메뉴 건너뛰기




Volumn 12, Issue 3, 2012, Pages 230-238

Efficacy and safety of SGLT2 inhibitors in the treatment of type 2 diabetes mellitus

Author keywords

Kidney; SGLT2 inhibition; Sodium glucose cotransport; Type 2 diabetes

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; CANAGLIFLOZIN; DAPAGLIFLOZIN; EMPAGLIFLOZIN; ERTUGLIFLOZIN; GLIPIZIDE; GLUCOSE; HEMOGLOBIN A1C; INSULIN; IPRAGLIFLOZIN; ISIS; LX 4211; METFORMIN; PHLORIZIN; PLACEBO; REMOGLIFLOZIN; SERGLIFLOZIN ETABONATE; SODIUM GLUCOSE COTRANSPORTER 1; SODIUM GLUCOSE COTRANSPORTER 2; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; SULFONYLUREA; THIAZIDE DIURETIC AGENT; TS 071; UNCLASSIFIED DRUG;

EID: 84861098920     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-012-0275-6     Document Type: Article
Times cited : (107)

References (60)
  • 1
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group
    • The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977-86.
    • (1993) N Engl J Med , vol.329 , pp. 977-986
  • 2
    • 0032511583 scopus 로고    scopus 로고
    • Intensive bloodglucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group. Intensive bloodglucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837-53.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 3
    • 64649104158 scopus 로고    scopus 로고
    • Banting lecture: From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus
    • DeFronzo RA. Banting lecture: from the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009;58:773-95.
    • (2009) Diabetes , vol.58 , pp. 773-795
    • Defronzo, R.A.1
  • 5
    • 33845996154 scopus 로고    scopus 로고
    • Standards of medical care in diabetes-2007
    • The American Diabetes Association
    • The American Diabetes Association. Standards of medical care in diabetes-2007. Diabetes Care. 2007;30(Supp I):S4-41.
    • (2007) Diabetes Care , vol.30 , Issue.SUPPL. 1
  • 7
    • 80052362968 scopus 로고    scopus 로고
    • Role of sodiumglucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes
    • Abdul-Ghani MA, Norton L, Defronzo RA. Role of sodiumglucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes. Endocr Rev. 2011;32:515-31.
    • (2011) Endocr Rev , vol.32 , pp. 515-531
    • Abdul-Ghani, M.A.1    Norton, L.2    Defronzo, R.A.3
  • 8
    • 75449120532 scopus 로고
    • Tubular reabsorption
    • Boston: Little, Brown and Company;
    • Valtin H. Tubular reabsorption. In renal function. Boston: Little, Brown and Company; 1983.
    • (1983) Renal Function
    • Valtin, H.1
  • 10
    • 64749094872 scopus 로고
    • Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose
    • Farber SJ, Berger EY, Earle DP. Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose. J Clin Invest. 1951;30:125-9.
    • (1951) J Clin Invest , vol.30 , pp. 125-129
    • Farber, S.J.1    Berger, E.Y.2    Earle, D.P.3
  • 12
    • 1842618397 scopus 로고
    • The action of phlorizin on the excretion of glucose, xylose, sucrose, creatinine, and urea by man
    • Chassis H, Jolliffe N, Smith H. The action of phlorizin on the excretion of glucose, xylose, sucrose, creatinine, and urea by man. J Clin Invest. 1933;12:1083-9.
    • (1933) J Clin Invest , vol.12 , pp. 1083-1089
    • Chassis, H.1    Jolliffe, N.2    Smith, H.3
  • 13
    • 0015598718 scopus 로고
    • Reevaluation of renal tubular glucose transport inhibition by phlorizin analogs
    • Vick HD, Deidrich DF. Reevaluation of renal tubular glucose transport inhibition by phlorizin analogs. Am J Physiol. 1973;224:552-7.
