Development of LC-MS/MS method for the determination of dapiprazole on dried blood spots and urine: Application to pharmacokinetics

Biomedical Chromatography

Volumn 28, Issue 5, 2014, Pages 615-620

  Ramesh, Thippani ^a   Rao, Pothuraju Nageswara ^a   Rao, Ramisetti Nageswara ^b  

^a NATIONAL INSTITUTE OF TECHNOLOGY   (India)

^b INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Dapiprazole; Dried blood spots; LC MS MS; Pharmacokinetics; Rat urine

Indexed keywords

BLOOD; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; RATS;

AMMONIUM ACETATE; CHROMATOGRAPHIC SEPARATIONS; DAPIPRAZOLE; DRIED BLOOD SPOT; LC-MS-MS; LC.MS/MS; MOBILE PHASIS; RAT URINE; REVERSE PHASIS; TANDEM MASS SPECTROMETRIC;

PHARMACOKINETICS;

ACETONITRILE; AMMONIUM ACETATE; DAPIPRAZOLE; MEPIPRAZOLE; PIPERAZINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD VISCOSITY; CALIBRATION; CONTROLLED STUDY; DRIED BLOOD SPOT TESTING; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STABILITY; DRUG URINE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; HEMATOCRIT; ION MONITORING; LIMIT OF DETECTION; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SIGNAL NOISE RATIO; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; URINALYSIS; VALIDATION PROCESS; ANIMAL; BLOOD; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; PROCEDURES; URINE; WISTAR RAT;

RATTUS;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; MALE; PIPERAZINES; RATS; RATS, WISTAR; TANDEM MASS SPECTROMETRY; TRIAZOLES;

EID: 84898868472     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.3079     Document Type: Article

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