메뉴 건너뛰기




Volumn 5, Issue 2, 2014, Pages 69-84

Fidaxomicin in Clostridium difficile infection: Latest evidence and clinical guidance

Author keywords

Clostridium difficile associated diarrhea (CDAD); Clostridium difficile infection (CDI); Fidaxomicin; Metronidazole; Vancomycin

Indexed keywords

BACITRACIN; CADAZOLID; FIDAXOMICIN; FUSIDIC ACID; METRONIDAZOLE; NITAZOXANIDE; PROBIOTIC AGENT; RAMOPLANIN; RIFAXIMIN; TEICOPLANIN; TIGECYCLINE; UNCLASSIFIED DRUG; VANCOMYCIN; VP 20621;

EID: 84898875472     PISSN: 20406223     EISSN: 20406231     Source Type: Journal    
DOI: 10.1177/2040622313511285     Document Type: Review
Times cited : (52)

References (104)
  • 1
    • 46249099130 scopus 로고    scopus 로고
    • Both oral metronidazole and oral vancomycin promote persistent overgrowth of vancomycin-resistant enterococci during treatment of Clostridium difficile-associated disease
    • Al-Nassir W. Sethi A. Li Y. Pultz M. Riggs M. Donskey C. (2008) Both oral metronidazole and oral vancomycin promote persistent overgrowth of vancomycin-resistant enterococci during treatment of Clostridium difficile-associated disease. Antimicrob Agents Chemother 52: 2403–2406.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 2403-2406
    • Al-Nassir, W.1    Sethi, A.2    Li, Y.3    Pultz, M.4    Riggs, M.5    Donskey, C.6
  • 2
    • 84863676899 scopus 로고    scopus 로고
    • Fidaxomicin is an inhibitor of the initiation of bacterial RNA synthesis
    • Artsimovitch I. Seddon J. Sears P. (2012) Fidaxomicin is an inhibitor of the initiation of bacterial RNA synthesis. Clin Infect Dis 55(Suppl. 2): S127–S131.
    • (2012) Clin Infect Dis , vol.55 , pp. S127-S131
    • Artsimovitch, I.1    Seddon, J.2    Sears, P.3
  • 3
    • 23944507069 scopus 로고    scopus 로고
    • Treatment of Clostridium difficile associated disease: old therapies and new strategies
    • Aslam S. Hamill R. Musher D. (2005) Treatment of Clostridium difficile associated disease: old therapies and new strategies. Lancet Infect Dis 5: 549–557.
    • (2005) Lancet Infect Dis , vol.5 , pp. 549-557
    • Aslam, S.1    Hamill, R.2    Musher, D.3
  • 4
    • 70949092042 scopus 로고    scopus 로고
    • Diversity of Clostridium difficile in pigs and other animals in Slovenia
    • Avbersek J. Janezic S. Pate M. Rupnik M. Zidaric V. Logar K. et al. (2009) Diversity of Clostridium difficile in pigs and other animals in Slovenia. Anaerobe 15: 252–255.
    • (2009) Anaerobe , vol.15 , pp. 252-255
    • Avbersek, J.1    Janezic, S.2    Pate, M.3    Rupnik, M.4    Zidaric, V.5    Logar, K.6
  • 7
    • 80051805496 scopus 로고    scopus 로고
    • Postantibiotic effect of fidaxomicin and its major metabolite, OP-1118, against Clostridium difficile
    • Babakhani F. Gomez A. Robert N. Sears P. (2011) Postantibiotic effect of fidaxomicin and its major metabolite, OP-1118, against Clostridium difficile. Antimicrob Agents and Chemother 55: 4427–4429.
    • (2011) Antimicrob Agents and Chemother , vol.55 , pp. 4427-4429
    • Babakhani, F.1    Gomez, A.2    Robert, N.3    Sears, P.4
  • 9
    • 66149146645 scopus 로고    scopus 로고
    • Clostridium difficile in ready-to-eat salads, Scotland
    • Bakri M. Brown D. Butcher J. Sutherland A. (2009) Clostridium difficile in ready-to-eat salads, Scotland. Emerg Infect Dis 15: 817–818.
    • (2009) Emerg Infect Dis , vol.15 , pp. 817-818
    • Bakri, M.1    Brown, D.2    Butcher, J.3    Sutherland, A.4
  • 10
    • 35048865459 scopus 로고    scopus 로고
    • Prospective study of Clostridium difficile infections in Europe with phenotypic and genotypic characterization of the isolates
    • Barbut F. Mastrantonio P. Delmee M. Brazier J. Kuijper E. Poxton I. et al. (2007) Prospective study of Clostridium difficile infections in Europe with phenotypic and genotypic characterization of the isolates. Clin Microbiol Infect 13: 1048–1057.
    • (2007) Clin Microbiol Infect , vol.13 , pp. 1048-1057
    • Barbut, F.1    Mastrantonio, P.2    Delmee, M.3    Brazier, J.4    Kuijper, E.5    Poxton, I.6
  • 11
    • 70649107673 scopus 로고    scopus 로고
    • European Society of Clinical Microbiology and Infectious Diseases (ESCMID): treatment guidance document for Clostridium difficile infection (CDI)
    • Bauer M. Kuijper E. van Dissel J. (2009) European Society of Clinical Microbiology and Infectious Diseases (ESCMID): treatment guidance document for Clostridium difficile infection (CDI). Clin Microbiol Infec 15: 1067–1079.