    • (1973) Am J Physiol , vol.224 , pp. 552-557
    • Vick, H.D.1    Deidrich, D.F.2
  • 17
    • 0026033325 scopus 로고    scopus 로고
    • Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression
    • Kahn BB, DeFronzo RA, Cushman SW, Rossetti L. Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression. J Clin Invest. 1999;87:561-70.
    • (1999) J Clin Invest , vol.87 , pp. 561-570
    • Kahn, B.B.1    Defronzo, R.A.2    Cushman, S.W.3    Rossetti, L.4
  • 18
    • 0023275573 scopus 로고
    • Correction of hyperglycemia with phlorizin normalizes tissues sensitivity to insulin in diabetic rats
    • Rossetti L, Smith D, Shulman GI, Papachristou D, DeFronzo RA. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest. 1987;79:1510-5. (Pubitemid 17099657)
    • (1987) Journal of Clinical Investigation , vol.79 , Issue.5 , pp. 1510-1515
    • Rossetti, L.1    Smith, D.2    Shulman, G.I.3
  • 19
    • 0023571397 scopus 로고
    • Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats
    • Rossetti L, Shulman GI, Zawalich W, DeFronzo RA. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. J Clin Invest. 1987;80:1037-44. (Pubitemid 18075639)
    • (1987) Journal of Clinical Investigation , vol.80 , Issue.4 , pp. 1037-1044
    • Rossetti, L.1    Shulman, G.I.2    Zawalich, W.3    DeFronzo, R.A.4
  • 22
    • 33845873376 scopus 로고    scopus 로고
    • Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level
    • DOI 10.1124/jpet.106.110296
    • Katsuno K, Fujimori Y, Takemura Y, Hiratochi M, Itoh F, Komatsu Y, Fujikura H, Isaji M. Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level. J Pharmacol Exp Ther. 2007;320:323-30. (Pubitemid 46025747)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.320 , Issue.1 , pp. 323-330
    • Katsuno, K.1    Fujimori, Y.2    Takemura, Y.3    Hiratochi, M.4    Itoh, F.5    Komatsu, Y.6    Fujikura, H.7    Isaji, M.8
  • 23
    • 77149128452 scopus 로고    scopus 로고
    • Early clinical studies to assess safety, tolerability, pharmacokinetics and pharmacodynamics of single dose of sergliflozin, a novel inhibitor of renal glucose reabsorption in healthy volunteers and subjects with type 2 diabetes mellitus
    • Hussey E, Clark R, Amin D, Kipnes M, Semmes R, Odriscoll E, Leong J, Murphy S, Dobbins R, Nunez D. Early clinical studies to assess safety, tolerability, pharmacokinetics and pharmacodynamics of single dose of sergliflozin, a novel inhibitor of renal glucose reabsorption in healthy volunteers and subjects with type 2 diabetes mellitus. Diabetes. 2007;56(Suppl1):A189.
    • (2007) Diabetes , vol.56 , Issue.SUPPL. 1
    • Hussey, E.1    Clark, R.2    Amin, D.3    Kipnes, M.4    Semmes, R.5    Odriscoll, E.6    Leong, J.7    Murphy, S.8    Dobbins, R.9    Nunez, D.10
  • 24
    • 77149180212 scopus 로고    scopus 로고
    • A double-blind randomized repeat dose study to assess safety, tolerability, pharmacokineticks and pharmacodynamics of three times daily dosing of sergliflozin, a novel inhibitor of renal glucose reabsorption in healthy overweight and obese subjects
    • Hussey E, Dobbins R, Stolz R, Stockman N, Semmes R, Murray S, Nunez D. A double-blind randomized repeat dose study to assess safety, tolerability, pharmacokineticks and pharmacodynamics of three times daily dosing of sergliflozin, a novel inhibitor of renal glucose reabsorption in healthy overweight and obese subjects. Diabetes. 2007;56(Suppl1):A491.
