy
-
Baily CJ, Gross JI, Yadav M, Iqbal N, Mansfield TA, List JF. Sustained efficacy of dapagliflozin when added to metformin in type 2 diabetes inadequately controlled by metformin monotherapy. Diabetologia. 2011;54(Suppl1):A146.
-
(2011)
Diabetologia
, vol.54
, Issue.SUPPL. 1
-
-
Baily, C.J.1
Gross, J.I.2
Yadav, M.3
Iqbal, N.4
Mansfield, T.A.5
List, J.F.6
-
37
-
-
84871165283
-
Long term efficacy and safety of ass-on dapagliflozin vs add-on glipizide in patients with type 2 diabetes mellitus inadequately controlled with metformin: 2 year results
-
Del Prato S, Nauck M, Rohwedder K, Theuerkauf A, Langkilde AM, Parikh S. Long term efficacy and safety of ass-on dapagliflozin vs add-on glipizide in patients with type 2 diabetes mellitus inadequately controlled with metformin: 2 year results. Diabetologia. 2011;54(Suppl1):A852.
-
(2011)
Diabetologia
, vol.54
, Issue.SUPPL. 1
-
-
Del Prato, S.1
Nauck, M.2
Rohwedder, K.3
Theuerkauf, A.4
Langkilde, A.M.5
Parikh, S.6
-
38
-
-
79956331954
-
Canagliflozin a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects
-
Sha S, Devineni D, Ghosh A, Polidori D, Chien S, Wexler D, Shalayda K, Demarest K. Rothenberg PCanagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects. Diabetes Obes Metab. 2011;13:669-72.
-
(2011)
Diabetes Obes Metab
, vol.13
, pp. 669-672
-
-
Sha, S.1
Devineni, D.2
Ghosh, A.3
Polidori, D.4
Chien, S.5
Wexler, D.6
Shalayda, K.7
Demarest, K.8
Rothenberg, P.9
-
39
-
-
84861088227
-
Canagliflozin, a novel inhibitor of sodium glucose cotransporter 2 (SGLT2) improves glycemic control and reduces body weight in Japanese type 2 diabetes Mellitus (T2DM)
-
Inagaki N, Kondo K, Iwasaki T, Maruyama N, Susuta Y, Sakai M, Kuki H. Canagliflozin, a novel inhibitor of sodium glucose cotransporter 2 (SGLT2) improves glycemic control and reduces body weight in Japanese type 2 diabetes Mellitus (T2DM). Diabetes. 2011;60(suppl):A999.
-
(2011)
Diabetes
, vol.60
, Issue.SUPPL.
-
-
Inagaki, N.1
Kondo, K.2
Iwasaki, T.3
Maruyama, N.4
Susuta, Y.5
Sakai, M.6
Kuki, H.7
-
40
-
-
77957593008
-
Canagliflozin an inhibitor of sodium glucose co-transporter 2 (SGLT2), improves glycemic control and lowers body weight in subjects with type 2 diabetes (T2D) on metformin
-
Rosensotck J, Arbit D, Usiskin K, Capuano G, Canovatchel W. Canagliflozin an inhibitor of sodium glucose co-transporter 2 (SGLT2), improves glycemic control and lowers body weight in subjects with type 2 diabetes (T2D) on metformin. Diabetes. 2010;59 suppl 1:A21.
-
(2010)
Diabetes
, vol.59
, Issue.SUPPL. 1
-
-
Rosensotck, J.1
Arbit, D.2
Usiskin, K.3
Capuano, G.4
Canovatchel, W.5
-
41
-
-
84860252876
-
Canagliflozin improves glycemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin
-
[ahead of print]
-
Devineni D, Morrow L, Hompesch M, Skee D, Vandebosch A, Murphy J, Ways K, Schwartz S. Canagliflozin improves glycemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin. Diabetes Obes Metab. 2012[ahead of print].
-
(2012)
Diabetes Obes Metab
-
-
Devineni, D.1
Morrow, L.2
Hompesch, M.3
Skee, D.4
Vandebosch, A.5
Murphy, J.6
Ways, K.7
Schwartz, S.8
-
42
-
-
80052084915
-
Canagliflozin treatment improves beta cell function in subject with type 2 diabetes
-
Polidori D, Zhao Y, Sha S, Canovatchel W. Canagliflozin treatment improves beta cell function in subject with type 2 diabetes. Diabetes. 2010;59 suppl 1:A176.