    • (2009) Clin Microbiol Infec , vol.15 , pp. 1067-1079
    • Bauer, M.1    Kuijper, E.2    van Dissel, J.3
  • 12
    • 77951231746 scopus 로고    scopus 로고
    • In vitro activity of fidaxomicin (OPT-80) tested against contemporary clinical isolates of Staphylococcus spp. and Enterococcus spp
    • Biedenbach D. Ross J. Putnam S. Jones R. (2010) In vitro activity of fidaxomicin (OPT-80) tested against contemporary clinical isolates of Staphylococcus spp. and Enterococcus spp. Antimicrob Agents Chemother 54: 2273–2275.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 2273-2275
    • Biedenbach, D.1    Ross, J.2    Putnam, S.3    Jones, R.4
  • 13
    • 0022491104 scopus 로고
    • Faecal metronidazole concentrations during oral and intravenous therapy for antibiotic associated colitis due to Clostridium difficile
    • Bolton R. Culshaw M. (1986) Faecal metronidazole concentrations during oral and intravenous therapy for antibiotic associated colitis due to Clostridium difficile. Gut 27: 1169–1172.
    • (1986) Gut , vol.27 , pp. 1169-1172
    • Bolton, R.1    Culshaw, M.2
  • 15
    • 84868570667 scopus 로고    scopus 로고
    • Consequences of Clostridium difficile infection: understanding the healthcare burden
    • Bouza E. (2012) Consequences of Clostridium difficile infection: understanding the healthcare burden. Clin Microbiol Infect 18(Suppl. 6): 5–12.
    • (2012) Clin Microbiol Infect , vol.18 , pp. 5-12
    • Bouza, E.1
  • 16
    • 0028945667 scopus 로고
    • Recommendations for preventing the spread of vancomycin resistance: recommendations of the Hospital Infection Control Practices Advisory Committee (HIC-PAC)
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention (1995) Recommendations for preventing the spread of vancomycin resistance: recommendations of the Hospital Infection Control Practices Advisory Committee (HIC-PAC). Am J Infect Control 23: 87–94.
    • (1995) Am J Infect Control , vol.23 , pp. 87-94
  • 17
    • 32544446901 scopus 로고    scopus 로고
    • Severe Clostridium difficile-associated disease in populations previously at low risk–four states, 2005
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention (2005) Severe Clostridium difficile-associated disease in populations previously at low risk–four states, 2005. MMWR Morb Mortal Wkly Rep 54: 1201–1205.
    • (2005) MMWR Morb Mortal Wkly Rep , vol.54 , pp. 1201-1205
  • 18
    • 77951026738 scopus 로고    scopus 로고
    • Clinical practice guidelines for Clostridium difficile infection in Adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA)
    • Cohen S. Gerding D. Johnson S. Kelly C. Loo V. McDonald L. et al. (2010) Clinical practice guidelines for Clostridium difficile infection in Adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol 31: 431–455.
    • (2010) Infect Control Hosp Epidemiol , vol.31 , pp. 431-455
    • Cohen, S.1    Gerding, D.2    Johnson, S.3    Kelly, C.4    Loo, V.5    McDonald, L.6
  • 19
    • 84868576303 scopus 로고    scopus 로고
    • Current and emerging management options for Clostridium difficile infection: what is the role of fidaxomicin?
    • Cornely O. (2012) Current and emerging management options for Clostridium difficile infection: what is the role of fidaxomicin? Clin Microbiol Infect 18(Suppl. 6): 28–35.
    • (2012) Clin Microbiol Infect , vol.18 , pp. 28-35
    • Cornely, O.1
  • 20
    • 84859007390 scopus 로고    scopus 로고
    • Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada and the USA: a double-blinded, non inferiority, randomised controlled trial
    • Cornely O. Crook D. Esposito R. Poirer A. Somero M. Weiss K. (2012 a) Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada and the USA: a double-blinded, non inferiority, randomised controlled trial. Lancet Infec Dis 12: 281–289.
    • (2012) Lancet Infec Dis , vol.12 , pp. 281-289
    • Cornely, O.1    Crook, D.2    Esposito, R.3    Poirer, A.4    Somero, M.5    Weiss, K.6
  • 21
    • 84883087444 scopus 로고    scopus 로고
    • Resolution of Clostridium difficile –associated diarrhea in cancer patients treated with fidaxomicin or vancomycin
    • Cornely O. Miller M. Fantin B. Mullane K. Kean Y. Gorbach S. (2013) Resolution of Clostridium difficile –associated diarrhea in cancer patients treated with fidaxomicin or vancomycin. J Clin Oncol 31: 2493–2499.
    • (2013) J Clin Oncol , vol.31 , pp. 2493-2499
    • Cornely, O.1    Miller, M.2    Fantin, B.3    Mullane, K.4    Kean, Y.5    Gorbach, S.6
  • 22
    • 84863676557 scopus 로고    scopus 로고
    • Treatment of first recurrence of Clostridium difficile infection: fidaxomicin versus vancomycin
    • Cornely O. Miller M. Louie T. Crook D. Gorbach S. (2012 b) Treatment of first recurrence of Clostridium difficile infection: fidaxomicin versus vancomycin. Clin Infect Dis 55(Suppl. 2): S154–S161.
    • (2012) Clin Infect Dis , vol.55 , pp. S154-S161
    • Cornely, O.1    Miller, M.2    Louie, T.3    Crook, D.4    Gorbach, S.5
  • 23
    • 0016592570 scopus 로고
    • A new antibiotic from actinoplanes; II. Isolation, chemical, biological and biochemical characterization
    • Coronelli C. White R. Lancini G. Parenti F. (1975) A new antibiotic from actinoplanes; II. Isolation, chemical, biological and biochemical characterization. J Antibiot (Tokyo) 28: 253–259.
    • (1975) J Antibiot (Tokyo) , vol.28 , pp. 253-259
    • Coronelli, C.1    White, R.2    Lancini, G.3    Parenti, F.4
  • 24
    • 84863686440 scopus 로고    scopus 로고
    • Fidaxomicin versus vancomycin for Clostridium difficile infection: meta-analysis of pivotal randomized controlled trials
    • Crook D. Walker A. Kean Y. Weiss K. Cornely O. Miller M. et al. (2012) Fidaxomicin versus vancomycin for Clostridium difficile infection: meta-analysis of pivotal randomized controlled trials. Clin Infect Dis 55(Suppl. 2): S93–S103.
