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Volumn 51, Issue 10, 2008, Pages 1843-1852

Insulin secretion from human beta cells is heterogeneous and dependent on cell-to-cell contacts

Author keywords

Beta cells; Heterogeneity; Human islets; Insulin secretion; Reverse haemolytic plaque assay

Indexed keywords

GLUCOSE; INSULIN;

EID: 51249098505     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-008-1103-z     Document Type: Article
Times cited : (109)

References (37)
  • 1
    • 0016754166 scopus 로고
    • Functional subdivision of islets of Langerhans and possible role of D cells
    • L Orci RH Unger 1975 Functional subdivision of islets of Langerhans and possible role of D cells Lancet 2 1243 1244
    • (1975) Lancet , vol.2 , pp. 1243-1244
    • Orci, L.1    Unger, R.H.2
  • 2
    • 0028245030 scopus 로고
    • Synchronous oscillations of cytoplasmic Ca2+ and insulin release in glucose-stimulated pancreatic islets
    • P Bergsten E Grapengiesser E Gylfe A Tengholm B Hellman 1994 Synchronous oscillations of cytoplasmic Ca2+ and insulin release in glucose-stimulated pancreatic islets J Biol Chem 269 8749 8753
    • (1994) J Biol Chem , vol.269 , pp. 8749-8753
    • Bergsten, P.1    Grapengiesser, E.2    Gylfe, E.3    Tengholm, A.4    Hellman, B.5
  • 3
    • 23244441271 scopus 로고    scopus 로고
    • Intra- and inter-islet synchronization of metabolically driven insulin secretion
    • MG Pedersen R Bertram A Sherman 2005 Intra- and inter-islet synchronization of metabolically driven insulin secretion Biophys J 89 107 119
    • (2005) Biophys J , vol.89 , pp. 107-119
    • Pedersen, M.G.1    Bertram, R.2    Sherman, A.3
  • 4
    • 0032992378 scopus 로고    scopus 로고
    • Pancreatic beta-cell-to-beta-cell interactions are required for integrated responses to nutrient stimuli: Enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets
    • AC Hauge-Evans PE Squires SJ Persaud PM Jones 1999 Pancreatic beta-cell-to-beta-cell interactions are required for integrated responses to nutrient stimuli: enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets Diabetes 48 1402 1408
    • (1999) Diabetes , vol.48 , pp. 1402-1408
    • Hauge-Evans, A.C.1    Squires, P.E.2    Persaud, S.J.3    Jones, P.M.4
  • 7
    • 0026036421 scopus 로고
    • A morphological and immunohistochemical investigation of endocrine pancreata from obese ob+/ob+ mice
    • GH Starich M Zafirova R Jablenska P Petkov CK Lardinois 1991 A morphological and immunohistochemical investigation of endocrine pancreata from obese ob+/ob+ mice Acta Histochem 90 93 101
    • (1991) Acta Histochem , vol.90 , pp. 93-101
    • Starich, G.H.1    Zafirova, M.2    Jablenska, R.3    Petkov, P.4    Lardinois, C.K.5
  • 8
    • 0027213313 scopus 로고
    • Tumor necrosis factor-alpha modifies adhesion properties of rat islet B cells
    • V Cirulli PA Halban DG Rouiller 1993 Tumor necrosis factor-alpha modifies adhesion properties of rat islet B cells J Clin Invest 91 1868 1876
    • (1993) J Clin Invest , vol.91 , pp. 1868-1876
    • Cirulli, V.1    Halban, P.A.2    Rouiller, D.G.3
  • 9
    • 0028931253 scopus 로고
    • Heterogeneous secretion of individual B cells in response to d-glucose and to nonglucidic nutrient secretagogues
    • D Bosco P Meda B Thorens WJ Malaisse 1995 Heterogeneous secretion of individual B cells in response to d-glucose and to nonglucidic nutrient secretagogues Am J Physiol 268 C611 C618
    • (1995) Am J Physiol , vol.268
    • Bosco, D.1    Meda, P.2    Thorens, B.3    Malaisse, W.J.4
  • 10
