-
1
-
-
84875163715
-
The SLCO (former SLC21) superfamily of transporters
-
Hagenbuch, B. and Stieger, B. (2013) The SLCO (former SLC21) superfamily of transporters Mol. Aspects Med. 34, 396-412
-
(2013)
Mol. Aspects Med.
, vol.34
, pp. 396-412
-
-
Hagenbuch, B.1
Stieger, B.2
-
2
-
-
78649656801
-
Uptake transporters of the human OATP family: Molecular characteristics, substrates, their role in drug-drug interactions, and functional consequences of polymorphisms
-
König, J. (2011) Uptake transporters of the human OATP family: Molecular characteristics, substrates, their role in drug-drug interactions, and functional consequences of polymorphisms Handb. Exp. Pharmacol. 201, 1-28
-
(2011)
Handb. Exp. Pharmacol.
, vol.201
, pp. 1-28
-
-
König, J.1
-
3
-
-
48749112588
-
Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family
-
Hagenbuch, B. and Gui, C. (2008) Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family Xenobiotica 38, 778-801
-
(2008)
Xenobiotica
, vol.38
, pp. 778-801
-
-
Hagenbuch, B.1
Gui, C.2
-
4
-
-
0037733365
-
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
-
König, J., Cui, Y., Nies, A. T., and Keppler, D. (2000) A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane Am. J. Physiol. 278, G156-G164
-
(2000)
Am. J. Physiol.
, vol.278
-
-
König, J.1
Cui, Y.2
Nies, A.T.3
Keppler, D.4
-
5
-
-
84857092984
-
OATPs, OATs and OCTs: The organic anion and cation transporters of the SLCO and SLC22A gene superfamilies
-
Roth, M., Obaidat, A., and Hagenbuch, B. (2012) OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies Br. J. Pharmacol. 165, 1260-1287
-
(2012)
Br. J. Pharmacol.
, vol.165
, pp. 1260-1287
-
-
Roth, M.1
Obaidat, A.2
Hagenbuch, B.3
-
6
-
-
0035710125
-
Pharmacokinetics and pharmacodynamics of fluvastatin in heart transplant recipients taking cyclosporine A
-
Park, J. W., Siekmeier, R., Lattke, P., Merz, M., Mix, C., Schuler, S., and Jaross, W. (2001) Pharmacokinetics and pharmacodynamics of fluvastatin in heart transplant recipients taking cyclosporine A J. Cardiovasc. Pharmacol. Ther. 6, 351-361
-
(2001)
J. Cardiovasc. Pharmacol. Ther.
, vol.6
, pp. 351-361
-
-
Park, J.W.1
Siekmeier, R.2
Lattke, P.3
Merz, M.4
Mix, C.5
Schuler, S.6
Jaross, W.7
-
7
-
-
0027327029
-
Altered disposition of pravastatin following concomitant drug therapy with cyclosporin A in transplant recipients
-
Regazzi, M. B., Iacona, I., Campana, C., Raddato, V., Lesi, C., Perani, G., Gavazzi, A., and Vigano, M. (1993) Altered disposition of pravastatin following concomitant drug therapy with cyclosporin A in transplant recipients Transplant. Proc. 25, 2732-2734
-
(1993)
Transplant. Proc.
, vol.25
, pp. 2732-2734
-
-
Regazzi, M.B.1
Iacona, I.2
Campana, C.3
Raddato, V.4
Lesi, C.5
Perani, G.6
Gavazzi, A.7
Vigano, M.8
-
8
-
-
3542992126
-
Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine
-
Simonson, S. G., Raza, A., Martin, P. D., Mitchell, P. D., Jarcho, J. A., Brown, C. D., Windass, A. S., and Schneck, D. W. (2004) Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine Clin. Pharmacol. Ther. 76, 167-177
-
(2004)
Clin. Pharmacol. Ther.
