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Volumn 96, Issue 1, 2005, Pages 117-126

Vitamin E therapy prevents hyperoxaluria-induced calcium oxalate crystal deposition in the kidney by improving renal tissue antioxidant status

Author keywords

Antioxidants; Ethylene glycol; Hyperoxaluria; Lipid peroxidation; Sprague Dawley rats; Urolithiasis; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; CALCIUM; CALCIUM OXALATE; ENZYME; ETHYLENE GLYCOL; FREE RADICAL; GLUTATHIONE; THIOL DERIVATIVE;

EID: 21744445645     PISSN: 14644096     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2005.05579.x     Document Type: Article
Times cited : (107)

References (60)
  • 1
    • 0003316415 scopus 로고
    • Pathogenesis of urolithiasis
    • Schneider HJ ed. Chapter 3. New York, Springer
    • Robertson WG, Peacock M. Pathogenesis of urolithiasis. In Schneider HJ ed. HS-V & Urolithiasis, Etiology, Diagnosis. Chapter 3. New York, Springer 1985:185-301
    • (1985) HS-V & Urolithiasis, Etiology, Diagnosis , pp. 185-301
    • Robertson, W.G.1    Peacock, M.2
  • 3
    • 0000033831 scopus 로고
    • Nordin BEC, AG Na HAM, Hong Kong: Churchill Livingston
    • Robertson WG. Urinary Tract Calculi. In Nordin BEC, AG Na HAM, Hong Kong: Churchill Livingston, 1993: 249
    • (1993) Urinary Tract Calculi , pp. 249
    • Robertson, W.G.1
  • 4
    • 0020979710 scopus 로고
    • The clinical chemistry of oxalate metabolism
    • Laker MF. The clinical chemistry of oxalate metabolism. Adv Clin Chem 1983; 23: 259-97
    • (1983) Adv Clin Chem , vol.23 , pp. 259-297
    • Laker, M.F.1
  • 5
    • 0035174408 scopus 로고    scopus 로고
    • Contribution of dietary oxalate to urinary oxalate excretion
    • Holmes RP, Goodman HO, Assimos DG. Contribution of dietary oxalate to urinary oxalate excretion. Kidney Int 2001; 59: 270-6
    • (2001) Kidney Int , vol.59 , pp. 270-276
    • Holmes, R.P.1    Goodman, H.O.2    Assimos, D.G.3
  • 7
    • 0026577986 scopus 로고
    • Clinical review 32: Calcium oxalate nephrolithiasis
    • Menon M, Koul H. Clinical review 32: Calcium oxalate nephrolithiasis. J Clin Endocrinol Metab 1992; 74: 703-7
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 703-707
    • Menon, M.1    Koul, H.2
  • 8
    • 0025696387 scopus 로고
    • Idiopathic calcium oxalate urolithiasis
    • Smith LH. Idiopathic calcium oxalate urolithiasis. Endocrinol Metab Clin North Am 1990; 19: 937-47
    • (1990) Endocrinol Metab Clin North Am , vol.19 , pp. 937-947
    • Smith, L.H.1
  • 9
    • 0035723912 scopus 로고    scopus 로고
    • Possibilities for preventing recurrent calcium stone formation. Principles for the metabolic evaluation of patients with calcium stone disease
    • Tiselius HG. Possibilities for preventing recurrent calcium stone formation. Principles for the metabolic evaluation of patients with calcium stone disease. BJU Int 2001; 88: 158-68
    • (2001) BJU Int , vol.88 , pp. 158-168
    • Tiselius, H.G.1
  • 10
    • 0038522834 scopus 로고    scopus 로고
    • Oxalate and calcium oxalate mediated free radical toxicity in renal epithelial cells: Effect of antioxidants
    • Thamilselvan S, Khan SR, Menon M. Oxalate and calcium oxalate mediated free radical toxicity in renal epithelial cells: effect of antioxidants. Urol Res 2003; 31: 3-9
    • (2003) Urol Res , vol.31 , pp. 3-9
    • Thamilselvan, S.1    Khan, S.R.2    Menon, M.3
  • 11
    • 0033920725 scopus 로고    scopus 로고
    • Free radical scavengers, catalase and superoxide dismutase provide protection from oxalate-associated injury to LLC-PK1 and MDCK cells