    • (2007) Diabetes , vol.56 , Issue.SUPPL. 1
    • Hussey, E.1    Dobbins, R.2    Stolz, R.3    Stockman, N.4    Semmes, R.5    Murray, S.6    Nunez, D.7
  • 25
    • 52649083832 scopus 로고    scopus 로고
    • Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models
    • Fujimori Y, Katsuno K, Nakashima I, Ishikawa-Takemura Y, Fujikura H, Isaji M. Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models. J Pharmacol Exp Ther. 2008;327:268-76.
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 268-276
    • Fujimori, Y.1    Katsuno, K.2    Nakashima, I.3    Ishikawa-Takemura, Y.4    Fujikura, H.5    Isaji, M.6
  • 26
    • 79952231648 scopus 로고    scopus 로고
    • Remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2) reduces serum glucose in type 2 diabetes mellitus (T2DM) patients
    • Dobbins RL, Kapur A, Kapitza C, O'connor-Semmes RL, Tao W, Hussey EK. Remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2) reduces serum glucose in type 2 diabetes mellitus (T2DM) patients. Diabetes. 2009;58 suppl 1:A573.
    • (2009) Diabetes , vol.58 , Issue.SUPPL. 1
    • Dobbins, R.L.1    Kapur, A.2    Kapitza, C.3    O'Connor-Semmes, R.L.4    Tao, W.5    Hussey, E.K.6
  • 27
    • 84861095507 scopus 로고    scopus 로고
    • http://www.pharmaceutical-business-review.com/news/glaxosmith kline-discontinues- development-of-remogliflozin-090703.
  • 28
    • 84861099826 scopus 로고    scopus 로고
    • http://www.fda.gov/downloads/AdvisoryCommittees/Committees MeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAd visoryCommittee/ UCM262996.
  • 29
    • 67349275999 scopus 로고    scopus 로고
    • Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus
    • Komoroski B, Vachharajani N, Feng Y, Li L, Kornhauser D, Pfister M. Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus. Clin Pharm Ther. 2009;85:513.
    • (2009) Clin Pharm Ther , vol.85 , pp. 513
    • Komoroski, B.1    Vachharajani, N.2    Feng, Y.3    Li, L.4    Kornhauser, D.5    Pfister, M.6
  • 31
    • 65349196064 scopus 로고    scopus 로고
    • Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
    • List J, Woo V, Morales E, Tang W, Fiedorek FT. Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes. Diabetes Care. 2009;32:650-7.
    • (2009) Diabetes Care , vol.32 , pp. 650-657
    • List, J.1    Woo, V.2    Morales, E.3    Tang, W.4    Fiedorek, F.T.5
  • 32
    • 77956921439 scopus 로고    scopus 로고
    • Dapagliflozin monotherapy in T2DM patients with inadequate glycemic control by diet and exercise: A randomized, double-blind, placebo-controlled, multicenter phase III trial
    • Ferrannini E, Ramos SJ, Tang W, Salsali A, List JF. Dapagliflozin monotherapy in T2DM patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, multicenter phase III trial. Diabetes Care. 2010;33:2217-24.
    • (2010) Diabetes Care , vol.33 , pp. 2217-2224
    • Ferrannini, E.1    Ramos, S.J.2    Tang, W.3    Salsali, A.4    List, J.F.5
  • 33
    • 69549095914 scopus 로고    scopus 로고
    • A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers. Applicability of a novel insulin-independent treatment
    • Wilding JPH, Norwood P, Tjoen C, Bastien A, List JF, Fiedorek FT. A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers. Applicability of a novel insulin-independent treatment. Diabetes Care. 2009;32:1656-62.
    • (2009) Diabetes Care , vol.32 , pp. 1656-1662
    • Wilding, J.P.H.1    Norwood, P.2    Tjoen, C.3    Bastien, A.4    List, J.F.5    Fiedorek, F.T.6
  • 34
    • 77953181310 scopus 로고    scopus 로고
    • Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: Effects on glycaemic control and body weight
    • Zhang L, Feng Y, List J, Kasichayanula S, Pfister M. Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: effects on glycaemic control and body weight. Diabetes Obes Metabol. 2010;12:510-6.
