Relative hyperoxaluria, crystalluria and haematuria after megadose ingestion of vitamin C

European Journal of Clinical Investigation

Volumn 28, Issue 9, 1998, Pages 695-700

  Auer, B L ^a   Auer, D ^a   Rodgers, A L ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Ascorbic acid; Calcium oxalate crystalluria; Haematuria; Relative hyperoxaluria; Vitamin C

Indexed keywords

ASCORBIC ACID; OXALIC ACID; SCORBEX; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CASE REPORT; CRYSTALLURIA; DRUG DETERMINATION; DRUG MEGADOSE; DRUG URINE LEVEL; HEMATURIA; HUMAN; HUMAN TISSUE; HYPEROXALURIA; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TITRIMETRY; URINALYSIS;

ADULT; ASCORBIC ACID; CALCIUM OXALATE; CRYSTALLIZATION; HEMATURIA; HUMANS; HYPEROXALURIA; KIDNEY CALCULI; MALE; MICROSCOPY, ELECTRON, SCANNING; RISK FACTORS; TIME FACTORS;

EID: 0031685282     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1998.00349.x     Document Type: Article

References (22)

1. Ringsdorf WM, Cheraskin E. Nutritional aspects of urolithiasis. Southern Med J 1981; 14: 41-7.
2. Urivetzky M, Kessaris D, Smith AD. Ascorbic acid overdosing: A risk factor for calcium oxalate nephrolithiasis. J Urol 1992; 147: 1215-8.
3. Hughes C, Dutton S, Stewart-Truswell A. High intakes of ascorbic acid and urinary oxalate. J Hum Nutr 1981; 35: 274-80.
4. Borsati A. Calcium oxalate nephrolithiasis: defective oxalate transport. Kidney Int 1991; 39: 1283-98.
5. Hatch M, Mulgrew S, Bourke E, Keogh B, Costello J. Effects of megadoses of ascorbic acid on serum and urinary oxalate. Eur Urol 1980; 6: 166-9.
6. Chalmers AH, Cowley DM, McWhinney BC. Stability of ascorbate in urine: Relevance to analysis for ascorbate and oxalate. Clin Chem 1985; 3: 1703-5.
7. McMurray W, Gowenlock AH. Vitamins. In: Gowenlock AH, ed. Varley's Practical Clinical Biochemistry, 6th edn. London: Heinemann Medical Books 1988: 894-930.
8. Werness PG, Brown CM, Smith LH, Finlayson B. EQUIL 2: a basic computer program for the calculation of urinary saturation. J Urol 1985; 134: 1242-4.
9. Tiselius HG. An improved method for the routine biochemical evaluation of patients with recurrent calcium oxalate stone disease. Clin Chim Acta 1982; 122: 409-18.
10. Tiselius HG, Almgard LE. The diurnal urinary excretion of oxalate and the effect of pyridoxine and ascorbate on oxalate excretion. Eur Urol 1977; 3: 41-6.
11. Chalmers AH, Cowley DM, Brown JM. A possible edological role for ascorbate in calculi formation. Clin Chem 1986; 32: 333-6.
12. Trinchieri A, Mandress A, Luongo P. The influence of diet on urinary risk factors for stones in healthy subjects and idiopathic renal calcium stone formers. Br J Urol 1991; 67: 230-6.
13. Briggs MH, Garcia-Webb P, Davies P. Urinary oxalate and vitamin C supplements. Lancet 1973; 2: 201.
14. Schmidt KH, Hagmaier V, Hornig DH, Vuilleumier JP, Rutishauser G. Urinary oxalate excretion after large intakes of ascorbic acid in man. Am J Clin Nutrition 1981; 34: 305-11.
15. Ralli EP, Friedman GJ, Rubin SH. The mechanism of excretion of vitamin C by the human kidney. J Clin Invest 1938; 17: 756-70.
16. Atkins GL, Dean BM, Griffin WJ, Watts RW. Quantitative aspects of ascorbic acid metabolism in man. J Biol Chem 1964; 239: 2975-80.
17. Davies MB, Austin J, Partridge DA. Vitamin C. Its Chemistry and Biochemistry. London: Royal Society of London Paperbacks 1991.
18. Conyers RA, Bais R, Rofe AM. Ascorbic acid intake, renal function and urinary oxalate excretion. Anst NZ J Med 1985; 15: 353-5.
19. Atkins GL, Dean BM, Griffin WJ, Scowen EF, Watts RW. Quantitative aspects of ascorbic acid metabolism in patients with primary hyperoxaluria. Clin Sci 1965; 29: 305-14.
20. Marcus R, Coulston AM. The vitamins. In: Goodman Gilman A, Rall TN, Nies AS, Taylor P, eds. The Pharmacological Basis of Therapeutics, 8th edn. New York: Pergamon Press 1990: 1530-52.
21. Lemann J, Pleuss JA, Gray RW, Hoffmann RG. Potassium administration increases and potassium deprivation reduces urinary calcium excretion in healthy adults. Kidney Int 1991; 39: 973-83.
22. Valyasevi A, Dhanamitta S. Epidemiology and pathogenesis of endemic bladder stone disease in Thailand. In: Brockis JG, Finalyson B, eds. Urinary Calculus. Massachusetts: PSG Publishing 1981: 177-84.