    • (2012) Clin Infect Dis , vol.55 , pp. S93-S103
    • Crook, D.1    Walker, A.2    Kean, Y.3    Weiss, K.4    Cornely, O.5    Miller, M.6
  • 25
    • 84933036039 scopus 로고    scopus 로고
    • Readmissions following hospitalizations with Clostridium difficile infections, 2009
    • HCUP Statistical Brief #145 Agency for Healthcare Research and Quality Rockville, MD: December 2012 Available at
    • Elixhauser A. Steiner C. Gould C. (2012) Readmissions following hospitalizations with Clostridium difficile infections, 2009. HCUP Statistical Brief #145, Agency for Healthcare Research and Quality, Rockville, MD, December 2012. Available at http://www.hcup-us.ahrq.gov/reports/statbriefs/sb145.pdf.
    • (2012)
    • Elixhauser, A.1    Steiner, C.2    Gould, C.3
  • 26
    • 84863651274 scopus 로고    scopus 로고
    • Predictors of first recurrence of Clostridium difficile infection: implications for initial management
    • Eyre D. Walker A. Wyllie D. Dingle K. Griffiths D. Finney J. et al. (2012) Predictors of first recurrence of Clostridium difficile infection: implications for initial management. Clin Infect Dis 55(Suppl. 2): S77–S87.
    • (2012) Clin Infect Dis , vol.55 , pp. S77-S87
    • Eyre, D.1    Walker, A.2    Wyllie, D.3    Dingle, K.4    Griffiths, D.5    Finney, J.6
  • 27
    • 77957020092 scopus 로고    scopus 로고
    • Epidemiology of community-onset Clostridium difficile infection in a community in the South of England
    • Fellmeth G. Yarlagadda S. Iyer S. (2010) Epidemiology of community-onset Clostridium difficile infection in a community in the South of England. J Infect Public Health 3: 118–123.
    • (2010) J Infect Public Health , vol.3 , pp. 118-123
    • Fellmeth, G.1    Yarlagadda, S.2    Iyer, S.3
  • 29
    • 56249107224 scopus 로고    scopus 로고
    • Meta-analysis to assess risk factors for recurrent Clostridium difficile infection
    • Garey K. Sethi S. Yadav Y. DuPont H. (2008) Meta-analysis to assess risk factors for recurrent Clostridium difficile infection. J Hosp Infect 70: 298–304.
    • (2008) J Hosp Infect , vol.70 , pp. 298-304
    • Garey, K.1    Sethi, S.2    Yadav, Y.3    DuPont, H.4
  • 30
    • 0019949758 scopus 로고
    • Clostridium difficile and its cytotoxin in feces of patients with antimicrobial agent-associated diarrhea and miscellaneous conditions
    • George W. Rolfe R. Finegold S. (1982) Clostridium difficile and its cytotoxin in feces of patients with antimicrobial agent-associated diarrhea and miscellaneous conditions. J Clin Microbiol 15: 1049–1053.
    • (1982) J Clin Microbiol , vol.15 , pp. 1049-1053
    • George, W.1    Rolfe, R.2    Finegold, S.3
  • 31
    • 77952564778 scopus 로고    scopus 로고
    • Economic healthcare costs of Clostridium difficile infection: a systematic review
    • Ghantoji S. Sail K. Lairson D. DuPont H. Garey K. (2010) Economic healthcare costs of Clostridium difficile infection: a systematic review. J Hosp Infect 74: 309–318.
    • (2010) J Hosp Infect , vol.74 , pp. 309-318
    • Ghantoji, S.1    Sail, K.2    Lairson, D.3    DuPont, H.4    Garey, K.5
  • 32
    • 80054711588 scopus 로고    scopus 로고
    • Comparative susceptibilities to fidaxomicin (OPT-80) of isolates collected at baseline, recurrence, and failure from patients in two phase III trials of fidaxomicin against Clostridium difficile infection
    • Goldstein E. Citron D. Sears P. Babakhani F. Sambol S. Gerding D. (2011) Comparative susceptibilities to fidaxomicin (OPT-80) of isolates collected at baseline, recurrence, and failure from patients in two phase III trials of fidaxomicin against Clostridium difficile infection. Antimicrob Agents Chemother 55: 5194–5199.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 5194-5199
    • Goldstein, E.1    Citron, D.2    Sears, P.3    Babakhani, F.4    Sambol, S.5    Gerding, D.6
  • 34
    • 80054736926 scopus 로고    scopus 로고
    • Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection
    • Gough E. Shaikh H. Manges A. (2011) Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection. Clin Infect Dis 53: 994–1002.
    • (2011) Clin Infect Dis , vol.53 , pp. 994-1002
    • Gough, E.1    Shaikh, H.2    Manges, A.3
  • 35
    • 84874866683 scopus 로고    scopus 로고
    • Electronic health record-based detection of risk factors for Clostridium difficile infection
    • Hebert C. Hongyan D. Peterson L. Robicsek A. (2013) Electronic health record-based detection of risk factors for Clostridium difficile infection. Infect Cont Hospital Epidemiol 34: 407–414.
    • (2013) Infect Cont Hospital Epidemiol , vol.34 , pp. 407-414
    • Hebert, C.1    Hongyan, D.2    Peterson, L.3    Robicsek, A.4
  • 36
    • 34547640095 scopus 로고    scopus 로고
    • In vitro activities of 15 antimicrobial agents against 110 toxigenic Clostridium difficile clinical isolates collected from 1983 to 2004
    • Hecht D. Galang M. Sambol S. Osmolski J. Johnson S. Gerding D. (2010) In vitro activities of 15 antimicrobial agents against 110 toxigenic Clostridium difficile clinical isolates collected from 1983 to 2004. Antimicrob Ag Chemother 51: 2716–2719.
