Epicardial adipose tissue in endocrine and metabolic diseases

Endocrine

Volumn 46, Issue 1, 2014, Pages 8-15

  Iacobellis, Gianluca ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Echocardiography; Epicardial adipose tissue; Epicardial fat; Visceral adiposity

Indexed keywords

ADIPOSE TISSUE; ADRENAL INCIDENTALOMA; BODY MASS; CARDIOMETABOLIC RISK; CARDIOVASCULAR RISK; ENDOCRINE DISEASE; EPICARDIAL ADIPOSE TISSUE; FAT THICKNESS; GROWTH HORMONE DEFICIENCY; HEART ATRIUM ENLARGEMENT; HEART LEFT VENTRICLE MASS; HEART VENTRICLE FILLING; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LIPID STORAGE; LIPOTOXICITY; METABOLIC DISORDER; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; REVIEW; THICKNESS; WAIST CIRCUMFERENCE; WEIGHT REDUCTION;

ADIPOSE TISSUE; ANIMALS; ENDOCRINE SYSTEM DISEASES; FEMALE; HUMANS; MALE; METABOLIC DISEASES; PERICARDIUM;

EID: 84898825259     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-013-0099-4     Document Type: Review

References (50)

1. G. Iacobellis, A.C. Bianco, Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features. Trend. Endocrinol. Metab. 22, 450-457 (2011)
2. G. Iacobellis, D. Corradi, A.M. Sharma, Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat. Clin. Pract. Cardiovasc. Med. 2, 536-543 (2005)
3. P. Iozzo, Myocardial, perivascular, and epicardial fat. Diabetes Care 34(Suppl 2), S371-S379 (2011)
4. G. Iacobellis, Epicardial and pericardial fat: close, but very different. Obesity 17, 625 (2009)
5. J.M. Marchington, C.A. Mattacks, C.M. Pond, Adipose tissue in the mammalian heart and pericardium; structure, foetal development and biochemical properties. Comp. Biochem. Physiol. 94B, 225-232 (1989)
6. H.S. Sacks, J.N. Fain, Human epicardial adipose tissue: a review. Am. Heart J. 153, 907-917 (2007)
7. T. Mazurek, L. Zhang, A. Zalewski, J.D. Mannion, J.T. Diehl, H. Arafat, Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 108, 2460-2466 (2003)
8. C. Bambace, M. Telesca, E. Zoico, A. Sepe, D. Olioso, A. Rossi, F. Corzato, V. Di Francesco, A. Mazzucco, F. Santini, M. Zamboni, Adiponectin gene expression and adipocyte diameter: a comparison between epicardial and subcutaneous adipose tissue in men. Cardiovasc. Pathol. 20(5), 153-156 (2010)
9. J.S. Judkin, E. Eringa, C.D.A. Stehouwer, "Vasocrine signalling" from perivascular fat: a mechanism linking insulin resistance to vascular disease. Lancet 365, 1817-1820 (2005)
10. J.M. Marchington, C.M. Pond, Site-specific properties of peri-cardial and epicardial adipose tissue. The effects of insulin and high-fat feeding on lipogenesis and the incorporation of fatty acids in vitro. Int. J. Obes. 14, 1013-1022 (1990)
11. M. Pezeshkian, M. Noori, H. Najjarpour-Jabbari, A. Abolfathi, M. Darabi, M. Darabi, M. Shaaker, G. Shahmohammadi, Fatty acid composition of epicardial and subcutaneous human adipose tissue. Metab. Syndr. Relat. Disord. 7, 125-131 (2009)
12. B. Vural, F. Atalar, C. Ciftci, A. Demirkan, B. Susleyici-Duman, D. Gunay, Presence of fatty-acid-binding protein 4 expression in human epicardial adipose tissue in metabolic syndrome. Cardio-vasc. Pathol. 17, 392-398 (2008)
13. H.S. Sacks, J.N. Fain, B. Holman, P. Cheema, A. Chary, F. Parks, Uncoupling protein-1 and related mRNAs in human epicardial and other adipose tissues: epicardial fat functioning as brown fat. J. Clin. Endocrinol. Metab. 94, 3611-3615 (2009)
14. A.M. Cypess, S. Lehman, G. Williams, I. Tal, D. Rodman, A.B. Goldfine, F.C. Kuo, E.L. Palmer, Y.H. Tseng, A. Doria, G.M. Kolodny, Kahn CR Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 360, 1509-1517 (2009)
15. H.S. Sacks, J.N. Fain, S.W. Bahouth, S. Ojha, A. Frontini, H. Budge, S. Cinti, M.E. Symonds, Adult epicardial fat exhibits beige features. J. Clin. Endocrinol. Metab. 98(9), 1448-1455 (2013)
16. G. Iacobellis, H.J. Willens, G. Barbaro, A.M. Sharma, Threshold values of high-risk echocardiographic epicardial fat thickness. Obesity (Silver Spring) 16, 887-892 (2008)
17. G. Iacobellis, H.J. Willens, Echocardiographic epicardial fat: a review of research and clinical applications. J. Am. Soc. Echo-cardiogr. 22, 1311-1319 (2009)