    • Thamilselvan S, Byer KJ, Hackett RL, Khan SR. Free radical scavengers, catalase and superoxide dismutase provide protection from oxalate-associated injury to LLC-PK1 and MDCK cells. J Urol 2000; 164: 224-9
    • (2000) J Urol , vol.164 , pp. 224-229
    • Thamilselvan, S.1    Byer, K.J.2    Hackett, R.L.3    Khan, S.R.4
  • 12
    • 0031150916 scopus 로고    scopus 로고
    • Effect of vitamin e and mannitol on renal calcium oxalate retention in experimental nephrolithiasis
    • Thamilselvan S, Selvam R. Effect of vitamin E and mannitol on renal calcium oxalate retention in experimental nephrolithiasis. Indian J Biochem Biophys 1997; 34: 319-23
    • (1997) Indian J Biochem Biophys , vol.34 , pp. 319-323
    • Thamilselvan, S.1    Selvam, R.2
  • 13
    • 0031971645 scopus 로고    scopus 로고
    • Oxalate and calcium oxalate crystals are injurious to renal epithelial cells: Results of in vivo and in vitro studies
    • Thamilselvan S, Khan SR. Oxalate and calcium oxalate crystals are injurious to renal epithelial cells: results of in vivo and in vitro studies. J Nephrol 1998; 11 (Suppl. 1): 66-9
    • (1998) J Nephrol , vol.11 , Issue.SUPPL. 1 , pp. 66-69
    • Thamilselvan, S.1    Khan, S.R.2
  • 14
    • 0036285355 scopus 로고    scopus 로고
    • Effects of oxalate on HK-2 cells, a line of proximal tubular epithelial cells from normal human kidney
    • Bhandari A, Koul S, Sekhon A et al. Effects of oxalate on HK-2 cells, a line of proximal tubular epithelial cells from normal human kidney. J Urol 2002; 168: 253-9
    • (2002) J Urol , vol.168 , pp. 253-259
    • Bhandari, A.1    Koul, S.2    Sekhon, A.3
  • 15
    • 0030033722 scopus 로고    scopus 로고
    • Oxalate toxicity in LLC-PK1 cells, role of free radicals
    • Scheid C, Koul H, Hill WA et al. Oxalate toxicity in LLC-PK1 cells, role of free radicals. Kidney Int 1996; 49: 413-9
    • (1996) Kidney Int , vol.49 , pp. 413-419
    • Scheid, C.1    Koul, H.2    Hill, W.A.3
  • 16
    • 0017872475 scopus 로고
    • Microsomal lipid peroxidation
    • Buege JA, Aust SD. Microsomal lipid peroxidation. Meth Enzymol 1978; 52: 302-10
    • (1978) Meth Enzymol , vol.52 , pp. 302-310
    • Buege, J.A.1    Aust, S.D.2
  • 17
    • 0028291974 scopus 로고
    • Carbonyl assays for determination of oxidatively modified proteins
    • Levine RL, Williams JA, Stadtman ER, Shacter E. Carbonyl assays for determination of oxidatively modified proteins. Meth Enzymol 1994; 233: 346-57
    • (1994) Meth Enzymol , vol.233 , pp. 346-357
    • Levine, R.L.1    Williams, J.A.2    Stadtman, E.R.3    Shacter, E.4
  • 18
    • 0026323470 scopus 로고
    • Simultaneous determination of retinol, alpha-tocopherol and beta-carotene in serum by isocratic high-performance liquid chromatography
    • Arnaud J, Fortis I, Blachier S, Kia D, Favier A. Simultaneous determination of retinol, alpha-tocopherol and beta-carotene in serum by isocratic high-performance liquid chromatography. J Chromatogr 1991; 572: 103-16
    • (1991) J Chromatogr , vol.572 , pp. 103-116
    • Arnaud, J.1    Fortis, I.2    Blachier, S.3    Kia, D.4    Favier, A.5
  • 19
    • 0015523099 scopus 로고
    • The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase
    • Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972; 247: 3170-5
    • (1972) J Biol Chem , vol.247 , pp. 3170-3175
    • Misra, H.P.1    Fridovich, I.2
  • 20
    • 0015353270 scopus 로고
    • Colorimetric assay of catalase
    • Sinha AK. Colorimetric assay of catalase. Anal Biochem 1972; 47: 389-94
