Down-regulation of the epithelial Na+ channel ENaC by Janus kinase 2

Journal of Membrane Biology

Volumn 247, Issue 4, 2014, Pages 331-338

  Hosseinzadeh, Zohreh ^a   Luo, Dong ^a   Sopjani, Mentor ^a,b   Bhavsar, Shefalee K ^a   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF PRISHTINA   (Serbia)

Author keywords

Amiloride; JAK2; JAK2 inhibitor AG490; Nedd4 2

Indexed keywords

AMILORIDE; ANIMALS; CELLS, CULTURED; COLON; DOWN-REGULATION; EPITHELIAL SODIUM CHANNEL BLOCKERS; EPITHELIAL SODIUM CHANNELS; FEMALE; INTESTINAL MUCOSA; JANUS KINASE 2; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; XENOPUS LAEVIS;

EID: 84898881782     PISSN: 00222631     EISSN: 14321424     Source Type: Journal    
DOI: 10.1007/s00232-014-9636-1     Document Type: Article

References (60)

1. Alesutan I, Sopjani M, Dermaku-Sopjani M, Munoz C, Voelkl J, Lang F (2012) Upregulation of Na-coupled glucose transporter SGLT1 by Tau tubulin kinase 2. Cell Physiol Biochem 30(2):458-465
2. Almilaji A, Munoz C, Hosseinzadeh Z, Lang F (2013a) Upregulation of Na+, Cl(-)-coupled betaine/gamma-amino-butyric acid transporter BGT1 by Tau tubulin kinase 2. Cell Physiol Biochem 32(2):334-343. doi: 10.1159/000354441
3. Almilaji A, Szteyn K, Fein E, Pakladok T, Munoz C, Elvira B, Towhid ST, Alesutan I, Shumilina E, Bock CT, Kandolf R, Lang F (2013b) Down-regulation of Na/K+ atpase activity by human parvovirus B19 capsid protein VP1. Cell Physiol Biochem 31(4-5):638-648. doi: 10.1159/000350083
4. Baskin R, Majumder A, Sayeski PP (2010) The recent medicinal chemistry development of Jak2 tyrosine kinase small molecule inhibitors. Curr Med Chem 17(36):4551-4558
5. Beltowski J, Wojcicka G, Jamroz-Wisniewska A, Wojtak A (2010) Chronic hyperleptinemia induces resistance to acute natriuretic and NO-mimetic effects of leptin. Peptides 31(1):155-163. doi: 10.1016/j.peptides.2009.10.012
6. Bhavsar SK, Hosseinzadeh Z, Merches K, Gu S, Broer S, Lang F (2011) Stimulation of the amino acid transporter SLC6A19 by JAK2. Biochem Biophys Res Commun 414(3):456-461
7. Bhavsar SK, Hosseinzadeh Z, Brenner D, Honisch S, Jilani K, Liu G, Szteyn K, Sopjani M, Mak TW, Shumilina E, Lang F (2013) Energy sensitive regulation of Na+/K+ ATPase by Janus kinase 2. Am J Physiol Cell Physiol. doi: 10.1152/ajpcell.00320.2013
8. Bohmer C, Wagner CA, Beck S, Moschen I, Melzig J, Werner A, Lin JT, Lang F, Wehner F (2000) The shrinkage-activated Na(+) conductance of rat hepatocytes and its possible correlation to rENaC. Cell Physiol Biochem 10(4):187-194
9. Brooks AJ, Waters MJ (2010) The growth hormone receptor: mechanism of activation and clinical implications. Nat Rev Endocrinol 6(9):515-525
10. Coatmellec-Taglioni G, Ribiere C (2003) Factors that influence the risk of hypertension in obese individuals. Curr Opin Nephrol Hypertens 12(3):305-308. doi: 10.1097/01.mnh.0000069863.94246.1e
11. Coaxum SD, Garnovskaya MN, Gooz M, Baldys A, Raymond JR (2009) Epidermal growth factor activates Na(+/)H(+) exchanger in podocytes through a mechanism that involves Janus kinase and calmodulin. Biochim Biophys Acta 1793(7):1174-1181
