Oxalate at physiological urine concentrations induces oxidative injury in renal epithelial cells: Effect of α-tocopherol and ascorbic acid

BJU International

Volumn 114, Issue 1, 2014, Pages 140-150

  Thamilselvan, Vijayalakshmi ^a   Menon, Mani ^a   Thamilselvan, Sivagnanam ^a  

^a HENRY FORD HEALTH SYSTEM   (United States)

Author keywords

antioxidants; calcium oxalate crystals; LLC PK1 cells; oxidative stress; renal epithelial cells; urolithiasis

Indexed keywords

ALKALINE PHOSPHATASE; ALPHA TOCOPHEROL; ASCORBIC ACID; CALCIUM OXALATE; CATALASE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; LIPID HYDROPEROXIDE; OXALIC ACID; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL DAMAGE; COMPARATIVE EFFECTIVENESS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; HUMAN CELL; KIDNEY EPITHELIUM; LLC PK1 CELL LINE; NORMAL HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; URINE LEVEL;

ANTIOXIDANTS; CALCIUM OXALATE CRYSTALS; LLC-PK1 CELLS; OXIDATIVE STRESS; RENAL EPITHELIAL CELLS; UROLITHIASIS;

ALPHA-TOCOPHEROL; ANTIOXIDANTS; ASCORBIC ACID; CATALASE; EPITHELIAL CELLS; GLUTATHIONE; HUMANS; KIDNEY; L-LACTATE DEHYDROGENASE; LIPID PEROXIDES; OXALATES; OXIDATIVE STRESS; TIME FACTORS;

EID: 84898860773     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/bju.12642     Document Type: Article

References (57)

