Immune subversion by Mycobacterium tuberculosis through CCR5 mediated signaling: Involvement of IL-10

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Das, Shibali ^a   Banerjee, Sayantan ^a   Majumder, Saikat ^a   Paul Chowdhury, Bidisha ^a   Goswami, Avranil ^b   Halder, Kuntal ^a   Chakraborty, Urmita ^b   Pal, Nishith K ^b,c   Majumdar, Subrata ^a  

^a BOSE INSTITUTE   (India)

^b INSTITUTE OF POST GRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

^c Malda Medical College   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; INTERLEUKIN 10; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; SMALL INTERFERING RNA; STAT3 PROTEIN; CCR5 PROTEIN, MOUSE; HLA ANTIGEN CLASS 2; IL10 PROTEIN, MOUSE; STAT3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FEMALE; GENE SILENCING; HOST; IMMUNE RESPONSE; IMMUNE SUBVERSION; IN VIVO STUDY; MACROPHAGE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; POSITIVE FEEDBACK; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; GENE EXPRESSION REGULATION; IMMUNE EVASION; IMMUNOLOGY; MICROBIOLOGY; TUBERCULOSIS;

ANIMALS; FEMALE; GENE EXPRESSION REGULATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNE EVASION; INTERLEUKIN-10; MACROPHAGES; MICE; MICE, INBRED BALB C; MYCOBACTERIUM TUBERCULOSIS; RECEPTORS, CCR5; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TUBERCULOSIS;

EID: 84898796213     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092477     Document Type: Article

References (47)

