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Volumn 63, Issue 5, 2014, Pages 1685-1697

Decreasing Cx36 gap junction coupling compensates for overactive K ATP channels to restore insulin secretion and prevent hyperglycemia in a mouse model of neonatal diabetes

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; ANIMALS, NEWBORN; BLOOD GLUCOSE; CALCIUM; CONNEXINS; DIABETES MELLITUS; HOMEOSTASIS; HYPERGLYCEMIA; INSULIN; ISLETS OF LANGERHANS; KATP CHANNELS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC;

EID: 84898839036     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-1048     Document Type: Article
Times cited : (21)

References (38)
  • 1
    • 33645322386 scopus 로고    scopus 로고
    • KATP channels as molecular sensors of cellular metabolism
    • Nichols CG. KATP channels as molecular sensors of cellular metabolism. Nature 2006;440:470-476
    • (2006) Nature , vol.440 , pp. 470-476
    • Nichols, C.G.1
  • 3
    • 58749114004 scopus 로고    scopus 로고
    • Secondary consequences of beta cell inexcitability: Identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus
    • Remedi MS, Kurata HT, Scott A, et al. Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus. Cell Metab 2009;9:140-151
    • (2009) Cell Metab , vol.9 , pp. 140-151
    • Remedi, M.S.1    Kurata, H.T.2    Scott, A.3
  • 4
    • 61749086774 scopus 로고    scopus 로고
    • Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes
    • Girard CA, Wunderlich FT, Shimomura K, et al. Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. J Clin Invest 2009;119:80-90
    • (2009) J Clin Invest , vol.119 , pp. 80-90
    • Girard, C.A.1    Wunderlich, F.T.2    Shimomura, K.3
  • 5
    • 0034677634 scopus 로고    scopus 로고
    • Targeted over-activity of beta cell K(ATP) channels induces profound neonatal diabetes
    • Koster JC, Marshall BA, Ensor N, Corbett JA, Nichols CG. Targeted over-activity of beta cell K(ATP) channels induces profound neonatal diabetes. Cell 2000;100:645-654
    • (2000) Cell , vol.100 , pp. 645-654
    • Koster, J.C.1    Marshall, B.A.2    Ensor, N.3    Corbett, J.A.4    Nichols, C.G.5
  • 8
    • 77954491071 scopus 로고    scopus 로고
    • Successful sulfonylurea treatment of an insulin-naïve neonate with diabetes mellitus due to a KCNJ11 mutation
    • Wambach JA, Marshall BA, Koster JC, White NH, Nichols CG. Successful sulfonylurea treatment of an insulin-naïve neonate with diabetes mellitus due to a KCNJ11 mutation. Pediatr Diabetes 2010;11:286-288
    • (2010) Pediatr Diabetes , vol.11 , pp. 286-288
    • Wambach, J.A.1    Marshall, B.A.2    Koster, J.C.3    White, N.H.4    Nichols, C.G.5
  • 10
    • 24144456153 scopus 로고    scopus 로고
    • + channels in neonatal diabetes: Implications for pharmacogenomic therapy
    • DOI 10.2337/diabetes.54.9.2645
    • Koster JC, Remedi MS, Dao C, Nichols CG. ATP and sulfonylurea sensitivity of mutant ATP-sensitive K+ channels in neonatal diabetes: implications for pharmacogenomic therapy. Diabetes 2005;54:2645-2654 (Pubitemid 41233586)
    • (2005) Diabetes , vol.54 , Issue.9 , pp. 2645-2654
    • Koster, J.C.1    Remedi, M.S.2    Dao, C.3    Nichols, C.G.4
  • 11
    • 0016209124 scopus 로고
    • The preparation of, and studies on, free cell suspensions from mouse pancreatic islets
    • Lernmark A. The preparation of, and studies on, free cell suspensions from mouse pancreatic islets. Diabetologia 1974;10:431-438
    • (1974) Diabetologia , vol.10 , pp. 431-438
    • Lernmark, A.1
  • 12
    • 0037961599 scopus 로고    scopus 로고
    • 2+ dynamics of isolated mouse beta-cells and islets: Implications for mathematical models
    • Zhang M, Goforth P, Bertram R, Sherman A, Satin L. The Ca2+ dynamics of isolated mouse beta-cells and islets: implications for mathematical models. Biophys J 2003;84:2852-2870 (Pubitemid 36531740)
    • (2003) Biophysical Journal , vol.84 , Issue.5 , pp. 2852-2870
    • Zhang, M.1    Goforth, P.2    Bertram, R.3    Sherman, A.4    Satin, L.5
  • 15
    • 84863197999 scopus 로고    scopus 로고
    • Connexin-36 gap junctions regulate in vivo first- and second-phase insulin secretion dynamics and glucose tolerance in the conscious mouse