    • 0028095283 scopus 로고
    • Physiologic relevance of heterogeneity in the pancreatic beta-cell population
    • Suppl 2
    • D Pipeleers R Kiekens Z Ling A Wilikens F Schuit 1994 Physiologic relevance of heterogeneity in the pancreatic beta-cell population Diabetologia 37 Suppl 2 S57 S64
    • (1994) Diabetologia , vol.37
    • Pipeleers, D.1    Kiekens, R.2    Ling, Z.3    Wilikens, A.4    Schuit, F.5
  • 11
    • 0025821452 scopus 로고
    • Functional subpopulations of individual pancreatic B cells in culture
    • M Hiriart MC Ramirez-Medeles 1991 Functional subpopulations of individual pancreatic B cells in culture Endocrinology 128 3193 3198
    • (1991) Endocrinology , vol.128 , pp. 3193-3198
    • Hiriart, M.1    Ramirez-Medeles, M.C.2
  • 12
    • 0026593276 scopus 로고
    • Differences in glucose recognition by individual rat pancreatic B cells are associated with intercellular differences in glucose-induced biosynthetic activity
    • R Kiekens P In 't Veld T Mahler F Schuit M Van De Winkel D Pipeleers 1992 Differences in glucose recognition by individual rat pancreatic B cells are associated with intercellular differences in glucose-induced biosynthetic activity J Clin Invest 89 117 125
    • (1992) J Clin Invest , vol.89 , pp. 117-125
    • Kiekens, R.1    In 'T Veld, P.2    Mahler, T.3    Schuit, F.4    Van De Winkel, M.5    Pipeleers, D.6
  • 13
    • 0025157271 scopus 로고
    • Single islet beta-cell stimulation by nutrients: Relationship between pyridine nucleotides, cytosolic Ca2+ and secretion
    • WF Pralong C Bartley CB Wollheim 1990 Single islet beta-cell stimulation by nutrients: relationship between pyridine nucleotides, cytosolic Ca2+ and secretion Embo J 9 53 60
    • (1990) Embo J , vol.9 , pp. 53-60
    • Pralong, W.F.1    Bartley, C.2    Wollheim, C.B.3
  • 14
    • 0030467497 scopus 로고    scopus 로고
    • Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation
    • Z Ling DG Pipeleers 1996 Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation J Clin Invest 98 2805 2812
    • (1996) J Clin Invest , vol.98 , pp. 2805-2812
    • Ling, Z.1    Pipeleers, D.G.2
  • 15
    • 0039829851 scopus 로고
    • Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells
    • FC Schuit PA In't Veld DG Pipeleers 1988 Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells Proc Natl Acad Sci USA 85 3865 3869
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 3865-3869
    • Schuit, F.C.1    In'T Veld, P.A.2    Pipeleers, D.G.3
  • 16
    • 0026026360 scopus 로고
    • In vivo modulation of connexin 43 gene expression and junctional coupling of pancreatic B cells
    • P Meda M Chanson M Pepper 1991 In vivo modulation of connexin 43 gene expression and junctional coupling of pancreatic B cells Exp Cell Res 192 469 480
    • (1991) Exp Cell Res , vol.192 , pp. 469-480
    • Meda, P.1    Chanson, M.2    Pepper, M.3
  • 17
    • 0025637049 scopus 로고
    • Differences in aggregation properties and levels of the neural cell adhesion molecule (NCAM) between islet cell types
    • DG Rouiller V Cirulli PA Halban 1990 Differences in aggregation properties and levels of the neural cell adhesion molecule (NCAM) between islet cell types Exp Cell Res 191 305 312
    • (1990) Exp Cell Res , vol.191 , pp. 305-312
    • Rouiller, D.G.1    Cirulli, V.2    Halban, P.A.3
  • 18
    • 34547459515 scopus 로고    scopus 로고
    • Differential expression of E-cadherin at the surface of rat β-cells as a marker of functional heterogeneity