    • (1972) Anal Biochem , vol.47 , pp. 389-394
    • Sinha, A.K.1
  • 21
    • 0014481378 scopus 로고
    • Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
    • Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 1969; 27: 502-22
    • (1969) Anal Biochem , vol.27 , pp. 502-522
    • Tietze, F.1
  • 22
    • 0014108436 scopus 로고
    • Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
    • Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Laboratory Clin Med 1967; 70: 158-69
    • (1967) J Laboratory Clin Med , vol.70 , pp. 158-169
    • Paglia, D.E.1    Valentine, W.N.2
  • 24
    • 0001422064 scopus 로고
    • Glucose-6-phosphate dehydrogenase
    • Bergmeyer HV ed. New York: Academic Press
    • Deutsch J. Glucose-6-phosphate dehydrogenase. In Bergmeyer HV ed. Methods in Enzymatic Analysis. 3rd edn. Vol. 3. New York: Academic Press, 1983: 190-7
    • (1983) Methods in Enzymatic Analysis. 3rd Edn. , vol.3 , pp. 190-197
    • Deutsch, J.1
  • 25
    • 0014123609 scopus 로고
    • Rapid determination of urea nitrogen in serum or plasma without deproteinization
    • Crocker CL. Rapid determination of urea nitrogen in serum or plasma without deproteinization. Am J Med Technol 1967; 33: 361-5
    • (1967) Am J Med Technol , vol.33 , pp. 361-365
    • Crocker, C.L.1
  • 26
    • 0000100285 scopus 로고
    • Endogenous creatinine in serum and urine
    • Hare RS. Endogenous creatinine in serum and urine. Proc Soc Exp Biol Medical 1950; 74: 148-51
    • (1950) Proc Soc Exp Biol Medical , vol.74 , pp. 148-151
    • Hare, R.S.1
  • 27
    • 0031013227 scopus 로고    scopus 로고
    • Lipid peroxidation in ethylene glycol induced hyperoxaluria and calcium oxalate nephrolithiasis
    • Thamilselvan S, Hackett RL, Khan SR. Lipid peroxidation in ethylene glycol induced hyperoxaluria and calcium oxalate nephrolithiasis. J Urol 1997; 157: 1059-63
    • (1997) J Urol , vol.157 , pp. 1059-1063
    • Thamilselvan, S.1    Hackett, R.L.2    Khan, S.R.3
  • 28
    • 0000191753 scopus 로고
    • Lactate dehydrogenase
    • Bergmeyer HV ed. New York: Academic Press
    • Vassault A. Lactate dehydrogenase. In Bergmeyer HV ed. Methods in Enzymatic Analysis. 3rd edn. Vol. 3. New York: Academic Press, 1983: 118-26
    • (1983) Methods in Enzymatic Analysis. 3rd Edn. , vol.3 , pp. 118-126
    • Vassault, A.1
  • 29
    • 0018935367 scopus 로고
    • An optimized assay of alanine aminopeptidase activity in urine
    • Jung K, Scholz D. An optimized assay of alanine aminopeptidase activity in urine. Clin Chem 1980; 26: 1251-4
    • (1980) Clin Chem , vol.26 , pp. 1251-1254
    • Jung, K.1    Scholz, D.2
  • 30
    • 0021890780 scopus 로고
    • Calcium oxalate urolithiasis in the rat. Is it a model for human stone disease? A review of recent literature
    • Khan SR, Hackett RL. Calcium oxalate urolithiasis in the rat. is it a model for human stone disease? A review of recent literature. Scon Electron Microsc 1985; PT2: 759-74
    • (1985) Scon Electron Microsc , vol.2 , pp. 759-774
    • Khan, S.R.1    Hackett, R.L.2
  • 31
    • 0026329727 scopus 로고
    • A new model of nephrolithiasis involving tubular dysfunction/injury
    • Kumar S, Sigmon D, Miller T et al. A new model of nephrolithiasis involving tubular dysfunction/injury. J Urol 1991; 146: 384-9
    • (1991) J Urol , vol.146 , pp. 384-389
    • Kumar, S.1    Sigmon, D.2    Miller, T.3
  • 32
    • 0028820172 scopus 로고
    • Etiology of calcium oxalate nephrolithiasis in rats. I. Can this be a model for human stone formation?
