Characterization of [125I]GLP-1(9-36), a novel radiolabeled analog of the major metabolite of glucagon-like peptide 1 to a receptor distinct from GLP1-R and function of the peptide in murine aorta

Life Sciences

Volumn 102, Issue 2, 2014, Pages 134-138

  Kuc, Rhoda E ^a   Maguire, Janet J ^a   Siew, Keith ^a   Patel, Sheena ^b   Derksen, David R ^b   Margaret Jackson, V ^b   O'Shaughnessey, Kevin M ^a   Davenport, Anthony P ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

Cyclic AMP; Glucagon like peptide 1 (GLP 1); Radioligand binding; Scintillation proximity assay; Vasoconstriction

Indexed keywords

CYCLIC AMP; DRUG DERIVATIVE; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 (9 36) AMIDE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE-1 (9-36)-AMIDE; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; PEPTIDE; RADIOACTIVE IODINE;

ANIMAL; ARTICLE; C57BL MOUSE; CHEMISTRY; CHO CELL LINE; CRICETULUS; FEMALE; GLUCAGON-LIKE PEPTIDE 1 (GLP-1); HAMSTER; HUMAN; MALE; METABOLISM; MOUSE; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; PROTEIN BINDING; RADIOLIGAND BINDING; SCINTILLATION PROXIMITY ASSAY; THORACIC AORTA; VASOCONSTRICTION;

CYCLIC AMP; GLUCAGON-LIKE PEPTIDE 1 (GLP-1); RADIOLIGAND BINDING; SCINTILLATION PROXIMITY ASSAY; VASOCONSTRICTION;

ANIMALS; AORTA, THORACIC; CHO CELLS; CRICETINAE; CRICETULUS; FEMALE; GLUCAGON-LIKE PEPTIDE 1; HUMANS; IODINE RADIOISOTOPES; MALE; MICE; MICE, INBRED C57BL; ORGAN CULTURE TECHNIQUES; PEPTIDES; PROTEIN BINDING; RECEPTORS, GLUCAGON;

EID: 84898811847     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2014.03.011     Document Type: Article

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