18. G. Iacobellis, F. Assael, M.C. Ribaudo, A. Zappaterreno, G. Alessi, U. Di Mario, F. Leonetti, Epicardial fat from echocardi-ography: a new method for visceral adipose tissue prediction. Obes. Res. 11, 304-310 (2003)
19. G. Iacobellis, M.C. Ribaudo, F. Assael, E. Vecci, C. Tiberti, A. Zappaterreno, U. Di Mario, Leonetti F Echocardiographic epi-cardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J. Clin. Endocrinol. Metab. 388, 5163-5168 (2003)
20. A.E. Malavazos, G. Di Leo, F. Secchi, E.N. Lupo, G. Dogliotti, C. Coman, L. Morricone, M.M. Corsi, F. Sardanelli, G. Iaco-bellis, Relation of echocardiographic epicardial fat thickness and myocardial fat. Am. J. Cardiol. 105, 1831-1835 (2010)
21. M. Kankaanpää, H.R. Lehto, J.P. Pärkkä, M. Komu, A. Viljanen, E. Ferrannini, J. Knuuti, P. Nuutila, R. Parkkola, P. Iozzo, Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels. J. Clin. Endocrinol. Metab. 91, 4689-4695 (2006)
22. G. Iacobellis, M.C. Ribaudo, A. Zappaterreno, C.V. Iannucci, F. Leonetti, Relation between epicardial adipose tissue and left ventricular mass. Am. J. Cardiol. 94, 1084-1087 (2004)
23. G. Iacobellis, Relation of epicardial fat thickness to right ventricular cavity size in obese subjects. Am. J. Cardiol. 104, 1601-1602 (2009)
24. G. Iacobellis, N. Singh, S. Wharton, A.M. Sharma, Substantial changes in epicardial fat thickness after weight loss in severely obese subjects. Obesity 16, 1693-1697 (2008)
25. H.J. Willens, P. Byers, J.A. Chirinos, E. Labrador, J.M. Hare, E. de Marchena, Effects of weight loss after bariatric surgery on epicardial fat measured using echocardiography. Am. J. Cardiol. 99, 1242-1245 (2007)
26. M.K. Kim, T. Tomita, M.J. Kim, H. Sasai, S. Maeda, K. Tanaka, Aerobic exercise training reduces epicardial fat in obese men. J. Appl. Physiol. 106, 5-11 (2009)
27. B. Gaborit, A. Jacquier, F. Kober, I. Abdesselam, T. Cuisset, S. Boullu-Ciocca, O. Emungania, M.C. Alessi, K. Clément, M. Bernard, A. Dutour, Effects of bariatric surgery on cardiac ectopic fat: lesser decrease in epicardial fat compared to visceral fat loss and no change in myocardial triglyceride content. J. Am. Coll. Cardiol. 60, 1381-1389 (2012)
28. G. Iacobellis, G. Barbaro, Gerstein HC Relationship of epicardial fat thickness and fasting glucose. Int. J. Cardiol. 128, 424-426 (2008)
29. M. Cetin, M. Cakici, M. Polat, A. Suner, C. Zencir, I. Ardic, Relation of epicardial fat thickness with carotid intima-media thickness in patients with type 2 diabetes mellitus. Int. J. Endo-crinol. 2013, 769175 (2013)
30. M. Pezeshkian, M.R. Mahtabipour, Epicardial and subcutaneous adipose tissue Fatty acids profiles in diabetic and non-diabetic patients candidate for coronary artery bypass graft. Bioimpacts 3, 83-89 (2013)
31. G. Iacobellis, F. Leonetti, Epicardial adipose tissue and insulin resistance in obese subjects. J. Clin. Endocrinol. Metab. 90, 6300-6302 (2005)
32. M. Manco, A. Morandi, M. Marigliano, F. Rigotti, R. Manfredi, C. Maffeis, Epicardial fat, abdominal adiposity and insulin resistance in obese pre-pubertal and early pubertal children. Atherosclerosis 226, 490-495 (2013)
33. H.J. Willens, O. Gómez-Marín, J.A. Chirinos, R. Goldberg, M.H. Lowery, G. Iacobellis, Comparison of epicardial and pericardial fat thickness assessed by echocardiography in African American and non-hispanic white men: a pilot study. Ethn. Dis. 18, 311-316 (2008)
34. S.S. Salami, M. Tucciarone, R. Bess, A. Kolluru, S. Szpunar, H. Rosman, G. Cohen, Race and epicardial fat: the impact of anthropometric measurements, percent body fat and sex. Ethn. Dis. 23, 281-285 (2013)
35. M. Bluher, Vaspin in obesity and diabetes: pathophysiological and clinical significance. Endocrine 41, 176-182 (2012)
36. S. Greulich, B. Maxhera, G. Vandenplas, D.H. de Wiza, K. Smiris, H. Mueller, J. Heinrichs, M. Blumensatt, C. Cuvelier, P. Akhyari, J.B. Ruige, D.M. Ouwens, J. Eckel, Secretory products from epicardial adipose tissue of patients with type 2 diabetes mellitus induce cardiomyocyte dysfunction. Circulation 126, 2324-2334 (2012)