, vol.76
, pp. 167-177
-
-
Simonson, S.G.1
Raza, A.2
Martin, P.D.3
Mitchell, P.D.4
Jarcho, J.A.5
Brown, C.D.6
Windass, A.S.7
Schneck, D.W.8
-
9
-
-
49949104757
-
SLCO1B1 variants and statin-induced myopathy -a genomewide study
-
Link, E., Parish, S., Armitage, J., Bowman, L., Heath, S., Matsuda, F., Gut, I., Lathrop, M., and Collins, R. (2008) SLCO1B1 variants and statin-induced myopathy -a genomewide study N. Engl. J. Med. 359, 789-799
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 789-799
-
-
Link, E.1
Parish, S.2
Armitage, J.3
Bowman, L.4
Heath, S.5
Matsuda, F.6
Gut, I.7
Lathrop, M.8
Collins, R.9
-
10
-
-
33751301012
-
Pharmacophore-based discovery of ligands for drug transporters
-
Chang, C., Ekins, S., Bahadduri, P., and Swaan, P. W. (2006) Pharmacophore-based discovery of ligands for drug transporters Adv. Drug Delivery Rev. 58, 1431-1450
-
(2006)
Adv. Drug Delivery Rev.
, vol.58
, pp. 1431-1450
-
-
Chang, C.1
Ekins, S.2
Bahadduri, P.3
Swaan, P.W.4
-
11
-
-
84859346272
-
In vitro and in silico strategies to identify OATP1B1 inhibitors and predict clinical drug-drug interactions
-
Karlgren, M., Ahlin, G., Bergstrom, C. A., Svensson, R., Palm, J., and Artursson, P. (2012) In vitro and in silico strategies to identify OATP1B1 inhibitors and predict clinical drug-drug interactions Pharm. Res. 29, 411-426
-
(2012)
Pharm. Res.
, vol.29
, pp. 411-426
-
-
Karlgren, M.1
Ahlin, G.2
Bergstrom, C.A.3
Svensson, R.4
Palm, J.5
Artursson, P.6
-
12
-
-
22944440991
-
Comparative pharmacophore modeling of organic anion transporting polypeptides: A meta-analysis of rat OATP1A1 and human OATP1B1
-
Chang, C., Pang, K. S., Swaan, P. W., and Ekins, S. (2005) Comparative pharmacophore modeling of organic anion transporting polypeptides: A meta-analysis of rat OATP1A1 and human OATP1B1 J. Pharmacol. Exp. Ther. 314, 533-541
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.314
, pp. 533-541
-
-
Chang, C.1
Pang, K.S.2
Swaan, P.W.3
Ekins, S.4
-
13
-
-
67349134132
-
i determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17β-glucuronide transport
-
i determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17β-glucuronide transport Pharmacol. Res. 60, 50-56
-
(2009)
Pharmacol. Res.
, vol.60
, pp. 50-56
-
-
Gui, C.1
Wahlgren, B.2
Lushington, G.H.3
Hagenbuch, B.4
-
14
-
-
33646442476
-
Organic anion transporting polypeptides of the OATP/SLCO superfamily: Identification of new members in nonmammalian species, comparative modeling and a potential transport mode
-
Meier-Abt, F., Mokrab, Y., and Mizuguchi, K. (2005) Organic anion transporting polypeptides of the OATP/SLCO superfamily: identification of new members in nonmammalian species, comparative modeling and a potential transport mode J. Membr. Biol. 208, 213-227
-
(2005)
J. Membr. Biol.
, vol.208
, pp. 213-227
-
-
Meier-Abt, F.1
Mokrab, Y.2
Mizuguchi, K.3
-
15
-
-
50849142229
-
Amino acid residues in transmembrane domain 10 of organic anion transporting polypeptide 1B3 are critical for cholecystokinin octapeptide transport
-
Gui, C. and Hagenbuch, B. (2008) Amino acid residues in transmembrane domain 10 of organic anion transporting polypeptide 1B3 are critical for cholecystokinin octapeptide transport Biochemistry 47, 9090-9097
-
(2008)
Biochemistry
, vol.47
, pp. 9090-9097
-
-
Gui, C.1
Hagenbuch, B.2
-
16
-
-
80051969226
-
Functional and structural relevance of conserved positively charged lysine residues in organic anion transporting polypeptide 1B3
-
Mandery, K., Sticht, H., Bujok, K., Schmidt, I., Fahrmayr, C., Balk, B., Fromm, M. F., and Glaeser, H. (2011) Functional and structural relevance of conserved positively charged lysine residues in organic anion transporting polypeptide 1B3 Mol. Pharmacol. 80, 400-406
-
(2011)
Mol. Pharmacol.