    • (2010) Diabetes Obes Metabol , vol.12 , pp. 510-516
    • Zhang, L.1    Feng, Y.2    List, J.3    Kasichayanula, S.4    Pfister, M.5
  • 35
    • 80155124676 scopus 로고    scopus 로고
    • Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: A randomized, 52-week, double-blind, active-controlled noninferiority trial
    • Nauck MA, Del Prato S, Meier JJ, Durán-García S, Rohwedder K, Elze M, Parikh SJ. Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial. Diabetes Care. 2011;34:2015-22.
    • (2011) Diabetes Care , vol.34 , pp. 2015-2022
    • Nauck, M.A.1    Del Prato, S.2    Meier, J.J.3    Durán-García, S.4    Rohwedder, K.5    Elze, M.6    Parikh, S.J.7
  • 36
    • 84861095547 scopus 로고    scopus 로고
    • Sustained efficacy of dapagliflozin when added to metformin in type 2 diabetes inadequately controlled by metformin monotherapy
    • Baily CJ, Gross JI, Yadav M, Iqbal N, Mansfield TA, List JF. Sustained efficacy of dapagliflozin when added to metformin in type 2 diabetes inadequately controlled by metformin monotherapy. Diabetologia. 2011;54(Suppl1):A146.
    • (2011) Diabetologia , vol.54 , Issue.SUPPL. 1
    • Baily, C.J.1    Gross, J.I.2    Yadav, M.3    Iqbal, N.4    Mansfield, T.A.5    List, J.F.6
  • 37
    • 84871165283 scopus 로고    scopus 로고
    • Long term efficacy and safety of ass-on dapagliflozin vs add-on glipizide in patients with type 2 diabetes mellitus inadequately controlled with metformin: 2 year results
    • Del Prato S, Nauck M, Rohwedder K, Theuerkauf A, Langkilde AM, Parikh S. Long term efficacy and safety of ass-on dapagliflozin vs add-on glipizide in patients with type 2 diabetes mellitus inadequately controlled with metformin: 2 year results. Diabetologia. 2011;54(Suppl1):A852.
    • (2011) Diabetologia , vol.54 , Issue.SUPPL. 1
    • Del Prato, S.1    Nauck, M.2    Rohwedder, K.3    Theuerkauf, A.4    Langkilde, A.M.5    Parikh, S.6
  • 38
    • 79956331954 scopus 로고    scopus 로고
    • Canagliflozin a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects
    • Sha S, Devineni D, Ghosh A, Polidori D, Chien S, Wexler D, Shalayda K, Demarest K. Rothenberg PCanagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects. Diabetes Obes Metab. 2011;13:669-72.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 669-672
    • Sha, S.1    Devineni, D.2    Ghosh, A.3    Polidori, D.4    Chien, S.5    Wexler, D.6    Shalayda, K.7    Demarest, K.8    Rothenberg, P.9
  • 39
    • 84861088227 scopus 로고    scopus 로고
    • Canagliflozin, a novel inhibitor of sodium glucose cotransporter 2 (SGLT2) improves glycemic control and reduces body weight in Japanese type 2 diabetes Mellitus (T2DM)
    • Inagaki N, Kondo K, Iwasaki T, Maruyama N, Susuta Y, Sakai M, Kuki H. Canagliflozin, a novel inhibitor of sodium glucose cotransporter 2 (SGLT2) improves glycemic control and reduces body weight in Japanese type 2 diabetes Mellitus (T2DM). Diabetes. 2011;60(suppl):A999.
    • (2011) Diabetes , vol.60 , Issue.SUPPL.