    • (2010) Antimicrob Ag Chemother , vol.51 , pp. 2716-2719
    • Hecht, D.1    Galang, M.2    Sambol, S.3    Osmolski, J.4    Johnson, S.5    Gerding, D.6
  • 38
    • 84856959278 scopus 로고    scopus 로고
    • Time interval of increased risk for Clostridium difficile infection after exposure to antibiotics
    • Hensgens M. Goorhuis A. Dekkers O. Kuijper E. (2012 a) Time interval of increased risk for Clostridium difficile infection after exposure to antibiotics. J Antimicr Chemother 67: 742–748.
    • (2012) J Antimicr Chemother , vol.67 , pp. 742-748
    • Hensgens, M.1    Goorhuis, A.2    Dekkers, O.3    Kuijper, E.4
  • 40
    • 62949146399 scopus 로고    scopus 로고
    • Prospective Derivation and Validation of a Clinical prediction Rule for recurrent Clostridium difficile Infection
    • Hu M. Katchar K. Kyne L. Maroo S. Tummala S. Dreisbach V. et al. (2009) Prospective Derivation and Validation of a Clinical prediction Rule for recurrent Clostridium difficile Infection. Gastroenterol 136: 1206–1214.
    • (2009) Gastroenterol , vol.136 , pp. 1206-1214
    • Hu, M.1    Katchar, K.2    Kyne, L.3    Maroo, S.4    Tummala, S.5    Dreisbach, V.6
  • 41
    • 33846016197 scopus 로고    scopus 로고
    • Treatment of recurrent Clostridium difficile diarrhea
    • Huebner E. Surawicz C. (2006) Treatment of recurrent Clostridium difficile diarrhea. Gastroenterol Hepatol 2: 203–208.
    • (2006) Gastroenterol Hepatol , vol.2 , pp. 203-208
    • Huebner, E.1    Surawicz, C.2
  • 42
    • 78049522796 scopus 로고    scopus 로고
    • Long-term impacts of antibiotic exposure on the human intestinal microbiota
    • Jernberg C. Lofmark S. Edlund C. Jansson J. (2010) Long-term impacts of antibiotic exposure on the human intestinal microbiota. Microbiology 15: 3216–3223.
    • (2010) Microbiology , vol.15 , pp. 3216-3223
    • Jernberg, C.1    Lofmark, S.2    Edlund, C.3    Jansson, J.4
  • 43
    • 33947304450 scopus 로고    scopus 로고
    • Drug evaluation: OPT-80, a narrow-spectrum macrocyclic antibiotic
    • Johnson A. (2007) Drug evaluation: OPT-80, a narrow-spectrum macrocyclic antibiotic. Curr Opin Investig Drugs 8: 168–173.
    • (2007) Curr Opin Investig Drugs , vol.8 , pp. 168-173
    • Johnson, A.1
  • 44
    • 0026663447 scopus 로고
    • Treatment of asymptomatic Clostridium difficile carriers (fecal excretors) with Vancomycin or Metronidazole: a randomized, placebo-controlled trial
    • Johnson S. Homann S.R. Bettin K.M. Quick J.N. Clabots C.R. Peterson L.R. et al. (1992) Treatment of asymptomatic Clostridium difficile carriers (fecal excretors) with Vancomycin or Metronidazole: a randomized, placebo-controlled trial. Ann Intern Med 117 (4): 297–302.
    • (1992) Ann Intern Med , vol.117 , Issue.4 , pp. 297-302
    • Johnson, S.1    Homann, S.R.2    Bettin, K.M.3    Quick, J.N.4    Clabots, C.R.5    Peterson, L.R.6
  • 45
    • 84871349683 scopus 로고    scopus 로고
    • Probiotics for the prevention of Clostridium adifficile associated diarrhea: A systematic review and meta analysis
    • Johnson B.C. Ma S.S.Y. Goldberg J.Z. Thorlund K. Vandvik P.O. Loeb M. et al. (2012) Probiotics for the prevention of Clostridium adifficile associated diarrhea: A systematic review and meta analysis. Ann Intern Med 157 (12): 878–888.
    • (2012) Ann Intern Med , vol.157 , Issue.12 , pp. 878-888
    • Johnson, B.C.1    Ma, S.S.Y.2    Goldberg, J.Z.3    Thorlund, K.4    Vandvik, P.O.5    Loeb, M.6
  • 46
    • 34250660545 scopus 로고    scopus 로고
    • Prevalence of PCR ribotypes among Clostridium difficile isolates from pigs, calves, and other species
    • Keel K. Brazier J. Post K. Weese S. Songer J. (2007) Prevalence of PCR ribotypes among Clostridium difficile isolates from pigs, calves, and other species. J Clin Microbiol 45: 1963–1964.
    • (2007) J Clin Microbiol , vol.45 , pp. 1963-1964
    • Keel, K.1    Brazier, J.2    Post, K.3    Weese, S.4    Songer, J.5
  • 47
    • 0031958706 scopus 로고    scopus 로고
    • Clostridium difficile infection
    • Kelly C. LaMont J. (1998) Clostridium difficile infection. Annu Rev Med 49: 375–390.
    • (1998) Annu Rev Med , vol.49 , pp. 375-390
    • Kelly, C.1    LaMont, J.2
  • 49
    • 77955260309 scopus 로고    scopus 로고
    • The growing incidence and severity of Clostridium difficile infection in inpatient and outpatient settings
    • Khanna S. Pardi D. (2010) The growing incidence and severity of Clostridium difficile infection in inpatient and outpatient settings. Expert Rev Gastroenterol Hepatol 4: 409–416.
    • (2010) Expert Rev Gastroenterol Hepatol , vol.4 , pp. 409-416
    • Khanna, S.1    Pardi, D.2
  • 51
    • 84855422347 scopus 로고    scopus 로고
    • The epidemiology of community-acquired Clostridium difficile infection: a population-based study
    • Khanna S. Pardi D. Aronson S. Kammer P. Orenstein R. St Sauver J. et al. (2012 b) The epidemiology of community-acquired Clostridium difficile infection: a population-based study. Am J Gastroenterol 107: 89–95.