    • de Bruijn WC, Boeve ER, van Run PR et al. Etiology of calcium oxalate nephrolithiasis in rats. I. Can this be a model for human stone formation? Scanning Microsc 1995; 9: 103-14
    • (1995) Scanning Microsc , vol.9 , pp. 103-114
    • De Bruijn, W.C.1    Boeve, E.R.2    Van Run, P.R.3
  • 33
    • 0028883857 scopus 로고
    • Etiology of calcium oxalate nephrolithiasis in rats. II. The role of the papilla in stone formation
    • de Bruijn WC, Boeve ER, van Run PR et al. Etiology of calcium oxalate nephrolithiasis in rats. II. The role of the papilla in stone formation. Scanning Microsc 1995; 9: 115-25
    • (1995) Scanning Microsc , vol.9 , pp. 115-125
    • De Bruijn, W.C.1    Boeve, E.R.2    Van Run, P.R.3
  • 34
    • 0030632544 scopus 로고    scopus 로고
    • Animal models of kidney stone formation: An analysis
    • Khan SR. Animal models of kidney stone formation: an analysis. World Urol 1997; 15: 236-43
    • (1997) World Urol , vol.15 , pp. 236-243
    • Khan, S.R.1
  • 35
    • 0025994821 scopus 로고
    • The inhibition of radical-initiated peroxidation of microsomal lipids by both alpha-tocopherol and beta-carotene
    • Palozza P, Krinsky NI. The inhibition of radical-initiated peroxidation of microsomal lipids by both alpha-tocopherol and beta-carotene. Free Radic Biol Med 1991; 11: 407-14
    • (1991) Free Radic Biol Med , vol.11 , pp. 407-414
    • Palozza, P.1    Krinsky, N.I.2
  • 36
    • 0027202219 scopus 로고
    • Electron spin resonance evidence for free radical generation in copper-treated vitamin E- And selenium-deficient rats: In vivo spin-trapping investigation
    • Kadiiska MB, Hanna PM, Jordan SJ, Mason RP. Electron spin resonance evidence for free radical generation in copper-treated vitamin E- and selenium-deficient rats: in vivo spin-trapping investigation. Mol Pharmacol 1993; 44: 222-7
    • (1993) Mol Pharmacol , vol.44 , pp. 222-227
    • Kadiiska, M.B.1    Hanna, P.M.2    Jordan, S.J.3    Mason, R.P.4
  • 37
    • 0031937950 scopus 로고    scopus 로고
    • Development of calcium oxalate crystals on urothelium: Effect of free radicals
    • Grases F, Garcia-Ferragut L, Costa-Bauza A. Development of calcium oxalate crystals on urothelium: effect of free radicals. Nephron 1998; 78: 296-301
    • (1998) Nephron , vol.78 , pp. 296-301
    • Grases, F.1    Garcia-Ferragut, L.2    Costa-Bauza, A.3
  • 38
    • 0344665768 scopus 로고    scopus 로고
    • Lipid peroxidation and its correlations with urinary levels of oxalate, citric acid, and osteopontin in patients with renal calcium oxalate stones
    • Huang HS, Ma MC, Chen CF, Chen J. Lipid peroxidation and its correlations with urinary levels of oxalate, citric acid, and osteopontin in patients with renal calcium oxalate stones. Urology 2003; 62: 1123-8
    • (2003) Urology , vol.62 , pp. 1123-1128
    • Huang, H.S.1    Ma, M.C.2    Chen, C.F.3    Chen, J.4
  • 39
    • 16844369272 scopus 로고    scopus 로고
    • Renal tubular cell damage and oxidative stress in renal stone patients and the effect of potassium citrate treatment