    • Head WS, Orseth ML, Nunemaker CS, Satin LS, Piston DW, Benninger RKP. Connexin-36 gap junctions regulate in vivo first- and second-phase insulin secretion dynamics and glucose tolerance in the conscious mouse. Diabetes 2012;61:1700-1707
    • (2012) Diabetes , vol.61 , pp. 1700-1707
    • Head, W.S.1    Orseth, M.L.2    Nunemaker, C.S.3    Satin, L.S.4    Piston, D.W.5    Benninger, R.K.P.6
  • 16
    • 33244458017 scopus 로고    scopus 로고
    • Critical role of gap junction coupled KATP channel activity for regulated insulin secretion
    • Rocheleau JV, Remedi MS, Granada B, et al. Critical role of gap junction coupled KATP channel activity for regulated insulin secretion. PLoS Biol 2006;4:e26
    • (2006) PLoS Biol , vol.4
    • Rocheleau, J.V.1    Remedi, M.S.2    Granada, B.3
  • 17
    • 34047149839 scopus 로고    scopus 로고
    • Cx36-mediated coupling reduces beta-cell heterogeneity, confines the stimulating glucose concentration range, and affects insulin release kinetics
    • DOI 10.2337/db06-0232
    • Speier S, Gjinovci A, Charollais A, Meda P, Rupnik M. Cx36-mediated coupling reduces beta-cell heterogeneity, confines the stimulating glucose concentration range, and affects insulin release kinetics. Diabetes 2007;56:1078-1086 (Pubitemid 46525063)
    • (2007) Diabetes , vol.56 , Issue.4 , pp. 1078-1086
    • Speier, S.1    Gjinovci, A.2    Charollais, A.3    Meda, P.4    Rupnik, M.5
  • 18
    • 81255177545 scopus 로고    scopus 로고
    • Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet
    • Benninger RKP, Head WS, Zhang M, Satin LS, Piston DW. Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet. J Physiol 2011;589:5453-5466
    • (2011) J Physiol , vol.589 , pp. 5453-5466
    • Benninger, R.K.P.1    Head, W.S.2    Zhang, M.3    Satin, L.S.4    Piston, D.W.5
  • 19
    • 0026651708 scopus 로고
    • Heterogeneity in pancreatic beta-cell population
    • Pipeleers DG. Heterogeneity in pancreatic beta-cell population. Diabetes 1992;41:777-781
    • (1992) Diabetes , vol.41 , pp. 777-781
    • Pipeleers, D.G.1
  • 21
    • 23244467098 scopus 로고    scopus 로고
    • Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase
    • DOI 10.1002/gene.20137
    • Zhang HJ, Fujitani Y, Wright CVE, Gannon M. Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase. Genesis 2005;42:210-217 (Pubitemid 41099681)
    • (2005) Genesis , vol.42 , Issue.3 , pp. 210-217
    • Zhang, H.1    Fujitani, Y.2    Wright, C.V.E.3    Gannon, M.4
  • 22
    • 84891866043 scopus 로고    scopus 로고
    • Dimensionality and size scaling of coordinated Ca2+ dynamics in MIN6 β-cell clusters
    • Hraha TH, Bernard AB, Nguyen LM, Anseth KS, Benninger RKP. Dimensionality and size scaling of coordinated Ca2+ dynamics in MIN6 β-cell clusters. Biophys J 2014;106:299-309
    • (2014) Biophys J , vol.106 , pp. 299-309
    • Hraha, T.H.1    Bernard, A.B.2    Nguyen, L.M.3    Anseth, K.S.4    Benninger, R.K.P.5
  • 23
    • 24144463906 scopus 로고    scopus 로고
    • How noise and coupling induce bursting action potentials in pancreatic beta-cells
    • DOI 10.1529/biophysj.104.053181
    • Jo J, Kang H, Choi MY, Koh DS. How noise and coupling induce bursting action potentials in pancreatic beta-cells. Biophys J 2005;89:1534-1542 (Pubitemid 41233511)
    • (2005) Biophysical Journal , vol.89 , Issue.3 , pp. 1534-1542
    • Jo, J.1    Kang, H.2    Choi, M.Y.3    Koh, D.-S.4
  • 24
    • 0033751674 scopus 로고    scopus 로고
    • Dynamical complexity and temporal plasticity in pancreatic beta-cells
    • Bertram R, Sherman A. Dynamical complexity and temporal plasticity in pancreatic beta-cells. J Biosci 2000;25:197-209
    • (2000) J Biosci , vol.25 , pp. 197-209
    • Bertram, R.1    Sherman, A.2
  • 26
    • 24144467758 scopus 로고    scopus 로고
    • Activating mutations in Kir6.2 and neonatal diabetes: New clinical syndromes, new scientific insights, and new therapy
    • DOI 10.2337/diabetes.54.9.2503
    • Hattersley AT, Ashcroft FM. Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapy. Diabetes 2005;54:2503-2513 (Pubitemid 41233571)
    • (2005) Diabetes , vol.54 , Issue.9 , pp. 2503-2513