    • (2012) Am J Gastroenterol , vol.107 , pp. 89-95
    • Khanna, S.1    Pardi, D.2    Aronson, S.3    Kammer, P.4    Orenstein, R.5    St Sauver, J.6
  • 52
    • 76149131339 scopus 로고    scopus 로고
    • Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA
    • Kutty P. Woods C. Sena A. Benoit S. Naggie S. Frederick J. et al. (2010) Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA. Emerg Infect Dis 16: 197–204.
    • (2010) Emerg Infect Dis , vol.16 , pp. 197-204
    • Kutty, P.1    Woods, C.2    Sena, A.3    Benoit, S.4    Naggie, S.5    Frederick, J.6
  • 53
    • 70350011973 scopus 로고    scopus 로고
    • Population-based surveillance of Clostridium difficile infection in Manitoba, Canada, by using interim surveillance definitions
    • Lambert P. Dyck M. Thompson L. Hammond G. (2009) Population-based surveillance of Clostridium difficile infection in Manitoba, Canada, by using interim surveillance definitions. Infect Control Hosp Epidemiol 30: 945–951.
    • (2009) Infect Control Hosp Epidemiol , vol.30 , pp. 945-951
    • Lambert, P.1    Dyck, M.2    Thompson, L.3    Hammond, G.4
  • 54
    • 84871928001 scopus 로고    scopus 로고
    • Lymphopenia as a novel marker of Clostridium difficile infection recurrence
    • Lavergne V. Beausejour Y. Pichette G. Ghannoum M. Hann S. (2013) Lymphopenia as a novel marker of Clostridium difficile infection recurrence. J Infect 66: 129–135.
    • (2013) J Infect , vol.66 , pp. 129-135
    • Lavergne, V.1    Beausejour, Y.2    Pichette, G.3    Ghannoum, M.4    Hann, S.5
  • 55
    • 84863676446 scopus 로고    scopus 로고
    • Current status of Clostridium difficile infection epidemiology
    • Lessa F. Gould C. McDonald L. (2012) Current status of Clostridium difficile infection epidemiology. Clin Infect Dis 55(Suppl. 2): S65–S70.
    • (2012) Clin Infect Dis , vol.55 , pp. S65-S70
    • Lessa, F.1    Gould, C.2    McDonald, L.3
  • 56
    • 28844441314 scopus 로고    scopus 로고
    • A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality
    • Loo V. Poirier L. Miller M. Oughton M. Libman M. Michaud S. et al. (2005) A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 353: 2442–2449.
    • (2005) N Engl J Med , vol.353 , pp. 2442-2449
    • Loo, V.1    Poirier, L.2    Miller, M.3    Oughton, M.4    Libman, M.5    Michaud, S.6
  • 57
    • 84863644993 scopus 로고    scopus 로고
    • Fidaxomicin preserves the intestinal microbiome during and after treatment of Clostridium difficile infection (CDI) and reduces both toxin re-expression and recurrence of CDI
    • Louie T. Cannon K. Byrne B. Emery J. Ward L. Eyben M. et al. (2012) Fidaxomicin preserves the intestinal microbiome during and after treatment of Clostridium difficile infection (CDI) and reduces both toxin re-expression and recurrence of CDI. Clin Infect Dis 55(Suppl. 2): S132–S142.
    • (2012) Clin Infect Dis , vol.55 , pp. S132-S142
    • Louie, T.1    Cannon, K.2    Byrne, B.3    Emery, J.4    Ward, L.5    Eyben, M.6
  • 58
    • 84993701945 scopus 로고    scopus 로고
    • Results of a phase III trial comparing tolevamer, vancomycin and metronidazole in patients with Clostridium difficile associated diarrhea (CDAD)
    • Program and abstracts of the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy Chicago, IL: Abstract K-425a.
    • Louie T. Gerson M. Grimard D. Johnson S. Poirier A. Weiss K. et al. (2007) Results of a phase III trial comparing tolevamer, vancomycin and metronidazole in patients with Clostridium difficile associated diarrhea (CDAD). Program and abstracts of the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, 17–20 September 2007; Abstract K-425a.
    • (2007)
    • Louie, T.1    Gerson, M.2    Grimard, D.3    Johnson, S.4    Poirier, A.5    Weiss, K.6
  • 59
  • 60
  • 62
    • 0031913854 scopus 로고    scopus 로고
    • The role of cost-consequence analysis in healthcare decision-making
    • Mauskopf J. Paus J. Grant D. Stergachis A. (1998) The role of cost-consequence analysis in healthcare decision-making. Pharmaco Economics 13: 277–288.
    • (1998) Pharmaco Economics , vol.13 , pp. 277-288
    • Mauskopf, J.1    Paus, J.2    Grant, D.3    Stergachis, A.4
  • 64
    • 33645455337 scopus 로고    scopus 로고
    • Meta analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease
    • McFarland L.V. (2006) Meta analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroent 101: 812–822.
    • (2006) Am J Gastroent , vol.101 , pp. 812-822
    • McFarland, L.V.1
  • 65
    • 0036311186 scopus 로고    scopus 로고
    • Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease
    • McFarland L. Elmer G. Surawicz C. (2002) Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease. Am J Gastroenterol 97: 1769–1775.
    • (2002) Am J Gastroenterol , vol.97 , pp. 1769-1775
    • McFarland, L.1    Elmer, G.2    Surawicz, C.3
  • 66
    • 0024545882 scopus 로고
    • Nosocomial acquisition of Clostridium difficile infection
    • McFarland L. Mulligan M. Kwok R. Stamm W. (1989) Nosocomial acquisition of Clostridium difficile infection. N Engl J Med 320: 204–210.