1. Pearle MS, Calhoun EA, Curhan GC,. Urologic diseases in America project: urolithiasis. J Urol 2005; 173: 848-857
2. Asplin JR,. Hyperoxaluric calcium nephrolithiasis. Endocrinol Metab Clin North Am 2002; 31: 927-949
3. Finlayson B, Reid F,. The expectation of free and fixed particles in urinary stone disease. Invest Urol 1978; 15: 442-448
4. Khan SR, Cockrell CA, Finlayson B, et al. Crystal retention by injured urothelium of the rat urinary bladder. J Urol 1984; 132: 153-157
5. Gill WB, Ruggiero K, Straus FH 2nd,. Crystallization studies in a urothelial-lined living test tube (the catheterized female rat bladder). I. Calcium oxalate crystal adhesion to the chemically injured rat bladder. Invest Urol 1979; 17: 257-261
6. Wiessner JH, Hung LY, Mandel NS,. Crystal attachment to injured renal collecting duct cells: influence of urine proteins and pH. Kidney Int 2003; 63: 1313-1320
7. Farell G, Huang E, Kim SY, et al. Modulation of proliferating renal epithelial cell affinity for calcium oxalate monohydrate crystals. J Am Soc Nephrol 2004; 15: 3052-3062
8. Thamilselvan S, Khan SR, Menon M,. Oxalate and calcium oxalate mediated free radical toxicity in renal epithelial cells: effect of antioxidants. Urol Res 2003; 31: 3-9
9. Thamilselvan S, Menon M,. Vitamin E therapy prevents hyperoxaluria- induced calcium oxalate crystal deposition in the kidney by improving renal tissue antioxidant status. BJU Int 2005; 96: 117-126
10. Thamilselvan V, Menon M, Thamilselvan S,. Oxalate-induced activation of PKC-alpha and -delta regulates NADPH oxidase-mediated oxidative injury in renal tubular epithelial cells. Am J Physiol Renal Physiol 2009; 297: F1399-1410
11. Thamilselvan V, Menon M, Thamilselvan S,. Selective Rac1 inhibition protects renal tubular epithelial cells from oxalate-induced NADPH oxidase-mediated oxidative cell injury. Urol Res 2012; 40: 415-423
12. Uttara B, Singh AV, Zamboni P, et al. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol 2009; 7: 65-74
13. Poljsak B, Šuput D, Milisav I,. Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants. Oxid Med Cell Longev 2013; 2013: 1-11
14. Niki E, Noguchi N, Tsuchihashi H, et al. Interaction among vitamin C, vitamin E, and beta-carotene. Am J Clin Nutr 1995; 62 (Suppl).): 1322S-1326
15. Calder PC, Albers R, Antoine JM, et al. Inflammatory disease processes and interactions with nutrition. Br J Nutr 2009; 101 (Suppl. 1): S1-45
16. Carr A, Frei B,. Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J 1999; 13: 1007-1024
17. Livingstone C, Davis J,. Targeting therapeutics against glutathione depletion in diabetes and its complications. Br J Diabetes Vasc Dis 2007; 7: 258-265
18. Gerster H,. No contribution of ascorbic acid to renal calcium oxalate stones. Ann Nutr Metab 1997; 41: 269-282
19. Deicher R, Horl WH,. Vitamin C in chronic kidney disease and hemodialysis patients. Kidney Blood Press Res 2003; 26: 100-106
20. Rathi S, Kern W, Lau K,. Vitamin C-induced hyperoxaluria causing reversible tubulointerstitial nephritis and chronic renal failure: a case report. J Med Case Rep 2007; 1: 155.1-155.6
21. Traxer O, Huet B, Poindexter J, et al. Effect of ascorbic acid consumption on urinary stone risk factors. J Urol 2003; 170: 397-401
22. Curhan GC, Willett WC, Rimm EB, et al. A prospective study of the intake of vitamins C and B6, and the risk of kidney stones in men. J Urol 1996; 155: 1847-1851
23. Scheid C, Koul H, Hill WA, et al. Oxalate toxicity in LLC-PK1 cells: role of free radicals. Kidney Int 1996; 49: 413-419
24. Wiessner JH, Hasegawa AT, Hung LY, et al. Oxalate-induced exposure of phosphatidylserine on the surface of renal epithelial cells in culture. J Am Soc Nephrol 1999; 10 (Suppl. 14): S441-445
25. Khaskhali MH, Byer KJ, Khan SR,. The effect of calcium on calcium oxalate monohydrate crystal-induced renal epithelial injury. Urol Res 2009; 37: 1-6
26. Lee HJ, Jeong SJ, Park MN, et al. Gallotannin suppresses calcium oxalate crystal binding and oxalate-induced oxidative stress in renal epithelial cells. Biol Pharm Bull 2012; 35: 539-544
27. Schepers MS, van Ballegooijen ES, Bangma CH, et al. Oxalate is toxic to renal tubular cells only at supraphysiologic concentrations. Kidney Int 2005; 68: 1660-1669
28. Rashed T, Menon M, Thamilselvan S,. Molecular mechanism of oxalate-induced free radical production and glutathione redox imbalance in renal epithelial cells: effect of antioxidants. Am J Nephrol 2004; 24: 557-568
29. Holmes RP, Ambrosius WT, Assimos DG,. Dietary oxalate loads and renal oxalate handling. J Urol 2005; 174: 943-947