1. World Health Organization, WHO Report (2009) Global Tuberculosis Control epidemiology, Strategy, Financing, WHO, Geneva, 2009.
2. MadanLala R, Peixoto KV, Re F, Rengarajan J (2011) Mycobacterium tuberculosis Hip1 dampens macrophage proinflammatory responses by limiting toll-like receptor 2 activation. Infect Immun 79: 4828-4838.
3. Simmons G, Reeves JD, Hibbitts S, Stine JT, Gray PW, et al. (2000) Co-receptor use by HIV and inhibition of HIV infection by chemokine receptor ligands. Immunol Rev 177: 112-26.
4. Pai RK, Convery M, Hamilton TA, Boom WH, Harding CV (2003) Inhibition of IFN-c induced class-II transactivator expression by a 19 kDa Lipoprotein from Mycobacterium tuberculosis: a potential mechanism for immune evasion. J Immunol 171: 175-184. (Pubitemid 36745286)
5. Fulton SA, Reba SM, Pai RK, Pennini M, Torres M (2004) Inhibition of Major Histocompatibility Complex-II Expression and Antigen Processing in Murine Alveolar Macrophages by Mycobacterium bovis BCG and the 19-Kilodalton Mycobacterial Lipoprotein. Infect Immun 72: 2101-2110. (Pubitemid 38419923)
6. Lee B, Sharron M, Montaner LJ, Weissman D, Doms RW (1999) Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages. Proc Natl Acad Sci U S A 96: 5215-5220. (Pubitemid 29214563)
7. Beamer GL, Flaherty DK, Assogba BD, Stromberg P, Gonzalez-Juarrero M, et al. (2008) Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice. J Immunol 181: 5545-5550.
8. Huffnagle GB, McNeil LK, Mcdonald RA, Murphy JW, Toews GB (1999) Cutting edge: role of C-C chemokine receptor 5 in organ-specific and innate immunity to Cryptococcus neoformans. J Immunol 163: 4642-4646. (Pubitemid 29501222)
9. Aliberti J, Reis e Sousa C, Schito M, Hieny S, Wells T (2000) CCR5 provides a signal for microbial induced production of IL-12 by CD8 α dendritic cells. Nat Immunol 1: 83-87.
10. Yurchenko E, Tritt M, Hay V, Shevach EM, Belkaid Y (2006) CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence. J Exp Med 203: 2451-2460. (Pubitemid 44664615)
11. Moreira AP, Cavassani KA, MassaferaTristão FS, Campanelli AP, Martinez R (2008) CCR5-dependent regulatory T cell migration mediates fungal survival and severe immunosuppression. J Immunol 180: 3049-3056.
12. Wilkin TJ, Gulick RM (2012) CCR5 antagonism in HIV infection: current concepts and future opportunities. Annu Rev Med 63: 81-93.
13. Yang X, Jiao YM, Wang R, Ji YX, Zhang HW (2012) High CCR5 density on central memory CD4+ T cells in acute HIV-1 infection is mostly associated with rapid disease progression. PLoS One 7: 1-7.
14. Bhattacharyya S, Dey R, Majumder N, Bhattacharjee S, Majumdar S (2008) A novel approach to regulate experimental visceral leishmaniasis in murine macrophages using CCR5 siRNA. Scand J Immunol 67: 345-3453.
15. Hondalus MK, Bardarov S, Russell R, Chan J, Jacobs WR (2000) Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosis. Infect Immun 68: 2888-2898. (Pubitemid 30253869)
16. + T cells after airborne M. tuberculosis infection. J Exp Med 205: 2359-2368.
17. Fremond CM, Yeremeev V, Nicolle DM, Jacobs M, Quesniaux VF (2004) Fatal Mycobacterium tuberculosis infection despite adaptive immune response inthe absence of MyD88. J Clin Invest114: 1790-1799. (Pubitemid 40385535)
18. Majumdar S, Kane LH, Rossi MW (1993) Protein kinase C isotypes and signal transduction in human neutrophils: selective substrate specificity of calcium dependent b-PKC and novel calcium independent n-PKC. Biochim Biophys Acta 1176: 276-286. (Pubitemid 23113770)
19. Ghosh S, Bhattacharyya S, Sirkar M, Sa GS, Das T, et al. (2002) Leishmania donovani suppresses activator protein-1 and NF- kB in host macrophages via ceramide generation: involvement of extracellular signal regulated kinase. Infect Immun 70: 6828-6838. (Pubitemid 35387915)
20. Bhattacharya P, Gupta G, Majumder S, Adhikari A, Banerjee S, et al. (2011) Arabinosylated lipoarabinomannan skews Th2 phenotype towards Th1 during Leishmania infection by chromatin modification: involvement of MAPK signaling. PLoS One 6: 1-12.
21. Algood HM, Flynn JL (2004) CCR5 deficient mice control Mycobacterium tuberculosis infection despite increased pulmonary lymphocytic infiltration. J Immunol173: 3287-3296. (Pubitemid 39142037)
22. Tomkowicz B, Lee C, Ravyn V, Cheung R, Ptasznik A, et al. (2006) The Src kinase Lyn is required for CCR5 signaling in response to MIP-1b and R5 HIV-1 gp120 in human macrophages. Blood 108: 1145-1150. (Pubitemid 44232008)
23. Chan LL, Cheung BK, Li JC, Lau AS (2010) A role for STAT3 and cathepsin S in IL-10 downregulation of IFN-gamma-induced MHC class II molecule on primary human blood macrophages. J Leukoc Biol 88: 303-311.
24. Redpath S, Angulo A, Gascoigne NR, Ghazal P (1999) Murine cytomegalovirus infection down-regulates MHC class II expression on macrophages by induction of IL-10. J Immunol 162: 6701-6707. (Pubitemid 29309395)