    • (1989) N Engl J Med , vol.320 , pp. 204-210
    • McFarland, L.1    Mulligan, M.2    Kwok, R.3    Stamm, W.4
  • 67
    • 0028226085 scopus 로고
    • A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease
    • McFarland L. Surawicz C. Greenberg R. Fekety R. Elmer G. Moyer K. et al. (1994) A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. JAMA 271: 1913–1918.
    • (1994) JAMA , vol.271 , pp. 1913-1918
    • McFarland, L.1    Surawicz, C.2    Greenberg, R.3    Fekety, R.4    Elmer, G.5    Moyer, K.6
  • 70
    • 79952585695 scopus 로고    scopus 로고
    • Comparison of the burdens of hospital-onset, healthcare facility-associated Clostridium difficile infection and of healthcare-associated infection due to methicillin resistant Staphylococcus aureus in community hospitals
    • Miller B. Chen L. Sexton D. Anderson D. (2011) Comparison of the burdens of hospital-onset, healthcare facility-associated Clostridium difficile infection and of healthcare-associated infection due to methicillin resistant Staphylococcus aureus in community hospitals. Infect Control Hosp Epidemiol 32: 387–390.
    • (2011) Infect Control Hosp Epidemiol , vol.32 , pp. 387-390
    • Miller, B.1    Chen, L.2    Sexton, D.3    Anderson, D.4
  • 71
    • 84993733153 scopus 로고    scopus 로고
    • Faster time to resolution of diarrhea with fidaxomicin vs. vancyomycin in patients with Clostridium difficile infection (CDI)
    • 47th Annual Infectious Diseases Society of America Meeting Philadelphia, PA
    • Miller M. Mullane K. Weiss K. Lentnek A. Golan Y. Sears P. et al. (2009) Faster time to resolution of diarrhea with fidaxomicin vs. vancyomycin in patients with Clostridium difficile infection (CDI). In 47th Annual Infectious Diseases Society of America Meeting, Philadelphia, PA, 29 October–1 November 2009.
    • (2009)
    • Miller, M.1    Mullane, K.2    Weiss, K.3    Lentnek, A.4    Golan, Y.5    Sears, P.6
  • 72
    • 79951551816 scopus 로고    scopus 로고
    • Deaths: preliminary data for 2008
    • National Vital Statistics Report Hyattsville, MD: National Center for Health Statistics Available at
    • Minino A. Xu J. Kochanek K. (2010) Deaths: preliminary data for 2008. National Vital Statistics Report 59. Hyattsville, MD: National Center for Health Statistics. Available at: http://www.cdc.gov/nchs/data/nvsr/nvsr59/nvsr59_02.pdf.
    • (2010) , vol.59
    • Minino, A.1    Xu, J.2    Kochanek, K.3
  • 73
    • 84879188071 scopus 로고    scopus 로고
    • Renal impairment and response to fidaxomicin versus vancomycin in patients with Clostridium difficile infection
    • Mullane K. Golan Y. Crook D. Cornely O. Miller M. Louie T. et al. (2013) Renal impairment and response to fidaxomicin versus vancomycin in patients with Clostridium difficile infection. Am J Nephrol 38: 1–11.
    • (2013) Am J Nephrol , vol.38 , pp. 1-11
    • Mullane, K.1    Golan, Y.2    Crook, D.3    Cornely, O.4    Miller, M.5    Louie, T.6
  • 74
    • 79961203458 scopus 로고    scopus 로고
    • Fidaxomicin: first-in-class macrocyclic antibiotic
    • Mullane K. Gorbach S. (2011) Fidaxomicin: first-in-class macrocyclic antibiotic. Exp Rev Anti Infec Ther 9: 767–777.
    • (2011) Exp Rev Anti Infec Ther , vol.9 , pp. 767-777
    • Mullane, K.1    Gorbach, S.2
  • 75
    • 80051957059 scopus 로고    scopus 로고
    • Efficacy of fidaxomicin versus vancomycin as therapy for Clostridium difficile infection in individuals taking concomitant antibiotics for other concurrent infections
    • Mullane K. Miller M. Weiss K. Lentnek A. Golan Y. Sears P. et al. (2011) Efficacy of fidaxomicin versus vancomycin as therapy for Clostridium difficile infection in individuals taking concomitant antibiotics for other concurrent infections. Clin Infect Dis 53: 440–447.
    • (2011) Clin Infect Dis , vol.53 , pp. 440-447
    • Mullane, K.1    Miller, M.2    Weiss, K.3    Lentnek, A.4    Golan, Y.5    Sears, P.6
  • 76
    • 84863705179 scopus 로고    scopus 로고
    • Reduced acquisition and overgrowth of vancomycin-resistant enterococci and Candida spp. in patients treated with fidaxomicin versus vancomycin for Clostridium difficile infection
    • Nerandzic M. Mullane K. Miller M. Fabakhani F. Donskey C. (2012) Reduced acquisition and overgrowth of vancomycin-resistant enterococci and Candida spp. in patients treated with fidaxomicin versus vancomycin for Clostridium difficile infection. Clin Infect Dis 55(Suppl. 2): S121–S126.
    • (2012) Clin Infect Dis , vol.55 , pp. S121-S126
    • Nerandzic, M.1    Mullane, K.2    Miller, M.3    Fabakhani, F.4    Donskey, C.5
  • 77
    • 84993785776 scopus 로고    scopus 로고
    • DIFICID® Prescribing Information. Data on File
    • Optimer Pharmaceuticals Inc Clinical Study Report OPT-80–004 Final, June 4, 2010 and Clinical Study Report OPT-80–003 Final, June 17, 2010 (Version 2). San Diego, CA: Optimer Pharmaceuticals, Inc
    • Optimer Pharmaceuticals Inc. (2011) DIFICID® Prescribing Information. Data on File. Clinical Study Report OPT-80–004 Final, June 4, 2010 and Clinical Study Report OPT-80–003 Final, June 17, 2010 (Version 2). San Diego, CA: Optimer Pharmaceuticals, Inc.