30. Mahfoud R, Maresca M, Garmy N, et al. The mycotoxin patulin alters the barrier function of the intestinal epithelium: mechanism of action of the toxin and protective effects of glutathione. Toxicol Appl Pharmacol 2002; 181: 209-218
31. Horwitz LD, Leff JA,. Catalase and hydrogen peroxide cytotoxicity in cultured cardiac myocytes. J Mol Cell Cardiol 1995; 27: 909-915
32. Schraufstatter IU, Hinshaw DB, Hyslop PA, et al. Glutathione cycle activity and pyridine nucleotide levels in oxidant-induced injury of cells. J Clin Invest 1985; 76: 1131-1139
33. Brunton VG, Grant MH, Wallace HM,. Mechanisms of spermine toxicity in baby-hamster kidney (BHK) cells. The role of amine oxidases and oxidative stress. Biochem J 1991; 280: 193-198
34. Coe FL, Parks JH, Asplin JR,. The pathogenesis and treatment of kidney stones. N Engl J Med 1992; 327: 1141-1152
35. Coe FL, Evan A, Worcester E,. Kidney stone disease. J Clin Invest 2005; 115: 2598-2608
36. Thamilselvan S, Hackett RL, Khan SR,. Lipid peroxidation in ethylene glycol induced hyperoxaluria and calcium oxalate nephrolithiasis. J Urol 1997; 157: 1059-1063
37. DeChatelet LR, Cooper MR,. A modified procedure for the determination of leukocyte alkaline phosphatase. Biochem Med 1970; 4: 61-68
38. Naftalin L, Sexton M, Whitaker JF, et al. A routine procedure for estimating serum gamma-glutamyltranspeptidase activity. Clin Chim Acta 1969; 26: 293-296
39. Thamilselvan V, Menon M, Thamilselvan S,. Carmustine enhances the anticancer activity of selenite in androgen-independent prostate cancer cells. Cancer Manag Res 2012; 4: 383-395
40. Huang HS, Ma MC, Chen CF, et al. Lipid peroxidation and its correlations with urinary levels of oxalate, citric acid, and osteopontin in patients with renal calcium oxalate stones. Urology 2003; 62: 1123-1128
41. Tungsanga K, Sriboonlue P, Futrakul P, et al. Renal tubular cell damage and oxidative stress in renal stone patients and the effect of potassium citrate treatment. Urol Res 2005; 33: 65-69
42. Balcke P, Zazgornik J, Sunder-Plassmann G, et al. Transient hyperoxaluria after ingestion of chocolate as a high risk factor for calcium oxalate calculi. Nephron 1989; 51: 32-34
43. Nguyen NU, Henriet MT, Dumoulin G, et al. Increase in calciuria and oxaluria after a single chocolate bar load. Horm Metab Res 1994; 26: 383-386
44. McMartin K,. Are calcium oxalate crystals involved in the mechanism of acute renal failure in ethylene glycol poisoning? Clin Toxicol (Phila) 2009; 47: 859-869
45. Lieske JC, Toback FG, Deganello S,. Direct nucleation of calcium oxalate dihydrate crystals onto the surface of living renal epithelial cells in culture. Kidney Int 1998; 54: 796-803
46. Bhandari A, Koul S, Sekhon A, et al. Effects of oxalate on HK-2 cells, a line of proximal tubular epithelial cells from normal human kidney. J Urol 2002; 168: 253-259
47. Fishman AI, Green D, Lynch A, et al. Preventive effect of specific antioxidant on oxidative renal cell injury associated with renal crystal formation. Urology 2013; 82: 489.e1-489.e7
48. Thamilselvan S, Byer KJ, Hackett RL, et al. Free radical scavengers, catalase and superoxide dismutase provide protection from oxalate-associated injury to LLC-PK1 and MDCK cells. J Urol 2000; 164: 224-229
49. Brown LA, Harris FL, Jones DP,. Ascorbate deficiency and oxidative stress in the alveolar type II cell. Am J Physiol 1997; 273: L782-788
50. Ansar S, Iqbal M,. Role of ascorbic acid in counteracting ferric nitrilotriacetate-induced nephrotoxicity in rats. Pharm Biol 2013; 51: 1559-1563
51. Auer BL, Auer D, Rodgers AL,. Relative hyperoxaluria, crystalluria and haematuria after megadose ingestion of vitamin C. Eur J Clin Invest 1998; 28: 695-700
52. Auer BL, Auer D, Rodgers AL,. The effect of ascorbic acid ingestion on the biochemical and physicochemical risk factors associated with calcium oxalate kidney stone formation. Clin Chem Lab Med 1998; 36: 143-147
53. Baxmann AC, De OGMC, Heilberg IP,. Effect of vitamin C supplements on urinary oxalate and pH in calcium stone-forming patients. Kidney Int 2003; 63: 1066-1071
54. Chalmers AH, Cowley DM, Brown JM,. A possible etiological role for ascorbate in calculi formation. Clin Chem 1986; 32: 333-336
55. Wandzilak TR, D'Andre SD, Davis PA, et al. Effect of high dose vitamin C on urinary oxalate levels. J Urol 1994; 151: 834-837
56. Preminger GM,. Oxaluria-the neglected stepchild of nephrolithiasis? J Urol 2003; 170: 402-403
57. Schwille PO, Schmiedl A, Herrmann U, et al. Ascorbic acid in idiopathic recurrent calcium urolithiasis in humans-does it have an abettor role in oxalate, and calcium oxalate crystallization? Urol Res 2000; 28: 167-177 Diseases