-
(2010)
Diabetes
, vol.59
, Issue.SUPPL. 1
-
-
Polidori, D.1
Zhao, Y.2
Sha, S.3
Canovatchel, W.4
-
43
-
-
83655184724
-
Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: Characterisation and comparison with other SGLT-2 inhibitors
-
Grempler R, Thomas L, EckhardtM, Himmelsbach F, Sauer A, Sharp DE, Bakker RA, Mark M, Klein T, Eickelmann P. Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. Diabetes Obes Metab. 2012;14:83-90.
-
(2012)
Diabetes Obes Metab
, vol.14
, pp. 83-90
-
-
Grempler, R.1
Thomas, L.2
Eckhardt, M.3
Himmelsbach, F.4
Sauer, A.5
Sharp, D.E.6
Bakker, R.A.7
Mark, M.8
Klein, T.9
Eickelmann, P.10
-
44
-
-
77957555722
-
Safety, tolerability, pharmacokinetics and pharmacodynamics of single doses of BI 10773, a sodium-glucose co-transporter inhibitor (SGLT2), in Japanese healthy volunteers
-
Koiwai K, Seman L, Yamamura N, Macha S, Taniguchi A, Negishi T, Sesoko S, Dugi KA. Safety, tolerability, pharmacokinetics and pharmacodynamics of single doses of BI 10773, a sodium-glucose co-transporter inhibitor (SGLT2), in Japanese healthy volunteers. Diabetes. 2010;59 suppl 1:2175PO.
-
(2010)
Diabetes
, vol.59
, Issue.SUPPL. 1
-
-
Koiwai, K.1
Seman, L.2
Yamamura, N.3
MacHa, S.4
Taniguchi, A.5
Negishi, T.6
Sesoko, S.7
Dugi, K.A.8
-
45
-
-
77957573037
-
BI 10773, a sodium-glucose cotransporter inhibitor (SGLT-2), is safe and efficacious following 4- week treatment in patients with type 2 diabetes
-
Heise T, Seewaldt-Becker E, Macha S, Hantel S, Huber K, Pinnetti S, Seman L, Hans-Juergen W. BI 10773, a sodium-glucose cotransporter inhibitor (SGLT-2), is safe and efficacious following 4- week treatment in patients with type 2 diabetes. Diabetes. 2010;59 (suppl):629P.
-
(2010)
Diabetes
, vol.59
, Issue.SUPPL.
, pp. 629
-
-
Heise, T.1
Seewaldt-Becker, E.2
MacHa, S.3
Hantel, S.4
Huber, K.5
Pinnetti, S.6
Seman, L.7
Hans-Juergen, W.8
-
46
-
-
84871634800
-
Efficacy and safety of BI 10773, a new sodium glucose cotransporter-2 (SGLT-2) inhibitor, in type 2 diabetes inadequately controlled on metformin
-
Rosenstock J, Jelaska A, Seman L, Pinnetti S, Hantel S, Woerle HJ. Efficacy and safety of BI 10773, a new sodium glucose cotransporter-2 (SGLT-2) inhibitor, in type 2 diabetes inadequately controlled on metformin. Diabetes. 2011;60(suppl):989P.
-
(2011)
Diabetes
, vol.60
, Issue.SUPPL.
, pp. 989
-
-
Rosenstock, J.1
Jelaska, A.2
Seman, L.3
Pinnetti, S.4
Hantel, S.5
Woerle, H.J.6
-
47
-
-
79952993665
-
ASP1941, a novel, selective SGLT2 inhibitor, was effective and safe in Japanese healthy volunteers and patients with type 2 diabetes mellitus
-
Kashiwagi A, Utsuno A, Kazuta K, Yoshida S, Kageyama S. ASP1941, a novel, selective SGLT2 inhibitor, was effective and safe in Japanese healthy volunteers and patients with type 2 diabetes mellitus. Diabetes. 2010;59 suppl 1:A21.
-
(2010)
Diabetes
, vol.59
, Issue.SUPPL. 1
-
-
Kashiwagi, A.1
Utsuno, A.2
Kazuta, K.3
Yoshida, S.4
Kageyama, S.5
-
48
-
-
84864283546
-
Ipragliflozin improved glycemic control with additional benefit of reduction of body weight and blood pressure in Japanese patients with type 2 diabetes mellitus BRIGHTEN Study
-
Takinami A, Takinami Y, Kazuta K, Yoshida S, Utsuno A, Nagase I, Kashiwagi A. Ipragliflozin improved glycemic control with additional benefit of reduction of body weight and blood pressure in Japanese patients with type 2 diabetes mellitus BRIGHTEN Study. Diabetologia. 2011;54(suppl):A149.