12. Deachapunya C, Poonyachoti S, Krishnamra N (2012) Site-specific regulation of ion transport by prolactin in rat colon epithelium. Am J Physiol Gastrointest Liver Physiol 302(10):G1199-G1206. doi: 10.1152/ajpgi.00143.2011
13. Dorkkam N, Wongdee K, Suntornsaratoon P, Krishnamra N, Charoenphandhu N (2013) Prolactin stimulates the L-type calcium channel-mediated transepithelial calcium transport in the duodenum of male rats. Biochem Biophys Res Commun 430(2):711-716. doi: 10.1016/j.bbrc.2012.11.085
14. Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Broer S, Wang J, Pearce D, Lang F (2003) The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha, beta, gamma-ENaC. Pflugers Arch 445(6):693-696. doi: 10.1007/s00424-002-0993-8
15. Garnovskaya MN, Mukhin YV, Vlasova TM, Raymond JR (2003) Hypertonicity activates Na+/H+ exchange through Janus kinase 2 and calmodulin. J Biol Chem 278(19):16908-16915
16. Gatsios P, Terstegen L, Schliess F, Haussinger D, Kerr IM, Heinrich PC, Graeve L (1998) Activation of the Janus kinase/signal transducer and activator of transcription pathway by osmotic shock. J Biol Chem 273(36):22962-22968
17. Gong TW, Meyer DJ, Liao J, Hodge CL, Campbell GS, Wang X, Billestrup N, Carter-Su C, Schwartz J (1998) Regulation of glucose transport and c-fos and egr-1 expression in cells with mutated or endogenous growth hormone receptors. Endocrinology 139(4):1863-1871
18. Han SH, Kim JH, Seo HS, Martin MH, Chung GH, Michalek SM, Nahm MH (2006) Lipoteichoic acid-induced nitric oxide production depends on the activation of platelet-activating factor receptor and Jak2. J Immunol 176(1):573-579
19. Helms MN, Yu L, Malik B, Kleinhenz DJ, Hart CM, Eaton DC (2005) Role of SGK1 in nitric oxide inhibition of ENaC in Na+-transporting epithelia. Am J Physiol Cell Physiol 289(3):C717-C726. doi: 10.1152/ajpcell.0 0006.2005
20. Henrion U, Zumhagen S, Steinke K, Strutz-Seebohm N, Stallmeyer B, Lang F, Schulze-Bahr E, Seebohm G (2012) Overlapping cardiac phenotype associated with a familial mutation in the voltage sensor of the KCNQ1 channel. Cell Physiol Biochem 29(5-6):809-818
21. Ho K, Valdez F, Garcia R, Tirado CA (2010) JAK2 Translocations in hematological malignancies: review of the literature. J Assoc Genet Technol 36(3):107-109
22. Hosseinzadeh Z, Bhavsar SK, Shojaiefard M, Saxena A, Merches K, Sopjani M, Alesutan I, Lang F (2011a) Stimulation of the glucose carrier SGLT1 by JAK2. Biochem Biophys Res Commun 408(2):208-213
23. Hosseinzadeh Z, Bhavsar SK, Sopjani M, Alesutan I, Saxena A, Dermaku-Sopjani M, Lang F (2011b) Regulation of the glutamate transporters by JAK2. Cell Physiol Biochem 28(4):693-702
24. Hosseinzadeh Z, Bhavsar SK, Lang F (2012a) Downregulation of ClC-2 by JAK2. Cell Physiol Biochem 29(5-6):737-742
25. Hosseinzadeh Z, Shojaiefard M, Bhavsar SK, Lang F (2012b) Up-regulation of the betaine/GABA transporter BGT1 by JAK2. Biochem Biophys Res Commun 420(1):172-177
26. Hosseinzadeh Z, Sopjani M, Pakladok T, Bhavsar SK, Lang F (2013) Downregulation of KCNQ4 by Janus kinase 2. J Membr Biol 246(4):335-341. doi: 10.1007/s00232-013-9537-8
27. Kamenicky P, Viengchareun S, Blanchard A, Meduri G, Zizzari P, Imbert-Teboul M, Doucet A, Chanson P, Lombes M (2008) Epithelial sodium channel is a key mediator of growth hormone-induced sodium retention in acromegaly. Endocrinology 149(7):3294-3305. doi: 10.1210/en.2008-0143