    • (2011)
  • 78
    • 0016680833 scopus 로고
    • Lipiarmycin, a new antibiotic from actinoplanes. I. Description of the producer strain and fermentation studies
    • Parenti F. Pagani H. Beretta G. (1975) Lipiarmycin, a new antibiotic from actinoplanes. I. Description of the producer strain and fermentation studies. J Antibiotics (Tokyo) 28: 247–252.
    • (1975) J Antibiotics (Tokyo) , vol.28 , pp. 247-252
    • Parenti, F.1    Pagani, H.2    Beretta, G.3
  • 79
    • 19344363493 scopus 로고    scopus 로고
    • Increasing risk of relapse after treatment of Clostridium difficile colitis in Quebec, Canada
    • Pepin J. Alary M. Valiquette L. Raiche E. Ruel J. Fulop K. et al. (2005) Increasing risk of relapse after treatment of Clostridium difficile colitis in Quebec, Canada. Clin Infect Dis 40: 1591–1597.
    • (2005) Clin Infect Dis , vol.40 , pp. 1591-1597
    • Pepin, J.1    Alary, M.2    Valiquette, L.3    Raiche, E.4    Ruel, J.5    Fulop, K.6
  • 80
    • 4444382260 scopus 로고    scopus 로고
    • Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity
    • Pepin J. Valiquette L. Alary M. Villemure P. Pelletier A. Forget K. et al. (2004) Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. CMAJ 171: 466–472.
    • (2004) CMAJ , vol.171 , pp. 466-472
    • Pepin, J.1    Valiquette, L.2    Alary, M.3    Villemure, P.4    Pelletier, A.5    Forget, K.6
  • 81
    • 61549089404 scopus 로고    scopus 로고
    • Effects of treatment with antimicrobial agents on the human colonic microflora
    • Rafii F. Sutherland J. Cerniglia C. (2008) Effects of treatment with antimicrobial agents on the human colonic microflora. Ther Clin Risk Manag 4: 1343–1357.
    • (2008) Ther Clin Risk Manag , vol.4 , pp. 1343-1357
    • Rafii, F.1    Sutherland, J.2    Cerniglia, C.3
  • 82
    • 84898925961 scopus 로고    scopus 로고
    • Impact of risk factors on recurrence of CDI: Comparison between CB-183,315 and oral vancomycin
    • European Congress of Clinical Microbiology and Infectious Diseases London
    • Rege S. Patino H. Bernardo P. Lee C. Mullane K. Vetticaden S. et al. (2012) Impact of risk factors on recurrence of CDI: Comparison between CB-183,315 and oral vancomycin. In European Congress of Clinical Microbiology and Infectious Diseases, London, 31 March–3 April.
    • (2012)
    • Rege, S.1    Patino, H.2    Bernardo, P.3    Lee, C.4    Mullane, K.5    Vetticaden, S.6
  • 84
    • 67649391053 scopus 로고    scopus 로고
    • Clostridium difficile infection: new developments in epidemiology and pathogenesis
    • Rupnik M. Wilcox M. Gerding D. (2009) Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat Rev Microbiol 7: 526–536.
    • (2009) Nat Rev Microbiol , vol.7 , pp. 526-536
    • Rupnik, M.1    Wilcox, M.2    Gerding, D.3
  • 85
    • 84863567901 scopus 로고    scopus 로고
    • Fidaxomicin for Clostridium difficile-associated diarrhoea; epidemiological method for estimation of warranted price
    • Sclar D. Robison L. Oganov A. Schmidt J. Bowen K. Castillo L. (2012) Fidaxomicin for Clostridium difficile-associated diarrhoea; epidemiological method for estimation of warranted price. Clin Drug investing 32: e17–e24.
    • (2012) Clin Drug investing , vol.32 , pp. e17-e24
    • Sclar, D.1    Robison, L.2    Oganov, A.3    Schmidt, J.4    Bowen, K.5    Castillo, L.6
  • 87
    • 84993685061 scopus 로고    scopus 로고
    • Typing and susceptibility of bacterial isolates from the OPT-80 (PAR-101) phase 2A study for C. difficile-associated diarrhea
    • Poster at the 9th Biennial Congress of the Anaerobe Society of the Americas Long Beach, CA
    • Sears P. Babakhani F. Citron D. (2008) Typing and susceptibility of bacterial isolates from the OPT-80 (PAR-101) phase 2A study for C. difficile-associated diarrhea. Poster at the 9th Biennial Congress of the Anaerobe Society of the Americas, Long Beach, CA.
    • (2008)
    • Sears, P.1    Babakhani, F.2    Citron, D.3
  • 88
    • 84863710720 scopus 로고    scopus 로고
    • Fidaxomicin attains high fecal concentrations with minimal plasma concentrations following oral administration in patients with clostridium difficile infection
    • Sears P. Crook D. Louie T. Miller M. Weiss K. (2012) Fidaxomicin attains high fecal concentrations with minimal plasma concentrations following oral administration in patients with clostridium difficile infection. Clin Infect Dis 55(Suppl. 2): S116e20.
    • (2012) Clin Infect Dis , vol.55 , pp. S116e20
    • Sears, P.1    Crook, D.2    Louie, T.3    Miller, M.4    Weiss, K.5
  • 89
    • 84993752921 scopus 로고    scopus 로고
    • Pharmacokinetics / pharmacodynamics (PK/PD) of fidaxomicin in treatment of Clostridium difficile infection (CDI)
    • 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) San Francisco, CA
    • Sears P. Louie T. Mullane K. Miller M. (2009) Pharmacokinetics / pharmacodynamics (PK/PD) of fidaxomicin in treatment of Clostridium difficile infection (CDI). In 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), 12–15 September, San Francisco, CA.
    • (2009)
    • Sears, P.1    Louie, T.2    Mullane, K.3    Miller, M.4
  • 90
    • 79961182388 scopus 로고    scopus 로고
    • Preliminary OPT-80 Mode of Action Studies
    • Report Number BIO090203A Optimer Pharmaceuticals, Inc San Diego, CA
    • Seddon J. Sears P. (2003) Preliminary OPT-80 Mode of Action Studies. Report Number BIO090203A, Optimer Pharmaceuticals, Inc., San Diego, CA.