    • Inagaki, N.1    Kondo, K.2    Iwasaki, T.3    Maruyama, N.4    Susuta, Y.5    Sakai, M.6    Kuki, H.7
  • 40
    • 77957593008 scopus 로고    scopus 로고
    • Canagliflozin an inhibitor of sodium glucose co-transporter 2 (SGLT2), improves glycemic control and lowers body weight in subjects with type 2 diabetes (T2D) on metformin
    • Rosensotck J, Arbit D, Usiskin K, Capuano G, Canovatchel W. Canagliflozin an inhibitor of sodium glucose co-transporter 2 (SGLT2), improves glycemic control and lowers body weight in subjects with type 2 diabetes (T2D) on metformin. Diabetes. 2010;59 suppl 1:A21.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Rosensotck, J.1    Arbit, D.2    Usiskin, K.3    Capuano, G.4    Canovatchel, W.5
  • 41
  • 42
    • 80052084915 scopus 로고    scopus 로고
    • Canagliflozin treatment improves beta cell function in subject with type 2 diabetes
    • Polidori D, Zhao Y, Sha S, Canovatchel W. Canagliflozin treatment improves beta cell function in subject with type 2 diabetes. Diabetes. 2010;59 suppl 1:A176.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Polidori, D.1    Zhao, Y.2    Sha, S.3    Canovatchel, W.4
  • 44
    • 77957555722 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacokinetics and pharmacodynamics of single doses of BI 10773, a sodium-glucose co-transporter inhibitor (SGLT2), in Japanese healthy volunteers
    • Koiwai K, Seman L, Yamamura N, Macha S, Taniguchi A, Negishi T, Sesoko S, Dugi KA. Safety, tolerability, pharmacokinetics and pharmacodynamics of single doses of BI 10773, a sodium-glucose co-transporter inhibitor (SGLT2), in Japanese healthy volunteers. Diabetes. 2010;59 suppl 1:2175PO.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Koiwai, K.1    Seman, L.2    Yamamura, N.3    MacHa, S.4    Taniguchi, A.5    Negishi, T.6    Sesoko, S.7    Dugi, K.A.8
  • 45
    • 77957573037 scopus 로고    scopus 로고
    • BI 10773, a sodium-glucose cotransporter inhibitor (SGLT-2), is safe and efficacious following 4- week treatment in patients with type 2 diabetes
    • Heise T, Seewaldt-Becker E, Macha S, Hantel S, Huber K, Pinnetti S, Seman L, Hans-Juergen W. BI 10773, a sodium-glucose cotransporter inhibitor (SGLT-2), is safe and efficacious following 4- week treatment in patients with type 2 diabetes. Diabetes. 2010;59 (suppl):629P.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. , pp. 629
    • Heise, T.1    Seewaldt-Becker, E.2    MacHa, S.3    Hantel, S.4    Huber, K.5    Pinnetti, S.6    Seman, L.7    Hans-Juergen, W.8
  • 46
    • 84871634800 scopus 로고    scopus 로고
    • Efficacy and safety of BI 10773, a new sodium glucose cotransporter-2 (SGLT-2) inhibitor, in type 2 diabetes inadequately controlled on metformin
    • Rosenstock J, Jelaska A, Seman L, Pinnetti S, Hantel S, Woerle HJ. Efficacy and safety of BI 10773, a new sodium glucose cotransporter-2 (SGLT-2) inhibitor, in type 2 diabetes inadequately controlled on metformin. Diabetes. 2011;60(suppl):989P.