28. Kamynina E, Staub O (2002) Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na(+) transport. Am J Physiol Renal Physiol 283(3):F377-F387. doi: 10.1152/ajprenal.00143.2002
29. Kunzelmann K, Mall M (2002) Electrolyte transport in the mammalian colon: mechanisms and implications for disease. Physiol Rev 82(1):245-289. doi: 10.1152/physrev.00026.2001
30. Kurdi M, Booz GW (2009) JAK redux: a second look at the regulation and role of JAKs in the heart. Am J Physiol Heart Circ Physiol 297(5):H1545-H1556
31. Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V (2006) (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol Rev 86(4):1151-1178. doi: 10.1152/physrev.00050.2005
32. Lopez AF, Hercus TR, Ekert P, Littler DR, Guthridge M, Thomas D, Ramshaw HS, Stomski F, Perugini M, D'Andrea R, Grimbaldeston M, Parker MW (2010) Molecular basis of cytokine receptor activation. IUBMB Life 62(7):509-518
33. Mahfouz RA, Hoteit R, Salem Z, Bazarbachi A, Mugharbel A, Farhat F, Ziyadeh A, Ibrahim A, Taher A (2011) JAK2 V617F gene mutation in the laboratory work-up of myeloproliferative disorders: experience of a major referral center in Lebanon. Genet Test Mol Biomarkers 15(4):263-265
34. Morris DL, Rui L (2009) Recent advances in understanding leptin signaling and leptin resistance. Am J Physiol Endocrinol Metab 297(6):E1247-E1259
35. Noon-Song EN, Ahmed CM, Dabelic R, Canton J, Johnson HM (2011) Controlling nuclear JAKs and STATs for specific gene activation by IFNgamma. Biochem Biophys Res Commun 410(3):648-653
36. Oh ST, Gotlib J (2010) JAK2 V617F and beyond: role of genetics and aberrant signaling in the pathogenesis of myeloproliferative neoplasms. Expert Rev Hematol 3(3):323-337
37. Pakladok T, Almilaji A, Munoz C, Alesutan I, Lang F (2013) PIKfyve sensitivity of hERG channels. Cell Physiol Biochem 31(6):785-794. doi: 10.1159/000350096
38. Pardanani A, Vannucchi AM, Passamonti F, Cervantes F, Barbui T, Tefferi A (2011) JAK inhibitor therapy for myelofibrosis: critical assessment of value and limitations. Leukemia 25(2):218-225
39. Park SO, Wamsley HL, Bae K, Hu Z, Li X, Choe SW, Slayton WB, Oh SP, Wagner KU, Sayeski PP (2013) Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans. PLoS ONE 8(3):e59675. doi: 10.1371/journal.pone.0059675
40. Pathare G, Foller M, Daryadel A, Mutig K, Bogatikov E, Fajol A, Almilaji A, Michael D, Stange G, Voelkl J, Wagner CA, Bachmann S, Lang F (2012) OSR1-sensitive renal tubular phosphate reabsorption. Kidney Blood Press Res 36(1):149-161
41. Qiu J, Fang Y, Ronnekleiv OK, Kelly MJ (2010) Leptin excites proopiomelanocortin neurons via activation of TRPC channels. J Neurosci 30(4):1560-1565. doi: 10.1523/JNEUROSCI.4816-09.2010
42. Rexhepaj R, Artunc F, Grahammer F, Nasir O, Sandu C, Friedrich B, Kuhl D, Lang F (2006) SGK1 is not required for regulation of colonic ENaC activity. Pflugers Arch 453(1):97-105. doi: 10.1007/s00424-006-0111-4
43. Ross SB, Fuller CM, Bubien JK, Benos DJ (2007) Amiloride-sensitive Na+ channels contribute to regulatory volume increases in human glioma cells. Am J Physiol Cell Physiol 293(3):C1181-C1185. doi: 10.1152/ajpcell.00066.2007