    • Hattersley, A.T.1    Ashcroft, F.M.2
  • 27
    • 0026803423 scopus 로고
    • Pancreatic beta cell heterogeneity in glucose-induced insulin secretion
    • Van Schravendijk CF, Kiekens R, Pipeleers DG. Pancreatic beta cell heterogeneity in glucose-induced insulin secretion. J Biol Chem 1992;267:21344-21348
    • (1992) J Biol Chem , vol.267 , pp. 21344-21348
    • Van Schravendijk, C.F.1    Kiekens, R.2    Pipeleers, D.G.3
  • 28
    • 51249098505 scopus 로고    scopus 로고
    • Insulin secretion from human beta cells is heterogeneous and dependent on cell-to-cell contacts
    • Wojtusciszyn A, Armanet M, Morel P, Berney T, Bosco D. Insulin secretion from human beta cells is heterogeneous and dependent on cell-to-cell contacts. Diabetologia 2008;51:1843-1852
    • (2008) Diabetologia , vol.51 , pp. 1843-1852
    • Wojtusciszyn, A.1    Armanet, M.2    Morel, P.3    Berney, T.4    Bosco, D.5
  • 29
    • 34247562272 scopus 로고    scopus 로고
    • Sulfonylurea treatment in young children with neonatal diabetes: Dealing with hyperglycemia, hypoglycemia, and sick days [1]
    • DOI 10.2337/dc06-2134
    • Codner E, Flanagan SE, Ugarte F, et al. Sulfonylurea treatment in young children with neonatal diabetes: dealing with hyperglycemia, hypoglycemia, and sick days. Diabetes Care 2007;30:e28-e29 (Pubitemid 46684676)
    • (2007) Diabetes Care , vol.30 , Issue.5
    • Codner, E.1    Flanagan, S.E.2    Ugarte, F.3    Garcia, H.4    Vidal, T.5    Ellard, S.6    Hattersley, A.T.7
  • 30
    • 55949116427 scopus 로고    scopus 로고
    • Chronic antidiabetic sulfonylureas in vivo: Reversible effects on mouse pancreatic beta-cells
    • Remedi MS, Nichols CG. Chronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cells. PLoS Med 2008;5:e206
    • (2008) PLoS Med , vol.5
    • Remedi, M.S.1    Nichols, C.G.2
  • 31
    • 84864442250 scopus 로고    scopus 로고
    • The intercellular synchronization of Ca2+ oscillations evaluates Cx36-dependent coupling
    • Bavamian S, Pontes H, Cancela J, et al. The intercellular synchronization of Ca2+ oscillations evaluates Cx36-dependent coupling. PLoS ONE 2012;7:e41535
    • (2012) PLoS ONE , vol.7
    • Bavamian, S.1    Pontes, H.2    Cancela, J.3
  • 32
    • 84863657669 scopus 로고    scopus 로고
    • Impaired β-cell-β-cell coupling mediated by Cx36 gap junctions in prediabetic mice
    • Carvalho CP, Oliveira RB, Britan A, et al. Impaired β-cell-β- cell coupling mediated by Cx36 gap junctions in prediabetic mice. Am J Physiol Endocrinol Metab 2012;303:E144-E151
    • (2012) Am J Physiol Endocrinol Metab , vol.303
    • Carvalho, C.P.1    Oliveira, R.B.2    Britan, A.3
  • 34
    • 0026562918 scopus 로고
    • Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus
    • Vionnet N, Stoffel M, Takeda J, et al. Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Nature 1992;356:721-722
    • (1992) Nature , vol.356 , pp. 721-722
    • Vionnet, N.1    Stoffel, M.2    Takeda, J.3
  • 36
    • 0032538883 scopus 로고    scopus 로고
    • Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line
    • Wang H, Maechler P, Hagenfeldt KA, Wollheim CB. Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line. EMBO J 1998;17:6701-6713 (Pubitemid 28521803)
    • (1998) EMBO Journal , vol.17 , Issue.22 , pp. 6701-6713
    • Wang, H.1    Maechler, P.2    Hagenfeldt, K.A.3    Wollheim, C.B.4
  • 37
    • 0033760442 scopus 로고    scopus 로고
    • Triggering and amplifying pathways of regulation of insulin secretion by glucose
    • Henquin JC. Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 2000;49:1751-1760
    • (2000) Diabetes , vol.49 , pp. 1751-1760
    • Henquin, J.C.1
  • 38
    • 25844454853 scopus 로고    scopus 로고
    • + channel signaling in glucokinase-deficient diabetes
    • DOI 10.2337/diabetes.54.10.2925
    • Remedi MS, Koster JC, Patton BL, Nichols CG. ATP-sensitive K+ channel signaling in glucokinase-deficient diabetes. Diabetes 2005;54:2925-2931 (Pubitemid 41401088)
    • (2005) Diabetes , vol.54 , Issue.10 , pp. 2925-2931
    • Remedi, M.S.1    Koster, J.C.2    Patton, B.L.3    Nichols, C.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.