Harmaline-induced tremor and impairment of learning are both blocked by dizocilpine in the rabbit

Brain Research

Volumn 745, Issue 1-2, 1997, Pages 183-188

  Du, Wei ^a   Harvey, John A ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Dizocilpine; Hannaline; Inferior olive; Nicitating membrane response; Rabbit; Tremor

Indexed keywords

DIZOCILPINE; HARMALINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; INFERIOR OLIVE; MALE; NICTITATING MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SUBCUTANEOUS DRUG ADMINISTRATION; TREMOR;

ANIMALS; CONDITIONING, CLASSICAL; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; HARMALINE; LEARNING DISORDERS; MALE; MOTOR ACTIVITY; NICTITATING MEMBRANE; OLIVARY NUCLEUS; RABBITS; RECEPTORS, N-METHYL-D-ASPARTATE; TREMOR;

EID: 0031035686     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01148-1     Document Type: Article

References (37)

1. Audinat, E., Knopfel, T. and Gahwiler, B.H., Responses to excitatory amino acids of Purkinje cells's and neurones of the deep nuclei in cerebellar slice cultures, J. Physiol., 430 (1990) 297-313.
2. Barragan, L.A. and Delhaye-Bouchaud, N., Harmaline-induced activation of the olivo-cerebellar system in young rabbits: further evidence for a transient multiinnervation of purkinje cells by climbing fibers, Neuropharmacology, 19 (1980) 305-310.
3. Cox, J., Guthrie, R., Macrae, M. and Kehoe, E.J., MK801 impairs acquisition and expression of conditioned responses in the rabbit nictitating membrane preparation, Psychobiology, 22 (1994) 156-166.
4. Demer, J.L. and Robinson, D.A., Effects of reversible lesions and stimulation of olivocerebellar system on vestibulo-ocular reflex plasticity, J. Neurophysiol., 47 (1982) 1084-1107.
5. de Montigny, C. and Lamarre, Y., Rhythmic activity induced by harmaline in the olive-cerebello-bulbar system of the cat, Brain Res., 53 (1973) 81-95.
6. Haddad, G.M., Demer, J.L. and Robinson, D.A., The effects of lesions of the dorsal cap of the inferior olive on the vestibulo-ocular and optokinetic system of the cat, Brain Res., 185 (1980) 265-275.
7. Harvey, J.A. and Romano, A.G., Harmaline-induced impairment of Pavlovian conditioning in the rabbit, J. Neurosci., 13 (1993) 1616-1623.
8. Harvey, J.A. and Welsh, J.P., Learning and performance: A critical review of the role of the cerebellum in instrumental and classical conditioning. In J. Bloedel, T.J. Ebner and S.P. Wise (Eds.), The Acquisition of Motor Behavior in Vertebrates, MIT Press, Cambridge, 1996, pp. 115-141.
9. Hernandez, L.L., Valentine, J.D. and Powell, D.A., Ethanol enhancement of Pavlovian conditioning, Behav. Neurosci., 100 (1986) 494-503.
10. Lamarre, Y., de Montigny, C. and Weiss, D.M., Harmaline-induced rhythmic activity of cerebellar and lower brain stem neurons, Brain Res., 32 (1971) 246-250.
11. Lamarre, Y. and Mercier, L., Neurophysiological studies of harmaline-induced tremor in the cat, Can. J. Physiol. Pharmacol., 49 (1971) 1049-1058.
12. Llinás, R. and Volkind, R.A., The olivo-cerebellar system: functional properties as revealed by harmaline-induced tremor, Exp. Brain Res., 18 (1973) 69-87.
13. LlinaÆs, R., Walton, K., Hillman, D.E. and Sotelo, C., Inferior olive: its role in motor learning, Science, 190 (1975) 1230-1231.
14. Mash, D.C., Staley, J.K., Pablo, J.P., Holohean, A.M., Hackman, J.C. and Davidoff, R.A., Properties of ibogaine and its principal metabolite (12-hydroxyibogamine) at the MK-801 binding site of the NMDA receptor complex, Neurosci. Lett., 192 (1995) 53-56.
15. 3H]glutamate-binding sites in rat brain, J. Neurosci., 5 (1985) 2909-2919.
16. Neuner, A. and Tappeiner, H., Über bei Wirkungen der alkaloide von Peganum harmala sonders der harmalins, Arch. Exp. Pathol. Pharmakol., 35 I (1894) 69.