    • Tungsanga K, Sriboonlue P, Futrakul P, Yachantha C, Tosukhowong P. Renal tubular cell damage and oxidative stress in renal stone patients and the effect of potassium citrate treatment. Urol Res 2005; 33: 65-9
    • (2005) Urol Res , vol.33 , pp. 65-69
    • Tungsanga, K.1    Sriboonlue, P.2    Futrakul, P.3    Yachantha, C.4    Tosukhowong, P.5
  • 40
    • 0041368543 scopus 로고    scopus 로고
    • Cigarette smoking cessation increases plasma levels of several antioxidant micronutrients and improves resistance towards oxidative challenge
    • Polidori MC, Mecocci P, Stahl W, Sies H. Cigarette smoking cessation increases plasma levels of several antioxidant micronutrients and improves resistance towards oxidative challenge. Br J Nutr 2003; 90: 147-50
    • (2003) Br J Nutr , vol.90 , pp. 147-150
    • Polidori, M.C.1    Mecocci, P.2    Stahl, W.3    Sies, H.4
  • 41
    • 0028632792 scopus 로고
    • Involvement of free radical mechanism in the toxic effects of alcohol: Implications for fetal alcohol syndrome
    • Guerri C, Montoliu C, Renau-Piqueras J. Involvement of free radical mechanism in the toxic effects of alcohol: implications for fetal alcohol syndrome. Adv Exp Med Biol 1994; 366: 291-305
    • (1994) Adv Exp Med Biol , vol.366 , pp. 291-305
    • Guerri, C.1    Montoliu, C.2    Renau-Piqueras, J.3
  • 42
    • 0024455138 scopus 로고
    • Urinary enzymes and calcium oxalate urolithiasis
    • Khan SR, Shevock PN, Hackett RL Urinary enzymes and calcium oxalate urolithiasis. J Urol 1989; 142: 846-9
    • (1989) J Urol , vol.142 , pp. 846-849
    • Khan, S.R.1    Shevock, P.N.2    Hackett, R.L.3
  • 43
    • 0020619888 scopus 로고
    • Increased urinary excretion of renal enzymes in idiopathic calcium oxalate nephrolithiasis
    • Baggio B, Gambaro G, Ossi E, Favaro S, Borsatti A. Increased urinary excretion of renal enzymes in idiopathic calcium oxalate nephrolithiasis. J Urol 1983; 129: 1161-2
    • (1983) J Urol , vol.129 , pp. 1161-1162
    • Baggio, B.1    Gambaro, G.2    Ossi, E.3    Favaro, S.4    Borsatti, A.5
  • 44
    • 0017818768 scopus 로고
    • Kinetics of early time calcium oxalate nephrolithiasis
    • Jordan WR, Finlayson B, Luxenberg M. Kinetics of early time calcium oxalate nephrolithiasis. Invest Urol 1978; 15: 465-8
    • (1978) Invest Urol , vol.15 , pp. 465-468
    • Jordan, W.R.1    Finlayson, B.2    Luxenberg, M.3
  • 46
    • 0017946024 scopus 로고
    • Renal tubular transport of organic acids. Studies with oxalate and para-aminohippurate in the rat
    • Weinman EJ, Frankfurt SJ, Ince A, Sansom S. Renal tubular transport of organic acids. Studies with oxalate and para-aminohippurate in the rat. J Clin Invest 1978; 61: 801-6
    • (1978) J Clin Invest , vol.61 , pp. 801-806
    • Weinman, E.J.1    Frankfurt, S.J.2    Ince, A.3    Sansom, S.4
  • 47
    • 0017809103 scopus 로고
    • The expectation of free and fixed particles in urinary stone disease