-
(2011)
Diabetologia
, vol.54
, Issue.SUPPL.
-
-
Takinami, A.1
Takinami, Y.2
Kazuta, K.3
Yoshida, S.4
Utsuno, A.5
Nagase, I.6
Kashiwagi, A.7
-
49
-
-
83655194268
-
LX4211, a dual SGLT2/SGLT1 inhibtor, shows rapid and significant improvements in glycemic control over 28 days in patients with type 2 diabetes (T2DM)
-
(late breaking abstract)
-
Freiman J, Ruff DA, Frazier KS, Combs K, Turnage A, Shadoan M, Powell D, Zambrowicz B, Brown P. LX4211, a dual SGLT2/SGLT1 inhibtor, shows rapid and significant improvements in glycemic control over 28 days in patients with type 2 diabetes (T2DM). Diabetes 2010;59(suppl 1), (late breaking abstract).
-
(2010)
Diabetes
, vol.59
, Issue.SUPPL. 1
-
-
Freiman, J.1
Ruff, D.A.2
Frazier, K.S.3
Combs, K.4
Turnage, A.5
Shadoan, M.6
Powell, D.7
Zambrowicz, B.8
Brown, P.9
-
50
-
-
84873079393
-
TS-071, a novel and selective SGLT2 inhibitor, improved glycemic control and decreased body weight in 12-week study of Japanese patients with type 2 diabetes mellitus
-
Seino Y, Sasaki T, Fukatsu A, Samukawa Y, Sakai S, Watanabe T. TS-071, a novel and selective SGLT2 inhibitor, improved glycemic control and decreased body weight in 12-week study of Japanese patients with type 2 diabetes mellitus. Diabetes. 2011;60(suppl): P998.
-
(2011)
Diabetes
, vol.60
, Issue.SUPPL.
-
-
Seino, Y.1
Sasaki, T.2
Fukatsu, A.3
Samukawa, Y.4
Sakai, S.5
Watanabe, T.6
-
51
-
-
84871625141
-
The sodium glucose co-transported PF04971729, provides multifaced improvement in diabetic patients inadequately controlled on metformin
-
Nucci G, Amin NB, Wang X, Lee DS, Rusnak JM. The sodium glucose co-transported PF04971729, provides multifaced improvement in diabetic patients inadequately controlled on metformin. Diabetologia. 2011;54(suppl):A850.
-
(2011)
Diabetologia
, vol.54
, Issue.SUPPL.
-
-
Nucci, G.1
Amin, N.B.2
Wang, X.3
Lee, D.S.4
Rusnak, J.M.5
-
52
-
-
84861092820
-
The effect of renal impairment on the pharmacokinetics and urinary glucose excretion of the SGLT2 inhibitor ipragliflozin in Japanese type 2 diabetes mellitus patients
-
Kadokura T, Ishikawa H, Nakajo I, Yoshida S, Utsuno A, Smulders RA, Morozumi K. The effect of renal impairment on the pharmacokinetics and urinary glucose excretion of the SGLT2 inhibitor ipragliflozin in Japanese type 2 diabetes mellitus patients. Diabetologia. 2011;54(suppl):A847.
-
(2011)
Diabetologia
, vol.54
, Issue.SUPPL.
-
-
Kadokura, T.1
Ishikawa, H.2
Nakajo, I.3
Yoshida, S.4
Utsuno, A.5
Smulders, R.A.6
Morozumi, K.7
-
53
-
-
0032707179
-
Glomerular hyperfiltration in experimental diabetes mellitus: Potential role of tubular reabsorption
-
Vallon V, Richter K, Blantz RC, Thomson S, Osswald H. Glomerular hyperfiltration in experimental diabetes mellitus: potential role of tubular reabsorption. J Am Soc Nephrol. 1999;10:2569-76.
-
(1999)
J Am Soc Nephrol
, vol.10
, pp. 2569-2576
-
-
Vallon, V.1
Richter, K.2
Blantz, R.C.3
Thomson, S.4
Osswald, H.5
-
54
-
-
0346099293
-
Kidney function in early diabetes: The tubular hypothesis of glomerular filtration
-
Thomson SC, Vallon V, Blantz RC. Kidney function in early diabetes: the tubular hypothesis of glomerular filtration. Am J Physiol. 2004;286:F8-18.