25. Pai RK, Askew D, Boom HW, Harding CV (2002) Regulation of Class II MHC Expression in APCs: Roles of Types I, III, and IV Class II Transactivator. J Immunol 169: 1326-1333. (Pubitemid 34809175)
26. Houle M, Thivierge M, Le Gouill C, Stankovà J, Rola-Pleszczynski M (1999) IL-10 up-regulates CCR5 gene expression in human monocytes. Inflammation 23: 241-251. (Pubitemid 29301567)
27. Makuta Y, Sonoda Y, Yamamoto D, Funakoshi MT, Aizu-yokota E, et al. (2003) Interleukin-10-Induced CCR5 Expression in Macrophage Like HL-60 Cells: Involvement of Erk1/2 and STAT-3. Biol Pharm Bull 26: 1076-1081. (Pubitemid 40012567)
28. Fahey TJ, Tracey KJ, Tekamp OP, Cousens LS, Jones WG (1992) Macrophage Inflammatory Protein 1 Modulates Macrophage Function. J Immunol 148: 2764-2769.
29. Mayanja-Kizza H, Wajja A, Wu M, Peters P, Nalugwa G, et al. (2001) Activation of beta-chemokines and CCR5 in persons infected with human immunodeficiency virus type 1 and tuberculosis. J Infect Dis 183: 1801-1804. (Pubitemid 32523244)
30. Lande R, Giacomini E, Grassi T, Remoli ME, Iona E, et al. (2003) IFN-alpha beta released by Mycobacterium tuberculosis-infected human dendritic cells induces the expression of CXCL10: selective recruitment of NK and activated T cells. J Immunol 170: 1174-1182. (Pubitemid 36139480)
31. Parveen N, Varman R, Nair S, Das G, Ghosh S, et al. (2013) Endocytosis of Mycobacterium tuberculosis Heat Shock Protein 60 Is Required to Induce Interleukin-10 Production in Macrophages. J Biol Chem 288: 24956-24971.
32. Ferwerda G, Kullberg BJ, de Jong DJ, Girardin SE, Langenberg DM, et al. (2007) Mycobacterium paratuberculosis is recognized by Toll-like receptors and NOD2. J Leukoc Biol 824: 1011-1018. (Pubitemid 47511061)
33. Rosati M, Valentin A, Patenaude DJ, Pavlakis GN (2001) CCAAT-enhancer-binding protein beta (C/EBP beta) activates CCR5 promoter: increased C/EBP beta and CCR5 in T lymphocytes from HIV-1-infected individuals. J Immunol 167: 1654-1662. (Pubitemid 32703168)
34. Kuipers HF, Biesta PJ, Montagne LJ, Van Haastert ES, Van der Valk P, et al. (2008) CC chemokine receptor 5 gene promoter activation by the cyclic AMP response element binding transcription factor. Blood 112: 1610-1619.
35. Liu Y, Guo YL, Zhou SJ, Liu F, Du FJ, et al. (2010) CREB is a positive transcriptional regulator of gamma interferon in latent but not active tuberculosis infections. Clin Vaccine Immunol 17: 1377-1380.
36. Wieland CW, Koppel EA, Dunnen J, Florquin S, McKenzie AN, et al. (2007) Mice lacking SIGNR1 have stronger T helper 1 responses to Mycobacterium tuberculosis. Microbes Infect 9: 134-141. (Pubitemid 46227998)
37. Zimmerli S, Edwards S, Ernst JD (1996) Selective receptor blockade during phagocytosis does not alter the survival and growth of Mycobacterium tuberculosis in human macrophages. Am J Respir Cell Mol Biol 15: 760-770. (Pubitemid 126441449)
38. Schäfer G, Guler R, Murray G, Brombacher F, Brown GD (2009) The role of scavenger receptor B1 in infection with Mycobacterium tuberculosis in a murine model. PLoS One 4: 8448.
39. Green AM, Difazio R, Flynn JL (2013) IFN-γ from CD4 T cells is essential for host survival and enhances CD8 T cell function during Mycobacterium tuberculosis infection. J Immunol 190: 270-277.
40. Fulton SA, Reba SM, Pai RK, Pennini M, Torres M, et al. (2004) Inhibition of major histocompatibility complex II expression and antigen processing in murine alveolar macrophages by Mycobacterium bovis BCG and the 19-kilodalton mycobacterial lipoprotein. Infect Immun 72: 2101-2110. (Pubitemid 38419923)
41. Cho H, Lasco TM, Allen SS, Yoshimura T, McMurray DN (2005) Recombinant guinea pig tumor necrosis factor alpha stimulates the expression of interleukin-12 and the inhibition of Mycobacterium tuberculosis growth in macrophages. Infect Immun 73: 1367-1376. (Pubitemid 40470722)
42. Olleros ML, Guler R, Vesin D, Parapanov R, Marchal G, et al. (2005) Contribution of transmembrane tumor necrosis factor to host defense against Mycobacterium bovis bacillus Calmette-Guerin and Mycobacterium tuberculosis infections. Am J Pathol 166: 1109-20. (Pubitemid 40524435)
43. Roach DR, Bean AG, Demangel C, France MP, Briscoe H, et al. (2002) TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection. J Immunol 168: 4620-4627. (Pubitemid 34441368)
44. Harris J, Keane J (2010) How tumour necrosis factor blockers interfere with tuberculosis immunity. Clin Exp Immunol 161: 1-9.
45. Moore KW, Malefyt R, Coffman RL, O'Garra A (2001) Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19: 683-765. (Pubitemid 32368050)
46. O'Garra A, Barrat FJ, Castro AG, Vicari A, Hawrylowicz C (2008) Strategies for use of IL-10 or its antagonists in human disease. Immunol Rev 223: 114-131. (Pubitemid 351986180)
47. Pawlowski A, Jansson M, Sköld M, Rottenberg ME, Källenius G (2012) Tuberculosis and HIV co-infection. PLoS Pathog 8: 1-7.