    • D Bosco DG Rouiller PA Halban 2007 Differential expression of E-cadherin at the surface of rat β-cells as a marker of functional heterogeneity J Endocrinol 194 21 29
    • (2007) J Endocrinol , vol.194 , pp. 21-29
    • Bosco, D.1    Rouiller, D.G.2    Halban, P.A.3
  • 19
    • 35848955929 scopus 로고    scopus 로고
    • E-cadherin and cell adhesion: A role in architecture and function in the pancreatic islet
    • GJ Rogers MN Hodgkin PE Squires 2007 E-cadherin and cell adhesion: a role in architecture and function in the pancreatic islet Cell Physiol Biochem 20 987 994
    • (2007) Cell Physiol Biochem , vol.20 , pp. 987-994
    • Rogers, G.J.1    Hodgkin, M.N.2    Squires, P.E.3
  • 20
    • 24344459011 scopus 로고    scopus 로고
    • Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy
    • M Brissova MJ Fowler WE Nicholson 2005 Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy J Histochem Cytochem 53 1087 1097
    • (2005) J Histochem Cytochem , vol.53 , pp. 1087-1097
    • Brissova, M.1    Fowler, M.J.2    Nicholson, W.E.3
  • 21
    • 0022572975 scopus 로고
    • Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells
    • D Salomon P Meda 1986 Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells Exp Cell Res 162 507 520
    • (1986) Exp Cell Res , vol.162 , pp. 507-520
    • Salomon, D.1    Meda, P.2
  • 23
    • 19944434343 scopus 로고    scopus 로고
    • Assessment of a novel two-component enzyme preparation for human islet isolation and transplantation
    • P Bucher Z Mathe P Morel 2005 Assessment of a novel two-component enzyme preparation for human islet isolation and transplantation Transplantation 79 91 97
    • (2005) Transplantation , vol.79 , pp. 91-97
    • Bucher, P.1    Mathe, Z.2    Morel, P.3
  • 25
    • 0014315154 scopus 로고
    • Guinea pig anti-insulin serum. Adjuvant effect of H. pertussis vaccine
    • PH Wright DR Makulu IJ Posey 1968 Guinea pig anti-insulin serum. Adjuvant effect of H. pertussis vaccine Diabetes 17 513 516
    • (1968) Diabetes , vol.17 , pp. 513-516
    • Wright, P.H.1    Makulu, D.R.2    Posey, I.J.3
  • 26
    • 0024430064 scopus 로고
    • Homologous but not heterologous contact increases the insulin secretion of individual pancreatic B cells
    • D Bosco L Orci P Meda 1989 Homologous but not heterologous contact increases the insulin secretion of individual pancreatic B cells Exp Cell Res 184 72 80
    • (1989) Exp Cell Res , vol.184 , pp. 72-80
    • Bosco, D.1    Orci, L.2    Meda, P.3
  • 27
    • 0027203345 scopus 로고
    • Heterogeneity in glucose sensitivity among pancreatic beta-cells is correlated to differences in glucose phosphorylation rather than glucose transport
    • H Heimberg A De Vos A Vandercammen E Van Schaftingen D Pipeleers F Schuit 1993 Heterogeneity in glucose sensitivity among pancreatic beta-cells is correlated to differences in glucose phosphorylation rather than glucose transport Embo J 12 2873 2879
    • (1993) Embo J , vol.12 , pp. 2873-2879
    • Heimberg, H.1    De Vos, A.2    Vandercammen, A.3    Van Schaftingen, E.4    Pipeleers, D.5    Schuit, F.6
  • 28
    • 0025923705 scopus 로고
    • Heterogeneous changes in [Ca2+]i induced by glucose, tolbutamide and K+ in single rat pancreatic B cells
    • A Herchuelz R Pochet C Pastiels A Van Praet 1991 Heterogeneous changes in [Ca2+]i induced by glucose, tolbutamide and K+ in single rat pancreatic B cells Cell Calcium 12 577 586
    • (1991) Cell Calcium , vol.12 , pp. 577-586
    • Herchuelz, A.1    Pochet, R.2    Pastiels, C.3    Van Praet, A.4
  • 29
    • 0025718832 scopus 로고