17. O'Hearn, E. and Molliver, M.E., Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline, Neuroscience, 55 (1993) 303-310.
18. O'Hearn, E. and Molliver, M.E., Glutamate receptors modulate ibogaine neurotoxicity, Soc. Neurosci. Abstr., 21 (1995) 1340.
19. Perkel, D.J., Hestrin, S., Sah, P. and Nicoll, R.A., Excitatory synaptic currents in Purkinje cells, Proc. R. Soc. Lond., 241 (1990) 116-121.
20. 3H]MK-801 binding to the NMDA receptor complex, Psychopharmacology, 114 (1994) 672-674.
21. Robinson, G.B., MK-801 retards acquisition of a classically conditioned response without affecting conditioning-related alterations in perforant path-granule cell synaptic transmission, Psychobiology, 21 (1993) 253-264.
22. Romano, A.G., Bormann, N.M. and Harvey, J.A., A unique enhancement of associative learning produced by methylenedioxyamphetamine, Behav. Pharmacol., 2 (1991) 225-231.
23. 3H]MK-801 binding sites in the normal human brainstem in relation to motor neuron disease, Brain Res., 572 (1992) 276-280.
24. Schmaltz, L.W. and Theios, J., Acquisition and extinction of a classically conditioned response in hippocampectomized rabbits, J. Comp. Physiol. Psychol., 79 (1972) 328-333.
25. Simantov, R., Snyder, S.H. and Oster-Granite, M.L., Harmaline-induced tremor in the rat: abolition by 3-acetylpyridine destruction of cerebellar climbing fibers, Brain Res., 131 (1976) 23-37.
26. Sinton, C.M., Krosser, B.I., Walton, K.D. and Llinás, R.R., The effectiveness of different isomers of octanol as blockers of harmaline-induced tremor, Pflügers Arch., 414 (1989) 31-36.
27. Sugihara, I., Lang, E.J. and Llinás, R., Serotonin modulation of inferior olivary oscillations and synchronicity: A multiple-electrode study in the rat cerebellum, Eur. J. Neurosci., 7 (1995) 521-534.
28. Sweetnam, P.M., Lancaster, J., Snowman, A., Collins, J.L., Perschke, S., Bauer, C. and Ferkany, J., Receptor binding profile suggests multiple mechanisms of action are responsible for ibogaine's putative anti-addictive activity, Psychopharmacology, 118 (1995) 369-376.
29. Thompson, L.T., Moskal, J.R. and Disterhoft, J.F., Hippocampus- dependent learning facilitated by a monoclonal antibody or D-cycloserine, Nature, 359 (1992) 638-642.
30. Trouvin, J.H., Jacqmin, P., Rouch, C., Lesne, M. and Jacquot, C., Benzodiazepine receptors are involved in tabernanthine-induced tremor: in vitro and in vivo evidence, Eur. J. Pharmcol., 140 (1987) 303-309.
31. Türker, K.S. and Miles, T.S., Harmaline disrupts acquisition of conditioned nictitating membrane responses, Brain Res. Bull., 13 (1984) 229-233.
32. Türker, K.S. and Miles, T.S., Climbing fiber lesions disrupt conditioning of the nictitating membrane response in the rabbit, Brain Res., 363 (1986) 376-378.
33. Weight, F.F., Aguayo, L.G., White, G., Lovinger, D.M. and Peoples, R.W., GABA-and glutamate-gated ion channels as molecular sites of alcohol and anesthetic action. In G. Biggio, A. Concas and E. Costa (Eds.), GABAergic Synaptic Transmission, Raven Press, New York, 1992, pp. 335-345.
34. Wilkinson, L., SYSTAT: The System for Statistics, SYSTAT, Evanston, IL, 1990.
35. Winer, B.J., Statistical Principles in Experimental Design, McGraw-Hill, New York, 1971.
36. Yeo, C.H., Hardiman, M.J. and Glickstein, M., Classical conditioning of the nictitating membrane response of the rabbit. IV. Lesions of the inferior olive, Exp. Brain. Res., 63 (1986) 81-92.
37. Zhang, N., Walberg, F., Laake, J.H., Meldrum, B.S. and Ottersen, O.P., Aspartate-like and glutamate-like immunoreactivities in the inferior olive and climbing fiber system: a light microscopic and semiquantatative electron microscopic study in rat and baboon (Papio anubis), Neuroscience, 38 (1990) 61-80.