High CCR5 Density on Central Memory CD4+ T Cells in Acute HIV-1 Infection Is Mostly Associated with Rapid Disease Progression

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Yang, Xue ^a   Jiao, Yan mei ^a   Wang, Rui ^a   Ji, Yun xia ^a   Zhang, Hong wei ^a   Zhang, Yong hong ^a   Chen, De xi ^a   Zhang, Tong ^a   Wu, Hao ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CELL PROTECTION; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE DURATION; EFFECTOR CELL; FLOW CYTOMETRY; HIGH RISK POPULATION; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; MALE; MALE HOMOSEXUAL; MEMORY T LYMPHOCYTE; PROGNOSIS; PROTEIN EXPRESSION; RECEPTOR DENSITY; VIRUS CELL INTERACTION; VIRUS LOAD;

ADULT; ANTIBODIES, MONOCLONAL; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; COHORT STUDIES; DISEASE PROGRESSION; FLOW CYTOMETRY; HIV ANTIGENS; HIV-1; HUMANS; MALE; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CCR5;

HUMAN IMMUNODEFICIENCY VIRUS 1; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 84869785259     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049526     Document Type: Article

References (27)

1. Ganesan A, Chattopadhyay PK, Brodie TM, Qin J, Gu W, et al. (2010) Immunologic and virologic events in early HIV infection predict subsequent rate of progression. J Infect Dis 201: 272-284.
2. Blattner WA, Oursler KA, Cleghorn F, Charurat M, Sill A, et al. (2004) Rapid clearance of virus after acute HIV-1 infection: correlates of risk of AIDS. J Infect Dis 189: 1793-1801.
3. Maddon PJ, Dalgleish AG, McDougal JS, Clapham PR, Weiss RA, et al. (1986) The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47: 333-348.
4. Clapham PR, Blanc D, Weiss RA, (1991) Specific cell surface requirements for the infection of CD4-positive cells by human immunodeficiency virus types 1 and 2 and by Simian immunodeficiency virus. Virology 181: 703-715.
5. Kalinkovich A, Borkow G, Weisman Z, Tsimanis A, Stein M, et al. (2001) Increased CCR5 and CXCR4 expression in Ethiopians living in Israel: environmental and constitutive factors. Clin Immunol 100: 107-117.
6. Pandrea I, Apetrei C, Gordon S, Barbercheck J, Dufour J, et al. (2007) Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hosts. Blood 109: 1069-1076.
7. Reynes J, Portales P, Segondy M, Baillat V, André P, et al. (2001) CD4 T cell surface CCR5 density as a host factor in HIV-1 disease progression. AIDS 15: 1627-1634.
8. Marmor M, Krowka J, Goldberg JD, (2000) CD4+ T cell surface CCR5 density and virus load in persons infected with human immunodeficiency virus type 1. J Infect Dis 182: 1284-1286.
9. Reynes J, Portales P, Segondy M, Baillat V, André P, et al. (2000) CD4+ T cell surface CCR5 density as a determining factor of virus load in persons infected with human immunodeficiency virus type 1. J Infect Dis 181: 927-932.
10. Brenchley JM, Hill BJ, Ambrozak DR, Price DA, Guenaga FJ, et al. (2004) T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis. J Virol 78: 1160-1168.
11. Heeregrave EJ, Geels MJ, Brenchley JM, Baan E, Ambrozak DR, et al. (2009) Lack of in vivo compartmentalization among HIV-1 infected naive and memory CD4+ T cell subsets. Virology 393: 24-32.
12. Bleul CC, Wu L, Hoxie JA, Springer TA, Mackay CR, (1997) The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc Natl Acad Sci U S A 94: 1925-1930.
13. Groot F, van Capel TM, Schuitemaker J, Berkhout B, de Jong EC, (2006) Differential susceptibility of naive, central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission. Retrovirology 3: 52.
14. Lanzavecchia A, Sallusto F, (2005) Understanding the generation and function of memory T cell subsets. Curr Opin Immunol 17: 326-332.
15. Picker LJ, Butcher EC, (1992) Physiological and molecular mechanisms of lymphocyte homing. Annu Rev Immunol 10: 561-591.
16. Eckstein DA, Penn ML, Korin YD, Scripture-Adams DD, Zack JA, (2001) HIV-1 actively replicates in naive CD4(+) T cells residing within human lymphoid tissues. Immunity 15: 671-682.
17. Heeregrave EJ, Geels MJ, Baan E, van der Sluis RM, Paxton WA, et al. (2010) Varied sensitivity to therapy of HIV-1 strains in CD4+ lymphocyte sub-populations upon ART initiation. AIDS Res Ther 7: 42.
18. Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, et al. (2007) Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection. J Exp Med 204: 2171-2185.
19. Letvin NL, Mascola JR, Sun Y, Gorgone DA, Buzby AP, et al. (2006) Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys. Science 312: 1530-1533.
20. Potter SJ, Lacabaratz C, Lambotte O, Perez-Patrigeon S, Vingert B, et al. (2007) Preserved central memory and activated effector memory CD4+ T-cell subsets in human immunodeficiency virus controllers: an ANRS EP36 study. J Virol 81: 13904-13915.
21. Hua W, Jiao Y, Zhang H, Zhang T, Chen D, et al. (2012) Central memory CD4 cells are an early indicator of immune reconstitution in HIV/AIDS patients with anti-retroviral treatment. Immunol Invest 41: 1-14.
22. Muñoz-Calleja C, Costantini A, Silvestri G, Butini L, Regnery CM, et al. (2001) Highly active antiretroviral therapy induces specific changes in effector and central memory T cell sub-populations. AIDS 15: 1887-1890.
23. Kolber M A, (2008) CD38+CD8+ T-cells negatively correlate with CD4 central memory cells in virally suppressed HIV-1-infected individuals. AIDS 22: 1937-1941.
24. Paiardini M, Cervasi B, Reyes-Aviles E, Micci L, Ortiz AM, et al. (2011) Low levels of SIV infection in sooty mangabey central memory CD(4)(+) T cells are associated with limited CCR5 expression. Nat Med 17: 830-836.
25. Mannioui A, Bourry O, Sellier P, Delache B, Brochard P, et al. (2009) Dynamics of viral replication in blood and lymphoid tissues during SIVmac251 infection of macaques. Retrovirology 6: 106.
26. Sabado RL, O'Brien M, Subedi A, Qin L, Hu N, et al. (2010) Evidence of dysregulation of dendritic cells in primary HIV infection. Blood 116: 3839-3852.
27. Fiebig EW, Wright DJ, Rawal BD, Garrett PE, Schumacher RT, et al. (2003) Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection. AIDS 17: 1871-1879.