    • Actively synthesizing beta-cells secrete preferentially after glucose stimulation
    • D Bosco P Meda 1991 Actively synthesizing beta-cells secrete preferentially after glucose stimulation Endocrinology 129 3157 3166
    • (1991) Endocrinology , vol.129 , pp. 3157-3166
    • Bosco, D.1    Meda, P.2
  • 30
    • 0023227779 scopus 로고
    • Stimulation of insulin secretion reveals heterogeneity of pancreatic B cells in vivo
    • Y Stefan P Meda M Neufeld L Orci 1987 Stimulation of insulin secretion reveals heterogeneity of pancreatic B cells in vivo J Clin Invest 80 175 183
    • (1987) J Clin Invest , vol.80 , pp. 175-183
    • Stefan, Y.1    Meda, P.2    Neufeld, M.3    Orci, L.4
  • 31
    • 0025169873 scopus 로고
    • Pulsatile insulin secretion in isolated rat islets
    • HF Chou E Ipp 1990 Pulsatile insulin secretion in isolated rat islets Diabetes 39 112 117
    • (1990) Diabetes , vol.39 , pp. 112-117
    • Chou, H.F.1    Ipp, E.2
  • 32
    • 0037315584 scopus 로고    scopus 로고
    • Connexin 36 controls synchronization of Ca2+ oscillations and insulin secretion in MIN6 cells
    • A Calabrese M Zhang V Serre-Beinier 2003 Connexin 36 controls synchronization of Ca2+ oscillations and insulin secretion in MIN6 cells Diabetes 52 417 424
    • (2003) Diabetes , vol.52 , pp. 417-424
    • Calabrese, A.1    Zhang, M.2    Serre-Beinier, V.3
  • 33
    • 0026059963 scopus 로고
    • Biophysical properties of gap junctions between freshly dispersed pairs of mouse pancreatic beta cells
    • M Perez-Armendariz C Roy DC Spray MV Bennett 1991 Biophysical properties of gap junctions between freshly dispersed pairs of mouse pancreatic beta cells Biophys J 59 76 92
    • (1991) Biophys J , vol.59 , pp. 76-92
    • Perez-Armendariz, M.1    Roy, C.2    Spray, D.C.3    Bennett, M.V.4
  • 34
    • 0031052405 scopus 로고    scopus 로고
    • Mechanisms for the coordination of intercellular calcium signaling in insulin-secreting cells
    • D Cao G Lin EM Westphale EC Beyer TH Steinberg 1997 Mechanisms for the coordination of intercellular calcium signaling in insulin-secreting cells J Cell Sci 110 497 504
    • (1997) J Cell Sci , vol.110 , pp. 497-504
    • Cao, D.1    Lin, G.2    Westphale, E.M.3    Beyer, E.C.4    Steinberg, T.H.5
  • 35
    • 0034775991 scopus 로고    scopus 로고
    • Nitric oxide induces synchronous Ca2+ transients in pancreatic beta cells lacking contact
    • E Grapengiesser E Gylfe H Dansk B Hellman 2001 Nitric oxide induces synchronous Ca2+ transients in pancreatic beta cells lacking contact Pancreas 23 387 392
    • (2001) Pancreas , vol.23 , pp. 387-392
    • Grapengiesser, E.1    Gylfe, E.2    Dansk, H.3    Hellman, B.4
  • 36
    • 3142614026 scopus 로고
    • Glucose-induced insulin release depends on functional cooperation between islet cells
    • D Pipeleers PI in't Veld E Maes M Van De Winkel 1982 Glucose-induced insulin release depends on functional cooperation between islet cells Proc Natl Acad Sci USA 79 7322 7325
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 7322-7325
    • Pipeleers, D.1    In'T Veld, P.I.2    Maes, E.3    Van De Winkel, M.4
  • 37
    • 0025149615 scopus 로고
    • Rapid and reversible secretion changes during uncoupling of rat insulin-producing cells
    • P Meda D Bosco M Chanson 1990 Rapid and reversible secretion changes during uncoupling of rat insulin-producing cells J Clin Invest 86 759 768
    • (1990) J Clin Invest , vol.86 , pp. 759-768
    • Meda, P.1    Bosco, D.2    Chanson, M.3


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