    • (2011) Diabetes , vol.60 , Issue.SUPPL. , pp. 989
    • Rosenstock, J.1    Jelaska, A.2    Seman, L.3    Pinnetti, S.4    Hantel, S.5    Woerle, H.J.6
  • 47
    • 79952993665 scopus 로고    scopus 로고
    • ASP1941, a novel, selective SGLT2 inhibitor, was effective and safe in Japanese healthy volunteers and patients with type 2 diabetes mellitus
    • Kashiwagi A, Utsuno A, Kazuta K, Yoshida S, Kageyama S. ASP1941, a novel, selective SGLT2 inhibitor, was effective and safe in Japanese healthy volunteers and patients with type 2 diabetes mellitus. Diabetes. 2010;59 suppl 1:A21.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Kashiwagi, A.1    Utsuno, A.2    Kazuta, K.3    Yoshida, S.4    Kageyama, S.5
  • 48
    • 84864283546 scopus 로고    scopus 로고
    • Ipragliflozin improved glycemic control with additional benefit of reduction of body weight and blood pressure in Japanese patients with type 2 diabetes mellitus BRIGHTEN Study
    • Takinami A, Takinami Y, Kazuta K, Yoshida S, Utsuno A, Nagase I, Kashiwagi A. Ipragliflozin improved glycemic control with additional benefit of reduction of body weight and blood pressure in Japanese patients with type 2 diabetes mellitus BRIGHTEN Study. Diabetologia. 2011;54(suppl):A149.
    • (2011) Diabetologia , vol.54 , Issue.SUPPL.
    • Takinami, A.1    Takinami, Y.2    Kazuta, K.3    Yoshida, S.4    Utsuno, A.5    Nagase, I.6    Kashiwagi, A.7
  • 49
    • 83655194268 scopus 로고    scopus 로고
    • LX4211, a dual SGLT2/SGLT1 inhibtor, shows rapid and significant improvements in glycemic control over 28 days in patients with type 2 diabetes (T2DM)
    • (late breaking abstract)
    • Freiman J, Ruff DA, Frazier KS, Combs K, Turnage A, Shadoan M, Powell D, Zambrowicz B, Brown P. LX4211, a dual SGLT2/SGLT1 inhibtor, shows rapid and significant improvements in glycemic control over 28 days in patients with type 2 diabetes (T2DM). Diabetes 2010;59(suppl 1), (late breaking abstract).
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Freiman, J.1    Ruff, D.A.2    Frazier, K.S.3    Combs, K.4    Turnage, A.5    Shadoan, M.6    Powell, D.7    Zambrowicz, B.8    Brown, P.9
  • 50
    • 84873079393 scopus 로고    scopus 로고
    • TS-071, a novel and selective SGLT2 inhibitor, improved glycemic control and decreased body weight in 12-week study of Japanese patients with type 2 diabetes mellitus
    • Seino Y, Sasaki T, Fukatsu A, Samukawa Y, Sakai S, Watanabe T. TS-071, a novel and selective SGLT2 inhibitor, improved glycemic control and decreased body weight in 12-week study of Japanese patients with type 2 diabetes mellitus. Diabetes. 2011;60(suppl): P998.
    • (2011) Diabetes , vol.60 , Issue.SUPPL.
    • Seino, Y.1    Sasaki, T.2    Fukatsu, A.3    Samukawa, Y.4    Sakai, S.5    Watanabe, T.6
  • 51
    • 84871625141 scopus 로고    scopus 로고
    • The sodium glucose co-transported PF04971729, provides multifaced improvement in diabetic patients inadequately controlled on metformin
    • Nucci G, Amin NB, Wang X, Lee DS, Rusnak JM. The sodium glucose co-transported PF04971729, provides multifaced improvement in diabetic patients inadequately controlled on metformin. Diabetologia. 2011;54(suppl):A850.
    • (2011) Diabetologia , vol.54 , Issue.SUPPL.
    • Nucci, G.1    Amin, N.B.2    Wang, X.3    Lee, D.S.4    Rusnak, J.M.5
  • 52
    • 84861092820 scopus 로고    scopus 로고
    • The effect of renal impairment on the pharmacokinetics and urinary glucose excretion of the SGLT2 inhibitor ipragliflozin in Japanese type 2 diabetes mellitus patients
    • Kadokura T, Ishikawa H, Nakajo I, Yoshida S, Utsuno A, Smulders RA, Morozumi K. The effect of renal impairment on the pharmacokinetics and urinary glucose excretion of the SGLT2 inhibitor ipragliflozin in Japanese type 2 diabetes mellitus patients. Diabetologia. 2011;54(suppl):A847.