44. Rossier BC, Pradervand S, Schild L, Hummler E (2002) Epithelial sodium channel and the control of sodium balance: interaction between genetic and environmental factors. Annu Rev Physiol 64:877-897. doi: 10.1146/annurev. physiol.64.082101.143243
45. Santos FP, Verstovsek S (2011) JAK2 inhibitors: what's the true therapeutic potential? Blood Rev 25(2):53-63
46. Schmid E, Bhandaru M, Nurbaeva MK, Yang W, Szteyn K, Russo A, Leibrock C, Tyan L, Pearce D, Shumilina E, Lang F (2012) SGK3 regulates Ca entry and migration of dendritic cells. Cell Physiol Biochem 30(6):1423-1435
47. Selvaraj NG, Omi E, Gibori G, Rao MC (2000) Janus kinase 2 (JAK2) regulates prolactin-mediated chloride transport in mouse mammary epithelial cells through tyrosine phosphorylation of Na+-K+-2Cl-cotransporter. Mol Endocrinol 14(12):2054-2065
48. Shen XL, Wei W, Xu HL, Zhang MX, Qin XQ, Shi WZ, Jiang ZP, Chen YJ, Chen FP (2010) JAK2V617F/STAT5 signaling pathway promotes cell proliferation through activation of pituitary tumor transforming gene 1 expression. Biochem Biophys Res Commun 398(4):707-712
49. Snyder PM (2009) Down-regulating destruction: phosphorylation regulates the E3 ubiquitin ligase Nedd4-2. Sci Signal 2(79):pe41. doi: 10.1126/scisignal.279pe41
50. Spivak JL (2010) Narrative review: thrombocytosis, polycythemia vera, and JAK2 mutations: the phenotypic mimicry of chronic myeloproliferation. Ann Intern Med 152(5):300-306
51. Tefferi A (2010) Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1. Leukemia 24(6):1128-1138
52. Venkitachalam S, Chueh FY, Yu CL (2012) Nuclear localization of lymphocyte-specific protein tyrosine kinase (Lck) and its role in regulating LIM domain only 2 (Lmo2) gene. Biochem Biophys Res Commun 417(3):1058-1062
53. Villarreal D, Reams G, Freeman RH, Taraben A (1998) Renal effects of leptin in normotensive, hypertensive, and obese rats. Am J Physiol 275(6 Pt 2):R2056-R2060
54. Villarreal D, Reams G, Freeman R, Spear R, Tchoukina I, Samar H (2006) Leptin blockade attenuates sodium excretion in saline-loaded normotensive rats. Mol Cell Biochem 283(1-2):153-157. doi: 10.1007/s11010-006-2567-0
55. Wolf A, Eulenfeld R, Gabler K, Rolvering C, Haan S, Behrmann I, Denecke B, Haan C, Schaper F (2013) JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells. JAK-STAT 2(3):e24574. doi: 10.4161/jkst.24574
56. Xia XM, Zeng X, Lingle CJ (2002) Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature 418(6900):880-884
57. Yang N, Jiang J, Deng L, Waters MJ, Wang X, Frank SJ (2010) Growth hormone receptor targeting to lipid rafts requires extracellular subdomain 2. Biochem Biophys Res Commun 391(1):414-418
58. Yao X, Balamurugan P, Arvey A, Leslie C, Zhang L (2010) Heme controls the regulation of protein tyrosine kinases Jak2 and Src. Biochem Biophys Res Commun 403(1):30-35
59. Yeh TC, Pellegrini S (1999) The Janus kinase family of protein tyrosine kinases and their role in signaling. CMLS 55(12):1523-1534
60. Yokota I, Hayashi H, Matsuda J, Saijo T, Naito E, Ito M, Ebina Y, Kuroda Y (1998) Effect of growth hormone on the translocation of GLUT4 and its relation to insulin-like and anti-insulin action. Biochim Biophys Acta 1404(3):451-456