    • (2003)
    • Seddon, J.1    Sears, P.2
  • 91
    • 0016828228 scopus 로고
    • Lipiamycin, a new antibiotic from actinoplanes; III. Mechanism of action
    • Sergio S. Pirali G. White R. Parenti F. (1975) Lipiamycin, a new antibiotic from actinoplanes; III. Mechanism of action. J Antibiotics (Tokyo) 38: 543–549.
    • (1975) J Antibiotics (Tokyo) , vol.38 , pp. 543-549
    • Sergio, S.1    Pirali, G.2    White, R.3    Parenti, F.4
  • 92
    • 42049099454 scopus 로고    scopus 로고
    • Safety, tolerance, and pharmacokinetic studies of OPT-80 in healthy volunteers following single and multiple oral doses
    • Shue Y. Sears P. Shangle S. Walsh R. Lee C. Gorbach S. et al. (2008) Safety, tolerance, and pharmacokinetic studies of OPT-80 in healthy volunteers following single and multiple oral doses. Antimicrob Agents Chemother 52: 1391–1395.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1391-1395
    • Shue, Y.1    Sears, P.2    Shangle, S.3    Walsh, R.4    Lee, C.5    Gorbach, S.6
  • 95
    • 84873538090 scopus 로고    scopus 로고
    • HCUP Projections: Clostridium difficile Hospitalizations 2011 to 2012
    • 2012. HCUP Projections Report # 2012–01. US Agency for Health-care Research and Quality. Available at 12/11/2012).
    • Steiner C. Barrett M. Terrel L. (2012) HCUP Projections: Clostridium difficile Hospitalizations 2011 to 2012. 2012. HCUP Projections Report # 2012–01. US Agency for Health-care Research and Quality. Available at: http://www.hcup-us.ahrq.gov/reports/projections/2012–01.pdf and http://www.hcup-us.ahqr.gov/reports/statbriefs/sb145(12/11/2012).
    • (2012)
    • Steiner, C.1    Barrett, M.2    Terrel, L.3
  • 96
    • 84875476436 scopus 로고    scopus 로고
    • Cost-effectiveness analysis evaluating fidaxomicin versus oral vancomycin for the treatment of Clostridium difficile infection in the United States
    • in press.
    • Stranges P. Hutton D. Collins C. (2013) Cost-effectiveness analysis evaluating fidaxomicin versus oral vancomycin for the treatment of Clostridium difficile infection in the United States. Value in Health, in press.
    • (2013) Value in Health
    • Stranges, P.1    Hutton, D.2    Collins, C.3
  • 97
    • 78049517194 scopus 로고    scopus 로고
    • New macrocycle antibiotic, fidaxomicin (OPT-80), causes less alteration to the bowel microbiota of Clostridium difficile-infected patients than does vancomycin
    • Tannock G. Munro K. Taylor C. Lawley B. Young W. Byrne B. et al. (2010) New macrocycle antibiotic, fidaxomicin (OPT-80), causes less alteration to the bowel microbiota of Clostridium difficile-infected patients than does vancomycin. Microbiology 156: 3354–3359.
    • (2010) Microbiology , vol.156 , pp. 3354-3359
    • Tannock, G.1    Munro, K.2    Taylor, C.3    Lawley, B.4    Young, W.5    Byrne, B.6
  • 100
    • 84863673580 scopus 로고    scopus 로고
    • Current state of Clostridium difficile treatment options
    • Venugopal A. Johnson S. (2012) Current state of Clostridium difficile treatment options. Clin Infect Dis 55(Suppl. 2): S71–S76.
    • (2012) Clin Infect Dis , vol.55 , pp. S71-S76
    • Venugopal, A.1    Johnson, S.2
  • 101
    • 84860348952 scopus 로고    scopus 로고
    • Clinical and economic burden of Clostridium difficile infection in Europe: A systematic review of health care facility acquired infection
    • Wiegand P.N. Nathwani D. Wilcox M.H. Stephens J. Shelbaya A. Haider S. (2012) Clinical and economic burden of Clostridium difficile infection in Europe: A systematic review of health care facility acquired infection. J Hosp Infect 81: 1–14.
    • (2012) J Hosp Infect , vol.81 , pp. 1-14
    • Wiegand, P.N.1    Nathwani, D.2    Wilcox, M.H.3    Stephens, J.4    Shelbaya, A.5    Haider, S.6
  • 102
    • 47249133004 scopus 로고    scopus 로고
    • A case control study of community-associated Clostridium difficile infection
    • Wilcox M. Mooney L. Bendall R. Settle C. Fawley W. (2008) A case control study of community-associated Clostridium difficile infection. Antimicrob Chemother 62: 388–396.
    • (2008) Antimicrob Chemother , vol.62 , pp. 388-396
    • Wilcox, M.1    Mooney, L.2    Bendall, R.3    Settle, C.4    Fawley, W.5
  • 103
    • 34547133720 scopus 로고    scopus 로고
    • A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity
    • Zar F. Bakkanagari S. Moorthi K. Davis M. (2007) A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity. Clin Infect Dis 45: 302–307.
    • (2007) Clin Infect Dis , vol.45 , pp. 302-307
    • Zar, F.1    Bakkanagari, S.2    Moorthi, K.3    Davis, M.4
  • 104
    • 77950682247 scopus 로고    scopus 로고
    • Clostridium difficile infections among hospitalized children, United States, 1997–2006
    • Zilberberg M. Tillotson G. McDonald L. (2010) Clostridium difficile infections among hospitalized children, United States, 1997–2006. Emerg Infect Dis 16: 604–609.
    • (2010) Emerg Infect Dis , vol.16 , pp. 604-609
    • Zilberberg, M.1    Tillotson, G.2    McDonald, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.