    • (2011) Diabetologia , vol.54 , Issue.SUPPL.
    • Kadokura, T.1    Ishikawa, H.2    Nakajo, I.3    Yoshida, S.4    Utsuno, A.5    Smulders, R.A.6    Morozumi, K.7
  • 53
    • 0032707179 scopus 로고    scopus 로고
    • Glomerular hyperfiltration in experimental diabetes mellitus: Potential role of tubular reabsorption
    • Vallon V, Richter K, Blantz RC, Thomson S, Osswald H. Glomerular hyperfiltration in experimental diabetes mellitus: potential role of tubular reabsorption. J Am Soc Nephrol. 1999;10:2569-76.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 2569-2576
    • Vallon, V.1    Richter, K.2    Blantz, R.C.3    Thomson, S.4    Osswald, H.5
  • 54
    • 0346099293 scopus 로고    scopus 로고
    • Kidney function in early diabetes: The tubular hypothesis of glomerular filtration
    • Thomson SC, Vallon V, Blantz RC. Kidney function in early diabetes: the tubular hypothesis of glomerular filtration. Am J Physiol. 2004;286:F8-18.
    • (2004) Am J Physiol , vol.286
    • Thomson, S.C.1    Vallon, V.2    Blantz, R.C.3
  • 55
    • 0035906916 scopus 로고    scopus 로고
    • Renal glucose reabsorption during hypertonic glucose infusion in female streptozotocin-induced diabetic rats
    • DOI 10.1016/S0024-3205(01)01090-6, PII S0024320501010906
    • Noonan WT, Shapiro VM, Banks RO. Renal glucose reabsorption during hypertonic glucose infusion in female streptozotocininduced diabetic rats. Life Sci. 2001;68:2967-77. (Pubitemid 32453264)
    • (2001) Life Sciences , vol.68 , Issue.26 , pp. 2967-2977
    • Noonan, W.T.1    Shapiro, V.M.2    Banks, R.O.3
  • 56
    • 0028280105 scopus 로고
    • Molecular adaptations of GLUT1 and GLUT2 in renal proximal tubules of diabetic rats
    • Dominguez JH, Camp K, Maianu L, Feister H, Garvey WT. Molecular adaptations of GLUT1 and GLUT2 in renal proximal tubules of diabetic rats. Am J Physiol. 1994;266:F283-90.
    • (1994) Am J Physiol , vol.266
    • Dominguez, J.H.1    Camp, K.2    Maianu, L.3    Feister, H.4    Garvey, W.T.5
  • 58
    • 0025910414 scopus 로고
    • Effect of strict glycemic control on renal hemodynamic response to amino acids and renal enlargement in insulindependent diabetes mellitus
    • Tuttle KR, Bruton JL, Perusek MC, Lancaster JL, Kopp DT, DeFronzo RA. Effect of strict glycemic control on renal hemodynamic response to amino acids and renal enlargement in insulindependent diabetes mellitus. N Engl J Med. 1991;324:1626-32.
    • (1991) N Engl J Med , vol.324 , pp. 1626-1632
    • Tuttle, K.R.1    Bruton, J.L.2    Perusek, M.C.3    Lancaster, J.L.4    Kopp, D.T.5    Defronzo, R.A.6
  • 60
    • 84871625789 scopus 로고    scopus 로고
    • Characterization of urinary tract infection in the setting of pharmacologically induced glucosuria
    • Parikh S, Johnsson K, Ptaszynska A, Schmitz B, Sugg J, List JF. Characterization of urinary tract infection in the setting of pharmacologically induced glucosuria. Diabetologia. 2011;54(suppl): A841.
    • (2011) Diabetologia , vol.54 , Issue.SUPPL.
    • Parikh, S.1    Johnsson, K.2    Ptaszynska, A.3    Schmitz, B.4    Sugg, J.5    List, J.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.