37. D. Yazici, B. Özben, D. Yavuz, O. Deyneli, H. Aydin, Ö. Tarcin, S. Akalin, Epicardial adipose tissue thickness in type 1 diabetic patients. Endocrine 40, 250-255 (2011)
38. D.P. Momesso, I. Bussade, M.A. Epifanio, C.D. Schettino, L.A. Russo, R. Kupfer, Increased epicardial adipose tissue in type 1 diabetes is associated with central obesity and metabolic syndrome. Diabetes Res. Clin. Pract. 91, 47-53 (2011)
39. J.H. Park, Y.S. Park, Y.J. Kim, I.S. Lee, J.H. Kim, J.H. Lee et al., Effects of statins on the epicardial fat thickness in patients with coronary artery stenosis underwent percutaneous coronary intervention: comparison of atorvastatin with simvastatin/ezetimibe. J. Cardiovasc. Ultrasound. 18, 121-126 (2010)
40. N. Alexopoulos, B.H. Melek, C.D. Arepalli, G.R. Hartlage, Z. Chen, S. Kim, A.E. Stillman, P. Raggi, Effect of intensive versus moderate lipid-lowering therapy on epicardial adipose tissue in hyperlipidemic post-menopausal women: a substudy of the BELLES trial (Beyond Endorsed Lipid Lowering with EBT Scanning). J. Am. Coll. Cardiol. 61, 1956-1961 (2013)
41. L. Nasarre, O. Juan-Babot, P. Gastelurrutia, A. Llucia-Vallde-peras, L. Badimon, A. Bayes-Genis, V. Llorente-Cortés, Low density lipoprotein receptor-related protein 1 is upregulated in epicardial fat from type 2 diabetes mellitus patients and correlates with glucose and triglyceride plasma levels. Acta Diabetol. (2012)
42. H.S. Sacks, J.N. Fain, P. Cheema, S.W. Bahouth, E. Garrett, R.Y. Wolf, Inflammatory genes in epicardial fat contiguous with coronary atherosclerosis in the metabolic syndrome and type 2 diabetes: changes associated with pioglitazone. Diabetes Care 34, 730-733 (2011)
43. E. Distel, G. Penot, T. Cadoudal, I. Balguy, S. Durant, C. Benelli, Early induction of a brown-like phenotype by rosiglitazone in the epicardial adipose tissue of fatty Zucker rats. Biochimie 94, 1660-1667 (2012)
44. T. Shimasaki, T. Masaki, K. Mitsutomi, D. Ueno, K. Gotoh, S. Chiba, T. Kakuma, Yoshimatsu H The dipeptidyl peptidase-4 inhibitor des-fluoro-sitagliptin regulates brown adipose tissue uncoupling protein levels in mice with diet-induced obesity. PLoS One 8, e63626 (2013)
45. S.D. Pierdomenico, A.M. Pierdomenico, F. Cuccurullo, G. I-acobellis, Metaanalysis of the relation of echocardiographic epicardial adipose tissue thickness and the metabolic syndrome. Am. J. Cardiol. 15, 1234-1236 (2012)
46. G. Iacobellis, L. Petramala, G. Barbaro, A.Y. Kargi, V. Serra, L. Zinnamosca, L. Colangelo, C. Marinelli, A. Ciardi, G. De Toma, C. Letizia, Epicardial fat thickness and left ventricular mass in subjects with adrenal incidentaloma. Endocrine 44(2), 532-536 (2013)
47. R. Lanes, A. Soros, K. Flores, P. Gunczler, E. Carrillo, J. Bandel, Endothelial function, carotid artery intima-media thickness, epi-cardial adipose tissue, and left ventricular mass and function in growth hormone-deficient adolescents: apparent effects of growth hormone treatment on these parameters. J. Clin. Endocrinol. Metab. 90, 3978-3982 (2005)
48. E. Ferrante, A.E. Malavazos, C. Giavoli, F. Ermetici, C. Coman, S. Bergamaschi, E. Profka, S. Briganti, C.L. Ronchi, E. Passeri, S. Corbetta, A.G. Lania, A. Spada, G. Iacobellis, B. Ambrosi, P. Beck-Peccoz, Epicardial fat thickness significantly decreases after short-term growth hormone (GH) replacement therapy in adults with GH deficiency. Nutr. Metab. Cardiovasc. Dis. 23, 459-465 (2013)
49. S. Borruel, E. Fernández-Durán, M. Alpañés, D. Martí, F. Alvarez-Blasco, M. Luque-Ramírez, H.F. Escobar-Morreale, Global adiposity and thickness of intraperitoneal and mesenteric adipose tissue depots are increased in women with polycystic ovary syndrome (PCOS). J. Clin. Endocrinol. Metab. 98, 1254-1263 (2013)
50. E. Cakir, M. Doǧan, O. Topaloglu, M. Ozbek, E. Cakal, M.G. Vural, E. Yeter, T. Delibasi, Subclinical atherosclerosis and hy-perandrogenemia are independent risk factors for increased epi-cardial fat thickness in patients with PCOS and idiopathic hirsutism. Atherosclerosis 226, 291-295 (2013)