, vol.80
, pp. 400-406
-
-
Mandery, K.1
Sticht, H.2
Bujok, K.3
Schmidt, I.4
Fahrmayr, C.5
Balk, B.6
Fromm, M.F.7
Glaeser, H.8
-
17
-
-
84860538064
-
Identification of amino acids essential for estrone-3-sulfate transport within transmembrane domain 2 of organic anion transporting polypeptide 1B1
-
Li, N., Hong, W., Huang, H., Lu, H., Lin, G., and Hong, M. (2012) Identification of amino acids essential for estrone-3-sulfate transport within transmembrane domain 2 of organic anion transporting polypeptide 1B1 PLoS One 7, e36647
-
(2012)
PLoS One
, vol.7
, pp. 36647
-
-
Li, N.1
Hong, W.2
Huang, H.3
Lu, H.4
Lin, G.5
Hong, M.6
-
18
-
-
84884697916
-
Conserved tryptophan residues within putative transmembrane domain 6 affect transport function of organic anion transporting polypeptide 1B1
-
Huang, J., Li, N., Hong, W., Zhan, K., Yu, X., Huang, H., and Hong, M. (2013) Conserved tryptophan residues within putative transmembrane domain 6 affect transport function of organic anion transporting polypeptide 1B1 Mol. Pharmacol. 84, 521-527
-
(2013)
Mol. Pharmacol.
, vol.84
, pp. 521-527
-
-
Huang, J.1
Li, N.2
Hong, W.3
Zhan, K.4
Yu, X.5
Huang, H.6
Hong, M.7
-
19
-
-
65649137667
-
The eighth and ninth transmembrane domains in organic anion transporting polypeptide 1B1 affect the transport kinetics of estrone-3-sulfate and estradiol-17beta- d -glucuronide
-
Miyagawa, M., Maeda, K., Aoyama, A., and Sugiyama, Y. (2009) The eighth and ninth transmembrane domains in organic anion transporting polypeptide 1B1 affect the transport kinetics of estrone-3-sulfate and estradiol-17beta- d -glucuronide J. Pharmacol. Exp. Ther. 329, 551-557
-
(2009)
J. Pharmacol. Exp. Ther.
, vol.329
, pp. 551-557
-
-
Miyagawa, M.1
Maeda, K.2
Aoyama, A.3
Sugiyama, Y.4
-
20
-
-
70350474996
-
Role of transmembrane domain 10 for the function of organic anion transporting polypeptide 1B1
-
Gui, C. and Hagenbuch, B. (2009) Role of transmembrane domain 10 for the function of organic anion transporting polypeptide 1B1 Protein Sci. 18, 2298-2306
-
(2009)
Protein Sci.
, vol.18
, pp. 2298-2306
-
-
Gui, C.1
Hagenbuch, B.2
-
21
-
-
78650197386
-
Several conserved positively charged amino acids in OATP1B1 are involved in binding or translocation of different substrates
-
Weaver, Y. M. and Hagenbuch, B. (2010) Several conserved positively charged amino acids in OATP1B1 are involved in binding or translocation of different substrates J. Membr. Biol. 236, 279-290
-
(2010)
J. Membr. Biol.
, vol.236
, pp. 279-290
-
-
Weaver, Y.M.1
Hagenbuch, B.2
-
22
-
-
84859356747
-
Interaction of three regiospecific amino acid residues is required for OATP1B1 gain of OATP1B3 substrate specificity
-
DeGorter, M. K., Ho, R. H., Leake, B. F., Tirona, R. G., and Kim, R. B. (2012) Interaction of three regiospecific amino acid residues is required for OATP1B1 gain of OATP1B3 substrate specificity Mol. Pharm. 9, 986-995
-
(2012)
Mol. Pharm.
, vol.9
, pp. 986-995
-
-
Degorter, M.K.1
Ho, R.H.2
Leake, B.F.3
Tirona, R.G.4
Kim, R.B.5
-
23
-
-
1342304081
-
+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition
-
+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition J. Biol. Chem. 279, 7213-7222
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 7213-7222
-
-
Ho, R.H.1
Leake, B.F.2
Roberts, R.L.3
Lee, W.4
Kim, R.B.5
-
24
-
-
0034857677
-
Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C
-
Tamai, I., Nozawa, T., Koshida, M., Nezu, J., Sai, Y., and Tsuji, A. (2001) Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C Pharm. Res. 18, 1262-1269
-
(2001)
Pharm. Res.