    • Finlayson B, Reid F. The expectation of free and fixed particles in urinary stone disease. Invest Urol 1978; 15: 442-8
    • (1978) Invest Urol , vol.15 , pp. 442-448
    • Finlayson, B.1    Reid, F.2
  • 48
    • 0037378489 scopus 로고    scopus 로고
    • Crystal attachment to injured renal collecting duct cells, influence of urine proteins and pH
    • Wiessner JH, Hung LY, Mandel NS. Crystal attachment to injured renal collecting duct cells, influence of urine proteins and pH. Kidney Int 2003; 63: 1313-20
    • (2003) Kidney Int , vol.63 , pp. 1313-1320
    • Wiessner, J.H.1    Hung, L.Y.2    Mandel, N.S.3
  • 49
    • 0030867876 scopus 로고    scopus 로고
    • Surface exposure of phosphatidylserine increases calcium oxalate crystal attachment to IMCD cells
    • Bigelow MW, Wiessner JH, Kleinman JG, Mandel NS. Surface exposure of phosphatidylserine increases calcium oxalate crystal attachment to IMCD cells. Am J Physiol 1997; 272: F55-62
    • (1997) Am J Physiol , vol.272
    • Bigelow, M.W.1    Wiessner, J.H.2    Kleinman, J.G.3    Mandel, N.S.4
  • 50
    • 0035086643 scopus 로고    scopus 로고
    • Oxalate-induced redistribution of phosphatidylserine in renal epithelial cells: Implications for kidney stone disease
    • Cao LC, Jonassen J, Honeyman TW, Scheid C. Oxalate-induced redistribution of phosphatidylserine in renal epithelial cells: implications for kidney stone disease. Am J Nephrol 2001; 21: 69-77
    • (2001) Am J Nephrol , vol.21 , pp. 69-77
    • Cao, L.C.1    Jonassen, J.2    Honeyman, T.W.3    Scheid, C.4
  • 51
    • 0032705806 scopus 로고    scopus 로고
    • Crystal-cell interaction and apoptosis in oxalate-associated injury of renal epithelial cells
    • Khan SR, Byer KJ, Thamilselvan S et al. Crystal-cell interaction and apoptosis in oxalate-associated injury of renal epithelial cells. J Am Soc Nephrol 1999; 10 (Suppl. 14): 5457-63
    • (1999) J Am Soc Nephrol , vol.10 , Issue.SUPPL. 14 , pp. 5457-5463
    • Khan, S.R.1    Byer, K.J.2    Thamilselvan, S.3
  • 52
    • 0025689414 scopus 로고
    • Cell injury associated calcium oxalate crystalluria
    • Hackett RL, Shevock PN, Khan SR. Cell injury associated calcium oxalate crystalluria. J Urol 1990; 144: 1535-8
    • (1990) J Urol , vol.144 , pp. 1535-1538
    • Hackett, R.L.1    Shevock, P.N.2    Khan, S.R.3
  • 53
    • 0345868263 scopus 로고    scopus 로고
    • Calcium oxalate crystal adherence in the rat bladder, restoration of anti-adherence after acid treatment
    • Smith CL. Calcium oxalate crystal adherence in the rat bladder, restoration of anti-adherence after acid treatment. J Urol 2004; 171: 882-4
    • (2004) J Urol , vol.171 , pp. 882-884
    • Smith, C.L.1
  • 54
    • 0035131925 scopus 로고    scopus 로고
    • Mechanisms of calcium oxalate crystal attachment to injured renal collecting duct cells
    • Wiessner JH, Hasegawa AT, Hung LY, Mandel GS, Mandel NS. Mechanisms of calcium oxalate crystal attachment to injured renal collecting duct cells. Kidney Int 2001; 59: 637-44
    • (2001) Kidney Int , vol.59 , pp. 637-644