-
(2004)
Am J Physiol
, vol.286
-
-
Thomson, S.C.1
Vallon, V.2
Blantz, R.C.3
-
55
-
-
0035906916
-
Renal glucose reabsorption during hypertonic glucose infusion in female streptozotocin-induced diabetic rats
-
DOI 10.1016/S0024-3205(01)01090-6, PII S0024320501010906
-
Noonan WT, Shapiro VM, Banks RO. Renal glucose reabsorption during hypertonic glucose infusion in female streptozotocininduced diabetic rats. Life Sci. 2001;68:2967-77. (Pubitemid 32453264)
-
(2001)
Life Sciences
, vol.68
, Issue.26
, pp. 2967-2977
-
-
Noonan, W.T.1
Shapiro, V.M.2
Banks, R.O.3
-
56
-
-
0028280105
-
Molecular adaptations of GLUT1 and GLUT2 in renal proximal tubules of diabetic rats
-
Dominguez JH, Camp K, Maianu L, Feister H, Garvey WT. Molecular adaptations of GLUT1 and GLUT2 in renal proximal tubules of diabetic rats. Am J Physiol. 1994;266:F283-90.
-
(1994)
Am J Physiol
, vol.266
-
-
Dominguez, J.H.1
Camp, K.2
Maianu, L.3
Feister, H.4
Garvey, W.T.5
-
57
-
-
0029827650
-
Development and progression of renal disease in Pima Indians with non- insulin-dependent diabetes mellitus
-
DOI 10.1056/NEJM199611283352203
-
Nelson RG, Bennett PH, Beck GJ, Tan M, Knowler WC, Mitch WE, Hirschman GH, Myers BD. Development and progression of renal disease in Pima Indians with non-insulin-dependent diabetes mellitus. Diabetic Renal Disease Study Group. N Engl J Med. 1996;335:1636-42. (Pubitemid 26392728)
-
(1996)
New England Journal of Medicine
, vol.335
, Issue.22
, pp. 1636-1642
-
-
Nelson, R.G.1
Bennett, P.H.2
Beck, G.J.3
Tan, M.4
Knowler, W.C.5
Mitch, W.E.6
Hirschman, G.H.7
Myers, B.D.8
-
58
-
-
0025910414
-
Effect of strict glycemic control on renal hemodynamic response to amino acids and renal enlargement in insulindependent diabetes mellitus
-
Tuttle KR, Bruton JL, Perusek MC, Lancaster JL, Kopp DT, DeFronzo RA. Effect of strict glycemic control on renal hemodynamic response to amino acids and renal enlargement in insulindependent diabetes mellitus. N Engl J Med. 1991;324:1626-32.
-
(1991)
N Engl J Med
, vol.324
, pp. 1626-1632
-
-
Tuttle, K.R.1
Bruton, J.L.2
Perusek, M.C.3
Lancaster, J.L.4
Kopp, D.T.5
Defronzo, R.A.6
-
59
-
-
0035122471
-
+-glucose cotransporter inhibitor T-1095
-
Arakawa K, Ishihara T, Oku A, Nawano M, Ueta K, Kitamura K, Matsumoto M, Saito A. Improved diabetic syndrome in C57BL/KsJ-db/db mice by oral administration of the Na(+)-glucose cotransporter inhibitor T-1095. Br J Pharmacol. 2001;132:578-86. (Pubitemid 32142370)
-
(2001)
British Journal of Pharmacology
, vol.132
, Issue.2
, pp. 578-586
-
-
Arakawa, K.1
Ishihara, T.2
Oku, A.3
Nawano, M.4
Ueta, K.5
Kitamura, K.6
Matsumoto, M.7
Saito, A.8
-
60
-
-
84871625789
-
Characterization of urinary tract infection in the setting of pharmacologically induced glucosuria
-
Parikh S, Johnsson K, Ptaszynska A, Schmitz B, Sugg J, List JF. Characterization of urinary tract infection in the setting of pharmacologically induced glucosuria. Diabetologia. 2011;54(suppl): A841.
-
(2011)
Diabetologia
, vol.54
, Issue.SUPPL.
-
-
Parikh, S.1
Johnsson, K.2
Ptaszynska, A.3
Schmitz, B.4
Sugg, J.5
List, J.F.6
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