, vol.18
, pp. 1262-1269
-
-
Tamai, I.1
Nozawa, T.2
Koshida, M.3
Nezu, J.4
Sai, Y.5
Tsuji, A.6
-
25
-
-
34547178337
-
Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3
-
Noe, J., Portmann, R., Brun, M. E., and Funk, C. (2007) Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3 Drug Metab. Dispos. 35, 1308-1314
-
(2007)
Drug Metab. Dispos.
, vol.35
, pp. 1308-1314
-
-
Noe, J.1
Portmann, R.2
Brun, M.E.3
Funk, C.4
-
26
-
-
84867301515
-
Predicting the functional effect of amino acid substitutions and indels
-
Choi, Y., Sims, G. E., Murphy, S., Miller, J. R., and Chan, A. P. (2012) Predicting the functional effect of amino acid substitutions and indels PLoS One 7, e46688
-
(2012)
PLoS One
, vol.7
, pp. 46688
-
-
Choi, Y.1
Sims, G.E.2
Murphy, S.3
Miller, J.R.4
Chan, A.P.5
-
27
-
-
34547100092
-
SNAP: Predict effect of non-synonymous polymorphisms on function
-
Bromberg, Y. and Rost, B. (2007) SNAP: predict effect of non-synonymous polymorphisms on function Nucleic Acids Res. 35, 3823-3835
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 3823-3835
-
-
Bromberg, Y.1
Rost, B.2
-
28
-
-
33745231761
-
Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans
-
Yamashiro, W., Maeda, K., Hirouchi, M., Adachi, Y., Hu, Z., and Sugiyama, Y. (2006) Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans Drug Metab. Dispos. 34, 1247-1254
-
(2006)
Drug Metab. Dispos.
, vol.34
, pp. 1247-1254
-
-
Yamashiro, W.1
Maeda, K.2
Hirouchi, M.3
Adachi, Y.4
Hu, Z.5
Sugiyama, Y.6
-
29
-
-
33747590985
-
Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1
-
Hänggi, E., Grundschober, A. F., Leuthold, S., Meier, P. J., and St-Pierre, M. V. (2006) Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1 Mol. Pharmacol. 70, 806-817
-
(2006)
Mol. Pharmacol.
, vol.70
, pp. 806-817
-
-
Hänggi, E.1
Grundschober, A.F.2
Leuthold, S.3
Meier, P.J.4
St-Pierre, M.V.5
-
30
-
-
41149140202
-
Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3
-
Gui, C., Miao, Y., Thompson, L., Wahlgren, B., Mock, M., Stieger, B., and Hagenbuch, B. (2008) Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3 Eur. J. Pharmacol. 584, 57-65
-
(2008)
Eur. J. Pharmacol.
, vol.584
, pp. 57-65
-
-
Gui, C.1
Miao, Y.2
Thompson, L.3
Wahlgren, B.4
Mock, M.5
Stieger, B.6
Hagenbuch, B.7
-
31
-
-
0035012075
-
Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes
-
Nakai, D., Nakagomi, R., Furuta, Y., Tokui, T., Abe, T., Ikeda, T., and Nishimura, K. (2001) Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes J. Pharmacol. Exp. Ther. 297, 861-867
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.297
, pp. 861-867
-
-
Nakai, D.1
Nakagomi, R.2
Furuta, Y.3
Tokui, T.4
Abe, T.5
Ikeda, T.6
Nishimura, K.7
-
32
-
-
0034725617
-
Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide
-
König, J., Cui, Y., Nies, A. T., and Keppler, D. (2000) Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide J. Biol. Chem. 275, 23161-23168
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 23161-23168
-
-
König, J.1
Cui, Y.2
Nies, A.T.3
Keppler, D.4
-
33
-
-
4644364576
-
Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans
-
Hirano, M., Maeda, K., Shitara, Y., and Sugiyama, Y. (2004) Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans J. Pharmacol. Exp. Ther. 311, 139-146
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.311
, pp. 139-146
-
-
Hirano, M.1
Maeda, K.2
Shitara, Y.3
Sugiyama, Y.4
|