    • Wiessner, J.H.1    Hasegawa, A.T.2    Hung, L.Y.3    Mandel, G.S.4    Mandel, N.S.5
  • 55
    • 0036280758 scopus 로고    scopus 로고
    • Selective peroxidation and externalization of phosphatidylserine in normal human epidermal keratinocytes during oxidative stress induced by cumene hydroperoxide
    • Shvedova AA, Tyurina JY, Kawai K et al. Selective peroxidation and externalization of phosphatidylserine in normal human epidermal keratinocytes during oxidative stress induced by cumene hydroperoxide. J Invest Dermatol 2002; 118: 1008-18
    • (2002) J Invest Dermatol , vol.118 , pp. 1008-1018
    • Shvedova, A.A.1    Tyurina, J.Y.2    Kawai, K.3
  • 56
    • 0028978173 scopus 로고
    • Vitamin E
    • Meydani M. Vitamin E. Lancet 1995; 345: 170-5
    • (1995) Lancet , vol.345 , pp. 170-175
    • Meydani, M.1
  • 57
    • 0032933234 scopus 로고    scopus 로고
    • Urinary excretion of 2,7,8-trimethyl-2-(beta-carboxyethyl)-6- hydroxylchroman is a major route of elimination of gamma-tocopherol in humans
    • Swanson JE, Ben RN, Burton GW, Parker RS. Urinary excretion of 2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxylchroman is a major route of elimination of gamma-tocopherol in humans. J Lipid Res 1999; 40: 665-71
    • (1999) J Lipid Res , vol.40 , pp. 665-671
    • Swanson, J.E.1    Ben, R.N.2    Burton, G.W.3    Parker, R.S.4
  • 58
    • 0028858639 scopus 로고
    • Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2 (2′-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin e supply?
    • Schultz M, Leist M, Petzika M, Gassmann B, Bridglius-Flohe R. Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2 (2′-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply? Am J Clin Nutr 1995; 62: 1527S-34S
    • (1995) Am J Clin Nutr , vol.62
    • Schultz, M.1    Leist, M.2    Petzika, M.3    Gassmann, B.4    Bridglius-Flohe, R.5
  • 59
    • 0036681851 scopus 로고    scopus 로고
    • In vitro antioxidant activity of 2,5,7,8-tetramethyl-2-2′- carboxyethyl-6-hydroxylchroman (alpha-CEHC), a vitamin e metabolite
    • Betancor-Fernandez A, Sies H, Stahl W, Poridori MC. In vitro antioxidant activity of 2,5,7,8-tetramethyl-2-(2′-carboxyethyl-6-hydroxylchroman (alpha-CEHC), a vitamin E metabolite. Free Rad Res 2002 36: 915-21
    • (2002) Free Rad Res , vol.36 , pp. 915-921
    • Betancor-Fernandez, A.1    Sies, H.2    Stahl, W.3    Poridori, M.C.4
  • 60
    • 0035816171 scopus 로고    scopus 로고
    • LLU-alpha, an endogenous metabolite of gamma-tocopherol, is more effective against metal nephrotoxicity in rats than gamma-tocopherol
    • Appenroth D, Karge E, Kiebling G, Wechter WJ, Winnefeld K, Fleck C. LLU-alpha, an endogenous metabolite of gamma-tocopherol, is more effective against metal nephrotoxicity in rats than gamma-tocopherol. Toxicol Lett 2001; 122: 255-65
    • (2001) Toxicol Lett , vol.122 , pp. 255-265
    • Appenroth, D.1    Karge, E.2    Kiebling, G.3    Wechter, W.J.4    Winnefeld, K.5    Fleck, C.6


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